Celiac disease (or coeliac disease) is a chronic, immune-mediated intestinal disorder, in which the body becomes intolerant to gliadin, which is a component of gluten. Individuals with celiac disease exhibit a lifelong intolerance of wheat, barley and rye – all of which contain prolamins.
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Nov 7, 2014 · Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food.
Jan 8, 2021 · Gliadins, rather than glutenins, have been implicated as being responsible for the onset of the inflammatory and immune responses in celiac ...
Gliadin is a glycoprotein extract from gluten that is believed to be directly toxic to the enterocytes of individuals with celiac disease, primarily through the ...
Dec 11, 2014 · In people who have celiac disease, the antibodies that are produced to attack dangerous substances also attack gliadin as well as tissue tTG.
Jul 17, 2018 · Association between innate response to gliadin and activation of pathogenic T cells in celiac disease. Lancet 362, 30–37 (2003). Article ...
This review covers the current knowledge of the role of gliadin peptides in CD disorders that are characterized by intraepithelial T-cells infiltration (IEL).
Feb 4, 2020 · Celiac disease could be treated, and potentially cured, by restoring T-cell tolerance to gliadin. We investigated the safety and efficacy of ...
We showed that the intestinal epithelium derived from celiac disease donors releases anti-inflammatory factors that curb the macrophage response to gliadin.
