WO2010051051A3 - Radial arrays of nano-electrospray ionization emitters and methods of forming electrosprays - Google Patents

Radial arrays of nano-electrospray ionization emitters and methods of forming electrosprays Download PDF

Info

Publication number
WO2010051051A3
WO2010051051A3 PCT/US2009/035817 US2009035817W WO2010051051A3 WO 2010051051 A3 WO2010051051 A3 WO 2010051051A3 US 2009035817 W US2009035817 W US 2009035817W WO 2010051051 A3 WO2010051051 A3 WO 2010051051A3
Authority
WO
WIPO (PCT)
Prior art keywords
nano
electrospray ionization
emitters
electrosprays
methods
Prior art date
Application number
PCT/US2009/035817
Other languages
French (fr)
Other versions
WO2010051051A2 (en
Inventor
Ryan Kelly
Keqi Tang
Richard D. Smith
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Publication of WO2010051051A2 publication Critical patent/WO2010051051A2/en
Publication of WO2010051051A3 publication Critical patent/WO2010051051A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H01J49/167—Capillaries and nozzles specially adapted therefor

Abstract

Electrospray ionization emitter arrays, as well as methods for forming electrosprays, are described. The arrays are characterized by a radial configuration of three or more nano- electrospray ionization emitters without an extractor electrode. The methods are characterized by distributing fluid flow of the liquid sample among three or more nano- electrospray ionization emitters, forming an electrospray at outlets of the emitters without utilizing an extractor electrode, and directing the electrosprays into an entrance to a mass spectrometry device. Each of the nano-electrospray ionization emitters can have a discrete channel for fluid flow. The nano-electrospray ionization emitters are circularly arranged such that each is shielded substantially equally from an electrospray-inducing electric field.
PCT/US2009/035817 2008-03-11 2009-03-03 Radial arrays of nano-electrospray ionization emitters and methods of forming electrosprays WO2010051051A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/046,207 US7816645B2 (en) 2008-03-11 2008-03-11 Radial arrays of nano-electrospray ionization emitters and methods of forming electrosprays
US12/046,207 2008-03-11

Publications (2)

Publication Number Publication Date
WO2010051051A2 WO2010051051A2 (en) 2010-05-06
WO2010051051A3 true WO2010051051A3 (en) 2010-09-02

Family

ID=41061985

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/035817 WO2010051051A2 (en) 2008-03-11 2009-03-03 Radial arrays of nano-electrospray ionization emitters and methods of forming electrosprays

Country Status (2)

Country Link
US (1) US7816645B2 (en)
WO (1) WO2010051051A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8373116B2 (en) * 2009-09-21 2013-02-12 Queen's University At Kingston Multi-channel electrospray emitter
US8237115B2 (en) * 2009-12-18 2012-08-07 Thermo Finnigan Llc Method and apparatus for multiple electrospray emitters in mass spectrometry
US8242441B2 (en) * 2009-12-18 2012-08-14 Thermo Finnigan Llc Apparatus and methods for pneumatically-assisted electrospray emitter array
US8207496B2 (en) * 2010-02-05 2012-06-26 Thermo Finnigan Llc Multi-needle multi-parallel nanospray ionization source for mass spectrometry
US8309916B2 (en) 2010-08-18 2012-11-13 Thermo Finnigan Llc Ion transfer tube having single or multiple elongate bore segments and mass spectrometer system
US8847154B2 (en) 2010-08-18 2014-09-30 Thermo Finnigan Llc Ion transfer tube for a mass spectrometer system
US8502162B2 (en) 2011-06-20 2013-08-06 Agilent Technologies, Inc. Atmospheric pressure ionization apparatus and method
CN103972019B (en) * 2014-05-12 2016-04-20 清华大学 Contactless DC induction electrospray ionization device and ioning method
US10297435B2 (en) * 2015-01-27 2019-05-21 Queen's University At Kingston Micro-nozzle array
US10329079B2 (en) * 2015-10-06 2019-06-25 Hamilton Sundstrand Corporation Aerosol/solvent delivery nozzles
GB201807914D0 (en) * 2018-05-16 2018-06-27 Micromass Ltd Impactor spray or electrospray ionisation ion source
US11139157B2 (en) * 2019-05-31 2021-10-05 Purdue Research Foundation Multiplexed inductive ionization systems and methods
US11222778B2 (en) 2019-10-30 2022-01-11 Thermo Finnigan Llc Multi-electrospray ion source for a mass spectrometer
CN115372450A (en) * 2021-05-19 2022-11-22 株式会社岛津制作所 Ion analysis apparatus
WO2023172785A1 (en) * 2022-03-11 2023-09-14 Ohio State Innovation Foundation Electrospray emitter devices and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020000516A1 (en) * 1999-12-30 2002-01-03 Schultz Gary A. Multiple electrospray device, systems and methods
US20020043624A1 (en) * 1998-03-27 2002-04-18 Ole Hindsgaul Device for delivery of multiple liquid sample streams to a mass spectrometer
US20030106996A1 (en) * 1999-12-15 2003-06-12 Covey Thomas R. Parallel sample introduction electrospray mass spectrometer with electronic indexing through multiple ion entrance orifices

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6066848A (en) * 1998-06-09 2000-05-23 Combichem, Inc. Parallel fluid electrospray mass spectrometer
EP1876442A3 (en) * 1998-09-17 2008-03-05 Advion BioSciences, Inc. Integrated monolithic microfabricated liquid chromatography system and method
US6670607B2 (en) * 2000-01-05 2003-12-30 The Research Foundation Of State University Of New York Conductive polymer coated nano-electrospray emitter
JP2003520962A (en) * 2000-01-18 2003-07-08 アドビオン バイオサイエンシーズ インコーポレーティッド Separation media, dual electrospray nozzle system and method
US6753521B1 (en) * 2000-02-18 2004-06-22 Bruker Daltonics, Inc. Method and apparatus for a nanoelectrosprayer for use in mass spectrometry
US6525313B1 (en) * 2000-08-16 2003-02-25 Brucker Daltonics Inc. Method and apparatus for an electrospray needle for use in mass spectrometry
US6657191B2 (en) * 2001-03-02 2003-12-02 Bruker Daltonics Inc. Means and method for multiplexing sprays in an electrospray ionization source
US6803565B2 (en) * 2001-05-18 2004-10-12 Battelle Memorial Institute Ionization source utilizing a multi-capillary inlet and method of operation
US6800849B2 (en) * 2001-12-19 2004-10-05 Sau Lan Tang Staats Microfluidic array devices and methods of manufacture and uses thereof
US6703611B2 (en) * 2002-02-25 2004-03-09 The University Of North Carolina At Chapel Hill Electrospray ionization device
US6831274B2 (en) * 2002-03-05 2004-12-14 Battelle Memorial Institute Method and apparatus for multispray emitter for mass spectrometry
CA2499657A1 (en) * 2005-03-03 2006-09-03 Richard Oleschuk Polymer entrapped particles
WO2008118808A1 (en) * 2007-03-23 2008-10-02 Advion Bioscience, Inc. Liquid chromatography-mass spectrometry

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020043624A1 (en) * 1998-03-27 2002-04-18 Ole Hindsgaul Device for delivery of multiple liquid sample streams to a mass spectrometer
US20030106996A1 (en) * 1999-12-15 2003-06-12 Covey Thomas R. Parallel sample introduction electrospray mass spectrometer with electronic indexing through multiple ion entrance orifices
US20020000516A1 (en) * 1999-12-30 2002-01-03 Schultz Gary A. Multiple electrospray device, systems and methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KOERNER, T., TURCK, K., BROWN, L. OLESCHUK, R.D.: "Porous Polymer Monolith Assisted Electrospray", ANAL. CHEM., vol. 76, no. 21, 1 November 2004 (2004-11-01), pages 6456 - 6460, XP002590402, DOI: 10.1021/ac049438y *

Also Published As

Publication number Publication date
US7816645B2 (en) 2010-10-19
WO2010051051A2 (en) 2010-05-06
US20090230296A1 (en) 2009-09-17

Similar Documents

Publication Publication Date Title
WO2010051051A3 (en) Radial arrays of nano-electrospray ionization emitters and methods of forming electrosprays
WO2009124298A3 (en) Electrospray ion sources with heated gas
WO2012125318A3 (en) Microchips with integrated multiple electrospray ionization emitters and related methods, systems and devices
EP2112681A3 (en) Mass spectrometer system
MX2017001307A (en) Ion funnel for efficient transmission of low mass-to-charge ratio ions with reduced gas flow at the exit.
GB2551294A (en) Liquid trap or separator for electrosurgical applications
WO2012175517A3 (en) Targeted analysis for tandem mass spectrometry
WO2013085572A3 (en) Plume collimation for laser ablation electrospray ionization mass spectrometry
US11029291B2 (en) Systems and methods for ionization
WO2012155090A3 (en) High sensitivity mass spectrometry systems
CA2539899A1 (en) Improved high performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel
WO2010125357A3 (en) Ion analysis apparatus having differential ion mobility spectrometer and mass spectrometer and method of use
DE602008006054D1 (en) LASER DESORPTION ELECTROSPRAY ION SOURCE FOR MASS SPECTROMETERS
EP2254142A2 (en) Low pressure electrospray ionization system and process for effective transmission of ions
WO2013067366A4 (en) Ion mobility spectrometer
WO2012123730A3 (en) Ion mobility spectrometer with variable effective drift length
EP2779207A3 (en) Microengineered multipole ion guide
WO2011148312A3 (en) Improvements relating to the control of ions
WO2014114808A3 (en) Laser ablation atmospheric pressure ionization mass spectrometry
EP3316277A4 (en) Repeller for ion implanter, cathode, chamber wall, slit member, and ion generating device comprising same
WO2015100233A8 (en) Atmospheric interface for electrically grounded electrospray
IL284844A (en) Online chromatography and electrospray ionization mass spectrometer
EP3537143A4 (en) Matrix-assisted laser desorption/ionization mass spectrometry method
WO2010026426A3 (en) Process
WO2014149847A3 (en) Ionization within ion trap using photoionization and electron ionization

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09810832

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09810832

Country of ref document: EP

Kind code of ref document: A2