In human subjects accustomed to smoking tobacco the withdrawal symptoms associated with the cessation or reduction of tobacco smoking may be prevented by administering to the subject an effective amount of an alpha-2 adrenergic agonist such as clonidine hydrochloride for a suitable period of time....http://www.google.ca/patents/US4683231?utm_source=gb-gplus-sharePatent US4683231 - Method of preventing withdrawal symptoms associated with the cessation or reduction of tobacco smoking
