WO2016065443A1

WO2016065443A1 - Oral preparation for reducing dentinal erosion, oral composition for reducing dentinal erosion and use of the preparation

Info

Publication number: WO2016065443A1
Application number: PCT/BR2014/050003
Authority: WO
Inventors: Rejane FUKUSHIMA; Roseli Alves de Sá ZUPELI
Original assignee: Hypermarcas S.A.
Priority date: 2014-10-28
Filing date: 2014-10-28
Publication date: 2016-05-06
Also published as: BR112015030093A2; AR098962A1

Abstract

The present invention describes a preparation that reduces dentinal erosion caused by acids for mouth care compositions. The active ingredient PHMB, up until now known for its antimicrobial activity, has a new function.

Description

ORAL PREPARATION FOR REDUCING DENTAL EROSION, ORAL COMPOSITION FOR REDUCING DENTAL EROSION AND USE

PREPARATION

Field of the Invention

The present invention belongs to the field of human needs, specifically to the field of personal hygiene and relates to a preparation with PHMB (polyhexamethylene biguanide) + silanol + fluoride ions. Such preparation and compositions thereof are used for the prevention of dentin erosion caused by acids.

Invention History

Dental erosion caused by intrinsic or extrinsic acids is a progressive and irreversible lesion of hard dental tissue, enamel, dentin and / or cementum resulting from a chemical process that does not involve bacterial action. Unlike dental caries, erosion occurs in places without bacterial biofilm as it protects the dental structure from the erosive process. Dental erosion can be caused by extrinsic acids such as acidic foods or beverages and medicines, or intrinsic acids such as stomach fluids or gases causing the loss of mineralized tissue and may stimulate dentin hypersensitivity.

Because dental erosion is a chemical process between an acid and the dental element, some chemical factors directly influence the erosive potential of acids. The main factor influencing erosion demineralization is the pH of the solution or food. Another factor is the presence of ions in the solution, as they determine the strength with which the dissolution of the tooth mineral occurs. The dissolution gradient of the ions depends on the degree of saturation of the enamel in relation to the oral medium. If a particular solution has a lower pH, or a lower concentration of calcium and phosphate, it will be unsaturated relative to the tooth. This solution has the ability to react with enamel and cause tooth demineralization.

Tooth erosion injury occurs through long-lasting, frequent, non-carious chemical processes without bacterial involvement. Exposure of the tooth to lower than critical enamel pH (5.5) may dissolve hydroxyapatite crystals, depending on calcium and ions concentrations. phosphate in saliva and the availability of fluoride to act in the remineralization process.

Dental erosion from acid etching can severely affect the layers of tooth materials such as enamel and dentin, leading to the exposure of tooth pulp. Dentin erosion occurs when dentin is affected after loss of tooth enamel or cementum. In this paper, we treat dentine erosion as part of total tooth erosion.

Dental erosion of intrinsic origin can be subdivided according to the degree of severity:

a) Superficial (class I) - affects only the enamel surface;

b) Localized (class II) - reaches less than 1/3 dentin and

c) Extensive (class III) - destruction of more than 1/3 of dentin.

The most observed signs and symptoms in dental erosion are dentin sensitivity, enamel wear with a smooth and shiny appearance, absence of pigmentation and aesthetic compromise. In more severe cases there may be diastema formation, alteration of the occlusal vertical dimension, muscle pain caused by occlusal instability and temporomandibular joint dysfunction.

When the enamel is lost or the root is exposed due to gum retraction, tooth erosion can reach the dentin. The loss of dentin tissue by erosion is not a simple superficial process. Peritubular dentin minerals are initially lost, and the tubules are enlarged.

In sequence, a surface layer of the demineralized organic matrix (DOM) is detectable. The DOM is capable of preventing ionic diffusion into and out of the demineralized area by modulating the progression of mineral loss. However, the DOM may be affected by enzymes or chemical degradation, in the acid case, and hence accelerate the process of dentin loss through dentin erosion.

The treatment of dental erosion

In the prior art it is found that the prevention of dental erosion should be done by decreasing the frequency and severity of acid etching. Many authors recommend the use of fluoride as an agent remineralizer to prevent tooth erosion. Appropriate treatment depends on the severity of the lesions, and weekly fluoride topical applications, fluoride varnishes, desensitizing agents can be performed and when the loss of tooth structure is large, restorative treatment becomes necessary.

Fluoride and other actives on dentin erosion

An acidic solution that is ingested and comes into contact with the teeth, readily dissolves calcium fluoride and removes traces of topical fluorine treatment, thus making it unlikely and limited to prevent erosion. Several authors report the formation of a CaF ₂ layer on the enamel surface after topical application of fluoride. The calcium fluoride layer provides additional minerals to be dissolved during the acid etching, so the acids will first have to demineralize this layer to subsequently demineralize the underlying tooth enamel. Thus, enamel demineralization is delayed, but not completely prevented.

New products and methods have been studied to increase calcium and phosphate supersaturation in saliva and / or biofilm to help prevent tooth erosion.

Other active ingredients, such as biguanides and green tea, have been studied by the inhibitory action of DOM degrading enzymes, such as matrix metalloproteinases (MMPs), cathepsins and collagenases. There are also studies of ingredients that contribute to the regularization of collagen biosynthesis, such as silanols. Collagen is extremely important in DOM and consequently for dentin.

Due to its ability to regulate silanol collagen biosynthesis, we hypothesized that it could complement the recovery of the demineralized organic matrix (DOM) in combination with enzymatic inhibitors and fluorinated compounds.

PI200724469: This document describes an antiseptic composition containing poly-biguanide with acidic radicals such as carboxylic or phosphoric, caries reducing, bad breath and other oral diseases. It also shows the antimicrobial action of poly-biguanide and uses concentrations high levels of this ingredient ranging from 1 to 20% and fluorides ranging from 1 to 10%. It does not cite the effect of the composition on preventing dentin erosion caused by acids.

PI0614927: This document describes an antimicrobial composition comprising at least one component of group a (antimicrobial), one of group b (second antimicrobial) and optionally of group c (antisthetic or fluoropolymer). PHMB is cited as an antimicrobial used at a concentration ranging from 0.1 to 99.9% of the total weight of the composition, different from those of the present invention. It does not cite the effect of the composition on preventing dentin erosion caused by acid exposure.

PI0702507: This document describes an antiseptic varnish with cavity reducing poly-biguanide and other oral diseases. The varnish composition employs acrylates, plasticizers and poly-biguanide at concentrations of 3 to 80% of the formulation, which hardens upon application to the tooth surface, a very different feature of the present invention to be described below. Furthermore, the document does not cite the use of poly-biguanide in preventing dentin erosion caused by acid etching.

US2008 / 0247972: This document describes a mouthwash to reduce or prevent halitosis, facilitate removal of the tongue coating, and to decrease the concentration and formation of volatile sulphate compounds. It includes PHMB as one of the bactericides on a large list of antibacterial agents that could be used in this mouthwash. The document does not cite the use of PHMB in preventing dentin erosion caused by acid etching.

Demineralized organic matrix (DOM) may be affected by enzymes available in the oral cavity, such as matrix metalloproteinases (MMPs) that mediate the hydrolysis of virtually all extracellular matrix molecules, including collagen. MMP-8 was found to be the most common collagenase in human dentin, MMP-2 and MMP-9 were also found in this tissue. However, in vivo DOM degradation does not depend solely on the action of MMPs. Other proteases suggest implication in this process such as cysteine cathepsins. Cysteine cathepsins are derived from tooth pulp by dentin fluid and may cleave the C-terminal telopeptide of type I collagen, possibly exposing the collagenase cleavage site following exposure to acids. Acid pH activates cysteine cathepsins, which in turn activate MMPs resulting in DOM degradation.

The present invention provides a preparation with PHMB, silanol and fluoride ions, with excellent action to reduce dentin erosion, not explained in prior art studies. PHMB presents excellent dentin erosion reducing action, being used alone and in preparation with silanol and fluoride ions.

Detailed Description of the Invention

The present invention aims to present an ingredient preparation that reduces dentin erosion containing PHMB and / or silanol and / or fluoride ionizable compounds.

Considering the ability of PHMB or its derivatives to act as an inhibitor of DOM-degrading enzymes, silanol as an aid in collagen biosynthesis and the protection of fluoride ions that form a CaF ₂ layer in teeth, we hypothesized that the three Combined ingredients could act in different ways and complement each other, preventing dentin erosion. In this way, we test these ingredients separately and together.

Various fluoride ionizable compounds can be used in preparations such as: sodium fluoride, tin fluoride, sodium monofluorophosphate, fluorinated amine, titanium tetrafluoride, 2-bis (hydroxyethyl) -aminopropyl-N-hydroxyethyloctadecyl dihydrofluoride, Ν, Ν, Ν -Tris (2-hydroxyethyl) -N-octadecyl-1,3, diaminopropane dihydrofluoride, ammonium monofluorophosphate, calcium monofluorophosphate, potassium monofluorophosphate, potassium fluoride, aluminum fluoride, magnesium fluoride, calcium fluoride , hexadecylammonium fluoride, 3- (N-hexadecyl-N-2-hydroxyethylammonium) propylbis (2-hydroxyethyl) ammonium dihydrofluoride, N, N, N-tris (polyoxyethylene) -N-hexadecyl propylenediamine hydrofluoride, nicomethanol hydrofluoride, octadicenyl ammonium, sodium fluororsilicate, ammonium fluororsilicate, magnesium fluororsilicate, cetylamine hydrofluoride, oleylamine and hexyldecylamine difluoride.

Silanols are organic derivatives of silicone and when synthesized in the presence of different radicals confer stability and specificity to the compounds. Other compounds in the group of silanols may have similar action on collagen biosynthesis, such as: methylsilanol manuronate, silanetriol arginate, ascorbyl methylsilanol pectinate, siloxanetriol alginate, silanediol salicylate, dimethylsilanol hyaluronate, methylsilanol hydroxyproline aspartate, methylsilylate dihydrate, methylsulfonate , dimethyl oxobenzene dioxasilane, methyl silanol carboxymethyl theophylline alginate, methylsilanol acetyl tyrosine, acetylmethionyl elastinate, copper acetyl tyrosinate methylsilanol, copper PCA methylsilanol, dimethiconol / methylsilanol / crosspolymer methylstannyl methanolyl methanolyl methanolyl methanolyl methanolyl methanolyl methanolyl methanolyl methanolyl methanolyl methanolyl methanolyl methanolyl methanolyl methanolyl methanolate , methylsilanol PCA, methylsilanol PEG-7 glyceryl cocoate, methylsilanol spirulinate, methylsilanol tri-PEG-8 glyceryl cocoate, methylsilanol / crosspolymer silicate, polysilicone-21, sodium hyaluronate dime methylsilanol, sodium manuronate methylsilanol, sodium PCA methylsilanol, hydrolyzed collagen PG-propyl methylsilanediol, keratin hydrolyzate PG-propyl methylsilanediol, keratin hydrolyzate PG-propyl methylsilanediol, protein hydrolyzate PG-propyl methylsilan dimethylsilanol hyaluronate and sorbityl silanediol.

PHMB is a broad spectrum polymeric biguanide of antimicrobial action against Gram-positive and Gram-negative bacteria and has been used for many years as an antiseptic agent in medicine, the food industry and various materials to prevent bacterial growth. It is also used to treat fungus and to treat infectious keratitis. Many documents describe the action of chlorhexidine (CHX) and polymeric biguanides (such as PHMB) as oral antimicrobial and against caries. Other nomenclatures are used for PHMB as: polyhexamethylene biguanide hydrochloride, polyaminopropyl biguanide, polyhexanide, among others. Commercial preparations are mixtures of polymeric biguanides containing from 2 to 40 monomers of primary structure of the type [- (CH ₂ ) 6.NH.C (= NH) .NH.C (= NH) .NH-] _n , shown in formula I, with an average size of n = 12 and molecular weight between 400 and 800 Daltons. This structure has several terminal group combinations which may have amides (-NH ₂ ), guanides [-HC (= NH) .NH ₂ ] or cyanoguanides [-NH.C (= NH) .NH.CN].

Formula I

n being an integer between 2 and 40.

The PHMB polymer under study has an integer number of monomers between 2 and 40 and particularly between 8 and 15.

In research, the preparation (PHMB, silanol and fluoride) showed much lower dentin loss results than the ingredients evaluated separately. With just one daily application of this preparation a reduction in dentin erosion is effectively observed.

The research was compared with the methodology described below:

Sample preparation: Sixty samples of bovine teeth were cut and had tooth enamel removed in the pre-preparation. Two coats of nail enamel were applied to part of the outer surface of dentin as a means of maintaining an initial total dentin thickness reference for subsequent determination of dentin loss by thickness difference.

Daily treatment of samples

All samples were subjected to demineralization and remineralization cycles within 6 days. Each day, the samples went through the following steps:

a) Demineralization - Demineralization challenges were performed day by day with all samples for 6 days for 5 minutes using 0.87M citric acid solution (pH 2.5 and 30 ml per sample).

b) Protection - After demineralization, each sample group was treated with one of the solutions below for 1 minute (30m l / sample) with: • Distilled water group (control group)

CHX group (0, 12%)

PHMB group (0.07%)

• PHMB + silanol + fluoride group (0.07% PHMB + 0.00045% silanol + 0.0226% fluoride ions)

• Fluoride Solution Group (0.0226% fluoride ions)

c) Enzymatic Challenge - After step "b", Each sample group was rinsed with deionized water and then subjected to bacterial collagenase (Clostridium hystoliticum, 100pg / ml, Sigma-Aldrich, USA) for 10 minutes in buffer containing 1 ml 50 mM TES buffer (TESCA) pH 7.4. This step simulates the activation of MMPs in the oral cavity.

d) Measurement of dentin loss - Measurements were performed by contact profilometry (MarSurf GD 25, Mahr, Gottingen, Germany). 5 measurements were made at a distance of 250 pm between them and the average value obtained. Nail polish was carefully removed with a scalpel and acetone solution (1: 1 in water). Height differences between the reference surface and eroded areas were quantified in microns. e) Storage - Between the demineralization and remineralization cycles, the samples were immersed in artificial saliva (1.5 mmol ¹ CaC, KH ₂ P0 ₄ 2.4 mmol ¹ , Na ₂ HP0 ₄ , 17 mmol ¹ KCI, 2 mmol ¹ NaSCN, 9.9 mmol ¹ NaCl, 3 mmol Γ ¹ NH ₄ CI, 3 mmol Γ ¹ urea, and 0.2 mmol Γ ¹ glucose, pH 6.8 - 30 ml / sample).

Statistical analysis was performed using GraphPad Prism software (GraphPad Software, San Diego, USA). Data were checked for normality and homogeneity using the Kolmogorov-Smirnov and Bartlett tests, respectively. Provided these criteria were met, then the data were analyzed using 2-way repeated measures ANOVA followed by Bonferroni post hoc test considering treatments and periods as factors (p <0.05).

Below are data on the average loss (pm, mean ± standard deviation) of final dentin in the different study groups on the sixth study day:

• Distilled Water Group (negative control group) 168.2 ± 6.2 pm • Fluoride group (0.0226% fluoride) 157.4 ± 6, 1 μηι

CHX group (0.12%) 135.3 ± 33.5 pm

PHMB group (0.07%) 129.9 ± 41.2 pm

• PHMB + silanol + fluoride group 94.4 ± 3.9 rn Results

Loss by dentin erosion progressed significantly for all groups over the six days. The highest dentin loss was observed in control samples treated with distilled water. The lowest dentin loss was observed in the group treated with the preparation PHMB + silanol + fluorides. The PHMB Group and the CHX Group led to intermediate dentin loss values that were significantly lower than those found for the control (water). The isolated fluoride group did not differ significantly from the negative control (water).

The PHMB + silanol + fluoride group had the best inhibitory effect on dentin erosion, the dentin loss was 94.4 ± 3.9 pm after 6 days. The dentin loss reducing action of the combination of the 3 active compounds cannot be denied, since the PHMB and Fluoride Groups alone showed significantly higher dentin losses (129.9 ± 41, 2 pm and 157.4 ± 6, 1 pm, respectively).

Knowing that the isolated fluoride group did not offer dentin erosion protection, the isolated PHMB group had intermediate dentin loss and the PHMB + silanol + fluoride combination group superseded the dentin erosion inhibitory effect of all groups, it appears that there is a synergistic combination between PHMB, silanol and fluoride ions.

Some compositions of gels, toothpastes and mouthwash containing the preparation with the active ingredients PHMB + silanol + fluorides were developed in order to prevent acid erosion of dentin. The compositions disclosed therein comprise at least one further ingredient selected below as carriers, sweeteners, preservatives, colorant, pH regulators, surfactants, abrasives, thickener, wetting, flavoring, opacifier, antimicrobial and anti-caries agent.

PHMB concentration in oral care compositions for the purpose of preventing dentin erosion may range from 0.01% to 0.3% and preferably from 0.02% to 0.1%.

The concentration of silanol in oral care compositions for the purpose of preventing dentin erosion may range from 0.0001% to 0.1% and preferably from 0.0001% to 0.01%.

The concentration of fluoride ions in oral care compositions for the purpose of preventing dentin erosion may range from 0.001% to 5.0% and preferably from 0.006% to 0.15%.

The preparation with PHMB, silanol and fluorides contains a silanol: PHMB ratio between 1: 100 and 1: 700, particularly 1: 155.

The preparation with PHMB, silanol and fluorides contains a silanol: fluoride ratio of 1: 40 to 1: 333, particularly 1: 50.

The preparation with PHMB, silanol and fluorides contains silanol: fluoride: PHMB ratios of about 1: 50: 155.

Below are some compositions of the present invention to exemplify the use of the preparation of PHMB + silanol + fluorides without, however, restricting use to such specific examples.

Example 1: Oral Solution Composition

Raw Material Quantity (%)

Water 82,460

Sorbitol 70% 15,000

Sodium saccharin 0.050

Sodium Benzoate 0.300

Sodium Phosphate 0.090

Disodium phosphate 0.050

Sodium Cocoanphodiacetate 1,500

Preparation:

0.050 Sodium Fluoride

PHMB 20% 0.350

Methylsilanol manuronate 0.15

Total 100,000

The manufacturing process consists of the preparation of 3 phases which are later added as follows: Phase A = Weigh to 1/3 of total water and solubilize the ingredients: dyes, sodium saccharin, sodium benzoate, sorbitol, sodium cocoamphodiacetate. Homogenized to full solubilization of ingredients, the solution is clear and transparent.

Phase B = Weigh 1/3 of the total water and solubilize the actives: sodium fluoride, silanediol manuronate and polyaminopropyl biguanide. Homogeneous. Add Phase B to Phase A. Homogeneous.

Phase C = Weigh 1/3 of total water and solubilize monobasic sodium phosphate and phosphatodisodium. Mix until fully solubilized.

Add this Phase C mixture to Phase A + Phase B. Mix until fully homogenized.

The ingredient PHMB 20% of the above composition is water (80%) and PHMB (20%). This solution is added to the formulation in a percentage of 0.350%, which implies a final concentration of 0.07% PHMB in the buccal solution.

The methylsilanol manuronate solution of the above composition is composed of: monomethylsilanetriol 0.3%; manuronic acid 0.6%; enough preservers and enough water to complete 100%. This solution is added to the formula in an amount of 0. 150%, which implies a final concentration of 0.00045% monomethylsilanetriol in the buccal solution.

Sodium fluoride solution is added to the above composition in an amount of 0.05%, which implies a final concentration of 0.0226% fluoride ions.

Example 2: Composition of Dental Gel

Raw Material Quantity (%)

Sorbitol 70% 58,000

Water 16.011

Hydrated Silica (Thickener) 8,000

Hydrated Silica (abrasive) 6,000

Cocoamidopropyl betaine 5,000

Glycerin 3,000

Polyethylene glycol 400 1,000 Aroma 0.800

Titanium dioxide 0.500

Carboxymethylcellulose 0.450

Xanthan Gum 0.400

Sodium saccharin 0.300

Preparation:

Sodium Fluoride 0.319

Silanediol Salicylate 0, 150

Polyamopropopropyl biguanide 0.070

Total 100,000

The manufacturing process consists of the preparation of 3 phases which are later added as follows:

Phase A = Weigh 1/3 of total water and solubilize sodium saccharin and titanium dioxide. Add the sorbitol. Homogeneous.

Phase B = Weigh 2/3 of total water and solubilize sodium fluoride, silanediol salicylate and polyaminopropyl biguanide. Homogenize and mix Phase B into Phase A. Homogenize.

Step C = Weigh the glycerin, add polyethylene glycol 400 and disperse the carboxymethylcellulose and xanthan gum. Mix until completely lump free. Stir Phase C into Phase A + Phase B. Homogenize until complete incorporation and lump-free.

Then add the silicas and homogenize until completely incorporated and free of lumps. Add the Aroma and then cocoamidopropibetaine. Homogeneous.

Claims

1 . Oral preparation for reducing dentin erosion, comprising PHMB according to formula I or its derivatives.

Formula I

NH NH

H H H n being an integer between 2 and 40, particularly between 8 and 15.

Oral preparation for reducing dentin erosion according to claim 1, characterized in that it further comprises one or more silanols and / or one or more fluoride ionizable compounds.

Oral composition for reducing dentin erosion comprising oral preparation according to one of claims 1 or 2.

Oral composition for reducing dentin erosion according to claim 3, comprising PHMB as a percentage of the total composition from 0.01% to 0.3%, preferably from 0.02% to 0.1%. .

Oral composition for reducing dentin erosion according to claim 2, comprising a ratio of silanol: PHMB between 1: 100 and 1: 700, particularly 1: 155 and silanol as a percentage of the total composition ranging from 0.0001% to 0.1%, preferably 0.0001% to 0.01%.

Oral composition for reducing dentin erosion according to Claim 3, characterized in that it comprises a ratio of silanol: fluoride from 1: 40 to 1: 333, particularly 1: 50 and the fluoride ionizable compounds as a percentage of the total. composition ranging from 0.001% to 5.0% preferably from 0.006% to 0.15%.

Oral composition for reducing dentin erosion according to claim 3, characterized in that it comprises silanol: fluoride: PHMB ratios of about 1: 50: 155.

Oral preparation for reducing dentin erosion according to claim 2, characterized in that silanol is one or more of methylsilanol manuronate, silanetriol arginate, ascorbyl methylsilanol pectinate, siloxanetriol alginate, silanediol salicylate, dimethylsilanol hyaluronate, methylsilanol hydroxyproline aspartate, sodium lactate, silanetriol lysinate, dioleyl tocopheryl methylsilanol, dimethyl oxobenzene dioxasilane, methyl silanol carboxymethyl theophylline alginate, methylsilanol acetyl tyrosine, acetylmethionyl elastinate, copper acetyl tyrosinate methylsulanolate, dimethiconyl methanolylate methanolylate methanolylate, dimethyl oxide methylsulfonate , methylsilanol elastinate, methylsilanol glycyrrhizinate, methylsilanol hydroxyproline, methylsilanol PCA, methylsilanol PEG-7 glyceryl cocoate, methylsilanol spirulinate, methylsilanol tri-PEG-8 glyceryl cocoate, methylsilanol / silicate crosspolymer, polysilicone-21, sodium hyaluronate dimethylsilanol, sodium manuronate Methylsilanol, sodium PCA Methylsilanol, PG-propyl methylsilanediol hydrolyzed collagen, keratin hydrolyzate PG-propyl methylsilanediol, keratin hydrolyzate PG-protein propyl hydrolysed hydrolyzate PG-propyl methylsilanediol, sodium hyaluronate dimethylsilanol and sorbityl silanediol.

Oral preparation for reducing dentin erosion according to claim 2, characterized in that the fluoride ionizable compounds are one or more of sodium fluoride, tin fluoride, sodium monofluorophosphate, fluorinated amine, titanium tetrafluoride, 2 - bis (hydroxyethyl) aminopropyl-N-hydroxyethyloctadecyl dihydrofluoride, N, N, N-Tris (2-hydroxyethyl) -N-octadecyl-1,3, diaminopropane, dihydrofluoride, ammonium monofluorphosphate, calcium monofluorophosphate , potassium fluoride, Ammonium fluoride, aluminum fluoride, magnesium fluoride, calcium fluoride, hexadecylammonium fluoride, 3- (N-hexadecyl-N-2-hydroxyethylammonium) propylbis (2-hydroxyethyl) ammonium dihydrofluoride Ν , Ν, Ν-tris (polyoxyethylene) -N-hexadecyl propylenediamine, nicomethanol hydrofluoride, octadicenyl ammonium fluoride, sodium fluororsilicate, ammonium fluororsilicate, magnesium fluororsilicate, hydrofluorid cetylamine hydrochloride, oleylamine hydrochloride and hexyldecylamine difluoride.

Oral composition for reducing dentin erosion comprising a preparation according to any one of claims 3 to 7 and at least one further ingredient selected from carrier, sweetener, preservative, pH regulator, surfactant, dye, abrasive, thickener, humectant. , flavoring, opacifying, antimicrobial and anti-caries agent.

1 1. Oral composition for reducing dentin erosion according to claim 10, characterized in that the antimicrobial is chlorhexidine.

Use of the preparation of any one of claims 1 or 2, characterized in that it is for the preparation of dental gels, toothpastes, mouthwashes, dental flosses, dental tapes, varnishes or professional dental products.

Use of the preparation of any one of claims 1 or 2 characterized in that it is in the preparation of a composition useful in the treatment of reduction or prevention of dentin erosion.