Catheter feedback methods and systems are disclosed for optimizing the infusion of a drug, such as a chemotherapeutic agent via retrograde perfusion through the venous side of the vascular network to a selectively determined portion of a solid tumor. Monitoring and regulatory capability are provided...http://www.google.ca/patents/US4714460?utm_source=gb-gplus-sharePatent US4714460 - Methods and systems for retrograde perfusion in the body for curing it of the disease or immume deficiency