WO2012125633A1 - Removable surgical staple cartridges - Google Patents
Removable surgical staple cartridges Download PDFInfo
- Publication number
- WO2012125633A1 WO2012125633A1 PCT/US2012/028921 US2012028921W WO2012125633A1 WO 2012125633 A1 WO2012125633 A1 WO 2012125633A1 US 2012028921 W US2012028921 W US 2012028921W WO 2012125633 A1 WO2012125633 A1 WO 2012125633A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- frame portion
- distal frame
- elongated channel
- surgical
- attachment
- Prior art date
Links
- 238000005520 cutting process Methods 0.000 claims abstract description 6
- 230000000295 complement effect Effects 0.000 claims description 4
- 230000033001 locomotion Effects 0.000 claims description 3
- 230000000712 assembly Effects 0.000 abstract 1
- 238000000429 assembly Methods 0.000 abstract 1
- 239000012636 effector Substances 0.000 description 29
- 238000010304 firing Methods 0.000 description 24
- 239000000463 material Substances 0.000 description 9
- 238000013459 approach Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 230000014759 maintenance of location Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 238000010276 construction Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000004775 Tyvek Substances 0.000 description 1
- 229920000690 Tyvek Polymers 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 238000012830 laparoscopic surgical procedure Methods 0.000 description 1
- 238000012978 minimally invasive surgical procedure Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B17/07207—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously the staples being applied sequentially
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/0046—Surgical instruments, devices or methods, e.g. tourniquets with a releasable handle; with handle and operating part separable
- A61B2017/00473—Distal part, e.g. tip or head
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00477—Coupling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B2017/07214—Stapler heads
- A61B2017/07271—Stapler heads characterised by its cartridge
Definitions
- the present invention relates to surgical cutting and stapling instruments and, in various embodiments, to disposable surgical staple cartridges.
- Endoscopic surgical instruments are often preferred over traditional open surgical devices since a smaller incision tends to reduce the post-operative recovery time and
- these endoscopic surgical instruments include an "end effector", a handle assembly and an elongated shaft that extends between the end effector and the handle assembly.
- the end effector is the portion of the instrument configured to engage the tissue in various ways to achieve a desired diagnostic or therapeutic effect (e.g., endocutter, grasper, cutter, staplers, clip applier, access device, drug/gene therapy delivery device, and energy device using ultrasound, RF, laser, etc.).
- the first design approach concerned the use of a disposable endocutter devices for each firing.
- Such endocutter end effectors were fabricated from relatively weak components that can only be fired once before a new end effector is required since the end effector components are markedly deformed after each firing.
- This type of end effector employed an "I-beam" feature on the knife to prevent the anvil from deflecting away from the cartridge during firing. Since the I-beam is riding on a relatively weak anvil component, the I-beam deforms the portion of the anvil located directly underneath the I-beam feature.
- the second primary design approach taken in the past is to make much stronger end effector components that can be used for multiple firings.
- this approach only the cartridge assembly is replaced after each firing. Because the end effector components have to resist multiple firing loads, they are purposefully designed such that they do not deform after each firing.
- This design concept employs a different set of features on the knife to keep the anvil positioned relative to the cartridge during deployment of the staples to improve staple form.
- the combination of the stiffer end effector components and a different clamping mechanism allows this type of device to reliably exert high clamping loads so the surgeon can easily manipulate the desired tissue.
- the stiffer components also allow the end effector to be reliably used on relatively thick tissue samples.
- Cartridge Having an Anvil With Tissue Locator For Use With Surgical Cutting and Fastening Instrument and Modular End Effector System Therefor discloses various disposable cartridge arrangements that employ a disposable anvil component. Such arrangement effectively address a variety of the shortcomings discussed above, but also include the additional expense of an anvil component. In addition, all of the foregoing arrangements require a separate support channel for supporting the staple cartridge therein. Such support components add to the expense of the surgical instrument.
- an integrated surgical fastener cartridge assembly that comprises an elongated channel that is configured for removable attachment to a distal frame portion of a surgical instrument.
- the elongated channel has an attachment portion that comprises a wedge-shaped portion that is configured for wedging engagement with the distal frame portion.
- the attachment portion further comprises a locking member for releasably retaining the wedge-shaped portion in wedging engagement with the distal frame portion.
- the integrated surgical fastener cartridge further comprises a cartridge body that is supported in the elongated channel and operably supports a plurality of tissue fasteners therein.
- a surgical staple cartridge for use with surgical stapling instruments that have a distal frame portion and an anvil movably supported thereon.
- the surgical staple cartridge comprises an elongated channel that has a proximal end portion for releasable attachment to the distal frame portion.
- the proximal end portion of the elongated channel has at least one angled portion that is shaped for wedging engagement with a corresponding
- a selectively movable locking member is configured for releasable engagement with one of the distal frame portion and the elongated channel such that when the locking member is in an engaged position, the at least one angled portion of the elongated channel is urged proximally into wedging engagement with the corresponding complementary shaped surface on the distal frame portion to releasably affix the elongated channel to the distal frame portion.
- a staple cartridge is operably supported within the elongated channel and operably supports a plurality of staples therein.
- the integrated surgical staple cartridge assembly comprises an elongated channel that has a proximal end portion for releasable attachment to the distal frame portion.
- the proximal end portion of the elongated channel has at least one angled portion that is shaped for wedging engagement with a corresponding complimentary shaped surface on the distal frame portion.
- a staple cartridge is operably supported within the elongated channel and operably supports a plurality of surgical staples therein.
- the surgical instrument further comprises a selectively movable locking member that is configured for releasable engagement with one of the distal frame portion and the elongated channel such that when the locking member is in an engaged position, the at least one angled portion of the elongated channel is urged proximally into wedging engagement with the corresponding complementary shaped surface on the distal frame portion to releasably affix the elongated channel to the distal frame portion.
- FIG. 1 is a side elevational view of one form of surgical instrument supporting a non- limiting integrated cartridge and channel embodiment of one form of the present invention
- FIG. 2 is an exploded assembly view of a non-limiting integrated cartridge and channel embodiment and a portion of a surgical instrument configured for use therewith;
- FIG. 2A is another exploded assembly view of the integrated cartridge and channel embodiment of FIG. 2 with the cartridge installed into the elongated channel;
- FIG. 3 is a perspective assembly view of an integrated cartridge and channel embodiment and a portion of a surgical instrument
- FIG. 4 is another perspective assembly view of an integrated cartridge and channel embodiment and a portion of a surgical instrument
- FIG. 5 is an enlarged perspective assembly view of a portion of an integrated cartridge and channel embodiment and a portion of a surgical instrument
- FIG. 6 is an enlarged cross-sectional perspective assembly view of a portion of an integrated cartridge and channel embodiment and a portion of a surgical instrument
- FIG. 7 is an enlarged cross-sectional perspective view of a portion of an integrated cartridge and channel embodiment attached to a portion of a surgical instrument
- FIG. 8 is a perspective view of another integrated cartridge and channel embodiment attached to a portion of a surgical instrument
- FIG. 9 is a perspective assembly view of another integrated cartridge and channel embodiment and a portion of a surgical instrument.
- FIG. 10 is an enlarged cross-sectional perspective assembly view of a portion of an integrated cartridge and channel embodiment and a portion of a surgical instrument
- FIG. 11 is another enlarged cross-sectional perspective assembly view of a portion of an integrated cartridge and channel embodiment attached to a portion of a surgical instrument;
- FIG. 12 is an exploded assembly view of an integrated cartridge and channel embodiment and a portion of a surgical instrument
- FIG. 13 is a cross-sectional view of a portion of the locking ring and integrated cartridge and channel embodiment taken along line 13-13 in FIG. 9;
- FIG. 14 is a cross-sectional perspective view of a portion of the locking ring and integrated cartridge and channel embodiment taken along line 14-14 in FIG. 9.
- proximal and distal are used herein with reference to a clinician manipulating the handle portion of the surgical instrument.
- proximal referring to the portion closest to the clinician and the term “distal” referring to the portion located away from the clinician.
- distal referring to the portion located away from the clinician.
- spatial terms such as “vertical”, “horizontal”, “up”, “down”, “right” and “left” may be used herein with respect to the drawings.
- surgical instruments are used in many orientations and positions, and these terms are not intended to be limiting and/or absolute.
- the working portions or end effector portions of the instruments can be inserted directly into a patient's body or can be inserted through an access device such as a trocar that has a working channel through which the end effector and elongated shaft of a surgical instrument can be advanced.
- an access device such as a trocar that has a working channel through which the end effector and elongated shaft of a surgical instrument can be advanced.
- FIG. 1 depicts one embodiment of a surgical stapling and severing instrument 10 that is capable of practicing various unique benefits of at least one form of the present invention.
- Various portions of the instrument 10 may be identical to portions of the devices disclosed in U.S. Patent No. 7,670,334, which has been herein incorporated by reference and/or U.S. Patent No. 7,000,818, entitled "Surgical Stapling Instrument Having Separate Distinct Closing and Firing Systems", the disclosure of which is herein incorporated by reference in its entirety.
- the surgical instrument 10 generally includes a handle portion 20 that is connected to an implement portion 12, the latter further comprising a shaft assembly 14 distally terminating in an end effector 100.
- the end effector 100 in general, comprises a pair of "jaws" 102, 104 that are configured to clamp and staple tissue.
- one "jaw” comprises an integrated cartridge and channel assembly 120 and the other jaw comprises a movable anvil 200.
- the handle portion 20 includes a pistol grip 24 toward which a closure trigger 26 is pivotally drawn by the clinician to cause clamping, or closing, of the anvil 200 toward the integrated cartridge and channel assembly 120.
- a firing trigger 28 is farther outboard of the closure trigger 26 and is pivotally drawn by the clinician to cause the stapling and severing of clamped tissue in the end effector 100.
- the closure trigger 26 is actuated first. Once the clinician is satisfied with the positioning of the end effector 100, the clinician may draw back the closure trigger 26 to its fully closed, locked position proximate to the pistol grip 24. Then, the firing trigger 28 is actuated. The firing trigger 28 springedly returns when the clinician removes pressure. A release button 30 when depressed on the proximal end of the handle portion 20 releases any locked closure trigger 26.
- the integrated cartridge and channel assembly 120 is detachably coupled to a frame 50 that protrudes from the handle portion 20.
- the frame 50 is enclosed within a movable closure tube assembly 40 that is configured to operably interface with the closure trigger 26 on one end and the anvil 200 on the other end.
- the closure tube 32 is moved proximally on the frame 50 by the closure trigger 26, the anvil 200 opens, pivoting away from the integrated cartridge and channel assembly 120.
- the various embodiments of the integrated cartridge and channel assembly 120 of the present invention may be employed with a variety of known surgical instruments designed to sever and staple tissue.
- the integrated cartridge and channel assembly 120 comprises a molded cartridge body 122 that is formed from that is supported in an elongated channel 123.
- the cartridge body 22 may be configured to snappingly engage the channel 123 or it may be attached thereto by other means.
- the staple cartridge body 122 operably supports a plurality of staples 124 that are operably supported on corresponding staple drivers 126 that are supported within respective upwardly open staple apertures 128 formed in the cartridge body 122.
- the instrument 10 further includes a firing bar 80 that is configured to longitudinally translate through the shaft assembly 14 and through a firing slot 54 in the frame 50.
- the firing bar 80 has a distal end portion 82 that has a sharpened cutting edge 84 formed thereon for severing tissue.
- a variety of firing bar configurations are known and may be adapted for use in connection with the integrated cartridge and channel assembly 120 without departing from the spirit and scope of the present invention.
- the distal end portion 82 of the firing bar 80 actuates the integrated cartridge and channel assembly 120 as the firing bar 80 is driven distally therethrough.
- a wedge sled 90 is driven distally by the distal end portion 82 of the firing bar 80.
- the wedge sled 90 upwardly cams the staple drivers 126 to force out the staples 124 into deforming contact with the closed anvil 200 while the cutting edge 84 of the distal end 82 portion of the firing bar 80 severs clamped tissue.
- the firing bar 80 is movably supported within the shaft assembly 14 such that it passes through the integrated cartridge and channel assembly 120 when the instrument 10 is fired (e.g., actuated).
- the anvil 200 is movably supported on the distal end portion 52 of the frame 50.
- a pair of apertures 55 may be provided in the distal end portion 52 to movably receive trunnions or pins 202 on the anvil 200, allowing the anvil 200 to pivot from an open position to a closed position relative to the integrated cartridge and channel assembly 120 in response to opening and closing motions received from the closure tube assembly 40.
- the distal end 41 of the closure tube assembly 40 includes a horseshoe aperture 42 and tab 43 for engaging an opening tab 204 on the anvil 200.
- a spring clip 205 is mounted in the distal portion 52 of the end effector frame 50 as a lockout for firing bar 80 in a known manner. It will be appreciated that various embodiments may include other types of lockouts or no lockouts at all.
- the elongated channel 123 has an attachment portion 130 that has at least one wedge-shaped attachment portion 132 thereon.
- two wedge-shaped attachment portions 132 are employed.
- the wedge-shaped attachment portions 132 are configured to wedgingly engage complementary- shaped angled engagement surfaces 56 formed on the distal end 51 of the frame 50 when the attachment portion 130 is moved proximally into engagement with the distal end 51 of the frame 50.
- the elongated channel 123 further includes a locking member 140 for releasably retaining the wedge-shaped attachment portions 132 in wedging engagement with the angled engagement surfaces 56 on the frame 50.
- the locking member 140 comprises at least one locking tab 144 that is formed on a spring arm 146 that protrudes proximally from the elongated channel 123.
- the locking tab 144 is configured to extend into locking engagement with a locking aperture 57 in the distal end 51 of the frame 50 as shown in FIG. 7.
- the locking tab 144 has a locking surface 148 for engaging the edge of the locking aperture 57.
- the locking surface 148 may be provided with a slight angle such that when the locking surface engages the edge of the locking aperture 57, the locking surface urges the elongated channel 123 in the proximal direction "PD". In other embodiments the locking surface 148 is substantially perpendicular to the bottom of the elongated channel 123.
- a clearance hole 46 is provided through the closure tube assembly 40 which is in registration with the locking aperture 57.
- the locking tab is provided on the distal end 51 of the frame and the locking aperture is provided in the elongated channel 123.
- FIGS. 8-14 illustrate another end effector 100' embodiment in accordance with various non-limiting embodiments of the present invention.
- the end effector 100' includes an integrated cartridge and channel assembly 320 that has a cartridge body 322 that is supported in an elongated channel 323 that is configured for removable attachment to the distal end 51 ' of the frame 50' .
- the integrated cartridge and channel assembly 320 comprises a molded cartridge body 322 that is supported in the elongated channel.
- the cartridge body 322 may be configured to snappingly engage the channel 323 or it may be attached thereto by other means.
- the staple cartridge body 322 operably supports a plurality of staples that are supported on corresponding staple drivers that are supported within respective upwardly open staple apertures 328 formed in the cartridge body as was discussed above. It will be understood that the integrated cartridge and channel assembly 320 is substantially identical in construction and operation to the integrated cartridge and channel assembly 120 described above, except for the differences discussed below.
- the elongated channel 323 has an attachment portion 430 that has at least one wedge-shaped attachment portion 432 and a proximally protruding attachment segment 450.
- two wedge- shaped attachment portions 432 are employed.
- the wedge-shaped attachment portions 432 are configured to wedgingly engage complementary- shaped angled engagement surfaces 56' formed on the distal end 51 ' of the frame 50' when the attachment portion is moved proximally into engagement with the distal end 51 ' of the frame 50' .
- the frame 50' is similar in construction and operation to the integrated frame 50 described above, except for the differences discussed below.
- the angled engagement surfaces 56' are formed on distally extending tangs 440 formed on the distal end 51 ' of the frame 50' .
- Each tang 440 has a trunion hole 442 therein for receiving a corresponding anvil trunion 202.
- the closure tube assembly 40' which is actuated in the same manner as closure tube assembly 40 described above, is configured to abut a closure ledge 203 formed on the anvil 200 as the closure tube assembly 40' is driven in the distal direction "DD". As the closure tube assembly 40' is driven distally and abuts the closure ledge 203, the anvil 200 is pivoted to the closed position towards the integrated cartridge and channel assembly 320.
- a spring (not shown) is attached to a proximal portion of the anvil or is otherwise employed such that as the closure tube assembly 40' is moved in the proximal direction "PD", the spring biases the anvil 200 into an open position (shown in FIG. 9).
- the end effector 100' further includes a locking member 460 for releasably retaining the wedge-shaped attachment portions 432 in wedging engagement with the angled engagement surfaces 56' on the frame 50'.
- a locking member 460 for releasably retaining the wedge-shaped attachment portions 432 in wedging engagement with the angled engagement surfaces 56' on the frame 50'.
- the locking member 460 comprises a locking ring 462 that is rotatably supported on the distal end 51 ' of the frame 50' .
- the locking ring 462 has a pair of diametrically opposed locking tabs 464 formed on the inner surface 463 thereof. As can be seen in FIG. 12, each locking tab 464 has a proximally- facing tapered end 466 formed thereon.
- the locking tabs 464 are received within a radial groove 446 formed in the distal end 51 ' of the frame 50' to rotatably journal the locking ring 44 on the frame 50'.
- the attachment segment 450 is inserted between the tangs 440 until the wedge shaped attachment portions 432 engage the corresponding angle attachment surfaces 56' on the frame 50'. See FIG. 11. When in that position, the radial groove 446 in the distal end 51 ' of the frame 50', radially aligns with a retention groove 452 in the attachment segment 450.
- the clinician simply rotates the locking ring 462 either in the clockwise "CW” direction or counter clockwise "CCW” direction to bring one of the locking tabs 464 into locking engagement within the retention groove 452 in the attachment segment 450.
- the devices disclosed herein can be designed to be disposed of after a single use, or they can be designed to be used multiple times. In either case, however, the device can be reconditioned for reuse after at least one use.
- Reconditioning can include any combination of the steps of disassembly of the device, followed by cleaning or replacement of particular pieces, and subsequent reassembly.
- the device can be disassembled, and any number of the particular pieces or parts of the device can be selectively replaced or removed in any combination.
- the device can be reassembled for subsequent use either at a reconditioning facility, or by a surgical team immediately prior to a surgical procedure.
- reconditioning of a device can utilize a variety of techniques for disassembly,
- the inventions described herein will be processed before surgery.
- a new or used instrument is obtained and if necessary cleaned.
- the instrument can then be sterilized.
- the instrument is placed in a closed and sealed container, such as a plastic or TYVEK bag.
- the container and instrument are then placed in a field of radiation that can penetrate the container, such as gamma radiation, x-rays, or high- energy electrons.
- the radiation kills bacteria on the instrument and in the container.
- the sterilized instrument can then be stored in the sterile container.
- the sealed container keeps the instrument sterile until it is opened in the medical facility.
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12711725.7A EP2685909B1 (en) | 2011-03-15 | 2012-03-13 | Removable surgical staple cartridges |
JP2013558115A JP6125438B2 (en) | 2011-03-15 | 2012-03-13 | Surgical staple cartridge |
AU2012230057A AU2012230057B2 (en) | 2011-03-15 | 2012-03-13 | Removable surgical staple cartridges |
RU2013145916/14A RU2599869C2 (en) | 2011-03-15 | 2012-03-13 | Removable surgical staple cartridges |
CN201280013187.8A CN103429172B (en) | 2011-03-15 | 2012-03-13 | Removable surgery nail bin |
CA2829926A CA2829926C (en) | 2011-03-15 | 2012-03-13 | Surgical staple cartridges |
BR112013023738-4A BR112013023738B1 (en) | 2011-03-15 | 2012-03-13 | SURGICAL INSTRUMENT |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/048,598 | 2011-03-15 | ||
US13/048,598 US8800841B2 (en) | 2011-03-15 | 2011-03-15 | Surgical staple cartridges |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012125633A1 true WO2012125633A1 (en) | 2012-09-20 |
Family
ID=45926922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/028921 WO2012125633A1 (en) | 2011-03-15 | 2012-03-13 | Removable surgical staple cartridges |
Country Status (9)
Country | Link |
---|---|
US (1) | US8800841B2 (en) |
EP (1) | EP2685909B1 (en) |
JP (1) | JP6125438B2 (en) |
CN (1) | CN103429172B (en) |
AU (1) | AU2012230057B2 (en) |
BR (1) | BR112013023738B1 (en) |
CA (1) | CA2829926C (en) |
RU (1) | RU2599869C2 (en) |
WO (1) | WO2012125633A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112741658A (en) * | 2020-12-14 | 2021-05-04 | 苏州法兰克曼医疗器械有限公司 | Cutting anastomat driven by one-time percussion of cutting knife |
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AU2012230057B2 (en) | 2017-03-16 |
BR112013023738B1 (en) | 2021-04-27 |
JP2014515640A (en) | 2014-07-03 |
EP2685909B1 (en) | 2019-11-20 |
CA2829926C (en) | 2019-05-14 |
CN103429172A (en) | 2013-12-04 |
RU2013145916A (en) | 2015-04-20 |
RU2599869C2 (en) | 2016-10-20 |
CA2829926A1 (en) | 2012-09-20 |
AU2012230057A1 (en) | 2013-09-12 |
JP6125438B2 (en) | 2017-05-10 |
EP2685909A1 (en) | 2014-01-22 |
US8800841B2 (en) | 2014-08-12 |
CN103429172B (en) | 2016-03-30 |
BR112013023738A2 (en) | 2016-12-13 |
US20120234896A1 (en) | 2012-09-20 |
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