(12) (10) Patent No.: US 7,951,129 B2 Chinchoy (45) Date of Patent: May 31, 2011 (54) DIASTOLIC CORONARY PERFUSION 20026/i,1i555igg; ii iégggg I(‘,Ie1i)°“ 1 ~~~~~~~~~~~~~~~~~~~~~~~ ~~ lég/753% Of I.1CC1 DETECTION FOR TIMED DELIVERY OF 2003/0083702 Ai 5/2003 Siadier ei ai, iiiiiiiiiiiiiiiii H 607/i4 THERAPEUTIC AND/OR DIAGNOSTIC AGENTS FOREIGN PATENT DOCUMENTS EP 0 582 162 A1 2/2004 (75) Inventor: Edward Chinchoy, Mirmeapolis, MN WO W0 03/089033 A1 10/2003 (US) OTHER PUBLICATIONS (73) Assignee: Medtronie, Inc-, Minneapolis, MN (US) Brellharclt et al. “Echocardiographic QL13.l1[lfiCa[lOn of Left _ _ _ _ _ Ventricular Asynclirony Predicts an Acute Hemodynamic Benefit of ( * ) NOUCP3 SubJeCt_ to any dlsclalmeri the term Ofthls Cardiac Resynchronization Therapy”, J 0fAm Coll of Cardio, 2002, patent is extended or adjusted under 35 V01, 4o, NO, 3 pp, 536545, U.S.C. l54(b) by 1840 days. * cited by examiner (21) Appl. No.: 10/636,857 Primary Examiner — Nicholas D Lucchesi (22) Filed: Aug. 7, 2003 Assistant Examiner — LauraA Bouchelle _ _ _ (74) Attorney, Agent, or Firm — Stephen W. Bauer; Reed A. (65) Prior Publication Data Duthjer US 2005/0043616 A1 Feb. 24, 2005 (57) ABSTRACT (51) Il1t- CL During diastolic coronary perfusion, blood perfuses through /16111431/00 (2006-01) the heart via the coronary arteries. Delivery of a therapeutic (52) U.S. Cl. .................... .. 604/505; 604/503; 604/ 890.1 and/or diagnostic agent to the heart during diastolic coronary (58) Field of Classification Search ............. .. 604/890.1, perfusion a110Ws the therapeutic and/or diagnostic agent t0 604/891,1, 115, 268, 503, 505 efliciently perfuse through the heart. A medical device See application file for complete Search history, according to the invention detects closure of the aortic valve of a heart, and initiates delivery of a therapeutic and/or diag(56) References Cited nostic agent upon detection of aortic valve closure. The medi
