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US007177674B2
(12) United States Patent ao) Patent No.: Us 7,177,674 B2
Echauz et al. (45) Date of Patent: Feb. 13,2007
(54) PATIENT-SPECIFIC PARAMETER
SELECTION FOR NEUROLOGICAL EVENT
DETECTION
(76) Inventors: Javier Echauz, 10933 Crabapple Rd.
#101, Roswell, GA (US) 30075;
Rosana Esteller, 10933 Crabapple Rd.
#101, Roswell, GA (US) 30075;
Thomas K. Tcheng, 255 Santa Ana Ct,
Sunnyvale, CA (US) 94085; Benjamin
D. Pless, 255 Santa Ana Ct., Sunnyvale,
CA (US) 94085
( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 392 days.
(21) Appl. No.: 10/146,663
(22) Filed: May 13, 2002
(65) Prior Publication Data
US 2003/0073917 Al Apr. 17, 2003
Related U.S. Application Data
(63) Continuation-in-part of application No. 09/977,052, filed on Oct. 12, 2001.
(51) Int. CI.
A61B 5/0476 (2006.01)
(52) U.S. CI 600/544; 607/45
(58) Field of Classification Search 607/45 46,
607/60; 600/544 See application file for complete search history.
(56) References Cited
U.S. PATENT DOCUMENTS
6,353,754 Bl * 3/2002 Fischell et al 600/544
6,473,639 Bl * 10/2002 Fischell et al 600/544
6,480,743 Bl * 11/2002 Kirkpatrick et al 607/45
6,658,287 Bl * 12/2003 Lift et al 600/544
2003/0004428 Al * 1/2003 Pless et al 600/544
* cited by examiner
Primary Examiner—Carl Layno
(57) ABSTRACT
An epileptiform activity patient-specific template creation system permits a user to efficiently develop an optimized set of patient-specific parameters for epileptiform activity detection algorithms. The epileptiform activity patient template creation system is primarily directed for use with an implantable neurostimulator system having EEG storage capability, in conjunction with a computer software program operating within a computer workstation having a processor, disk storage and input/output facilities for storing, processing and displaying patient EEG signals. The implantable neurostimulator is operative to store records of EEG data when neurological events are detected, when it receives external commands to record, or at preset or arbitrary times. The computer workstation operates on stored and uploaded records of EEG data to derive the patient-specific templates via a single local minimum variant of a multidimensional greedy line search process and a feature overlay process.
51 Claims, 20 Drawing Sheets
