A biosensor (10) has a hydrogel (30) in a rigid and preferably biocompatible enclosure (20). The hydrogel (30) includes an immobilized analyte binding molecule (ABM) and an immobilized analyte. The immobilized analyte competitively binds with free analyte to the ABM, thus changing the number of crosslinks...http://www.google.ca/patents/US6514689?utm_source=gb-gplus-sharePatent US6514689 - Hydrogel biosensor