WO2014146147A3 - Multi-measurement flow cell assembly for liquid chromatography - Google Patents

Multi-measurement flow cell assembly for liquid chromatography Download PDF

Info

Publication number
WO2014146147A3
WO2014146147A3 PCT/US2014/038070 US2014038070W WO2014146147A3 WO 2014146147 A3 WO2014146147 A3 WO 2014146147A3 US 2014038070 W US2014038070 W US 2014038070W WO 2014146147 A3 WO2014146147 A3 WO 2014146147A3
Authority
WO
WIPO (PCT)
Prior art keywords
flow cell
optical flow
cell body
liquid
liquid chromatography
Prior art date
Application number
PCT/US2014/038070
Other languages
French (fr)
Other versions
WO2014146147A2 (en
Inventor
Nicholas Demarco
Steven R. TJENSVOLD
Bryant J. DEAKINS
Original Assignee
Practichem, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Practichem, Llc filed Critical Practichem, Llc
Priority to EP14764986.7A priority Critical patent/EP2972154A4/en
Publication of WO2014146147A2 publication Critical patent/WO2014146147A2/en
Publication of WO2014146147A3 publication Critical patent/WO2014146147A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/066—Modifiable path; multiple paths in one sample
    • G01N2201/0668—Multiple paths; optimisable path length

Abstract

A detector for detecting constituents of a liquid for use in liquid chromatography is disclosed. The detector includes a first optical flow cell body and a second optical flow cell body, each having a channel therethrough that allows passage of a liquid from an inlet port to an outlet port. The first and second optical flow cell bodies are arranged in series such that the liquid exiting the outlet port of the first optical flow cell body enters the inlet port of the second optical flow cell body. An insulator resides between the first optical flow cell body and the second optical flow cell body, which is adapted to electrically insulate the first optical flow cell body from the second optical flow cell body while allowing the liquid to pass from the first optical flow cell body to the second optical flow cell body. The first optical flow cell body is adapted to facilitate measurement of absorption by the liquid of a first wavelength of light, and second optical flow cell body is adapted to facilitate measurement of absorption by the liquid of a second wavelength of light. The first and second optical flow cell bodies are further adapted to perform as electrodes for measuring the conductivity of the liquid.
PCT/US2014/038070 2013-03-15 2014-05-15 Multi-measurement flow cell assembly for liquid chromatography WO2014146147A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14764986.7A EP2972154A4 (en) 2013-03-15 2014-05-15 Multi-measurement flow cell assembly for liquid chromatography

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361794081P 2013-03-15 2013-03-15
US61/794,081 2013-03-15
US201361824219P 2013-05-16 2013-05-16
US61/824,219 2013-05-16
US201461953284P 2014-03-14 2014-03-14
US61/953,284 2014-03-14

Publications (2)

Publication Number Publication Date
WO2014146147A2 WO2014146147A2 (en) 2014-09-18
WO2014146147A3 true WO2014146147A3 (en) 2015-01-08

Family

ID=51538624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/038070 WO2014146147A2 (en) 2013-03-15 2014-05-15 Multi-measurement flow cell assembly for liquid chromatography

Country Status (2)

Country Link
EP (1) EP2972154A4 (en)
WO (1) WO2014146147A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10274428B2 (en) * 2014-11-25 2019-04-30 Ge Healthcare Bio-Sciences Ab Intergration of fluorescence detection capability into light absorbance measurement apparatus
WO2021094009A1 (en) * 2019-11-14 2021-05-20 World Precision Instruments Germany Gmbh Flow cell system for optical fluid analysis and bioreactor system

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462962A (en) * 1982-07-19 1984-07-31 Toyo Soda Manufacturing Co., Ltd. Liquid chromatographic flow cell
US6307204B1 (en) * 1997-11-14 2001-10-23 Jasco Corporation UV detector for liquid chromatography
US6391541B1 (en) * 1999-05-28 2002-05-21 Kurt E. Petersen Apparatus for analyzing a fluid sample
US20040188333A1 (en) * 2001-02-27 2004-09-30 Isco, Inc. Liquid chromatographic method and system
US20050011836A1 (en) * 2003-07-17 2005-01-20 Brian Bidlingmeyer Additives for reversed-phase HPLC mobile phases
US20050213088A1 (en) * 2004-03-23 2005-09-29 Lockheed Martin Corporation Optical flow cell for tribological systems
US20060132770A1 (en) * 2003-04-04 2006-06-22 Hach Ultra Analytics, Inc. Particle detection system implemented with an immersed optical system
US20070103681A1 (en) * 2004-11-15 2007-05-10 Luna Innovations Incorporated Optical device for measuring optical properties of a sample and method relating thereto
US20080246954A1 (en) * 2007-04-05 2008-10-09 Mitsuo Kitaoka Fluorescence detector and liquid chromatograph having the fluorescence detector
US20080252884A1 (en) * 2002-04-29 2008-10-16 Robert Jeffrey Geddes Carr Optical detection and analysis of particles
US20090116011A1 (en) * 2005-06-27 2009-05-07 Ojk Consulting Limited Optical Arrangement for a Flow Cytometer
US20100165325A1 (en) * 2006-07-31 2010-07-01 Sysmex Corporation Optical system for a particle analyzer and particle analyzer using same
US20100230353A1 (en) * 2009-03-13 2010-09-16 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
US20110141465A1 (en) * 2008-05-22 2011-06-16 Waters Technologies Corporation Light-Guiding Flow Cells And Analytical Devices Using The Same
US20110228271A1 (en) * 2006-12-29 2011-09-22 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US20120193555A1 (en) * 2009-10-08 2012-08-02 Colin Steel Multi-stream high-pressure liquid chromatography module

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0143901B1 (en) * 1983-11-23 1988-06-29 Bacharach, Inc. Multifunctional detector
AU2002952602A0 (en) * 2002-11-12 2002-11-28 Varian Australia Pty Ltd Flow through cell for optical spectroscopy

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462962A (en) * 1982-07-19 1984-07-31 Toyo Soda Manufacturing Co., Ltd. Liquid chromatographic flow cell
US6307204B1 (en) * 1997-11-14 2001-10-23 Jasco Corporation UV detector for liquid chromatography
US6391541B1 (en) * 1999-05-28 2002-05-21 Kurt E. Petersen Apparatus for analyzing a fluid sample
US20120009667A1 (en) * 1999-05-28 2012-01-12 Peterson Kurt E Apparatus and method for analyzing fluid sample
US20040188333A1 (en) * 2001-02-27 2004-09-30 Isco, Inc. Liquid chromatographic method and system
US20080252884A1 (en) * 2002-04-29 2008-10-16 Robert Jeffrey Geddes Carr Optical detection and analysis of particles
US20060132770A1 (en) * 2003-04-04 2006-06-22 Hach Ultra Analytics, Inc. Particle detection system implemented with an immersed optical system
US20050011836A1 (en) * 2003-07-17 2005-01-20 Brian Bidlingmeyer Additives for reversed-phase HPLC mobile phases
US20050213088A1 (en) * 2004-03-23 2005-09-29 Lockheed Martin Corporation Optical flow cell for tribological systems
US20070103681A1 (en) * 2004-11-15 2007-05-10 Luna Innovations Incorporated Optical device for measuring optical properties of a sample and method relating thereto
US20090116011A1 (en) * 2005-06-27 2009-05-07 Ojk Consulting Limited Optical Arrangement for a Flow Cytometer
US20100165325A1 (en) * 2006-07-31 2010-07-01 Sysmex Corporation Optical system for a particle analyzer and particle analyzer using same
US20110228271A1 (en) * 2006-12-29 2011-09-22 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US20080246954A1 (en) * 2007-04-05 2008-10-09 Mitsuo Kitaoka Fluorescence detector and liquid chromatograph having the fluorescence detector
US20110141465A1 (en) * 2008-05-22 2011-06-16 Waters Technologies Corporation Light-Guiding Flow Cells And Analytical Devices Using The Same
US20100230353A1 (en) * 2009-03-13 2010-09-16 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
US20120193555A1 (en) * 2009-10-08 2012-08-02 Colin Steel Multi-stream high-pressure liquid chromatography module

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2972154A4 *

Also Published As

Publication number Publication date
EP2972154A4 (en) 2016-11-16
EP2972154A2 (en) 2016-01-20
WO2014146147A2 (en) 2014-09-18

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