WO2010111977A3 - Method for determining local toxicity of substances - Google Patents

Method for determining local toxicity of substances Download PDF

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Publication number
WO2010111977A3
WO2010111977A3 PCT/CZ2010/000034 CZ2010000034W WO2010111977A3 WO 2010111977 A3 WO2010111977 A3 WO 2010111977A3 CZ 2010000034 W CZ2010000034 W CZ 2010000034W WO 2010111977 A3 WO2010111977 A3 WO 2010111977A3
Authority
WO
WIPO (PCT)
Prior art keywords
measured
change
substances
local toxicity
corneal
Prior art date
Application number
PCT/CZ2010/000034
Other languages
French (fr)
Other versions
WO2010111977A2 (en
Inventor
Jitka Cejkova
Cestmir Cejka
Jiri Michalek
Jakub Sirc
Original Assignee
Ustav Experimentalni Mediciny Av Cr, V.V.I.
Ustav Makromolekularni Chemie Av Cr, V.V.I.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ustav Experimentalni Mediciny Av Cr, V.V.I., Ustav Makromolekularni Chemie Av Cr, V.V.I. filed Critical Ustav Experimentalni Mediciny Av Cr, V.V.I.
Priority to EP10729687A priority Critical patent/EP2414814A2/en
Publication of WO2010111977A2 publication Critical patent/WO2010111977A2/en
Publication of WO2010111977A3 publication Critical patent/WO2010111977A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se

Abstract

The invention relates to a method of testing the local toxicity of a substance, characterized in that a cornea of an animal is exposed to the substance and the change in the corneal thickness is measured, and optionally also the change in the corneal light absorption or light transmission properties is measured. The change in the cornea thickness can be measured by a pachymeter, the change in the corneal absorption or transmission properties can be measured pectrophotometrically. The invention further relates to an insert to a cuvette for the spectrophotometric measurement. ˙
PCT/CZ2010/000034 2009-03-30 2010-03-29 Method for determining local toxicity of substances WO2010111977A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10729687A EP2414814A2 (en) 2009-03-30 2010-03-29 Method for determining local toxicity of substances

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20090190A CZ2009190A3 (en) 2009-03-30 2009-03-30 Method of measuring local toxicity of substances and apparatus for making the same
CZPV2009-190 2009-03-30

Publications (2)

Publication Number Publication Date
WO2010111977A2 WO2010111977A2 (en) 2010-10-07
WO2010111977A3 true WO2010111977A3 (en) 2010-11-25

Family

ID=42710512

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2010/000034 WO2010111977A2 (en) 2009-03-30 2010-03-29 Method for determining local toxicity of substances

Country Status (3)

Country Link
EP (1) EP2414814A2 (en)
CZ (1) CZ2009190A3 (en)
WO (1) WO2010111977A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1188613A (en) * 1967-08-03 1970-04-22 Montedison Spa Spectrophotometry
SU1617377A1 (en) * 1988-02-24 1990-12-30 Московский научно-исследовательский институт глазных болезней им.Гельмгольца Method of assessing injuring action of substances in contact with cornea
RU2102069C1 (en) * 1992-05-22 1998-01-20 Сендзю Фармасьютикал Ко., Лтд. Pharmaceutical composition for glaucoma treatment
US5833923A (en) * 1995-12-22 1998-11-10 Universal Healthwatch, Inc. Sampling-assay interface system
WO2003052391A1 (en) * 2001-12-14 2003-06-26 Optiscan Biomedical Corporation Spectroscopic method of determining an analyte concentration in a sample
RU2207828C2 (en) * 2001-03-22 2003-07-10 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" Method for producing biological coating transplant for performing superficial medical keratoplastic operation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1188613A (en) * 1967-08-03 1970-04-22 Montedison Spa Spectrophotometry
SU1617377A1 (en) * 1988-02-24 1990-12-30 Московский научно-исследовательский институт глазных болезней им.Гельмгольца Method of assessing injuring action of substances in contact with cornea
RU2102069C1 (en) * 1992-05-22 1998-01-20 Сендзю Фармасьютикал Ко., Лтд. Pharmaceutical composition for glaucoma treatment
US5833923A (en) * 1995-12-22 1998-11-10 Universal Healthwatch, Inc. Sampling-assay interface system
RU2207828C2 (en) * 2001-03-22 2003-07-10 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" Method for producing biological coating transplant for performing superficial medical keratoplastic operation
WO2003052391A1 (en) * 2001-12-14 2003-06-26 Optiscan Biomedical Corporation Spectroscopic method of determining an analyte concentration in a sample

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DENOYER A. ET AL: "Very-high-frequency ultrasound corneal imaging as a new tool for early diagnosis of ocular surface toxicity in rabbits treated with a preserved glaucoma drug", OPHTHALMIC RES., vol. 40, no. 6, October 2008 (2008-10-01), pages 298 - 308, Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/pubmed?term=DENOYER%202008%20298-308> *

Also Published As

Publication number Publication date
WO2010111977A2 (en) 2010-10-07
CZ2009190A3 (en) 2010-10-13
EP2414814A2 (en) 2012-02-08

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