WO2016032177A1

WO2016032177A1 - Rope for loop for forming loop during mitral valve cerclage coronary sinus annuloplastry and apparatus for manufacturing same

Info

Publication number: WO2016032177A1
Application number: PCT/KR2015/008799
Authority: WO
Inventors: 김준홍; 신일균
Original assignee: (주)타우피엔유메디칼
Priority date: 2014-08-29
Filing date: 2015-08-24
Publication date: 2016-03-03
Also published as: KR101677193B1; KR20160026292A

Abstract

The present invention relates to a rope for a loop used to form a loop during a mitral valve cerclage coronary sinus annuloplastry and an apparatus for manufacturing the same and, more particularly, to a rope for a loop and a method for manufacturing the same, wherein a mitral valve annuloplastry coronary artery protector-integrated rope, which has an integrated arch-type coronary artery protector, and a guide wire are connected integrally. The present invention is characterized in that a coronary artery protector-integrated rope, which is used during a mitral valve cerclage coronary sinus annuloplastry, and a guide wire (40) are integrally connected by a single line. In this regard, the coronary artery protector-integrated rope is a coronary artery protector-integrated rope, to which an arch-type coronary artery protector (30) for protecting coronary arteries is integrally fixed and coupled, and the guide wire is a slender straight wire. An apparatus for manufacturing a rope for a loop for forming a loop during a mitral valve cerclage coronary sinus annuloplastry, according to a preferred embodiment of the present invention, comprises: a power unit that receives power; and a processing unit, which receives power from the power unit, and which simultaneously generates heat and conducts compression.

Description

Rope for forming a loop in mitral valve circle large coronary sinusplasty and apparatus for manufacturing same

The present invention relates to a loop rope used to form a loop in a mitral valve circle large coronary sinus procedure, and a manufacturing apparatus thereof, and more particularly, to a coronary artery protector integrated rope and an mitral valve procedure. The guide wire is connected to a rope for a loop and a device for manufacturing the same.

The heart is an organ that acts as a blood pump. To operate this muscle pump (heart) requires a valve that allows blood flow to flow in a constant direction rather than backflow. The heart has four rooms, two atriums and two ventricles, which are connected to four vessels: the aorta, veins, pulmonary arteries, and pulmonary veins.

The valve between the left atrium and the left ventricle is the mitral valve (MV), the valve between the right atrium and the right ventricle is the tricuspid valve (TV), and the valve between the left ventricle and the aorta is the aortic valve, the right ventricle and The valve between the pulmonary arteries is the pulmonary valve (PV).

The valve should open and close completely according to the heartbeat. If it does not move properly, such as not fully closed or fully open, fluid will flow back or flow badly. This is heart valve disease. Heart valve disease can be divided into two types: a disease of leaking blood (regurgitation) that does not close completely when the valve needs to be closed, and a disease that does not open completely when the valve needs to open (stenosis, stenosis).

Mitral regurgitation is a disease in which the mitral valve, the valve between the left atrium and the left ventricle, does not close completely when it is closed, resulting in blood backflow, which results in a burden on the heart, which results in heart failure and eventually causes heart failure.

To date, treatment for mitral regurgitation is the standard treatment of surgery, which involves opening the sternum of the chest and opening the heart to repair the mitral valve or replace it with an artificial valve. This is a very invasive method of treatment that is effective but can occur up to 5% of the risk of death of the patient due to surgery alone. Due to these limitations, until now only very severe mitral regurgitation has been treated with surgery.

Against this backdrop, many studies have been made on the development of percutaneous mitral valve repair that can repair the mitral valve through a relatively simple procedure using a catheter without opening the patient's chest and requiring a heart incision. As part of this international study, we recently published a Mitral cerclage coronarysinus annuloplasty (MVA) in an international paper, which would apply circular pressure around the mitral annulus (MA). It can prove that the therapeutic effect is excellent. The contents of the paper have been filed in international patent applications (International Application No .: PCT / US2007 / 023836) and are now published internationally by the International Bureau (International Publication No. WO2008 / 060553).

Briefly describing the percutaneous mitral valve surgery (mitral valve circle large procedure) described in the above paper and the patent application, the catheter is placed into the 'coronary venous sinus' after accessing the right atrium through the jugular vein and the 'proximal septal vein' Pass through the yarn needed for the circle large (named 'circle yarn'). This thread can easily come out as one of the right ventricular outflow tracts (RVOTs) of the right ventricle. This method was named mitral cerclage annuloplasty. This thread can be easily grasped into the right atrium, thereby placing the circle large yarn in the tissue around the mitral annulus. Applying tension to the thread gives the effect of imprisoning the mitral valve, which reduces the incomplete closure of the valve by bringing the two valves of the mitral valve closer together. This principle has a very similar effect to the surgical treatment of direct mitral mitral valve repair, which is a therapeutic effect that reduces the backflow of blood through the mitral valve.

However, the above international patent application has a problem to be solved. First, there is a need for a tension locking device that can apply and maintain proper tension on the circle large yarn at the site of the procedure. The previous study used 0.014 inches of nylon, which can vary in thickness, which can damage adjacent tissues.

In order to solve this problem, the present inventors have applied Korean Patent Application No. 2009-0080708 (filed on Aug. 28, 2009) (Invention name: tissue protection mechanism of coronary sinus and three thousand valves, knot delivery mechanism and mitral valve including them) Just a large circle device). (Korean Patent Registration No.:10-1116867. 2012.02.08 registration)

In the patent application, the circle large yarn is wrapped in a coronary sinus tube (CS Tube) and three thousand valve tube (TV Tube) to protect the tissue damage (ie, tissue protection mechanism to protect the human tissue), circle large A knot tied at the end of the thread was transferred to the upper end of the tissue protection device by using a knot delivery device to complete the circle large procedure.

In this patent application, a large yarn of nylon that is passed through a tissue protection apparatus (CSTV TUBE) is used. Nylon is a material suitable for living beings, does not deform even at a certain portion of tension, and has a durable feature, and is suitable as a circle yarn in a circle large procedure. However, the circle large nylon yarn is not visible at all in the fluoroscopic image (X-ray) used as an induction image in the mitral circular circle procedure, and thus, the mitral circle circular procedure is not easy and the circle large during the mitral circle circular procedure In order to deliver the nylon thread to the circle large target area in the heart, it is necessary to push the circle large nylon thread through a catheter having a thin inner diameter. However, due to the nature of the nylon thread, pushability is weak and it is not easy to deliver.

In addition, the arch portion, which is a coronary sinus protector (coronary artery protector) proposed in the international patent application (International Application No.:PCT/US2007/023836), can be easily moved by the flow of the heart while being loosely fitted in a circle large thread. Im, there was a disadvantage that it does not guarantee safety.

In order to overcome these disadvantages, the present inventors proposed a patent application (Korean Patent Application No.:10-2014-0072525) suggesting a circular rope for mitral valve circle large procedure in which an arcuate coronary protective device is integrated.

FIG. 1 shows a mitral valve circular lodge with integrated arch coronary protection (also referred to as an “integral coronary device integrated circular rope”, “coronary artery integrated rope”, or “unified rope”) and tissue protective device (CSTV). tube), Figure 2 shows the procedure. The procedure involves first accessing the right atrium through the jugular vein using a guide wire, then through the coronary sinus and the proximal septal vein, the right ventricular outflow tract of the right ventricle. RVOT) to the right atrium, forming a reverse alpha-shaped loop, and then progressively pushing the microcatheter along the guide wire (a). Next, the guide wire is pulled out of the body (b). Only the microcatheter remains. Then, insert the 'Coronary Artery Protection Integral Rope' into the microcatheter (c).

Once the coronary artery harness integral rope is fully inserted, the microcatheter is pulled out of the body (d). Then, finally, a tissue protective device (CSTV tube) is inserted (e) to complete the mitral valve loop coronary sinus procedure.

However, in the case of inserting the coronary artery protector integrated rope into the microcatheter lumen, the coronary artery protector is not easy to insert into the catheter because it is larger than the microcatheter inner diameter. Thus, the microcatheter is inserted into the coronary prosthesis connection portion of the integrated rope, and the microcatheter and the integrated rope are pulled out at the same time so that the coronary prosthesis is in the correct position (when the coronary artery is protected). Only the catheter is pulled towards the inferior vena cava to remove the microcatheter. This method leads to the complexity and inconvenience of the procedure, such as the microcatheter insertion step, the integrated rope insertion and correct positioning step, the microcatheter removal step, in order to put the integrated rope in place.

Therefore, there is a need to propose a new method and apparatus for simpler and simpler positioning of the 'integral rope' coronary protection on the coronary artery.

The present invention has been made to solve the above problems, and an object of the present invention is to break away from the conventional method that causes the inconvenience of the procedure, and to form a loop to position the coronary artery protection integrated circular loop in the heart. Rope for the mitral valve procedure integrated with a guide wire and a loop for the manufacture of a mitral valve circle large coronary device integrated rope that can be inserted into the heart very simply and simply without the need for the introduction of a microcatheter. To provide a device.

The object of the present invention is not limited to the above-mentioned object, and other objects which are not mentioned will be clearly understood from the following description.

The present invention is to achieve the above object, characterized in that the coronary artery protector integrated rope and the guide wire 40 used in the mitral valve circle large coronary sinus plastic surgery of the present invention is integrally connected by a single line. .

Preferably, the coronary artery protector integral rope is a coronary artery protector integral rope to which the arcuate coronary artery protector 30 is integrally fixedly coupled to protect the coronary artery, and the guide wire is a thin straight wire.

According to a preferred embodiment of the present invention, a device for manufacturing a loop rope for forming a loop in mitral valve circle large coronary sinus surgery includes a power supply unit receiving power; And a processing unit which receives power from the power supply unit and generates heat and simultaneously compresses the power.

Preferably, the power supply unit is coupled in a form in which the built-in charging unit can be detachably attached, and the processing unit generates a heat by power supplied from the power supply unit, and a heat generating plate to which heat is generated by transferring heat generated from the heater. (60).

As described above, since the loop rope of the present invention is integrally connected with the guide wire and the coronary artery protector integrated rope, it is not necessary to introduce a catheter for inserting the integrated rope. It can be easily performed, the surgical instruments introduced can also be reduced to increase the economics of the circle large procedure, thereby reducing the economic burden of the patient.

In addition, by introducing a loop rope manufacturing apparatus of a simple structure, there is an advantage that can simply manufacture the rope for the loop.

1 is a perspective view of a circular rope and tissue protective device for mitral valve circle large procedure integrated with an arcuate coronary artery protector proposed by the inventor.

Figure 2 is a schematic diagram showing a mitral valve circle large procedure using a circular rope for mitral valve circle large procedure, which has been proposed by the present inventors, an arcuate coronary artery protector.

3 is a perspective view of a rope for a loop, according to a preferred embodiment of the present invention.

4 is a partial cross-sectional view of the integrated rope and the guide wire inserted into the heat shrink tube according to another preferred embodiment of the present invention, (a) shows the state inserted into the heat shrink tube, (b) is applied to heat shrink The state in which the tube is compressed is shown.

Figure 5 is a photograph of the integrated rope and the guide wire inserted into the heat shrink tube as shown in FIG.

6 is a perspective view of a rope manufacturing apparatus for a loop, according to a preferred embodiment of the present invention.

Figure 7 is a perspective view of a rope manufacturing apparatus for a loop, according to another embodiment of the present invention.

8 is a perspective view of a roof rope manufacturing apparatus according to another preferred embodiment of the present invention.

Hereinafter, with reference to the accompanying drawings, it will be described in more detail with respect to the loop rope of the present invention, and a manufacturing apparatus for manufacturing the same.

First, the terms will be described.

A guide wire (RVOT wire, 40) is a relative venous, coronary sinus, ventricular septum, right ventricle, right atrium, or inferior vena cava (or relative vein) prior to insertion of the circle large thread (circle rope, 10) during mitral circular circle procedure. Turning to form a circle, it means a guide wire for inserting the circle large thread to be inserted later. The guide wire is referred to as the "RVOT wire" in the sense of penetrating the RVOT in the heart. In other words, "RVOT wire" means a wire that enters the right ventriculat outflow tract (RVOT), which is the preferred target structure past the coronary sinus and ventricular septum, and in a broad sense completes a circle in a circular procedure. Means "guide wire". That is, in the mitral valve circle large procedure, the RVOT wire first forms a circle, and a circle large thread (circular rope, 10) is inserted later. The guide wire (RVOT wire) is a straight metal wire that is relatively thinner than the circular rope (see FIGS. 3 and 4).

A circular thread (10, cerclage suture) is a thin thread of about 0.014 used in the mitral cerclage coronary sinus annuloplasty (MVA). (coronary sinus, CS) part, tricuspid valve (TV) part, ventricular septal part is named in the sense of coming out of the body in a circular shape.When it comes out of the body, one end and the other end are connected It becomes a thread. That is, as shown in FIG. 1, a circle is drawn to connect one yarn. The material of the circle large yarn may be made of synthetic resin such as nylon, or metal (stainless steel, nylon coated metal). It is also possible to use wires made by twisting a plurality of thin wires (also called "circle ropes"). Therefore, it is variously referred to as "circle yarn", "circle rope", "circle wire", "roof rope", "roof wire", etc., all of which will be referred to as a kind of circle yarn of the present invention. It will belong to the scope of the present invention.

In addition, the arcuate coronary artery protector 34 has an arch shape and is a portion that protects the coronary artery by the circular rope 10. In the circle large procedure, the circle large rope enters the coronary sinus, and when the circle large rope is confined to block the mitral annulus of the patient with mitral regurgitation, the circle large rope in the coronary sinus passing over the coronary artery presses on the coronary artery. Problems occur that block the flow of blood in the coronary arteries and damage them. In order to prevent this problem, in order to protect the coronary artery in the above-mentioned International Publication (WO2008 / 060553, published May 22, 2008), a technique for protecting the coronary artery by inserting an arch in the coronary sinus is disclosed. It is. The arcuate coronary artery protector 34 is also called a "coronary sinus protector" in the sense of being inserted into the coronary sinus or "coronary artery protector" in the sense of protecting the coronary artery. "Archial coronary artery protector" is a name given in the sense of being arched to be inserted into the coronary sinus and to protect the coronary artery. The arcuate coronary care device may be made of synthetic resin or metal, preferably stainless steel.

On the other hand, the coronary artery protector integrated circle large rope (also referred to as "coronary artery protector integrated rope", "unified rope") 30 means a circular rope that the arcuate coronary artery protector 34 is integrally fixed. . After inserting the arcuate coronary artery protector into the circle large rope, the arcuate coronary artery protector is wrapped with a biocompatible material to complete the integral circular loaf. Integral coronary protection rope eliminates the need to insert a separate arch-type coronary artery through the circular rope during the circle large procedure.The coronary artery is fixed to the circular rope to protect the arch from coronary heartbeat. The bulbs do not move independently, increasing the safety of the circle large procedure.

In addition, the "rope for loop connecting the coronary artery protector integrated rope and the guide wire for mitral valve procedure" used in the mitral valve circle large coronary sinus plastic surgery to be described in the present invention (roof rope) is a coronary artery protector integrated rope and guide As a rope to which wires are connected, it means that the wires are directly connected to each other or connected by a connecting tube (for example, a medical heat shrink tube, a medical tube, a metal tube, etc.).

Tissue protection mechanism (20, CSTV tube) is a hollow coronary sinus tube (coronary sinus tube, CS tube, 22) to protect the coronary sinus tissue; Hollow tricuspid valve tubes (TV tubes, 24) to protect the tissues of the three thousand valves and the ventricular septum; The tubular sinus tube and the three thousand valve tube includes a stem portion 26 is coupled to each other side. In other words, the tissue protection mechanism of the present invention comprises a hollow tube for coronary sinus (CS tube) to protect the coronary sinus tissue; It consists of a hollow three thousand valve tube (TV tube) to protect the tissues of the three thousand valves and ventricular septum, the tube for the coronary sinus and the three thousand valves from the upper side to a predetermined length, the lower side, On the side has a structure separated from each other. The coronary sinus tube 22 is inserted into the coronary sinus and serves to protect the coronary sinus tissue applied by the circular rope, the three thousand valve tube 24 is inserted into the three thousand valves are applied by the circular rope It protects the tissues of the three thousand valves and the ventricular septum. Coronary sinus tube (CS tube) and three thousand valve tube (TV tube) is made of a rubber or synthetic catheters, or a metal coil spring.

Next, a loop rope (also referred to as "circle rope", "circle wire") and a manufacturing apparatus thereof in which a coronary artery protector integrated rope and a guide wire are connected according to the present invention will be described. .

The loop rope of the present invention means a rope in which the coronary artery protector integrated rope 30 and the guide wire 40 are integrally connected by one line. Here, the coronary artery protector integral rope 30 is an arcuate coronary artery protector 34 integral circle large rope that protects the coronary artery, and the guide wire (RVOT wire) is a straight wire that is relatively thinner than the integral circle large rope (Fig. 3). , 4).

The unitary circle large rope 30 is an integral circle large rope in which an arcuate coronary artery protector 34 for protecting a coronary artery is integrated, and the circle large rope 32, the arcuate coronary artery protector 34, and the coating unit 36 are formed. Is made of.

* The circular cladding 32 is composed of a metal wire inside and a coating layer coated with a biocompatible material on the outer surface of the wire. Preferably, the metal is one or more selected from biocompatible metals such as stainless steel, cobalt chromium, titanium, and nickel cobalt chromium alloy. The biocompatible coating material is at least one selected from nylon, teflon, silicone and polyurethane. Here, the wire is preferably a form made by twisting a plurality of thin wires. This is because the wire is prevented from twisting and the elasticity is high.

The arcuate coronary artery protector 34 is inserted into the circular rope and protects the coronary artery, and has an arcuate shape.

The coating part 36 is an integral part of the arcuate coronary artery protector 34 and the circular rope 32, and is preferably formed of a biocompatible material. For example, it is used as medical polyurethane, polyolefin, silicone, stretch molded Teflon (e-PTFE), Teflon (PTFE), etc., which are used as a permanent transplant material in vivo. The method of forming the coating part may be a method of immersion in a coating liquid and drying, a method of thermal fusion after winding in a sheet-type material, a method of using a medical cyanoacrylic instant adhesive, and a method of thermal fusion. Most preferably, after dipping, a drying method will be used.

The guide wire (RVOT wire) 40 is a straight wire that is relatively thinner than the circular rope and serves to guide the way before the circular rope is inserted.

As in the present invention, since the loop rope is connected to the guide wire 40 and the coronary artery protector integrated circle large rope 30 integrally, there is no need to insert a microcatheter along the guide wire, and thus the circle (in the heart) A coronary artery protector integrated circle large rope 30 can be inserted directly along the guide wire (RVOT wire) 40 formed with a circle. That is, since the guide wire and the coronary artery protection integrated circle large rope are connected, the continuous pulling of the guide wire naturally inserts the coronary artery protection integrated circle large rope connected to the guide wire into the heart. It can be placed in the heart. Accordingly, the mitral valve procedure can be performed very simply and simply.

The loop rope of the present invention may be coupled to each other by means of heat fusion between the coronary artery protector integrated rope and the guide wire without any other medium, but may be coupled to each other through a medium called a connection tube in the middle. As the connection tube, for example, a medical heat shrink tube, a medical tube, a metal tube and the like are used. 4 shows a case where a medium called a heat shrink tube 50 is used.

4 is a partial cross-sectional view of the coronary artery protector integrated rope and the guide wire inserted in the heat shrink tube according to another preferred embodiment of the present invention, (a) shows the state inserted into the heat shrink tube, (b) the heat The state in which the heat-shrinkable tube is compressed by adding is shown.

The heat shrink tube 50 is a biocompatible material, for example, it may be selected from polyolefin, polytetrafluoroethylene (PTFE), polyetheretherketone (PEEK). Medical grade of USP GRADE 6 is used, and one of PEBAX 7233, 7033, 6333, 5533, 4033, 3500 can be used.

The heat shrink tube 50 has high flexibility, and has excellent sterilization stability using gamma rays, electron beams, etc., and has excellent dimensional stability with longitudinal shrinkage of 15% or less. do.

Preferably, the heat shrink tube 50 has a diameter of 0.1 to 10 mm, and the heat shrinkage ratio is 2: 1 to 4: 1. After the heat shrink through the heat shrink equipment (loop rope manufacturing apparatus), the final thickness can be reduced to 1/2 to 1/4 from the original diameter, it is possible to effectively connect the integral rope and the outside of the guide wire to combine.

5 is inserted into the coronary artery guard integrated rope 30 and the guide wire 40 respectively on both sides of the heat shrink tube 50, the heat shrink tube by applying heat to shrink the coronary artery guard integrated rope 30 and the guide wire It is a photograph of the state which combined 40.

Next, an apparatus for manufacturing the above-described loop rope, that is, a device for connecting the coronary artery protector integrated rope and the guide wire will be described.

6 to 8 are perspective views showing examples of the rope manufacturing apparatus for the loop according to the preferred embodiment of the present invention.

FIG. 6 is a plier-type device having an X-shaped processing part, and FIG. 7 is a press-type device, in which a groove 62 is dug in the center with a mold type consisting of an upper mold and a lower mold. The metal tube is placed in the center of the groove in the lower mold, and the corrugated artery integrated rope and the guide wire are overlapped and the press is applied to the upper mold to connect the coronary artery integrated rope and the guide wire to each other. The device is manufactured, and FIG. 8 shows an electric curling iron type device having a straight working part rotated by a hinge part. As such, the rope manufacturing apparatus for the loop may use various types of apparatus.

The rope manufacturing apparatus for the loop is applicable to both a device for directly integrating a coronary artery protector rope and a guide wire or a device for contracting / compressing a heat shrink tube. That is, it can be selectively used for two purposes according to the temperature of the heat generating plate heat is generated, or can be used for both purposes by controlling the exothermic temperature by the temperature controller. Compressing the heat shrink tube will require a lower exothermic temperature than direct contact between the coronary articulating body integrated rope and the guide wire.

The rope manufacturing apparatus for a loop of the present invention includes a power supply unit capable of controlling the molding temperature, and a processing unit for generating and compressing heat. The power supply unit may receive power from an external source or may be supplied by an internal battery. Of course, batteries can be used for both rechargeable and disposable applications. Preferably, the power supply unit is coupled in a form in which the built-in charging unit (battery) can be detached to give convenience to the procedure. In addition, preferably, the power supply unit includes a temperature controller for adjusting the temperature.

The processing unit includes a heater generating heat by the supplied power, and a heat generating plate 60 through which heat generated by the heater is transferred to generate heat.

Preferably, the heating plate 60 is formed with a groove 62 into which a rope for loop is inserted. This is to prevent the flat distortion when heat is applied to the heating plate when connecting the coronary protection unitary rope and the guide wire, and to maintain the circular tube shape, so that the heat shrink tube can be easily fixed on the heating plate.

The heating plate is detachably configured so that it can be easily replaced according to the size of the groove. That is, although not shown, by forming a bolt hole on the side of the heating plate to fasten the bolt, it can be easily removed. The groove of the detachable heat sink is 0.2mm ~ 3mm in length and 3 ~ 10cm in length.

The above description is merely illustrative of the technical idea of the present invention, and those skilled in the art to which the present invention pertains may make various modifications and changes without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical spirit of the present invention, but are intended to explain, and the scope of the technical spirit of the present invention is not limited by these embodiments. The protection scope of the present invention should be interpreted by the claims below, and all technical ideas within the equivalent scope should be interpreted as being included in the scope of the present invention.

The present invention relates to a loop rope used to form a loop in a mitral valve circle large coronary sinus procedure, and a manufacturing apparatus thereof, and more particularly, to a coronary artery protector integrated rope and an mitral valve procedure. The guide wire is available in the field of ropes connected to one and the device for manufacturing the same.

Claims

A loop rope for forming a loop in mitral valve circle large coronary sinusplasty,

A loop rope, characterized in that the coronary artery guard integrated rope and the guide wire are integrally connected by a single line.
The method of claim 1,

The coronary artery protector integrated rope is a coronary artery protector integrated rope in which an arcuate coronary artery protector is integrally fixedly coupled to protect the coronary artery.

The guide wire is a rope for a loop, characterized in that the thin straight wire.
The method of claim 2,

The coronary artery protection unitary rope

A circular rope consisting of a metal wire inside and a coating layer coated with a biocompatible material on an outer surface of the wire;

An arcuate coronary artery protector inserted into the circular rope and protecting the coronary artery; And

And a coating portion for wrapping the arcuate coronary artery protector and a portion of the circular rope on an outer surface to integrate the arcuate coronary artery protector and the circular rope.
The method of claim 3, wherein

The metal is one or more selected from stainless steel, nitinol (nickel-titanium alloy), cobalt-chromium alloy, titanium, and nickel-cobalt-chromium alloy.

The biocompatible coating material is a rope for a loop, characterized in that at least one selected from nylon, teflon, silicone and polyurethane.
The method of claim 3, wherein

The coating part is a medical rope, loop, characterized in that at least one selected from polyurethane, polyolefin, silicone, stretch molded Teflon (e-PTFE), Teflon (PTFE).
The method of claim 3, wherein

The coating part is immersed in a coating liquid and dried, a method of drying a sheet-type material, followed by heat fusion, a method using a medical cyanoacrylic instant adhesive, or a heat-rope loop. .
The method of claim 1,

And the coronary artery protector integrated rope and the guide wire are connected by a connecting tube.
The method of claim 7, wherein

The connecting tube is a heat-shrinkable tube, and the coronary articulation device integrated rope and the guide wire are respectively inserted into both sides, and heat is applied from the outside to connect the coronary artery protection integrated rope and the guide wire. Dragon rope.
The method of claim 8,

The material of the heat shrink tube is a rope for a loop, characterized in that at least one of polyolefin, polytetrafluoroethylene (PTFE), polyether ether ketone (PEEK) is selected.
The method of claim 8,

The heat-shrink tube has a high flexibility, excellent sterilization safety, and the rope for a loop characterized in that the longitudinal shrinkage is less than 15%.
In the device for producing a loop for forming a loop in mitral valve circle large coronary sinus plastic surgery,

A power supply unit receiving power; And

And a processing unit for generating heat and simultaneously compressing power from the power supply unit.
The method of claim 11,

Rope manufacturing apparatus for the power supply unit is characterized in that the built-in charging unit is coupled in a removable form.
The method of claim 11,

The processing part

A heater for generating heat by the power supplied from the power supply unit;

Rope manufacturing apparatus for a loop, characterized in that it comprises a heat generating plate 60 is heat generated by the heat generated from the heater.
The method of claim 13,

Loop device for producing a loop, characterized in that the heating plate is formed with a groove 62 is inserted into the loop rope.
The method of claim 11,

The processing unit is a rope manufacturing apparatus for a loop, characterized in that the plier (plier) type having a processing unit of the X-shape.
The method of claim 11,

Rope manufacturing apparatus for the processing unit, characterized in that the press mold type.
The method of claim 11,

The processing unit is a rope manufacturing apparatus for a loop, characterized in that the curling machine (electric curling iron) type having a straight processing unit rotated by the hinge portion.