United States Patent m
Eggers et al.
US005670322A [ii] Patent Number: [45] Date of Patent:
[54] MULTI SITE MOLECULE DETECTION METHOD
[76] Inventors: Mitchell D. Eggers. 10 Plum Ct;
Michael E. Hogan. 103 Golden Shadow Cir.; Kenneth Loren Beattie. 2 Hollymead Dr., all of The Woodlands, Tex. 77381; John Shumaker, 2250 Wroxton Rd.. Houston. Tex. 77005; Daniel J. Ehrlich. 11 Grant PL, Lexington, Mass. 02173; Mark Hollis. 45 Staffordshire La., Concord, Mass. 01742
[21] Appl. No.: 457,096 [22] Filed: Jun. 1, 1995
Related U.S. Application Data
[62] Division of Ser. No. 353,957, Dec 12, 1994, Pat. No. 5,532,128, which is a continuation of Ser. No. 794,036, Nov. 19, 1991, abandoned.
[51] Int Q.6 G01H 33/543; G01H 33/551;
G01H 33/553; G01H 33/552
[52] U.S. CI 435/6; 704/400; 704/403
422/82.01; 422/82.02; 435/7.1; 435/7.2 435/287.1; 435/287.2; 436/518; 436/524: 436/525; 436/527; 436/806; 436/809
[58] Field of Search 204/400, 403;
422/82.01. 82.02; 435/6. 7.1. 7.2. 287.1, 287.2; 436/518, 524, 525, 527, 806, 809
[56] References Cited
U.S. PATENT DOCUMENTS
4,072,576 2/1978 Arwin et al 195/103.5
4,096,645 7/1978 Hartdegen et al 195/68
4,293,310 10/1981 Weber 23/230
4,414,323 11/1983 Masuda 435/7
4,414,325 11/1983 Masuda et al 435/7
4,728,882 3/1988 Stanbro et al 324/61
4,769,121 9/1988 Newman 5/6
4,786,600 11/1988 Kramer etal 435/235
4,822,566 4/1989 Newman 422/68
4,935,207 6/1990 Stanbro et al 422/68.1
4,938,742 7/1990 Smits 604/67
4,963,245 10/1990 WeetaU 204/403
5,001,051 3/1991 Miller etal 435/6
5,063,081 11/1991 Cozzette et al 427/2
5,064,754 11/1991 Mills 435/6
5,071,733 12/1991 Uekitaetal 430/326
5,082,627 1/1992 Stanbro 422/82.01
5,164,319 11/1992 Hafeman etal 435/291
5,187,096 2/1993 Giaever et al 435/291
5,194,133 3/1993 dark etal 204/299
5,532,128 7/1996 Eggertetal 436/518
FOREIGN PATENT DOCUMENTS
0347579 5/1989 European Pat. Off. .
0402917 12/1990 European Pat. Off. 33/48
3801987 7/1989 Germany 11/12
9002327 3/1990 WIPO 33/545
9003382 4/1990 WIPO C07H 21/00
9005300 5/1990 WIPO 27/48
9015070 12/1990 WIPO C07K 1/04
OTHER PUBLICATIONS
"A 1024—Element High-Performance Silicon Tactile Imager
Suzuki et al., EDM 88 1983 IEEE pp. 674-677. "Micro-Diaphragm Pressure Sensor". Sugiyama et al., EDM 86, 1986 IEEE, pp. 184-187. "Silicon Pressure Sensor Based on a Resonating Element", Buser et al. SENSORS AND ACTUATORS A, 25-27 (1991) Elsevier Sequoia. The Netherlands, pp. 717-722.
(List continued on next page.)
Primary Examiner—Christopher L. Chin Attorney, Agent, or Firm—Vinson & Elkins
![[blocks in formation]](http://www.google.ca/patents?id=sSYdAAAAEBAJ&ie=ISO-8859-1&output=text&pg=PA1&img=1&zoom=3&hl=en&q=&cds=1&sig=ACfU3U3zvMZsUjQYMURJjEHagBQyMne5yg&edge=0&edge=stretch&ci=473,789,424,246)
![[merged small][graphic][merged small]](http://www.google.ca/patents?id=sSYdAAAAEBAJ&ie=ISO-8859-1&output=text&pg=PA1&img=1&zoom=3&hl=en&q=&cds=1&sig=ACfU3U3zvMZsUjQYMURJjEHagBQyMne5yg&edge=0&edge=stretch&ci=119,1036,742,299)
OTHER PUBLICATIONS
"Q-Factor and Frequency Shift Of Resonating Silicon Diaphragms in Air", Piak et al., SENSORS AND ACTUATORS A, (1991) Elsevier Sequoia/The Netherlands, pp. 691-698. "A Digital Optically Multiplexed Charge Coupled Device (CCD) Based Deoxyribonucleic Acid (DNA) Sequence Header", Craine et al., SPIE, vol. 914 MEDICAL IMAGING H, (1988), pp. 512 -517.
"Biotinyl and Phosphotyrosinyl Phosphoramidite Derivatives Useful in the Incorporation of Multiple Reporter Groups on Synthetic Oligonucleotides" Misiura et al., 1990 Oxford University Press. NUCLEIC ACIDS RESEARCH, vol. 18, No. 15. pp. 4345-4354.
Sensitive Detection Systems, "Chemiluminescent and Bioluroinescent Techniques", L. J. Kricka, Clin. Chem. 37/9, (1991) pp. 1472-1481.
"Nonradioactive Nucleic Acid Detection by Enhanced Chemilurninescences Using Probes Directly Labeled with Horseradish Peroxidase", Pollard-Knight et al, ANALYTICAL BIOCHEMISTRY 195 (1990). pp. 84-89. "Multiwavelenght Fluorescence Detectino for DNA Sequencing Using Capillary Electrophoresis", Oxford University Press. NUCLEIC ACIDS RESEARCH, Vol. 19, No. 18, pp. 4955-1962.
"Imaging of Fluorescent and Chemuumiiiescent DNA Hybrids Using a 2-D CCD Camera", Karger et el., SPIE Vol. 1206, New Technologies in Cytometry and Molecular Biology (1990), pp. 78-89.
PRODUCT REVIEW. NATURE, Vol. 329 (Oct. 8, 1987) "Biosensors emerge from the laboratory", J. Briggs, pp. 565. "Sub-Femtomole Quantitation of Proteins with Threshold®, for the Biopharmaceutical Industry". Briggs et el.. BioTechmques. Vol 9, No. 5 (1990) pp. 1-8.
"Swept-Frequency Magnitude Method for the Dielectric Characterization of Chemical and Biological Systems", Hollis et al., Jul. 1980 IEEE TRANSACTIONS AND MICROWAVE THEORY AND TECHNIQUES, Vol. MTT-28, No. 7, pp. 791-801.
"Two-Dimensional Spatial Light Modulators: A Tutorial", Neff et al., IEEE vol. 78, No. 5.
"Deformable-Mirror Spatial Light Modulators". Hornbeck et al., SPIE Critical Reviews Series Vol. 1150. pp. 86-. A proposal sent by Houston Advanced Research Center (HARC) to the National Institutes of Health in July 1991. This material describes the overall background and approaches for the fabrication of geo-sensors that were envisioned by HARC at that time. "A Method for DNA Sequencing by Hybridization With Oligonucleotide Matrix", DNA SEQUENCE —J. DNA SEQUENCING AND MAPPING, Vol 1,1991, pp. 375-388. "Genetic Analysis of Amplified DNA with Immobilized Sequence-Specific Oligonucleotide Probes", PROC. NATL. ACAD. SCI. USA, Vol. 86, Aug. 1989, pp. 6230-6234. "Use of Thiol-Texminal Silanes and Heterobifunctional Crosslinkers for Immobilization of Antibodies on Silica Surfaces". ANALYTICAL BIOCHEMISTRY 178, 1989, pp. 408-413/
"Immobilization of Acetylcholinesterase on Solid Surfaces: Chemistry and Activity Studies", SENSORS AND ACTUA- TORS. B. 3, 1991, pp. 311-337.
"Covalent Immobilization of DNA onto Polystyrene Microwells: The Molecules Are Only Bound at the 5' End", Analytical biochemistry 198. 1991, pp. 138-142. "A Sub-Micron Particle Filter in Silicon", SENSORS AND ACTUATORS, A21-A23, 1990, pp. 904 -907.
U.S. Patent Sep. 23,1997 sheet 2 of 2 5,670,322
« PreviousContinue » |