Method and apparatus for providing calibration of analyte sensor including applying a control signal, detecting a measured response to the control signal, determining a variance in the detected measured response, and estimating a sensor sensitivity based on the variance in the detected measured response...http://www.google.ca/patents/US7653425?utm_source=gb-gplus-sharePatent US7653425 - Method and system for providing calibration of an analyte sensor in an analyte monitoring system