Compositions and methods are provided for the treatment and diagnosis of diseases associated with the expression of one or more of the I, II, , , , or isoforms (isozymes) of protein kinase C (PKC). Oligonucleotides are provided which are targeted to nucleic acids encoding PKC-I, PKC-II, PKC-, PKC-,...http://www.google.ca/patents/US6339066?utm_source=gb-gplus-sharePatent US6339066 - Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate 
