WO2012048277A3 - Injection methods using a servo-controlled needle-free injector - Google Patents

Injection methods using a servo-controlled needle-free injector Download PDF

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Publication number
WO2012048277A3
WO2012048277A3 PCT/US2011/055454 US2011055454W WO2012048277A3 WO 2012048277 A3 WO2012048277 A3 WO 2012048277A3 US 2011055454 W US2011055454 W US 2011055454W WO 2012048277 A3 WO2012048277 A3 WO 2012048277A3
Authority
WO
WIPO (PCT)
Prior art keywords
substance
injected
servo
injection
transport device
Prior art date
Application number
PCT/US2011/055454
Other languages
French (fr)
Other versions
WO2012048277A2 (en
Inventor
Brian D. Hemond
Ian W. Hunter
Andrew J. Taberner
Dawn M. Wendell
Catherine N. Hogan
Original Assignee
Massachusetts Institute Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute Of Technology filed Critical Massachusetts Institute Of Technology
Priority to CN201180058910.XA priority Critical patent/CN103269737B/en
Priority to EP11787954.4A priority patent/EP2621564B1/en
Priority to JP2013532990A priority patent/JP2013539689A/en
Publication of WO2012048277A2 publication Critical patent/WO2012048277A2/en
Publication of WO2012048277A3 publication Critical patent/WO2012048277A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/30Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/48Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
    • A61M5/486Indicating injection pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3331Pressure; Flow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3331Pressure; Flow
    • A61M2205/3358Measuring barometric pressure, e.g. for compensation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3368Temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/82Internal energy supply devices
    • A61M2205/8275Mechanical
    • A61M2205/8287Mechanical operated by an external magnetic or electromagnetic field

Abstract

A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.
PCT/US2011/055454 2010-10-07 2011-10-07 Injection methods using a servo-controlled needle-free injector WO2012048277A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201180058910.XA CN103269737B (en) 2010-10-07 2011-10-07 Use the injecting method of servo-controlled needleless injector
EP11787954.4A EP2621564B1 (en) 2010-10-07 2011-10-07 Injection methods using a servo-controlled needle-free injector
JP2013532990A JP2013539689A (en) 2010-10-07 2011-10-07 Injection method using a servoless needleless syringe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39104510P 2010-10-07 2010-10-07
US61/391,045 2010-10-07

Publications (2)

Publication Number Publication Date
WO2012048277A2 WO2012048277A2 (en) 2012-04-12
WO2012048277A3 true WO2012048277A3 (en) 2012-08-30

Family

ID=45034156

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/055454 WO2012048277A2 (en) 2010-10-07 2011-10-07 Injection methods using a servo-controlled needle-free injector

Country Status (6)

Country Link
US (3) US8740838B2 (en)
EP (2) EP2915552A1 (en)
JP (2) JP2013539689A (en)
CN (2) CN103269737B (en)
HK (1) HK1212265A1 (en)
WO (1) WO2012048277A2 (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7833189B2 (en) 2005-02-11 2010-11-16 Massachusetts Institute Of Technology Controlled needle-free transport
US8398583B2 (en) * 2008-07-09 2013-03-19 Massachusetts Institute Of Technology Method and apparatus for extraction of a sample from a sample source
US8758271B2 (en) 2009-09-01 2014-06-24 Massachusetts Institute Of Technology Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties
US9333060B2 (en) 2009-12-15 2016-05-10 Massachusetts Institute Of Technology Plaque removal and differentiation of tooth and gum
US8740838B2 (en) 2010-10-07 2014-06-03 Massachusetts Institute Of Technology Injection methods using a servo-controlled needle-free injector
EP2621565B1 (en) 2010-10-07 2018-07-11 Massachusetts Institute of Technology Delivery of a solid body and/or a fluid using a linear lorentz-force actuated needle-free jet injection system
US9555379B2 (en) 2013-03-13 2017-01-31 Bayer Healthcare Llc Fluid path set with turbulent mixing chamber, backflow compensator
CN103816587A (en) * 2014-02-28 2014-05-28 华南理工大学 Electric needle-free injection propulsion plant
US20170049966A1 (en) * 2015-08-19 2017-02-23 Auckland Uniservices Ltd. Coaxial piston injector
US10737032B2 (en) 2015-11-25 2020-08-11 Portal Instruments, Inc. Needle-free transdermal injection device
US10842467B2 (en) * 2015-12-15 2020-11-24 Portal Instruments, Inc. Biospecimen extraction apparatus
WO2017115867A1 (en) * 2015-12-28 2017-07-06 株式会社ダイセル Administering device design system, administering system, administering device design method, administering device design program, and medical device design system
US9724473B2 (en) * 2016-01-12 2017-08-08 Nickolas Peter Demas Multi-directional low-displacement force sensor
WO2017152036A1 (en) 2016-03-03 2017-09-08 Bayer Healthcare Llc System and method for improved fluid delivery in multi-fluid injector systems
US11077255B2 (en) * 2016-03-11 2021-08-03 Quio Technologies Llc Automatic injector devices and systems for controlled delivery of dosage and associated methods
US20180028755A1 (en) * 2016-07-28 2018-02-01 Portal Instruments, Inc. Connected health platform including needle-free injector system
SG10201609111WA (en) 2016-10-31 2018-05-30 Miracle Man Pte Ltd Safety-Enhanced Needle-Free Injector And System For Use Through Both Porous And Non-Porous Materials
US20180117252A1 (en) * 2016-11-02 2018-05-03 Portal Instruments, Inc. Encoding information for drug delivery
WO2018089882A1 (en) * 2016-11-14 2018-05-17 Bayer Healthcare Llc Methods and systems for verifying the contents of a syringe used for medical fluid delivery
US10569020B2 (en) * 2016-11-29 2020-02-25 Portal Instruments, Inc. Method and device for delivering a subcutaneous dose through multiple injections
EP3551251B1 (en) * 2016-12-09 2020-12-23 Fresenius Vial SAS Infusion device constituted to detect an abnormal condition during bolus injection
AU2018247005B2 (en) * 2017-03-31 2023-09-21 Becton, Dickinson And Company Smart wearable injection and/or infusion device
KR102038671B1 (en) * 2017-06-26 2019-10-30 주식회사 지티지웰니스 Air jet handpiece with pressure display
JP7329307B2 (en) * 2017-06-27 2023-08-18 株式会社ダイセル Method for manufacturing needle-free injector, method for setting amounts of igniter and gas generating agent in needle-free injector, and injection parameter calculation program for needle-free injector
DE102017114930A1 (en) * 2017-07-04 2019-01-10 Eto Magnetic Gmbh ejector
AU2018323442A1 (en) 2017-08-31 2020-01-23 Bayer Healthcare Llc Fluid path impedance assessment for improving fluid delivery performance
US11598664B2 (en) 2017-08-31 2023-03-07 Bayer Healthcare Llc Injector pressure calibration system and method
WO2019046267A1 (en) 2017-08-31 2019-03-07 Bayer Healthcare Llc Fluid injector system volume compensation system and method
CA3068544A1 (en) 2017-08-31 2019-03-07 Bayer Healthcare Llc Method for dynamic pressure control in a fluid injector system
US11786652B2 (en) 2017-08-31 2023-10-17 Bayer Healthcare Llc System and method for drive member position and fluid injector system mechanical calibration
CN111712289B (en) * 2017-12-18 2022-09-02 赛诺菲 Drug delivery device and charging device
EP3545992A1 (en) * 2018-03-29 2019-10-02 Tecpharma Licensing AG State estimation for drug delivery systems
EP3545993A1 (en) 2018-03-29 2019-10-02 Tecpharma Licensing AG Status indicator for drug delivery systems
US11801343B2 (en) 2018-07-12 2023-10-31 Alcon Inc. Methods and systems for delivering material to a body part
CN109490286B (en) * 2018-10-23 2021-08-17 焦占峰 Urine analyzer for hospital clinical laboratory and urology department
CN113509615B (en) * 2020-04-10 2023-09-22 昆明桑达科技有限公司 Mechanical transmission mode of needleless injector
US11957542B2 (en) 2020-04-30 2024-04-16 Automed Patent Holdco, Llc Sensing complete injection for animal injection device
CA3228205A1 (en) 2020-04-30 2021-11-04 Bayer Healthcare Llc System, device, and method for safeguarding wellbeing of patients for fluid injection
US20230372626A1 (en) * 2020-09-09 2023-11-23 Jaber Medical, Pllc Systems and methods for needleless injection
CN116322842A (en) * 2020-10-05 2023-06-23 贝克顿迪金森法国公司 Injection device with sensor assembly
CN112412733B (en) * 2020-11-17 2021-11-23 武汉大学 Double-channel needleless injection device with controllable jet velocity and method
CN113384778A (en) * 2021-06-10 2021-09-14 苏芮 Controllable needleless injection device
CN115245610A (en) * 2021-12-27 2022-10-28 李�杰 Multi-needle depth controllable electronic injector

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035149A1 (en) * 2001-10-24 2003-05-01 Weston Medical Limited Needleless injector with shock absorbing means between ram and piston
US20060258986A1 (en) * 2005-02-11 2006-11-16 Hunter Ian W Controlled needle-free transport

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1008238A (en) 1910-03-09 1911-11-07 William Bretsnyder Collar-buttoner.
US1031193A (en) 1910-11-26 1912-07-02 Horace L Mccurdy Transmission-gearing.
US1025762A (en) 1911-02-17 1912-05-07 George Edward Ocain Auto or gas engine starter and indicator.
US1016654A (en) 1911-11-11 1912-02-06 Corry Castor Company Caster.
US4346708A (en) * 1981-04-20 1982-08-31 Leveen Harry H Syringe
US6056716A (en) * 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
US5024656A (en) * 1988-08-30 1991-06-18 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
FR2718357B1 (en) 1994-04-06 1997-10-03 Defarges Alain Moreau Improvements made to a needleless jet injection device.
DE19650115C1 (en) * 1996-12-03 1998-07-02 Fraunhofer Ges Forschung Medication dosing device
US6673033B1 (en) * 1999-11-24 2004-01-06 Medrad, Inc. Injectors, injector systems and injector control
IL156245A0 (en) * 2000-12-22 2004-01-04 Dca Design Int Ltd Drive mechanism for an injection device
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6939323B2 (en) 2001-10-26 2005-09-06 Massachusetts Institute Of Technology Needleless injector
US6796955B2 (en) * 2002-02-14 2004-09-28 Chf Solutions, Inc. Method to control blood and filtrate flowing through an extracorporeal device
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
WO2004021882A2 (en) 2002-09-06 2004-03-18 Massachusetts Institute Of Technology Measuring properties of an anatomical body
US20060184101A1 (en) * 2003-04-21 2006-08-17 Ravi Srinivasan Microjet devices and methods for drug delivery
US20040260234A1 (en) 2003-04-21 2004-12-23 Ravi Srinivasan Apparatus and methods for repetitive microjet durg delivery priority statement
EP1681069A4 (en) * 2003-10-29 2007-09-12 Nemoto Kyorindo Co Ltd Medicinal liquid infusion apparatus
US7833189B2 (en) 2005-02-11 2010-11-16 Massachusetts Institute Of Technology Controlled needle-free transport
WO2006086719A1 (en) 2005-02-11 2006-08-17 Massachusetts Institute Of Technology Surface injection device
US20070118093A1 (en) * 2005-06-20 2007-05-24 Von Muhlen Marcio G High-speed jet devices for drug delivery
US8998881B2 (en) * 2005-08-10 2015-04-07 Alza Corporation Method for delivering drugs to tissue under microjet propulsion
JP4539517B2 (en) * 2005-09-29 2010-09-08 ブラザー工業株式会社 ink cartridge
WO2007058966A1 (en) * 2005-11-11 2007-05-24 Massachusetts Institute Of Technology Controlled needle-free eye injector
US7988660B2 (en) * 2005-12-20 2011-08-02 Eli Lilly And Company Needle-free injection device
WO2008001378A2 (en) * 2006-06-28 2008-01-03 Perf-Action Technologies Ltd Intradermal needle-less injection device
WO2008011125A2 (en) * 2006-07-20 2008-01-24 Neurosystec Corporation Devices, systems and methods for ophthalmic drug delivery
WO2008027579A1 (en) * 2006-09-01 2008-03-06 Massachusetts Institute Of Technology Needle-free injector device with autoloading capability
US20090030285A1 (en) * 2007-07-25 2009-01-29 Andersen Bjorn K Monitoring of use status and automatic power management in medical devices
WO2009042577A2 (en) * 2007-09-24 2009-04-02 Mallinckrodt Inc. Injection monitor
CA2701464A1 (en) * 2007-10-04 2009-04-09 Baxter International Inc. Apparatus for a fluid delivery system with controlled fluid flow rate
BRPI0821457A2 (en) * 2007-12-31 2015-06-16 Novo Nordisk As Electronically monitored injection device
JP5134142B2 (en) * 2008-09-22 2013-01-30 フラウンホーファー−ゲゼルシャフト ツル フェルデルング デル アンゲヴァンテン フォルシュング エー ファウ Apparatus and method for measuring at least one flow parameter
US8361054B2 (en) * 2008-12-23 2013-01-29 Cook Medical Technologies Llc Apparatus and methods for containing and delivering therapeutic agents
CA2744224C (en) * 2008-12-29 2016-12-13 Ams Research Corporation Method and apparatus for compensating for injection media viscosity in a pressurized drug injection system
CN101574551A (en) * 2009-03-25 2009-11-11 郑晓林 Automatic controller of high-pressure injection missing needle
WO2011028716A1 (en) 2009-09-01 2011-03-10 Massachusetts Institute Of Technology Nonlinear system identification technique for testing the efficacy of skin care products
US8758271B2 (en) 2009-09-01 2014-06-24 Massachusetts Institute Of Technology Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties
US8657783B2 (en) * 2010-11-08 2014-02-25 DentistInJerseyCity.net Injectable solution container and syringe
US9333060B2 (en) 2009-12-15 2016-05-10 Massachusetts Institute Of Technology Plaque removal and differentiation of tooth and gum
EP2621565B1 (en) 2010-10-07 2018-07-11 Massachusetts Institute of Technology Delivery of a solid body and/or a fluid using a linear lorentz-force actuated needle-free jet injection system
US8740838B2 (en) 2010-10-07 2014-06-03 Massachusetts Institute Of Technology Injection methods using a servo-controlled needle-free injector

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035149A1 (en) * 2001-10-24 2003-05-01 Weston Medical Limited Needleless injector with shock absorbing means between ram and piston
US20060258986A1 (en) * 2005-02-11 2006-11-16 Hunter Ian W Controlled needle-free transport

Also Published As

Publication number Publication date
EP2621564A2 (en) 2013-08-07
JP6338624B2 (en) 2018-06-06
HK1212265A1 (en) 2016-06-10
WO2012048277A2 (en) 2012-04-12
US20140257236A1 (en) 2014-09-11
CN103269737B (en) 2017-06-06
US20170065769A1 (en) 2017-03-09
EP2621564B1 (en) 2016-10-05
CN107096101A (en) 2017-08-29
JP2013539689A (en) 2013-10-28
US20120089114A1 (en) 2012-04-12
JP2016221309A (en) 2016-12-28
CN103269737A (en) 2013-08-28
US8740838B2 (en) 2014-06-03
EP2915552A1 (en) 2015-09-09

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