WO2010141139A1 - Multiple-sample microfluidic chip for dna analysis - Google Patents
Multiple-sample microfluidic chip for dna analysis Download PDFInfo
- Publication number
- WO2010141139A1 WO2010141139A1 PCT/US2010/026791 US2010026791W WO2010141139A1 WO 2010141139 A1 WO2010141139 A1 WO 2010141139A1 US 2010026791 W US2010026791 W US 2010026791W WO 2010141139 A1 WO2010141139 A1 WO 2010141139A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- domain
- dna
- microfluidic chip
- module
- dna fragments
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N2021/4173—Phase distribution
- G01N2021/4186—Phase modulation imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/22—Details, e.g. general constructional or apparatus details
- G01N29/32—Arrangements for suppressing undesired influences, e.g. temperature or pressure variations, compensating for signal noise
Definitions
- Fig. 1 shows a block diagram of an exemplary DNA analyzer 100 according to an embodiment of the disclosure.
- the DNA analyzer 100 includes a rnicrofluidic chip module 110, a thermal module 120, a pressure module 130, a high voltage module 140, a detection module 150, a power module 160, a computing module 170, and a controller module 180. Additionally, the DNA analyzer 100 can include a magnetic module 190. These elements can be coupled together as shown in Fig. 1.
- liquid phase extraction method instead of the silica solid phase method can reduce the overall hydraulic pressure requirement to induce solution flow through the microfluidic chip 111.
- the liquid phase extraction can enable a valveless design for the microfluidic chip 111.
- the liquid phase extraction can simplify the DNA analyzer 100 and simplify the manufacturing and testing steps in association with the solid-phase extraction.
- Fig. 2A shows a swab storage example 212
- Figs. 2B-2C show a side elevation view and a front elevation view of a sample cartridge example 215 according to an embodiment of the disclosure.
- the swab storage 212 includes a case 203, a seal cap 202 and a swab 205.
- the seal cap 202 and the swab 205 are attached together.
- the swab storage 212 includes an identifier, such as a barcode label 204 that can be attached to the case 203, an RFID tag 201 that can be implanted in the seal cap 202, and the like.
- the sample cartridge 215 can include a microfluidic chip 211, a sample acceptor 207 and a reagent carrier 206.
- the sample acceptor 207 includes a plurality of separated wells 207A-207D for taking swabs.
- Each well includes a liquid phase mixture 214 that is sealed by a membrane 208 at a bottom portion of the well.
- the liquid phase mixture 214 can conduct enzymatic digestion of all proteins and other cellular interferences, with the exception of DNA, and thus can perform DNA extraction and purification when a swab with DNA sample is inserted in the liquid phase mixture 214.
- the user takes a swab 205, and lets the DNA analyzer 400 to identify the swab 205.
- the DNA analyzer 400 includes a barcode reader that can read the barcode label 204 attached to the case 203 for storing the swab 205.
- the DNA analyzer 400 excites the RFID 201 implanted in the seal cap 202 of the swab 205 to obtain a unique serial number of the swab 205. Then, the process proceeds to S535.
- the plot 800 shows five curves 810-850.
- the curve 810 shows detected fluorescence intensity versus time for a first wavelength.
- the curve 820 shows detected fluorescence intensity versus time for a second wavelength.
- the curve 830 shows detected fluorescence intensity versus time for a third wavelength.
- the curve 840 shows detected fluorescence intensity versus time for a fourth wavelength, and the curve 850 shows detected fluorescence intensity versus time for a fifth wavelength.
- the fifth wavelength corresponds to the fluorescent label used to tag the ILS, thus spikes in the curve 850 are of known sizes.
- Spikes in the curves 810-840 correspond to STR alleles in the sample under analysis.
- the sizes of the STR alleles can be determined based on comparison to the spikes in the curve 850.
- the STR alleles can be identified based on the wavelength and the size comparison with the ILS.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2010257126A AU2010257126B2 (en) | 2009-06-04 | 2010-03-10 | Multiple-sample microfluidic chip for DNA analysis |
CA2764704A CA2764704C (en) | 2009-06-04 | 2010-03-10 | Dna analyzer |
DE112010002246.1T DE112010002246B4 (en) | 2009-06-04 | 2010-03-10 | DNA analysis facility |
EP10708680.3A EP2437889B1 (en) | 2009-06-04 | 2010-03-10 | Multiple-sample microfluidic chip for dna analysis |
GB1121511.8A GB2483588A (en) | 2009-06-04 | 2010-03-10 | Multiple sample microfluidic chip for DNA analysis |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21340409P | 2009-06-04 | 2009-06-04 | |
US21340509P | 2009-06-04 | 2009-06-04 | |
US21340609P | 2009-06-04 | 2009-06-04 | |
US61/213,406 | 2009-06-04 | ||
US61/213,405 | 2009-06-04 | ||
US61/213,404 | 2009-06-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010141139A1 true WO2010141139A1 (en) | 2010-12-09 |
Family
ID=42148393
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/025904 WO2010141131A1 (en) | 2009-06-04 | 2010-03-02 | Multiple-sample microfluidic chip for dna analysis |
PCT/US2010/026791 WO2010141139A1 (en) | 2009-06-04 | 2010-03-10 | Multiple-sample microfluidic chip for dna analysis |
PCT/US2010/026801 WO2010141140A1 (en) | 2009-06-04 | 2010-03-10 | Optical approach for microfluidic dna electrophoresis detection |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/025904 WO2010141131A1 (en) | 2009-06-04 | 2010-03-02 | Multiple-sample microfluidic chip for dna analysis |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/026801 WO2010141140A1 (en) | 2009-06-04 | 2010-03-10 | Optical approach for microfluidic dna electrophoresis detection |
Country Status (7)
Country | Link |
---|---|
US (6) | US20110065101A1 (en) |
EP (3) | EP2437887B1 (en) |
AU (3) | AU2010257118B2 (en) |
CA (3) | CA2764678C (en) |
DE (3) | DE112010002222B4 (en) |
GB (3) | GB2483402B (en) |
WO (3) | WO2010141131A1 (en) |
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US8961764B2 (en) | 2010-10-15 | 2015-02-24 | Lockheed Martin Corporation | Micro fluidic optic design |
US9067207B2 (en) | 2009-06-04 | 2015-06-30 | University Of Virginia Patent Foundation | Optical approach for microfluidic DNA electrophoresis detection |
DE102014105437A1 (en) | 2014-04-16 | 2015-10-22 | Amodia Bioservice Gmbh | Microfluidic module and cassette for immunological and molecular diagnostics in an automated analyzer |
US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
US9862984B2 (en) | 2006-04-21 | 2018-01-09 | Nanobiosym, Inc. | Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents |
US10933417B2 (en) | 2013-03-15 | 2021-03-02 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
US11207677B2 (en) | 2018-03-07 | 2021-12-28 | University Of Virginia Patent Foundation | Devices, systems, and methods for detecting substances |
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