WO2011035222A1 - Method of forming hollow tubular drug eluting medical devices - Google Patents
Method of forming hollow tubular drug eluting medical devices Download PDFInfo
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- WO2011035222A1 WO2011035222A1 PCT/US2010/049439 US2010049439W WO2011035222A1 WO 2011035222 A1 WO2011035222 A1 WO 2011035222A1 US 2010049439 W US2010049439 W US 2010049439W WO 2011035222 A1 WO2011035222 A1 WO 2011035222A1
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- Prior art keywords
- hollow wire
- lumen
- outer member
- wire
- stent
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/88—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0041—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using additional screws, bolts, dowels or rivets, e.g. connecting screws
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0058—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49995—Shaping one-piece blank by removing material
Abstract
A method of a forming a hollow, drug-eluting medical device includes utilizing a hollow wire having an outer member and a lumen of the outer member, and filling the lumen with a fluid to form a supported hollow wire. The supported hollow wire is shaped into a stent pattern. Openings are formed through the outer member. The supported hollow wire is processed to remove the fluid from the lumen of the outer member without adversely affecting the outer member, leaving the hollow wire shaped into a stent pattern. The lumen is filled with a biologically or pharmacologically active substance.
Description
METHOD OF FORMING HOLLOW TUBULAR DRUG ELUTING MEDICAL DEVICES
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application claims the benefit of U.S. Provisional Patent Application No. 61/244,049 filed September 20, 2009, the contents of which is hereby incorporated by reference.
FIELD OF THE INVENTION
[0002] The present invention relates to implantable medical devices that release a therapeutic substance and methods of forming such medical devices.
BACKGROUND OF THE INVENTION
[0003] Drug-eluting implantable medical devices have become popular in recent times for their ability to perform their primary function (such as structural support) and their ability to medically treat the area in which they are implanted.
[0004] For example, drug-eluting stents have been used to prevent restenosis in coronary arteries. Drug-eluting stents may administer biologically or pharmacologically active substances such as anti-inflammatory compounds that block local invasion/activation of monocytes, thus preventing the secretion of growth factors that may trigger VSMC proliferation and migration. Other potentially anti-restenotic compounds include anti-proliferative agents, such as chemotherapeutics, which include rapamycin and paclitaxel. Other classes of drugs such as anti-thrombotics, anti-oxidants, platelet aggregation inhibitors and cytostatic agents have also been suggested for anti-restenotic use.
[0005] Drug-eluting medical devices may be coated with a polymeric material which, in turn, is impregnated with a biologically or pharmacologically active substance or a combination of biologically or pharmacologically active substances. Once the medical device is implanted at a target location, the biologically or pharmacologically active substance is released from the polymer for treatment of the local tissues. The biologically or pharmacologically active substance is released by a process of diffusion through the polymer layer for biostable polymers, and/or as the polymer material degrades for biodegradable polymers.
[0006] Controlling the rate of elution of a biologically or pharmacologically active substance from the drug impregnated polymeric material is generally based on the properties of the polymer material. However, at the conclusion of the elution process,
the remaining polymer material in some instances has been linked to an adverse reaction with the vessel, possibly causing a small but dangerous clot to form. Further, drug impregnated polymer coatings on exposed surfaces of medical devices may flake off or otherwise be damaged during delivery, thereby preventing the biologically or pharmacologically active substance from reaching the target site. Still further, drug impregnated polymer coatings are limited in the quantity of the biologically or pharmacologically active substance to be delivered by the amount of a biologically or pharmacologically active substance that the polymer coating can carry and the size of the medical devices. Controlling the rate of elution using polymer coatings is also difficult.
[0007] Accordingly, drug-eluting medical devices that enable increased quantities of a biologically or pharmacologically active substance to be delivered by the medical device, and allow for improved control of the elution rate of the biologically or pharmacologically active substance, and improved methods of forming such medical devices are needed.
SUMMARY OF INVENTION
[0008] In an embodiment of a method of forming a stent, the lumen of a hollow wire is filled with a fluid to form a supported hollow wire. The supported hollow wire is shaped into a stent pattern. Openings are formed through the wire to access the lumen. The supported hollow wire is processed to remove the fluid from the lumen of the outer member without adversely affecting the outer member, leaving the hollow wire shaped into a stent pattern. The lumen is filled with a biologically or pharmacologically active substance. The fluid may be pressurized prior to shaping the support hollow wire into the stent pattern.
[0009] In another embodiment of a method of forming a stent, the lumen of a hollow wire is filled with a liquefied wax. The liquefied wax is allowed to solidify or harden within the lumen to form a supported hollow wire. The supported hollow wire is shaped into a stent pattern. Openings are formed through the wire to access the lumen. The supported hollow wire is processed to remove the wax from the lumen without adversely affecting the wire, leaving the hollow wire shaped into a stent pattern. The lumen may then be filled with a biologically or pharmacologically active substance.
BRIEF DESCRIPTION OF DRAWINGS
[0010] The foregoing and other features and advantages of the invention will be apparent from the following description of the invention as illustrated in the accompanying drawings. The accompanying drawings, which are incorporated herein and form a part of the specification, further serve to explain the principles of the invention and to enable a person skilled in the pertinent art to make and use the invention. The drawings are not to scale.
[0011] FIG. 1 is a schematic illustration of an exemplary stent in accordance with an embodiment hereof.
[0012] FIG. 2 is a cross-sectional view taken along line 2-2 of FIG. 1 .
[0013] FIG. 3 is a longitudinal cross-section of an end of the wire of the stent of
FIG. 1 .
[0014] FIGS. 4-7 are cross-sectional views of a hollow wire in accordance with an embodiment hereof.
[0015] FIGS. 8-1 1 are schematic illustrations of a method of forming wave forms in a wire.
[0016] FIG. 12-14 are cross-sectional views of hollow wire in a method of forming a hollow wire into a stent in accordance with an embodiment hereof.
[0017] FIGS. 15-16 are schematic illustrations of a method of forming a wave form in a hollow wire in accordance with an embodiment hereof.
[0018] FIG. 17 is a schematic illustration of an apparatus for forming a wave form in a hollow wire in accordance with an embodiment hereof.
[0019] FIG. 18 is a cross-section view of a hollow wire taken along line 18-18 of FIG. 17.
[0020] FIGS. 19-20 are schematic illustrations of a hollow wire including a spring element in the lumen of the hollow wire.
[0021] FIGS. 21 -22 are cross-sectional views of a portion of a hollow wire including a supporting element surrounding the hollow wire.
[0022] FIGS. 23-25 are cross-sectional views of a hollow wire with an outer member and an inner member, wherein the outer member is deformed to form a lumen between the outer and inner members.
[0023] FIGS. 26-30 are schematic illustrations of a method for forming a stent with hollow struts in accordance with an embodiment hereof.
[0024] FIGS. 31 -36 are schematic illustrations of method of bonding adjacent crowns of a stent.
[0025] FIGS. 37-38 are schematic illustrations of an apparatus and methods of forming a wave form in a wire.
[0026] FIGS. 39-40 are schematic illustrations of an apparatus and method of forming a bend in a wire.
DETAILED DESCRIPTION OF THE INVENTION
[0027] Specific embodiments of the present invention are now described with reference to the figures, where like reference numbers indicate identical or functionally similar elements.
[0028] An embodiment of a stent 100 disclosed herein is shown in FIGS. 1 -3. In particular, stent 100 is formed from a hollow wire 102. In the embodiment shown in FIG. 1 , stent 100 is formed into a series of generally sinusoidal waves including generally straight segments or struts 106 joined by bent segments or crowns 108 and form a generally tubular stent 100. The generally sinusoidal pattern is formed into a tube, as shown in FIG. 1. In the embodiment shown in FIG. 1 , selected crowns 108 of longitudinally adjacent sinusoids may be joined by, for example, fusion points 1 10. The invention hereof is not limited to the pattern shown in FIG. 1. Stent 100 can be formed into any pattern suitable for use as a stent. For example, and not by way of limitation, stent 100 can be formed into patterns disclosed in U.S. Patent No.
4,800,882 to Gianturco, U.S. Patent No. 4,886,062 to Wiktor, U.S. Patent No.
5,133,732 to Wiktor, U.S. Patent No. 5,782,903 to Wiktor, U.S. Patent No. 6,136,023 to Boyle, and U.S. Patent No. 5,019,090 to Pinchuk, each of which is incorporated by reference herein in its entirety. Further, instead of a single length of wire formed into a stent pattern, a plurality of wires may be formed into a two-dimensional waveform and wrapped into individual cylindrical elements. The cylindrical elements may then be aligned along a common longitudinal axis and joined to form the stent.
[0029] As shown in FIG. 2, hollow wire 102 of stent 100 allows for a biologically or pharmacologically active substance 1 12 to be deposited within the lumen 103 of hollow wire 102. Although hollow wire 102 is shown as generally having a circular cross-section, hollow wire 102 may be generally elliptical or rectangular in cross- section. Hollow wire 102 further includes cuts or openings 104 dispersed along its length to permit biologically or pharmacologically active substance 1 12 to be released
from lumen 103. Openings 104 may be disposed only on generally straight segments 106 of stent 100, only on crowns 108 of stent 100, or both generally straight segments 106 and crowns 108. Openings 104 may be sized and shaped as desired to control the elution rate of biologically or pharmacologically active substance 1 12 from stent 100. Larger sized openings 104 generally permit a faster elution rate and smaller sized openings 104 generally provide a slower elution rate. Further, the size and/or quantity of openings 104 may be varied along stent 100 in order to vary the quantity and/or rate of biologically or pharmacologically active substance 1 12 being eluted from stent 100 at different portions of stent 100. Openings 104 may be, for example and not by way of limitation, 5-30pm in diameter. Openings 104 may be provided only on an outwardly facing or abluminal surface 1 16 of stent 100, as shown in FIG. 2, only on the inwardly facing or luminal surface 1 18 of stent 100, both surfaces, or may be provided anywhere along the circumference of wire 102. Openings 104 may have a constant diameter through the depth or have a tapered or conical shape.
[0030] Ends 1 14 of wire 102 may be closed, as shown in FIG. 3. Ends 1 14 may be closed by crimping excess material of wire 102 to close lumen 103. Closing ends 1 14 prevents drug 1 14 from prematurely releasing from ends 1 14. However, closing ends 1 14 is not required as drug 1 12 may be dried, provided within a polymer matrix, enclosed within a liner (not shown), or otherwise protected from premature release from ends 1 14. Further, ends 1 14 may be welded, crimped or otherwise connected to other portions of wire 102 such that the ends 1 14 are not free ends. Ends 1 14 may alternatively be provided as free ends.
Embodiments for Bending a Hollow Wire
[0031] Forming a hollow wire stent by bending a hollow wire into a stent form may cause kinking, cracking, or other undesirable properties in the finished stent.
Accordingly, co-pending U.S. Application No. 12/500,359, filed July 9, 2009, incorporated by reference herein in its entirety, describes methods for forming a hollow wire stent by forming a core wire, bending the core wire into the selected stent shape, and then removing the sacrificial or inner member of the core wire. However, it may be beneficial to form the stent using a hollow wire if concerns regarding kinking or cracking can be overcome.
[0032] A method for forming a stent pattern from a wire utilizes fingers to bend the wire into the desired pattern. An example of such a system is described in co-pending
U.S. Patent Application No. 12/428,581 , filed April 23, 2009, which is incorporated by reference herein in its entirety. Other systems may also be used to bend the wire into the desired pattern. The pattern, such as a sinusoidal pattern, is then wrapped around a mandrel and selected crowns may be bonded together to form a stent. The crowns may be bonded together by welding, or other methods of bonding such as mechanical means, spring clips, interconnecting crowns, adhesives, brazing, solder, rivets, sutures, or other suitable means known to those skilled in the art. FIGS. 31 -36 show examples of such alternative bonding methods. FIGS. 31 and 32 show
interconnecting crowns. The crowns can be electropolished, swaged, or otherwise processed after interconnection in order to reduce the profile of the interconnection. FIG. 33 also shows interconnecting crowns in ball and socket type of interconnection. The crowns can be swaged to lock the "ball" into the "socket". FIG. 34 shows the crowns coupled to each other with a suture. The suture can be made of any material suitable to couple the crowns together. FIGS. 35-36 show a rivet connection, wherein the holes are drilled through the crowns as shown in FIG. 35 and a rivet is inserted through the holes to connect the crowns, as shown in FIG. 36. It is understood that these are merely examples of connections between the crowns, and that those skilled in the art would recognize other alternative connections.
[0033] FIGS. 4-7 show cross-sectional views of hollow wire 102 in a method of forming a stent from a hollow wire. Wires forming stents are generally as thin as possible while still providing radial strength in the stent form. In a hollow wire coronary stent, an example of an inner diameter for the wire is about 0.0015 inch and an outer diameter is of about 0.0035 inch. The dimension range for the wire in a coronary hollow wire stent is an outside diameter range of 0.002 inches to 0.005 inches with an inside diameter of 50% or less of the outside diameter. The dimension range for the wire in a peripheral or other anatomy location hollow wire stent/implant is an outside diameter range of 0.002 inches to 0.012 inches with an inside diameter of 75% or less of the outside diameter. In the embodiment shown in FIGS. 4-7, a hollow wire 102 is shaped into a stent pattern. In this embodiment, a relatively large outer diameter compared to the inner diameter D2 is utilized, resulted in a relatively thick wall of hollow wire 102. Due to the relatively large outer diameter D1 relative to the inner diameter D2, {i.e., thick wall) kinking, cracking, or closing of the lumen 103 is reduced or prevented. The stent pattern can be the pattern shown in FIG. 1 or any other suitable pattern formed from a wire. Shaping wire 102 into the stent pattern shown in
FIG. 1 generally includes the steps of forming wire 102 into a two dimensional sinusoid pattern followed by wrapping the pattern around a mandrel, as known to those skilled in the art. The end result is a helical stent pattern formed onto a mandrel.
[0034] After wire 102 has been shaped into the stent pattern, wire 1 02 is electropolished or otherwise processed to remove material from wire 102. Additional removal processes include but are not limited to plasma etching, sand blasting, bead blasting, acid etching, tumbling, grinding and laser etching. The acid etching processes may include any wet chemical etching mixture that attacks the metals directly. Examples are heated mixtures of, HF:HN03 (hydrofluoric & nitric acids) or HCI:H2C>2 (hydrochloric & hydrogen peroxide), both mixtures can etch the metals directly. Many other wet metal etch mixtures exist. Such processing reduces the outer diameter of wire 102. Accordingly, as shown in FIG. 6, outer diameter D3 of wire 102 may be about 0.0035 inch while inner diameter D2 remains about 0.0015 inch, with a wall thickness T2 of about .001 inches. The material removal process will alter the dimension, but the proportion of outside diameter to inside diameter dimension would stay within the limits of inside diameter being 50% or less of the outside diameter for coronary applications and the inside diameter being 75% or less of the outside diameter for applications outside of the coronary vasculature. After removing the appropriate amount of material, selected crowns 1 08 of the helical pattern may be bonded together or alternatively the material can be removed after the bonding process.
[0035] Openings 104 may then be provided through wire 1 02. Openings 1 04 may be laser cut, drilled, etched, or otherwise provided in wire 1 02, as shown in FIG. 6. A biologically or pharmacologically active substance 1 1 2 may be injected into lumen 103 of outer member 102 as shown FIG. 7. This produces a hollow wire 1 02 with biologically or pharmacologically active substance 1 1 2 disposed in lumen 103 thereof, and openings 1 04 through which biologically or pharmacologically active substance 1 12 may be eluted, as shown in FIG. 7.
[0036] In another embodiment of a method for forming a hollow wire stent, a hollow metal wire is provided. The wire is heated to a temperature to soften the material. The wire is then shaped into a stent pattern, as described above. By heating the hollow wire prior to shaping the hollow wire into the stent pattern, kinking, cracking, and other deformations may be reduced or eliminated. In a particular, non-limiting example, a hollow wire made from MP35N is heated to 1 140 Kelvin to 1450 Kelvin and
formed into a stent shape at this elevated temperature. Openings are then formed through the hollow wire to the lumen and the stent is filled with a drug, as described above. Other materials such as but not limited to 316 stainless steel, tantalum, niobium, molybdenum-rhenium alloys, nickel-titanium alloys, L605, magnesium and magnesium alloys may be used to form the hollow wire, and may be heated to 65% to 85% of the absolute melting temperature to soften the material prior to forming
[0037] Another method for forming a stent from a hollow wire is shown in FIGS. 8- 1 1 . As discussed above, a method process for forming a wire into a stent form utilizes fingers to bend a straight wire. Schematically represented in FIGS. 8-1 1 , and described in more detail in U.S. Application No. 12/428,581 , filed April 23, 2009, which is incorporated herein in its entirety, is a portion of an apparatus 200 for forming a wave form for a stent from a hollow wire 102. Briefly describing apparatus 200, the hollow wire 102 is provided to the apparatus 200 by a supply 210, which may include a spool upon which the hollow wire 102 is wound. Alternatively the hollow wire can be provided to the apparatus in discrete sections. The hollow wire 102 may be fed in the first direction 1 D along an axis into a wire forming area. A suitable clamp 220 may be located just outside the wire forming area, as illustrated, or may be located within the wire forming area. The clamp 220 is configured to clamp the hollow wire 102 so that tension may be applied to the hollow wire 102 as the hollow wire 102 is formed into a predetermined shape. The apparatus 200 also includes a plurality of first forming members or fingers 202 located on one side of the hollow wire 102 and a plurality of second forming members or fingers 204 located on the opposite side of the hollow wire 102. The first and second forming members 202, 204 have substantially elongated shapes and include wire engaging surfaces 206, 208, respectively.
[0038] As shown in FIG. 9, first forming members 202 move in a second direction 2D that is substantially orthogonal to the first direction 1 D to engage hollow wire 102. After the wire engaging surfaces 206 have engaged the hollow wire 102, the first forming members 202 continue to move in the second direction 2D to deform the hollow wire 102, as shown in FIG. 9. Each of the first forming members 202 may be moved in the second direction 2D by a respective first actuator 212, all of which may be configured to move in the first direction 1 D along a suitable structure, such as a rail 214. Similarly, second forming members 204 move in a third direction 3D such that wire engaging surfaces 208 engage hollow wire 102. After the wire engaging surfaces
206 have engaged the hollow wire 1 02, the second forming members 204 continue to move in the third direction 3D to deform the hollow wire 1 02, as shown in FIG. 9.
[0039] As illustrated in FIG. 10, after a wave form has been formed, the first forming members 202 may be moved in the third direction 3D to disengage from the wire hollow 1 02, and the second forming members 204 may be moved in the second direction 2D to disengage from the hollow wire 1 02. The clamp 220 may then be opened and wire 102 may be advances by supply 210 so that a new section of hollow wire 102 may be advanced into the wire forming area, as shown in FIG. 1 1 . At about the same time, the first and second forming members 202, 204 may be moved along their respective rails 212, 214 in the fourth direction 4D so that another cycle may begin. It would be understood by those skilled in the art that this description is merely an example of method to bend a wire into a wave form for a stent.
[0040] In order to reduce or eliminate the kinking, cracking, closing of lumen 103, or other deformations, hollow wire 1 02 may be swaged or otherwise processed to alter its cross-sectional shape to be generally elliptical. Thus, a hollow wire 102 of generally circular cross-section, as shown in FIG. 12, is swaged or otherwise processed to form a wire 1 02 with a generally elliptical cross-section, as shown in FIG. 13. Swaging or other processes to alter the cross-sectional shape could be done only at select locations such as crowns. The generally elliptically shaped wire includes a long axis 250 in cross-section, as shown in FIG. 13. The forming members 204, 206 (only one is shown in FIG. 14) are aligned with the long axis 250 of the hollow wire 102, as shown in FIG. 14. The process as described with respect to FIGS. 8-1 1 is then performed to bend hollow wire 1 02 into the wave form for a stent and wrapped around a mandrel to form the stent pattern. Selected crowns of the stent pattern may then be bonded together, openings 104 may be cut through the wall of hollow wire 102 to access lumen 1 03, and the lumen filled with a biologically or pharmacologically active substance, as described above. Alternatively, the swaging or other processes to alter the cross-sectional shape could be done after forming to return the cross section to a circular or more circular shape if the wires become elliptical during forming. The forming could be done only at select locations such as crowns.
[0041] Using the method described generally at FIGS. 8-1 1 , hollow wire 1 02 is bent into shape at a speed of 20-100 mm/s for the forming members with a preferable speed of approximately 60 mm/s. In another method of reducing kinking, cracking, closing of the lumen, and other deformations, the rate of bending is reduced to the
speed to 0.5-19 mm/s for the forming members. The radii of the forming members contacting the hollow wire should be 1 - 2.5 times the radius of the wire. An alternative forming movement to reduce tension and thereby reduce elongation of the hollow wire during bending is described in FGS. 37 and 38. FIG. 37 shows steps A-D for forming a waveform in a wire in a similar fashion as described, for example, in U.S. Application No. 12/428,581 , filed April 23, 2009, which is incorporated herein in its entirety. FIG. 38 shows steps A-E of an embodiment of a method for forming a waveform in a hollow wire, wherein a less severe angle Θ is created in the wire, thereby reducing tension and elongation of the hollow wire.
[0042] In another method, the hollow wire 102 is bent incrementally in order to reduce the risk of kinking, cracking, or other deformations. In particular, a hollow wire 102 is partially bent. Hollow wire 1 02 is then annealed to allow stress relief using a temperature of 50% of the absolute melt temperature of the material or greater. The hollow wire 1 02 is then further bent. The bending and annealing process may be repeated as necessary to bend hollow wire 1 02 while limiting kinking, cracking, or other deformation of the lumen 1 03. An embodiment of an apparatus 3900 for incrementally bending the hollow wire 1 02 is shown in FIGS. 39-40, although other apparatuses or methods for incrementally bending wire 102 may be used. Bending apparatus 3900 includes a roller element 3902 and a support element 3904. Rotating bending apparatus 3900 as indicated by the arrow bends wire 1 02.
[0043] In another embodiment, hollow wire 102 is bent into the desired waveform using a clamshell type apparatus 300. As shown in FIGS. 15 and 16, hollow wire 102 is provided to the apparatus 300 by a supply 310, which may include a spool upon which the hollow wire 1 02 is wound. Alternatively the hollow wire can be provided to the apparatus in discrete sections. The hollow wire 102 may be fed in the first direction 1 D along an axis. A suitable clamp (not shown) may be provided to clamp the wire 1 02 so that tension may be applied to the wire 1 02 as hollow wire 102 is formed into a predetermined shape, as described above with respect to apparatus 300. The apparatus 300 also includes a first clamshell half 302 located on one side of hollow wire 102 and a second clamshell half 304 located on the opposite side of hollow wire 102. An end of first clamshell half 302 facing hollow wire 102 is shaped as a waveform 306 with a plurality of peaks 330 and valleys 332. An end of second clamshell half 304 facing hollow wire 1 02 is shaped as a waveform including a plurality of peaks 334 and valleys 336. Peaks 330 of first clamshell half 302 align with valleys
336 of second clamshell half 304 and peaks 334 of second clamshell half 304 align with valleys 332 of first clamshell half 302. The ends of clamshell halves 302, 304 opposite the waveforms 306, 308 are coupled to actuators 312, 314, respectively. Actuators 312, 314 may be coupled to rails 316, 318, respectively, or other suitable support structures.
[0044] Actuators 312 move first clamshell half 302 in direction 2D and actuators 314 move second clamshell half 304 in direction 3D, as shown in FIG. 16. Hollow wire 102 is deformed between peaks 330, 334 and valleys 336, 332, respectively such that hollow wire 102 becomes a waveform. Actuators 312, 314 then move first and second clamshell halves 302, 304 back to the position of FIG. 15, supply 310 feeds hollow wire 102 in direction 1 D, and the process is repeated for another section of wire 102. By using clamshell halves 302, 304, hollow wire 102 is supported while being bent into the waveform to reduce kinking, cracking, and other deformations. Other forming options include using pair(s) of matching gears wherein the hollow wire sample is formed by the interlocking of the gear teeth.
Embodiments Bending a Supported Wire
[0045] As disclosed in co-pending U.S. Application No. 12/500,359, filed July 9, 2009, which is incorporated herein in its entirety, a method for reducing or preventing kinking, cracking, and other deformations in a hollow wire when shaping the hollow wire into a stent pattern is to internally support the wire during the shaping step, and then removing the supporting element after the wire has been shaped into the stent pattern. In some applications where the lumen is small, it may be difficult to remove the supporting element.
[0046] FIGS. 17 and 18 show an embodiment wherein the lumen 103 of a hollow wire 102 is coupled to a pump 260. Tubing 262 may be used to couple the pump 260 to the hollow wire 102. An end of lumen 103 may be plugged or otherwise closed to assist in building pressure in the lumen. Pump 260 pressurizes lumen 103 with a fluid, such as air, water, alcohol, oils (hydrocarbon or silicone based), waxes, meltable polymers, slurries of water and/or organic solvents and particles where the particles can be metal, silica or polymeric or other suitable fluids. As shown by the arrows 264 in FIG. 18, this fluid pressure supports the walls of hollow wire 102 while hollow wire 102 is shaped into a stent pattern using the apparatus 200 as described with respect to FIGS. 8-1 1 , the method and apparatus described in co-pending U.S. Application
No. 12/428,581 , filed April 23, 2009, or suitable shaping apparatuses and methods. In certain embodiments, pump 260 may not be required. For example, when using relatively non-compressible fluids such as oils, water, and other non-compressible fluids known to those of ordinary skill in the art, the non-compressible fluid itself may sufficiently support hollow wire 102 during the process of shaping hollow wire 102 into a stent pattern.
[0047] Once hollow wire 102 has been shaped into the stent pattern, pump 260 is turned off (if used) and the fluid is drained from hollow wire 102. The fluid may be drained/removed by vacuum or pressure applied to the lumen, flushing the fluid out with another fluid, or other methods known to those skilled in the art. Further, any residual fluid remaining fluid may be vaporized during an annealing process step typically performed on stents.
[0048] In a non-limiting embodiment, a wax, such as an industrial grade wax such as paraffin, is liquefied/melted and inserted into the lumen 103 of hollow wire 102. Pressure or vacuum may be used to assist the liquefied wax fill lumen 103. The wax is permitted to solidify or harden within lumen 103, such as by cooling. The wire 102 is then shaped into the stent pattern with the wax supporting the walls of wire 102. After the wire has been shaped into the stent pattern, the wax is again liquefied and removed from the lumen 103. Vacuum or pressure assistance, or a solvent, may be used to assist in draining the liquefied wax from lumen 103. Further, the annealing process, as discussed above, may vaporize any residual wax remaining in the lumen 103.
[0049] Openings 104 are formed through the wall of hollow wire 102 to access lumen 103 and may assist in draining the fluid, depending on the fluid used. Thus, openings 104 may be formed before or after the step of draining the fluid from hollow wire 102. Lumen 103 is then filled with a drug, thereby providing a hollow, drug- eluting stent.
[0050] In another embodiment, lumen 103 is filled with the biologically or pharmacologically active substance prior to bending hollow wire 102. The biologically or pharmacologically active substance may be pressurized as described above with respect to FIGS. 17-18, but need not be. The biologically or pharmacologically active substance is densely packed into lumen 103, thereby providing support to hollow wire 102 as hollow wire 102 is formed into the stent pattern. In some applications, after forming the stent in the stent pattern, fusing selected crowns of the stent may
adversely affect some biologically or pharmacologically active substances due to heat at the fusion site. In some embodiments, the crowns need not be attached to each other at all, thereby avoiding the issue. In other embodiments, the crowns can be attached by mechanical means, spring clips, interconnecting crowns, soldering, adhesives, brazing, sutures, rivets, clamps, micro machined interlocking surfaces or other connecting means known to those skilled in the art, some of which are shown in FIGS. 31 -36.
[0051] In another embodiment shown in FIGS. 19-20, a spring element 280 is disposed within lumen 103 of hollow wire 102. Spring element 280 may be inserted into lumen 103 of hollow wire 102 or hollow wire 102 may be formed around spring element 280. Spring element 280 may be formed of flattened steel or other suitable materials. Spring element 280 supports hollow wire 102 while hollow wire 102 is shaped into a stent pattern. Alternatively, the spring element could be placed on the outside of the hollow wire. After shaping hollow wire 102 into a stent pattern, spring element 280 is pulled, as shown by the arrow in FIG. 20. Pulling spring element 280 causes spring element 280 to straighten, as indicated at 282, thereby simplifying its removal from lumen 103. After spring element 280 is removed, openings may be cut in hollow wire 102 to access lumen 103 and lumen 103 may be filled with a biologically or pharmacologically active substance, as explained above, resulting in a hollow wire drug-eluting stent.
[0052] In another embodiment shown in FIGS. 21 -22, instead of supporting wire 102 with a supporting element in the lumen 103, an outer member 290 envelops wire 102. Outer member 290 may be softer than wire 102. For example, outer member 290 may be made from tantalum and hollow wire 102 may be made from MP35N. Outer member 290 may not be attached to hollow wire 102. Outer member 290 and hollow wire 102 are bent together into a stent pattern, such as a sinusoidal pattern. Outer member 290 may then be removed, for example, by the methods described in co-pending U.S. Application No. 12/500,359, filed July 9, 2009, which is incorporated herein in its entirety. By having outer member 290 on the outside of hollow wire 102, it may be easier to remove outer member 290 compared to a supporting member disposed in lumen 103. After outer member 290 is removed, the stent forming process is finalized as described above and lumen 103 is loaded with a biologically or pharmacologically active substance, resulting in a hollow drug-eluting stent.
[0053] In other embodiments, the lumen of the hollow wire may be filled with a filler material such as a gel, hydrogel, alcohol, silica or a polymer, shaped into a stent pattern, and then the filler material may be removed. The filler material may be removed after the wire is shaped into a stent pattern, by exposing the shaped wire to solvent or solution in which the filler material is soluble or reacts but the wire is not soluble or reacts to remove the filler material, which can then be drained from the lumen with the solvent or solution. Examples of solvents may be water or alcohol and examples of a solution would be an acidic or basic solution such as HCL, sulfuric, ammonia, etc. If alcohol is used as a filler material, it can simply evaporate from the lumen.
[0054] In another embodiment shown in FIGS. 23-25, a core wire including an outer member 2302 and a core or inner member 2304 is swaged, for example, in a press 2308 such that a force is directed in the direction of arrows 2306. In this embodiment, inner member 2304 is made from a material that is harder than the material of the outer member 2302. In a non-limiting example, outer member 2302 may be made from MP35N and inner member 2304 may be made from a
molybdenum-rhenium alloy, which is approximately twice as hard as MP35N. Thus, when the core wire is swaged, outer member 2302 deforms into a generally elliptical shape, but inner member 2304 remains generally circular, as shown in FIG. 24. This provides a gap or lumen 2310 between outer member 2302 and inner member 2304, generally to one side of inner member 2304. The wire is then shaped into a stent pattern and openings 2312 are laser-cut through outer member 2302 to expose inner member 2304. The stent is then exposed to an etchant, for example, xenon difluoride, as described in co-pending U.S. Application No. 12/500,359, filed July 9, 2009, incorporated by reference herein in its entirety. In some instances, some of the openings 2312 may become clogged and therefore impede the etching process. In the present embodiment, with lumen 2310 running the length of the wire between outer member 2302 and 2304, if a hole 2312 becomes clogged, the etchant from an adjacent hole 2312 flows through lumen 2310, as depicted by arrows 2314, to etch inner member 2302 along the length of the wire.
Sheet Embodiment
[0055] Another method for forming a stent including hollow struts is described referring to FIGS. 26-30. In this embodiment, rather than forming the stent from a wire
bent into a stent pattern, the stent pattern is cut into flat sheets, rolled into a tube, and welded to form a stent with hollow struts. As illustrated schematically in FIG. 26, a first sheet 402 and second sheet 404 sandwich a third sheet 406 therebetween. First and second sheets 402, 404 are made from materials that form a finished stent, such as stainless steel, nitinol, MP35N, etc. Third sheet 406 is made from a material that can be removed from between first and second sheets 402, 404 after forming. For example, the materials described in co-pending U.S. Application No. 12/500,359, filed July 9, 2009 and incorporated by reference herein, for the outer member can be used for first and second sheets 402, 404, and the materials described therein for the sacrificial or core member can be used as third sheet 406. In a non-limiting example, first and second sheets 402, 404 are formed from MP35N and third sheet 406 is formed from tantalum.
[0056] With sheets 402, 404, 406 stacked, a flat stent pattern is stamped out of the sheets, as shown in FIG. 27. The stamping device cuts through sheets 402, 404, 406, leaving struts 407 of the flat stent pattern. The stamping device has curved edges that push third sheet 406 inward and first and second sheets 402, 404 together at edges 408, as shown in the cross-sectional view of struts 407 in FIG. 28. Openings 104 may be laser cut through strut 407 to reach the remaining material of sheet 406. The remaining material of sheet 406 can be removed by the methods described herein or in co-pending application no. 12/500,359, for example, using xenon difluoride gas. After the remaining material of sheet 406 is removed, the flat stent is rolled such that edges 410, 412 abut each other, and edges 410, 412 are bonded to each other, for example by a weld 414 as shown in FIG. 29. A cross-sectional view of the struts 407 of FIG. 29 is shown in FIG. 30, with hole 104 accessing lumen 103. The stent can then be filled with a biologically or pharmacologically active substance through openings 104 and/or additional openings drilled for the purpose of filling the stent. Those of ordinary skill in the art would recognize that the step of removing the remaining material of third sheet 406 may be performed before or after the flat stent is rolled and edges 410, 412 are welded to each other.
[0057] Examples of biologically or pharmacologically active substance that may be used to fill the lumen of the stents described above are listed in co-pending U.S.
Application no. 12/500,359, filed July 9, 2009, which is incorporated by reference herein in its entirety. The term "biologically or pharmacologically active substance" refers to any substance, whether synthetic or natural, that has a pharmacological,
chemical, or biological effect on the body or a portion thereof. Suitable biologically or pharmacologically active materials that can be used in embodiments of the present invention include without limitation glucocorticoids (e.g. dexamethasone,
betamethasone), antithrombotic agents such as heparin, cell growth inhibitors, hirudin, angiopeptin, aspirin, growth factors such as VEGF, antisense agents, anti-cancer agents, anti-proliferative agents, oligonucleotides, antibiotics, and, more generally, antiplatelet agents, anti-coagulant agents, antimitotic agents, antioxidants,
antimetabolite agents, and anti-inflammatory agents may be used. Antiplatelet agents can include drugs such as aspirin and dipyridamole. Aspirin is classified as an analgesic, antipyretic, anti-inflammatory and antiplatelet drug. Dipyridamole is a drug similar to aspirin in that it has anti-platelet characteristics. Dipyridamole is also classified as a coronary vasodilator. Anticoagulant agents may include drugs such as heparin, protamine, hirudin and tick anticoagulant protein. Anti-cancer agents may include drugs such as taxol and its analogs or derivatives. Taxol is also classified as a cell-growth inhibitor. Antioxidant agents may include probucol. Anti-proliferative agents may include drugs such as amlodipine, doxazosin, and sirolimus (rapamycin) or other— limus family compounds. Antimitotic agents and antimetabolite agents may include drugs such as methotrexate, azathioprine, vincristine, vinblastine, 5- fluorouracil, adriamycin and mutamycin. Antibiotic agents can include penicillin, cefoxitin, oxacillin, tobramycin, and gentamicin. Suitable antioxidants include probucol. Also, genes or nucleic acids, or portions thereof may be used. Such genes or nucleic acids can first be packaged in liposomes or nanoparticles. Furthermore, collagen- synthesis inhibitors, such as tranilast, may be used.
[0058] Further, due to the relatively large volume of the biologically or
pharmacologically active substance that can be carried by a hollow stent, such stent may be particularly useful for delivering chemotherapy or radiation therapy directly to a target location.
[0059] The step of filling lumen 1 03 with biologically or pharmacologically active substances 1 12, and other steps in processing the stent, such as cleaning, may be accomplished by the methods described in co-pending U.S. Application Nos.
(Attorney Docket Nos. P36494, P37957, P38015, P38005, P37967, and P36172), each of which is incorporated by reference herein in its entirety, or any other suitable methods known to those skilled in the art.
[0060] While various embodiments of the present invention have been described above, it should be understood that they have been presented by way of illustration and example only, and not limitation. It will be apparent to persons skilled in the relevant art that various changes in form and detail can be made therein without departing from the spirit and scope of the invention. Thus, the breadth and scope of the present invention should not be limited by any of the above-described exemplary embodiments, but should be defined only in accordance with the appended claims and their equivalents. It will also be understood that each feature of each embodiment discussed herein, and of each reference cited herein, can be used in combination with the features of any other embodiment. Furthermore, there is no intention to be bound by any expressed or implied theory presented in the preceding technical field, background, brief summary or the detailed description. All patents and publications discussed herein are incorporated by reference herein in their entirety.
Claims
1. A method of forming a medical device comprising the steps of:
utilizing a hollow wire having an outer member and a lumen of the outer member;
filling the lumen with a liquid to form a supported hollow wire; shaping the supported hollow wire into a pattern;
forming openings through the outer member; and
after the step of shaping the supported hollow wire into the pattern, processing the supported hollow wire such that the liquid is removed from the lumen of the outer member without adversely affecting the outer member.
2. The method of claim 1 , further comprising the step of filling the lumen of the outer member with a biologically or pharmacologically active substance after the liquid has been removed.
3. The method of claim 2, wherein the biologically or pharmacologically active is selected from the group consisting of antineoplastic, antimitotic,
antiinflammatory, antiplatelet, anticoagulant, anti fibrin, antithrombin, antiproliferative, antibiotic, antioxidant, and antiallergic substances as well as combinations thereof.
4. The method of claim 2, wherein the medical device is a stent.
5. The method of claim 1 , wherein the liquid is oil.
6. The method of claim 1 , wherein the liquid is pressurized during the step of shaping the supported hollow wire.
7. The method of claim 1 , wherein the liquid is a noncompressible fluid.
8. The method of claim 1 , further comprising the step of solidifying the liquid in the lumen prior to the step of shaping the support hollow wire.
9. A method of forming a medical device comprising the steps of:
utilizing a hollow wire having an outer member and a lumen of the outer member;
filling the lumen with a fluid;
pressurizing the fluid within the lumen to form a supported hollow wire; shaping the supported hollow wire into a pattern;
forming openings through the outer member; and
after the step of shaping the supported hollow wire into the pattern, processing the supported hollow wire such that the fluid is removed from the lumen of the outer member without adversely affecting the outer member.
10. The method of claim 9, further comprising the step of filling the lumen of the outer member with a biologically or pharmacologically active substance after the liquid has been removed.
1 1. The method of claim 9, wherein the fluid is selected from the group consisting of air, water, alcohol, oils (hydrocarbon or silicone based), waxes, meltable polymers, and slurries of water and particles where the particles can be metal, silica or polymeric.
12. A method of forming a medical device comprising the steps of:
utilizing a hollow wire having an outer member and a lumen of the outer member;
filling the lumen with a liquefied wax;
solidifying the liquefied wax within the lumen to form a supported hollow wire;
shaping the supported hollow wire into a pattern;
forming openings through the outer member; and
after the step of shaping the supported hollow wire into the pattern, processing the supported hollow wire such that the wax is removed from the lumen of the outer member without adversely affecting the outer member.
13. The method of claim 12, wherein the step of processing the supported hollow wire comprises re-liquefying the wax and draining it from the lumen.
14. The method of claim 13, wherein the step of processing the supported hollow wire further comprises adding pressure or a vacuum to remove the re-liquefied wax from the lumen.
15. The method of claim 13, wherein the step of re-liquefying the wax comprises heating the supported hollow wire to a temperature higher than the melt temperature of the wax and lower than the melt temperature of the outer member.
16. The method of claim 12, wherein the wax is paraffin.
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EP10766152.2A EP2477673B1 (en) | 2009-09-20 | 2010-09-20 | Method of forming hollow tubular drug eluting medical devices |
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Also Published As
Publication number | Publication date |
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US8916226B2 (en) | 2014-12-23 |
EP2477673A1 (en) | 2012-07-25 |
EP2477673B1 (en) | 2014-11-26 |
US20110070358A1 (en) | 2011-03-24 |
US20140091057A1 (en) | 2014-04-03 |
CN102596279B (en) | 2015-08-12 |
CN102596279A (en) | 2012-07-18 |
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