The present invention provides multi-layer microfluidic systems, by providing additional substrate layers, e.g., third, fourth, fifth and more substrate layers, mated with the typically described first and second layers. Microfabricated elements, e.g., grooves, wells and the like, are manufactured into...http://www.google.ca/patents/US6648015?utm_source=gb-gplus-sharePatent US6648015 - Multi-layer microfluidic devices