US2564400A - Atomizer - Google Patents

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US2564400A
US2564400A US124440A US12444049A US2564400A US 2564400 A US2564400 A US 2564400A US 124440 A US124440 A US 124440A US 12444049 A US12444049 A US 12444049A US 2564400 A US2564400 A US 2564400A
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container
air
liquid
nozzle
spray
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US124440A
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Victor C Hall
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Sharp and Dohme Inc
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Sharp and Dohme Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/08Inhaling devices inserted into the nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0021Mouthpieces therefor
    • A61M15/0025Mouthpieces therefor with caps
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/04Deformable containers producing the flow, e.g. squeeze bottles
    • B05B11/042Deformable containers producing the flow, e.g. squeeze bottles the spray being effected by a gas or vapour flow in the nozzle, spray head, outlet or dip tube
    • B05B11/043Deformable containers producing the flow, e.g. squeeze bottles the spray being effected by a gas or vapour flow in the nozzle, spray head, outlet or dip tube designed for spraying a liquid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/30Dip tubes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S239/00Fluid sprinkling, spraying, and diffusing
    • Y10S239/19Nozzle materials

Definitions

  • This invention relates to atomizers, and more particularly to an atomizer for spraying medicated liquids through the nasal cavities.
  • the article of the invention also is useful to supply drops of the medicated liquid.
  • Atomizers for spraying medicated liquids into the nose are old in the art. However, they have had the disadvantage that the spray from the atomizer generally diverges to such an extent that the liquid is deposited upon the interior Walls of the nose immediately adjacent to the nozzle of the atomizer. This has been objectionable because such liquid performs no useful function at this site, and moreover will not remain upwardly within the nostril.
  • a foremost feature of the present invention is the construction of an atomizer which overcomes the tendency of the usual atomizer to produce a divergent spray.
  • the spray is confined to a small size, and because of this, the spray is carried upwardly into the nasal passageways to the uppermost portions thereof where the medication is principally desired. This has the further important advantage that the liquid does not run downwardly out of the nasal passageways.
  • the spray delivered from the nozzle of the atomizer is confined within an enveloping stream of air.
  • This enveloping stream of air serves as a shield between the spray itself and the immediately adjacent surfaces of the interior of the nose so that the spray does not reach these nasal surfaces. It will therefore be seen that this enveloping body of air serves as a protecting sheath which directs the spray upwardly against the higher nasal surfaces where the medication is intended to perform its therapeutic function. It will be appreciated that due to the fact that the enveloping stream of air carries the spray upwardly to the desired surfaces in the nose, a lesser amount of medication is used. That is, the medicated liquid is not deposited upon the lower portions of the nasal passageway where it performs no, or but very slight, useful function, and in most instances merely runs downwardly out of the nose.
  • Figure 1 illustrates the general mode of using the device.
  • Figure 2 is an elevational view, the uppermost and lowermost portions bein broken away to show the structure.
  • Figure 3 is a vertical, sectional view through the device showing its relationship to the lower portion of a nose.
  • Figure 4 is a sectional view on the line 4--4 of Figure 3
  • Figure 5 is a sectional view on the line 5-5 of Figure 3.
  • the medicated liquid which is to be sprayed is retained within the container [0.
  • This container is preferably made of a material which is of sufliciently elastic charactenthat its side walls can be compressed in order to eject the contained liquid.
  • a preferred material for the container I0 is polyethylene, inasmuch as this plastic is highly resistant to the liquids which will ordinarily be used and because of its elastic properties.
  • other plastics, and even metals may be used as the material for making the container [0 so long as at least a portion of its walls is compressible so that an internal pressure may be created to serve to eject the liquid.
  • a cap H is affixed to the open top mouth of the container IE.
  • the top of the container ID is formed with a reduced neck portion, as is best shown in Figure 3.
  • the cap II is screw threaded upon the exterior of the neck portion of the container in, but it is to be understood that this is not an essential mode of attachment. Thus, it is possibleto'merely relay upon an internal or external frictional fit if this should be desired, but the screw thread attachment illustrated has the advantage of minimizing accidental separation of the two parts.
  • a generally dome-shaped projection l3 Upon the upper side of the cap II is a generally dome-shaped projection l3.
  • the topmost surface of this projection 13 is of generally conical or rounded formation so that it will fit upwardly into the nostril openings of varying sizes. This relationship is shown in Figure 3, the walls of the nose beingindicated at M.
  • This domeshancd projection It therefore serves as a nosefitting body.
  • annular passageway 15 Within the dome-shaped projection 13 is an annular passageway 15. It will be noted that this annular passageway [5 leaves standing a centrally located nozzle H5.
  • the nozzle l6 therefore is an upwardly projecting formation which preferably extends above the top most edge of the rounded surface of the dome-shaped projection
  • the annular passageway l5 which surrounds the upwardly projecting nozzle l6 therefore opens outwardly in an upward direction, and this passageway
  • Lateral passageways H are formed through the side wall of the lower portion of the dome-shaped projection 3. These laterally extending passageways Il provide a communication between the annular passageway
  • a bore I8 Extending axially through the nozzle I6 is a bore I8. At the topmost end of the nozzle I6, this bore I8 is of reduced size to form the nozzle opening I9. It will be noted from Figure 3 that the top of the nozzle I6 is slightly recessed, and this is preferable so that the nozzle opening I9 will be slightly below the topmost surface or the nozzle IS. The advantage of this arrangement will be made clear hereinafter.
  • Fitting within the bore I8 is a stem 2
  • is flattened at one or more places on its side, as is best shown in Figure 5, so that passageways 22 are formed upwardly alongside of the stem 2
  • terminates at its top sufficiently below the nozzle opening
  • has an axial opening 24 therethrough.
  • a tube 25 fits tightly upwardly within this opening 24.
  • the tube 25 extends downwardly to the bottom of the container l0 so that its lowermost opening is within the medicated liquid retained therein.
  • the liquid When the liquid is forced upwardly through the tube 25, therefore, it flows upwardly through the opening 24, through the stem 2
  • the interior bottom wall of the container l0 slopes downwardly to a sump 2B.
  • the provision of this sump 26 is not essential, but it is desirable so that only a minimum amount of liquid will not be completely removed from the container l0.
  • a closure 27 is provided to enclose the cap I I when the atomizer is not inuse.
  • This closure 2! is preferably screwed upon the threads 28 upon the exterior of the drum-shaped projection I3, but it is apparent that a frictional fit may suffice.
  • Within the closure 2! is a small projection 29 which bears against the surface around the nozzle opening l9 to form a fluid-tight fit. It is therefore apparent that even when the device is inverted, liquid cannot escape when the closure 21 is in place.
  • the medicated liquid is placed within the container I0 after removal of the cap
  • pressure is created within the container II).
  • This pressure serves to force some liquid up through the tube 25 and into the mixing chamber 23.
  • air is forced into the mixing chamber 23 through the passageways IS.
  • the intermingling of this air and liquid within the mixing chamber 23 serves to break the liquid up into droplets, and these droplets are ejected through the nozzle opening l9.
  • the intermixing of the air and liquid within the chamber 23 is made more complete and a resulting fine spray issues from the nozzle opening IS.
  • the dome-shaped protuberance I3 is, of course, applied to the nose M in substantial airtight relationship.
  • air should be inhaled into the nose.
  • This in,- halation of air draws the external atmospheric air inwardly through the lateral openings I! and upwardly through the annular passageway l5.
  • Due to the relative length of the annular passageway l5, the air stream is guided upwardly closely around the nozzle l6. It will therefore be seen that this air stream issuing upwardly through the annular passageway l5 serves as an envelopin shield between the spray from the nozzle opening I9 and the immediately adjacent internal surfaces of the nose l4. Due to the slightly lowered position of the nozzle opening I9, this surrounding stream of air is shielded from the opening 3 so that it does not tend to divert the liquid being sprayed.
  • the spray is carried in its entirety upwardly to the nasal passageways which are desiredto be treated.
  • the liquid will be deposited at these higher portions of the nasal passageways and none, or practically none, of it will be deposited upon the lower surfaces of the nasal passageway, no liquid will run downwardly out of the nose.
  • and the closure 2'! are. preferably made of a plastic material such, for example, as polystyrene. However, it is apparent that other plastics such as phenolic resins, and even metal, may be used as the material for making these parts.
  • the tube 25 is preferably made of polyethylene, but is may as Well be made of a plastic or metal or may be made of rubber.
  • the atomizer of the invention serves to confine the spray, when the spray is inhaled through the nasal cavity, nearly all of the medicament will be carried down into the respiratory system. Asa consequence of this, as has been pointed out, Very little of the medicament remains in the nostril openings.
  • An atomizer comprising a container, a cap on the container having a nose-fitting body, a nozzle disposed centrally of said body and separated therefrom by an annular passageway, said passageway being of substantially similar cross sectional area throughout its depth to thereby impart linear movement to the air flowing therethrough, conduit means for supplying liquid and air from within the container to said nozzle upon a rise of pressure within the container and for intermixing the liquid and air so that they issue as a spray from said nozzle, said body having a lateral opening from the atmosphere to said passageway so that external air may be inhaled through said body and an encircling stream of confining air having said linear flow will be formed around the spray.
  • An atomizer comprisin a collapsible container, a cap on the container having a, nosefitting body, a nozzle disposed centrally of said body and separated therefrom by an annular passageway, said passageway being of substantially similar cross sectional area throughout its depth to thereby impart linear movement to the air flowing therethrough, conduit means for supplying liquid and air from within the container to said nozzle upon an increase of pressure in the container and for intermixing the liquid and air so that they issue as a spray from said nozzle, said body having a lateral opening from the atmosphere to said passageway so that external air may be inhaled through said body and an encircling stream of confining air havin said linear flow will be formed around the spray.
  • An atomizer comprising a, nose-fitting body, a nozzle disposed centrally of said body and sepa rated therefrom by an annular passageway, said passageway being of substantially similar cross sectionl area throughout its full extent and to its discharge opening to impart linear movement to the air flowing therethrough and issuing therefrom, said body having an opening from the atmosphere to said passageway so that external air may be inhaled through said body, means for admixing liquid and air for ejection as a spray of liquid through said nozzle, said passageway serving to encircle said spray with a confining stream of inhaled air having said linear flow generally parallel to the direction of flow of the spray from the nozzle.

Description

Patented Aug. 14, 1951 ATOMIZER Victor C. Hall, Media, Pa., assignor to Sharp &
Dohme, Incorporated, Philadelphia, Pa., a corporation ofMaryland Application October 29, 1949, Serial N0. 124,440
3 Claims.
This invention relates to atomizers, and more particularly to an atomizer for spraying medicated liquids through the nasal cavities. The article of the invention also is useful to supply drops of the medicated liquid.
Atomizers for spraying medicated liquids into the nose are old in the art. However, they have had the disadvantage that the spray from the atomizer generally diverges to such an extent that the liquid is deposited upon the interior Walls of the nose immediately adjacent to the nozzle of the atomizer. This has been objectionable because such liquid performs no useful function at this site, and moreover will not remain upwardly within the nostril.
A foremost feature of the present invention, therefore, is the construction of an atomizer which overcomes the tendency of the usual atomizer to produce a divergent spray. With the device of the present invention, the spray is confined to a small size, and because of this, the spray is carried upwardly into the nasal passageways to the uppermost portions thereof where the medication is principally desired. This has the further important advantage that the liquid does not run downwardly out of the nasal passageways.
In accordance with the invention, the spray delivered from the nozzle of the atomizer is confined within an enveloping stream of air. This enveloping stream of air serves as a shield between the spray itself and the immediately adjacent surfaces of the interior of the nose so that the spray does not reach these nasal surfaces. It will therefore be seen that this enveloping body of air serves as a protecting sheath which directs the spray upwardly against the higher nasal surfaces where the medication is intended to perform its therapeutic function. It will be appreciated that due to the fact that the enveloping stream of air carries the spray upwardly to the desired surfaces in the nose, a lesser amount of medication is used. That is, the medicated liquid is not deposited upon the lower portions of the nasal passageway where it performs no, or but very slight, useful function, and in most instances merely runs downwardly out of the nose.
' A. preferred embodiment of the atomizer of the invention is disclosed in the accompanying drawings in which Figure 1 illustrates the general mode of using the device. Figure 2 is an elevational view, the uppermost and lowermost portions bein broken away to show the structure. Figure 3 is a vertical, sectional view through the device showing its relationship to the lower portion of a nose. Figure 4 is a sectional view on the line 4--4 of Figure 3, and. Figure 5 is a sectional view on the line 5-5 of Figure 3.
The medicated liquid which is to be sprayed is retained within the container [0. This container is preferably made of a material which is of sufliciently elastic charactenthat its side walls can be compressed in order to eject the contained liquid. A preferred material for the container I0 is polyethylene, inasmuch as this plastic is highly resistant to the liquids which will ordinarily be used and because of its elastic properties. However, it is to be understood that other plastics, and even metals, may be used as the material for making the container [0 so long as at least a portion of its walls is compressible so that an internal pressure may be created to serve to eject the liquid.
A cap H is affixed to the open top mouth of the container IE. For convenience, the top of the container ID is formed with a reduced neck portion, as is best shown in Figure 3. As here shown, the cap II is screw threaded upon the exterior of the neck portion of the container in, but it is to be understood that this is not an essential mode of attachment. Thus, it is possibleto'merely relay upon an internal or external frictional fit if this should be desired, but the screw thread attachment illustrated has the advantage of minimizing accidental separation of the two parts.
I The under side of the interior of the cap is formed with a generally conical protuberance l2. When the cap is screwed into place, the external surface of this protuberance l2 bears upon the container H), as shown in Figure 3, to estab- ,lish a liquid-tight seal. However, it is obvious that other fluid-tight arrangements may be used, such the provision of the ordinary sealing gasket.
Upon the upper side of the cap II is a generally dome-shaped projection l3. The topmost surface of this projection 13 is of generally conical or rounded formation so that it will fit upwardly into the nostril openings of varying sizes. This relationship is shown in Figure 3, the walls of the nose beingindicated at M. This domeshancd projection It therefore serves as a nosefitting body.
Within the dome-shaped projection 13 is an annular passageway 15. It will be noted that this annular passageway [5 leaves standing a centrally located nozzle H5. The nozzle l6 therefore is an upwardly projecting formation which preferably extends above the top most edge of the rounded surface of the dome-shaped projection |3 which fits against the nose. The advantage of this will be explained later.
The annular passageway l5 which surrounds the upwardly projecting nozzle l6 therefore opens outwardly in an upward direction, and this passageway |5 extends downwardly to the lowermost portion of the dome-shaped projection l3. Lateral passageways H are formed through the side wall of the lower portion of the dome-shaped projection 3. These laterally extending passageways Il provide a communication between the annular passageway |5 and the external atmosphere so that air may enter through the passageways I? and flow upwardly through the annular passageway |5.
Extending axially through the nozzle I6 is a bore I8. At the topmost end of the nozzle I6, this bore I8 is of reduced size to form the nozzle opening I9. It will be noted from Figure 3 that the top of the nozzle I6 is slightly recessed, and this is preferable so that the nozzle opening I9 will be slightly below the topmost surface or the nozzle IS. The advantage of this arrangement will be made clear hereinafter.
, Fitting within the bore I8 is a stem 2|. This is preferably a frictional fit so that the stem 2| will be retained in place. The stem 2| is flattened at one or more places on its side, as is best shown in Figure 5, so that passageways 22 are formed upwardly alongside of the stem 2| and within the nozzle projection l6. These flattened surfaces must extend downwardly sufficiently far along the stem 2| so that they open out below the cap so that the passageways 22 communicate with the interior of the container Ill.
The stem 2| terminates at its top sufficiently below the nozzle opening |8 to form a mixing chamber 23 at the uppermost portion of the enlarged part of the bore l8. It will therefore be seen that there is an open communication between the interior of the container l0 and the mixing chamber 23.
The stem 2| has an axial opening 24 therethrough. A tube 25 fits tightly upwardly within this opening 24. The tube 25 extends downwardly to the bottom of the container l0 so that its lowermost opening is within the medicated liquid retained therein. When the liquid is forced upwardly through the tube 25, therefore, it flows upwardly through the opening 24, through the stem 2| and into the mixing chamber 23.. From the mixing chamber 23 this liquid and the air which has also entered the mixing chamber 23 from the passageways I8, are ejected outwardly through the nozzle opening I 9.
It may be here observed that the interior bottom wall of the container l0 slopes downwardly to a sump 2B. The provision of this sump 26 is not essential, but it is desirable so that only a minimum amount of liquid will not be completely removed from the container l0.
To enclose the cap I I when the atomizer is not inuse, a closure 27 is provided. This closure 2! is preferably screwed upon the threads 28 upon the exterior of the drum-shaped projection I3, but it is apparent that a frictional fit may suffice. Within the closure 2! is a small projection 29 which bears against the surface around the nozzle opening l9 to form a fluid-tight fit. It is therefore apparent that even when the device is inverted, liquid cannot escape when the closure 21 is in place.
To use the device, the medicated liquid is placed within the container I0 after removal of the cap When the cap is then replaced and the side walls of the container are compressed between the fingers, as is shown in Figure 1, pressure is created within the container II). This pressure serves to force some liquid up through the tube 25 and into the mixing chamber 23. At the same time air is forced into the mixing chamber 23 through the passageways IS. The intermingling of this air and liquid within the mixing chamber 23 serves to break the liquid up into droplets, and these droplets are ejected through the nozzle opening l9. Inasmuch as there are preferably a plurality of passage-ways 22, the intermixing of the air and liquid within the chamber 23 is made more complete and a resulting fine spray issues from the nozzle opening IS.
The dome-shaped protuberance I3 is, of course, applied to the nose M in substantial airtight relationship. At the same time that the side walls of the container III are being compressed to eject a spray from the nozzle opening l9, air should be inhaled into the nose. This in,- halation of air draws the external atmospheric air inwardly through the lateral openings I! and upwardly through the annular passageway l5. Due to the relative length of the annular passageway l5, the air stream is guided upwardly closely around the nozzle l6. It will therefore be seen that this air stream issuing upwardly through the annular passageway l5 serves as an envelopin shield between the spray from the nozzle opening I9 and the immediately adjacent internal surfaces of the nose l4. Due to the slightly lowered position of the nozzle opening I9, this surrounding stream of air is shielded from the opening 3 so that it does not tend to divert the liquid being sprayed.
Inasmuch as the stream of air which flows upwardly out of the annular passageway l5 serves as a sheath about the spray from the nozzle opening IS, the spray is carried in its entirety upwardly to the nasal passageways which are desiredto be treated. Inasmuch as the liquid will be deposited at these higher portions of the nasal passageways and none, or practically none, of it will be deposited upon the lower surfaces of the nasal passageway, no liquid will run downwardly out of the nose.
When it is desired to obtain drops of the liquid,
it. is merely necessary to invert the atomizer. Liquid then runs downwardly into the neck of the bottle through the passageways 22 into the mixing chamber 23 and out of the nozzle opening is. Because of the relatively small size of these passageways, only droplets will be ejected unless the side walls of the container III are compressed at the same time.
The cap II, the stem 2| and the closure 2'! are. preferably made of a plastic material such, for example, as polystyrene. However, it is apparent that other plastics such as phenolic resins, and even metal, may be used as the material for making these parts. The tube 25 is preferably made of polyethylene, but is may as Well be made of a plastic or metal or may be made of rubber.
It will be apparent that variations may be made in the preferred embodiment of the invention which is illustrated, without departing from the invention. For example, instead of having a continuous annular passageway :between the nozzle and the nose-fitting body, it would be possible to have a plurality of circularly arranged passageways in its stead so that their streams merge to form a circular enveloping stream. In like manner it would be possible to create the necessary pressure within the container ID by a separate compressible bulb which delivers air into the container, instead of having the container of the collapsible type which is specifically illustrated. Mention may also be made of the fact that the nozzle opening is not necessarily higher than the nose-fitting body but that this is preferable because the air stream has an opportunity to assume a more uniform flow within the nose before it reaches the level of the spray.
Inasmuch as the atomizer of the invention serves to confine the spray, when the spray is inhaled through the nasal cavity, nearly all of the medicament will be carried down into the respiratory system. Asa consequence of this, as has been pointed out, Very little of the medicament remains in the nostril openings.
What is claimed is:
1. An atomizer comprising a container, a cap on the container having a nose-fitting body, a nozzle disposed centrally of said body and separated therefrom by an annular passageway, said passageway being of substantially similar cross sectional area throughout its depth to thereby impart linear movement to the air flowing therethrough, conduit means for supplying liquid and air from within the container to said nozzle upon a rise of pressure within the container and for intermixing the liquid and air so that they issue as a spray from said nozzle, said body having a lateral opening from the atmosphere to said passageway so that external air may be inhaled through said body and an encircling stream of confining air having said linear flow will be formed around the spray.
2. An atomizer comprisin a collapsible container, a cap on the container having a, nosefitting body, a nozzle disposed centrally of said body and separated therefrom by an annular passageway, said passageway being of substantially similar cross sectional area throughout its depth to thereby impart linear movement to the air flowing therethrough, conduit means for supplying liquid and air from within the container to said nozzle upon an increase of pressure in the container and for intermixing the liquid and air so that they issue as a spray from said nozzle, said body having a lateral opening from the atmosphere to said passageway so that external air may be inhaled through said body and an encircling stream of confining air havin said linear flow will be formed around the spray.
3. An atomizer comprising a, nose-fitting body, a nozzle disposed centrally of said body and sepa rated therefrom by an annular passageway, said passageway being of substantially similar cross sectionl area throughout its full extent and to its discharge opening to impart linear movement to the air flowing therethrough and issuing therefrom, said body having an opening from the atmosphere to said passageway so that external air may be inhaled through said body, means for admixing liquid and air for ejection as a spray of liquid through said nozzle, said passageway serving to encircle said spray with a confining stream of inhaled air having said linear flow generally parallel to the direction of flow of the spray from the nozzle.
VICTOR C. HALL.
REFERENCES CITED The following references are of record in the file of this patent:
UNITED STATES PATENTS Great Britain Feb. 6, 1912
US124440A 1949-10-29 1949-10-29 Atomizer Expired - Lifetime US2564400A (en)

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US7513953B1 (en) 2003-11-25 2009-04-07 Nano Scale Surface Systems, Inc. Continuous system for depositing films onto plastic bottles and method
US20110087174A1 (en) * 2009-10-08 2011-04-14 Mark Carpenter High Flow Volume Nasal Irrigation Device and Method for Alternating Pulsatile and Continuous Fluid Flow
US20120132676A1 (en) * 2010-11-30 2012-05-31 Reginal Rhodes Liquid dispenser
WO2013133989A1 (en) * 2012-03-07 2013-09-12 Medinvent, Llc Portable nebulizer device
US8925544B2 (en) 2009-12-08 2015-01-06 Medinvent, Llc Portable nebulizer device
US20160144083A1 (en) * 2014-11-24 2016-05-26 Dai Vinh Nasal aspirator device
US9402947B2 (en) 2010-07-01 2016-08-02 Medinvent, Llc Portable fluid delivery system for the nasal and paranasal sinus cavities
US9440020B2 (en) 2009-12-08 2016-09-13 Medinvent, Llc Nasal irrigator
US10144021B2 (en) 2015-12-11 2018-12-04 Michael Tinsley Container with improved liquid dispensing ability
US10617832B2 (en) 2017-11-22 2020-04-14 Southwest Research Institute High precision, low dose atomizer
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US2577321A (en) * 1949-10-29 1951-12-04 Joseph B Filger Nose drop dispenser
US2783919A (en) * 1954-06-28 1957-03-05 S H Ansell & Sons Fluid dispenser
US2805795A (en) * 1955-01-17 1957-09-10 Coca Cola Co Tanks
US3010613A (en) * 1957-05-03 1961-11-28 Stossel Ernest Foam producing and dispensing device
US2980342A (en) * 1957-09-05 1961-04-18 Plax Corp Liquid spray dispenser
US3175553A (en) * 1960-03-07 1965-03-30 Memorial Hospital Urine test kit
US3682168A (en) * 1970-06-10 1972-08-08 Ahldea Corp Sterile liquid entraining system
FR2628638A1 (en) * 1985-03-06 1989-09-22 Sandoz Lab Medicinal nasal spray - with tapered inner surface to base of flask and tube descending into it from sprayer
US5078129A (en) * 1987-05-01 1992-01-07 Research Foundation Of State University Of New York Device for stimulating salivation
US4979642A (en) * 1987-06-22 1990-12-25 Centre Regional De Transfusion Sanguine De Lille Sprayer for sterile products, more particularly for aseptic solutions used in medical and surgical treatments
US5224652A (en) * 1992-01-23 1993-07-06 Maui Toys, Inc. Lawn water shower
US5368016A (en) * 1992-09-22 1994-11-29 Henry; Richard A. Airway anaesthesia
USRE37324E1 (en) 1994-04-04 2001-08-14 Bernard S. Esrock Method for making disposable tubular device
US5591389A (en) * 1994-04-04 1997-01-07 Esrock; Bernard S. Method for making disposable tubular device
US5460619A (en) * 1994-04-04 1995-10-24 Esrock; Bernard S. Disposable tubular device and method
US5495965A (en) * 1994-04-25 1996-03-05 Aptar Group, Inc. Dip tube for hand operated dispensing device
US5518151A (en) * 1994-04-25 1996-05-21 Aptar Group, Inc. Dip tube for hand operated dispensing device
USD384881S (en) * 1995-05-31 1997-10-14 Schering-Plough Healthcare Products, Inc. Combined spray bottle and cap
US5988870A (en) * 1998-03-02 1999-11-23 Partsky; Howard Apparatus and method for diluting nasal sprays containing addictive compounds
WO2001089984A1 (en) * 2000-05-23 2001-11-29 Carter-Wallace, Inc. Dispensing container
US7513953B1 (en) 2003-11-25 2009-04-07 Nano Scale Surface Systems, Inc. Continuous system for depositing films onto plastic bottles and method
US20090008414A1 (en) * 2005-02-18 2009-01-08 Michael Tinsley Sure Shot
US8657794B2 (en) * 2009-10-08 2014-02-25 Skylab Development, Inc. High flow volume nasal irrigation device and method for alternating pulsatile and continuous fluid flow
US20110087174A1 (en) * 2009-10-08 2011-04-14 Mark Carpenter High Flow Volume Nasal Irrigation Device and Method for Alternating Pulsatile and Continuous Fluid Flow
US8925544B2 (en) 2009-12-08 2015-01-06 Medinvent, Llc Portable nebulizer device
US9440020B2 (en) 2009-12-08 2016-09-13 Medinvent, Llc Nasal irrigator
US9402947B2 (en) 2010-07-01 2016-08-02 Medinvent, Llc Portable fluid delivery system for the nasal and paranasal sinus cavities
US20120132676A1 (en) * 2010-11-30 2012-05-31 Reginal Rhodes Liquid dispenser
US10682331B2 (en) 2012-02-24 2020-06-16 Nasoneb, Inc. Nasal drug delivery and method of making same
EP2822623A4 (en) * 2012-03-07 2015-04-29 Medinvent Llc Portable nebulizer device
WO2013133989A1 (en) * 2012-03-07 2013-09-12 Medinvent, Llc Portable nebulizer device
US11679210B2 (en) 2014-10-03 2023-06-20 Glenmark Specialty S.A. Dispensing device and pharmaceutical composition for the treatment of rhinitis
US20160144083A1 (en) * 2014-11-24 2016-05-26 Dai Vinh Nasal aspirator device
US10144021B2 (en) 2015-12-11 2018-12-04 Michael Tinsley Container with improved liquid dispensing ability
JP2020526233A (en) * 2017-06-28 2020-08-31 グレンマーク・スペシャルティー・エスエー Administration device and pharmaceutical composition for the treatment of rhinitis
US10617832B2 (en) 2017-11-22 2020-04-14 Southwest Research Institute High precision, low dose atomizer
US11679401B2 (en) * 2020-06-09 2023-06-20 Briotech, Inc. Reusable container system and method that reduces the use of plastic

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