A non-invasive method of enhancing the permeability of the skin to a biologically active permeant or compound is described utilizing a combination of sonophoresis and chemical enhancers. Synergism brought simultaneously applying iontophoresis, electroporation, mechanical vibrations and magnetophoresis...http://www.google.ca/patents/US6795727?utm_source=gb-gplus-sharePatent US6795727 - Devices and methods for promoting transcutaneous movement of substances