WO2012142516A8 - Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection - Google Patents
Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection Download PDFInfo
- Publication number
- WO2012142516A8 WO2012142516A8 PCT/US2012/033667 US2012033667W WO2012142516A8 WO 2012142516 A8 WO2012142516 A8 WO 2012142516A8 US 2012033667 W US2012033667 W US 2012033667W WO 2012142516 A8 WO2012142516 A8 WO 2012142516A8
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- WIPO (PCT)
- Prior art keywords
- methods
- scanning
- thermocycling
- synchronized
- optical detection
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
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- G01N35/00584—Control arrangements for automatic analysers
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- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2300/18—Means for temperature control
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- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N2035/00346—Heating or cooling arrangements
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
- G01N21/278—Constitution of standards
Abstract
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16199078.3A EP3159697B1 (en) | 2011-04-15 | 2012-04-13 | Scanning real-time microfluidic thermo-cycler |
BR112013026451-9A BR112013026451B1 (en) | 2011-04-15 | 2012-04-13 | system and method to perform molecular diagnostic tests on several samples in parallel and simultaneously amplification in real time in plurality of amplification reaction chambers |
RU2013146386A RU2690374C2 (en) | 2011-04-15 | 2012-04-13 | Scanning in real time microfluid thermal cycler and methods of synchronized thermal cycling and scanning optical detection |
CA2833262A CA2833262C (en) | 2011-04-15 | 2012-04-13 | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
EP12718504.9A EP2697657B8 (en) | 2011-04-15 | 2012-04-13 | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
CN201280029319.6A CN103597358B (en) | 2011-04-15 | 2012-04-13 | Scan real-time microfluid thermal cycler and for the thermal cycle synchronized and the method for scanning optical detection |
AU2012242510A AU2012242510B2 (en) | 2011-04-15 | 2012-04-13 | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
EP19218621.1A EP3709025A1 (en) | 2011-04-15 | 2012-04-13 | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
ES12718504.9T ES2617599T3 (en) | 2011-04-15 | 2012-04-13 | Real-time scanning microfluidic thermocycler and methods for synchronized thermocycling and optical scanning detection |
JP2014505377A JP6088487B2 (en) | 2011-04-15 | 2012-04-13 | Scanning real-time microfluidic thermal cycler and method of synchronous thermal cycling and scanning optical detection |
US14/054,397 US9765389B2 (en) | 2011-04-15 | 2013-10-15 | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
ZA2013/07781A ZA201307781B (en) | 2011-04-15 | 2013-10-18 | Scanning real-time microfluidic thermocycler and mehods for synchronized thermocycling and scanning optical detection |
AU2015210344A AU2015210344B2 (en) | 2011-04-15 | 2015-08-04 | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US15/706,313 US10781482B2 (en) | 2011-04-15 | 2017-09-15 | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
AU2017265124A AU2017265124B2 (en) | 2011-04-15 | 2017-11-23 | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
AU2020201285A AU2020201285B2 (en) | 2011-04-15 | 2020-02-21 | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US17/026,653 US11788127B2 (en) | 2011-04-15 | 2020-09-21 | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US18/486,391 US20240110236A1 (en) | 2011-04-15 | 2023-10-13 | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161476175P | 2011-04-15 | 2011-04-15 | |
US201161476167P | 2011-04-15 | 2011-04-15 | |
US61/476,167 | 2011-04-15 | ||
US61/476,175 | 2011-04-15 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/054,397 Continuation US9765389B2 (en) | 2011-04-15 | 2013-10-15 | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012142516A1 WO2012142516A1 (en) | 2012-10-18 |
WO2012142516A8 true WO2012142516A8 (en) | 2013-06-20 |
Family
ID=46025934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/033667 WO2012142516A1 (en) | 2011-04-15 | 2012-04-13 | Scanning real-time microfluidic thermo-cycler and methods for synchronized thermocycling and scanning optical detection |
Country Status (11)
Country | Link |
---|---|
US (4) | US9765389B2 (en) |
EP (3) | EP3159697B1 (en) |
JP (2) | JP6088487B2 (en) |
CN (3) | CN106190806B (en) |
AU (1) | AU2012242510B2 (en) |
BR (1) | BR112013026451B1 (en) |
CA (2) | CA3082652A1 (en) |
ES (2) | ES2769028T3 (en) |
RU (1) | RU2690374C2 (en) |
WO (1) | WO2012142516A1 (en) |
ZA (1) | ZA201307781B (en) |
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