WO2011135531A3 - MEDICAL DEVICES FOR DELIVERY OF siRNA - Google Patents

MEDICAL DEVICES FOR DELIVERY OF siRNA Download PDF

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Publication number
WO2011135531A3
WO2011135531A3 PCT/IB2011/051862 IB2011051862W WO2011135531A3 WO 2011135531 A3 WO2011135531 A3 WO 2011135531A3 IB 2011051862 W IB2011051862 W IB 2011051862W WO 2011135531 A3 WO2011135531 A3 WO 2011135531A3
Authority
WO
WIPO (PCT)
Prior art keywords
sirna
medical devices
delivery
devices
microneedles
Prior art date
Application number
PCT/IB2011/051862
Other languages
French (fr)
Other versions
WO2011135531A2 (en
Inventor
Russell Frederick Ross
Original Assignee
Kimberly-Clark Worldwide, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US13/641,502 priority Critical patent/US9522262B2/en
Priority to AU2011246880A priority patent/AU2011246880B2/en
Priority to KR1020127031012A priority patent/KR101794376B1/en
Priority to EP11774519.0A priority patent/EP2563451B1/en
Priority to CA2797205A priority patent/CA2797205C/en
Priority to CN201180032035.8A priority patent/CN102985131B/en
Priority to JP2013506797A priority patent/JP5860033B2/en
Priority to RU2012150729/14A priority patent/RU2585138C2/en
Application filed by Kimberly-Clark Worldwide, Inc. filed Critical Kimberly-Clark Worldwide, Inc.
Priority to MX2012012564A priority patent/MX336139B/en
Publication of WO2011135531A2 publication Critical patent/WO2011135531A2/en
Publication of WO2011135531A3 publication Critical patent/WO2011135531A3/en
Priority to US15/378,109 priority patent/US10029083B2/en
Priority to US16/040,773 priority patent/US11135414B2/en
Priority to US17/464,402 priority patent/US20210393934A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

Abstract

Disclosed are medical devices that incorporate siRNA. In addition to one or more siRNA constructs, devices include nanostructures fabricated on a surface to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Microneedles may be incorporated on devices. The pattern including nanostructures may be formed on the surface of the microneedles.
PCT/IB2011/051862 2010-04-28 2011-04-27 MEDICAL DEVICES FOR DELIVERY OF siRNA WO2011135531A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP2013506797A JP5860033B2 (en) 2010-04-28 2011-04-27 Medical devices for siRNA delivery
KR1020127031012A KR101794376B1 (en) 2010-04-28 2011-04-27 MEDICAL DEVICES FOR DELIVERY OF siRNA
EP11774519.0A EP2563451B1 (en) 2010-04-28 2011-04-27 MEDICAL DEVICES FOR DELIVERY OF siRNA
CA2797205A CA2797205C (en) 2010-04-28 2011-04-27 Medical devices for delivery of sirna
CN201180032035.8A CN102985131B (en) 2010-04-28 2011-04-27 For delivering the medical treatment device of siRNA
US13/641,502 US9522262B2 (en) 2010-04-28 2011-04-27 Medical devices for delivery of siRNA
RU2012150729/14A RU2585138C2 (en) 2010-04-28 2011-04-27 Medical devices for delivery of sirna
AU2011246880A AU2011246880B2 (en) 2010-04-28 2011-04-27 Medical devices for delivery of siRNA
MX2012012564A MX336139B (en) 2010-04-28 2011-04-27 MEDICAL DEVICES FOR DELIVERY OF siRNA.
US15/378,109 US10029083B2 (en) 2010-04-28 2016-12-14 Medical devices for delivery of siRNA
US16/040,773 US11135414B2 (en) 2010-04-28 2018-07-20 Medical devices for delivery of siRNA
US17/464,402 US20210393934A1 (en) 2010-04-28 2021-09-01 MEDICAL DEVICES FOR DELIVERY OF siRNA

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32872310P 2010-04-28 2010-04-28
US61/328,723 2010-04-28
US41605710P 2010-11-22 2010-11-22
US61/416,057 2010-11-22

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/641,502 A-371-Of-International US9522262B2 (en) 2010-04-28 2011-04-27 Medical devices for delivery of siRNA
US15/378,109 Continuation US10029083B2 (en) 2010-04-28 2016-12-14 Medical devices for delivery of siRNA

Publications (2)

Publication Number Publication Date
WO2011135531A2 WO2011135531A2 (en) 2011-11-03
WO2011135531A3 true WO2011135531A3 (en) 2012-03-15

Family

ID=44861973

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/051862 WO2011135531A2 (en) 2010-04-28 2011-04-27 MEDICAL DEVICES FOR DELIVERY OF siRNA

Country Status (10)

Country Link
US (4) US9522262B2 (en)
EP (1) EP2563451B1 (en)
JP (1) JP5860033B2 (en)
KR (1) KR101794376B1 (en)
CN (1) CN102985131B (en)
AU (1) AU2011246880B2 (en)
CA (1) CA2797205C (en)
MX (1) MX336139B (en)
RU (1) RU2585138C2 (en)
WO (1) WO2011135531A2 (en)

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