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United States Patent

Dixon

[19]

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US005737121A [li] Patent Number: [45] Date of Patent:

5,737,121 Apr. 7, 1998

[54] REAL TIME SCANNING OPTICAL MACROSCOPE

[76] Inventor: Arthur E. Dixon, 601 Stonebury

Crescent, Waterloo, Ontario, Canada,
N2K 3R2

[21] Appl. No.: 674,145
[22] Filed: Jul. 1, 1996

Related U.S. Application Data

[62] Division of Ser. No. 117,797, Sep. 8, 1993, Pat No. 5,532, 873.

[51] Int CL6 G02B 21/06; G02B 21/00

[52] U.S. CI 359/388; 359/368; 359/385

[58] Field of Search 359/368,377,

359/372-374, 379, 381, 385-389, 660, 205-208; 356/72. 318, 326, 417, 376; 250/201.3,

216, 234

[56] References Cited

U.S. PATENT DOCUMENTS

5,067,805 11/1991 Corleetal 359/368

5,101,295 3/1992 Lichtman et al 359/368

5225,923 7/1993 Montagu 359/368

5,386,112 1/1995 Dixon 359/368

Primary Examiner—Thong Nguyen

[57] ABSTRACT

A new real-time confocal scanning laser macroscope is disclosed which images macroscopic specimens in reflected light and fluorescence or photoluminescence. The optical arrangement of a Nipkow disk microscope has been altered to include a telecentric scan lens which enables a large area of a specimen to be imaged with micron resolution, and when interchanged with a microscope objective, allows a small area of the specimen to be imaged with submicron resolution.

5 Claims, 3 Drawing Sheets

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