WO2010041204A3 - Measurement of cerebral hemodynamic parameters - Google Patents

Measurement of cerebral hemodynamic parameters Download PDF

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Publication number
WO2010041204A3
WO2010041204A3 PCT/IB2009/054388 IB2009054388W WO2010041204A3 WO 2010041204 A3 WO2010041204 A3 WO 2010041204A3 IB 2009054388 W IB2009054388 W IB 2009054388W WO 2010041204 A3 WO2010041204 A3 WO 2010041204A3
Authority
WO
WIPO (PCT)
Prior art keywords
head
current
finding
measuring
impedance waveform
Prior art date
Application number
PCT/IB2009/054388
Other languages
French (fr)
Other versions
WO2010041204A2 (en
Inventor
Ben Zion Poupko
Alon Rappaport
Shlomi Ben-Ari
Mooly Auerbach
Original Assignee
Orsan Medical Technologies Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orsan Medical Technologies Ltd. filed Critical Orsan Medical Technologies Ltd.
Priority to US13/122,966 priority Critical patent/US20110196245A1/en
Priority to CN200980148981.1A priority patent/CN102238905B/en
Priority to JP2011530614A priority patent/JP2012505010A/en
Priority to EP09743915A priority patent/EP2346403A2/en
Publication of WO2010041204A2 publication Critical patent/WO2010041204A2/en
Publication of WO2010041204A3 publication Critical patent/WO2010041204A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02028—Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0295—Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2505/00—Evaluating, monitoring or diagnosing in the context of a particular type of medical care
    • A61B2505/01—Emergency care
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0535—Impedance plethysmography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7239—Details of waveform analysis using differentiation including higher order derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7242—Details of waveform analysis using integration

Abstract

A method of finding an indication of a degree of cerebro-vascular bilateral asymmetry in a subject, comprising: a) measuring a first impedance waveform and a second impedance waveform of the subject’s head as functions of time, in each case by finding a potential difference between two voltage electrodes associated with passing a given injected current through the head between at least two current electrodes, wherein in each case the voltage electrodes are located asymmetrically on the head, or the current is injected asymmetrically into the head, or both, and wherein the locations of the voltage electrodes and the distribution of current injection in measuring the second impedance waveform are mirror images of what they are in measuring the first impedance waveform; and b) finding the indication of the degree of bilateral asymmetry from a difference between characteristics of the first and second impedance waveforms.
PCT/IB2009/054388 2008-10-07 2009-10-07 Measurement of cerebral hemodynamic parameters WO2010041204A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US13/122,966 US20110196245A1 (en) 2008-10-07 2009-10-07 Measurement of cerebral hemodynamic parameters
CN200980148981.1A CN102238905B (en) 2008-10-07 2009-10-07 Measurement of cerebral hemodynamic parameters
JP2011530614A JP2012505010A (en) 2008-10-07 2009-10-07 Measurement of cerebral hemodynamic parameters
EP09743915A EP2346403A2 (en) 2008-10-07 2009-10-07 Measurement of cerebral hemodynamic parameters

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10328708P 2008-10-07 2008-10-07
US61/103,287 2008-10-07

Publications (2)

Publication Number Publication Date
WO2010041204A2 WO2010041204A2 (en) 2010-04-15
WO2010041204A3 true WO2010041204A3 (en) 2010-06-03

Family

ID=41383542

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/IB2009/054392 WO2010041205A2 (en) 2008-10-07 2009-10-07 Monitoring of acute stroke patients
PCT/IB2009/054394 WO2010041206A1 (en) 2008-10-07 2009-10-07 Diagnosis of acute strokes
PCT/IB2009/054388 WO2010041204A2 (en) 2008-10-07 2009-10-07 Measurement of cerebral hemodynamic parameters

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/IB2009/054392 WO2010041205A2 (en) 2008-10-07 2009-10-07 Monitoring of acute stroke patients
PCT/IB2009/054394 WO2010041206A1 (en) 2008-10-07 2009-10-07 Diagnosis of acute strokes

Country Status (5)

Country Link
US (3) US20110201950A1 (en)
EP (4) EP3031395A1 (en)
JP (3) JP2012505011A (en)
CN (3) CN102238906B (en)
WO (3) WO2010041205A2 (en)

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