A method for quantitatively measuring nucleic acid amplification reactions, especially the polymerase chain reaction, employing microparticles as hybridization solid phase, a probe sequence labeled with a fluorescent label and a fluorescence detection system which is based on two-photon fluorescence...http://www.google.ca/patents/US6310354?utm_source=gb-gplus-sharePatent US6310354 - Method and a device for monitoring nucleic acid amplification reactions