WO2010004436A3 - Enhanced immunoassay sensor - Google Patents

Enhanced immunoassay sensor Download PDF

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Publication number
WO2010004436A3
WO2010004436A3 PCT/IB2009/006688 IB2009006688W WO2010004436A3 WO 2010004436 A3 WO2010004436 A3 WO 2010004436A3 IB 2009006688 W IB2009006688 W IB 2009006688W WO 2010004436 A3 WO2010004436 A3 WO 2010004436A3
Authority
WO
WIPO (PCT)
Prior art keywords
disclosed
fluid sample
target analyte
enhanced immunoassay
immunoassay sensor
Prior art date
Application number
PCT/IB2009/006688
Other languages
French (fr)
Other versions
WO2010004436A2 (en
WO2010004436A8 (en
Inventor
Dennis Rylatt
Alastair Hodges
Original Assignee
University Biosensors Pty Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41507499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2010004436(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to MX2011000417A priority Critical patent/MX2011000417A/en
Priority to BRPI0915491A priority patent/BRPI0915491A2/en
Priority to JP2011517271A priority patent/JP5769620B2/en
Priority to CN200980126745.XA priority patent/CN102105790B/en
Priority to CA2730544A priority patent/CA2730544C/en
Priority to AU2009269702A priority patent/AU2009269702B2/en
Priority to NZ590411A priority patent/NZ590411A/en
Application filed by University Biosensors Pty Ltd. filed Critical University Biosensors Pty Ltd.
Priority to ES09794067.0T priority patent/ES2568252T3/en
Priority to EP09794067.0A priority patent/EP2318837B1/en
Priority to US13/003,752 priority patent/US8951749B2/en
Publication of WO2010004436A2 publication Critical patent/WO2010004436A2/en
Publication of WO2010004436A3 publication Critical patent/WO2010004436A3/en
Priority to IL210543A priority patent/IL210543A/en
Priority to ZA2011/00234A priority patent/ZA201100234B/en
Publication of WO2010004436A8 publication Critical patent/WO2010004436A8/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • G01N33/541—Double or second antibody, i.e. precipitating antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/08—Geometry, shape and general structure
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves

Abstract

Disclosed herein are devices for detecting the presence of a target analyte in a fluid sample. The biosensor device can comprise at least a reaction chamber and a detection chamber. The device can comprise a amplifying mechanism such that one target analyte molecule present in the fluid sample can lead to generation/activation of multiple detection agent molecules, and therefore, an amplified signal. Also disclosed are the methods of manufacturing and using such a biosensor device.
PCT/IB2009/006688 2008-07-11 2009-07-10 Enhanced immunoassay sensor WO2010004436A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
US13/003,752 US8951749B2 (en) 2008-07-11 2009-07-10 Enhanced immunoassay sensor
NZ590411A NZ590411A (en) 2008-07-11 2009-07-10 Enhanced immunoassay sensor
JP2011517271A JP5769620B2 (en) 2008-07-11 2009-07-10 Improved immunoassay sensor
CN200980126745.XA CN102105790B (en) 2008-07-11 2009-07-10 The immunoassays sensor of enhancing
ES09794067.0T ES2568252T3 (en) 2008-07-11 2009-07-10 Enhanced Immunoassay Sensor
AU2009269702A AU2009269702B2 (en) 2008-07-11 2009-07-10 Enhanced immunoassay sensor
BRPI0915491A BRPI0915491A2 (en) 2008-07-11 2009-07-10 immunoassay sensor
MX2011000417A MX2011000417A (en) 2008-07-11 2009-07-10 Enhanced immunoassay sensor.
CA2730544A CA2730544C (en) 2008-07-11 2009-07-10 Enhanced immunoassay sensor
EP09794067.0A EP2318837B1 (en) 2008-07-11 2009-07-10 Enhanced immunoassay sensor
ZA2011/00234A ZA201100234B (en) 2008-07-11 2011-01-10 Enhanced immunoassay sensor
IL210543A IL210543A (en) 2008-07-11 2011-01-10 Enhanced immunoassay sensor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12968808P 2008-07-11 2008-07-11
US61/129,688 2008-07-11

Publications (3)

Publication Number Publication Date
WO2010004436A2 WO2010004436A2 (en) 2010-01-14
WO2010004436A3 true WO2010004436A3 (en) 2010-02-25
WO2010004436A8 WO2010004436A8 (en) 2011-02-24

Family

ID=41507499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/006688 WO2010004436A2 (en) 2008-07-11 2009-07-10 Enhanced immunoassay sensor

Country Status (17)

Country Link
US (1) US8951749B2 (en)
EP (1) EP2318837B1 (en)
JP (1) JP5769620B2 (en)
KR (1) KR101644144B1 (en)
CN (1) CN102105790B (en)
AU (1) AU2009269702B2 (en)
BR (1) BRPI0915491A2 (en)
CA (1) CA2730544C (en)
ES (1) ES2568252T3 (en)
IL (1) IL210543A (en)
MX (1) MX2011000417A (en)
NZ (1) NZ590411A (en)
PL (1) PL2318837T3 (en)
SG (1) SG192481A1 (en)
TW (1) TWI485403B (en)
WO (1) WO2010004436A2 (en)
ZA (1) ZA201100234B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011010823A (en) 2009-04-17 2011-12-06 Universal Biosensors Pty Ltd On-board control detection.
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
US10114020B2 (en) 2010-10-11 2018-10-30 Mbio Diagnostics, Inc. System and device for analyzing a fluidic sample
JP5584151B2 (en) * 2011-02-23 2014-09-03 協立電機株式会社 Trace substance detector
US20140127288A1 (en) * 2011-05-17 2014-05-08 Mitsubishi Gas Chemical Company, Inc. Liposome containing pyrroloquinoline quinone and sugar
US9063121B2 (en) 2012-05-09 2015-06-23 Stat-Diagnostica & Innovation, S.L. Plurality of reaction chambers in a test cartridge
SG11201501853SA (en) * 2012-09-19 2015-04-29 Universal Biosensors Pty Ltd Systems and methods for enzyme detection
US9739714B2 (en) * 2012-10-29 2017-08-22 Mbio Diagnostics, Inc. Particle identification system, cartridge and associated methods
CN103519828B (en) * 2013-11-04 2015-04-29 理康互联科技(北京)有限公司 Analyte detection system and sensing label thereof
GB2555403B (en) * 2016-10-24 2021-03-24 Entia Ltd A Cuvette
WO2018107012A1 (en) 2016-12-09 2018-06-14 Abbott Point Of Care Inc. Crossover analytical systems and methods using an immunosensor and magnetic immunosensor
ES2869625T3 (en) 2016-12-09 2021-10-25 Abbott Point Of Care Inc Combined immunoassay and magnetic immunoassay systems and devices for an extended range of sensitivity
CN110178032B (en) 2016-12-09 2023-08-11 雅培医护站股份有限公司 Combined immunoassay and magnetic immunoassay methods for extended range sensitivity
WO2018107016A1 (en) * 2016-12-09 2018-06-14 Abbott Point Of Care Inc. Ameliorated crosstalk immunoassay test device for determining a concentration of an analyte
CN116879544A (en) 2016-12-09 2023-10-13 雅培医护站股份有限公司 Extended range immunoassay device using immunosensor and magnetic immunosensor
WO2019224815A1 (en) * 2018-05-21 2019-11-28 Diagnoz Me Ltd. Imaging system for identification of objects of interest
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN209829010U (en) * 2019-03-01 2019-12-24 南京岚煜生物科技有限公司 Multi-channel microfluid blood coagulation detection chip
CN111517997B (en) * 2020-04-17 2022-06-07 杭州博拓生物科技股份有限公司 Ethyl sulfate artificial antigen, preparation method and application
CN117063068A (en) * 2021-01-07 2023-11-14 科尼库公司 System and method for detecting volatile organic compounds in air
US11753516B2 (en) 2021-10-08 2023-09-12 Covestro Llc HFO-containing compositions and methods of producing foams

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007398A1 (en) * 1995-08-11 1997-02-27 Dade International Inc. Polypeptide-dendrimer complexes
WO1999018433A1 (en) * 1997-10-02 1999-04-15 Biosite Diagnostics, Incorporated A lysis chamber for use in an assay device
WO2002008763A2 (en) * 2000-07-14 2002-01-31 Usf Filtration And Separations Group Inc. Immunosensor
WO2002082078A2 (en) * 2001-04-09 2002-10-17 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Activated enzyme-linked detection systems for detecting and quantifying nucleid acids, antigens antibodies and other analytes
EP1347302A2 (en) * 2002-03-21 2003-09-24 Lifescan, Inc. Direct immunosensor assay
US20040203137A1 (en) * 2000-07-14 2004-10-14 Alastair Hodges Immunosensor
US20060134713A1 (en) * 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use
US20070289880A1 (en) * 2001-09-04 2007-12-20 Zweig Stephen E Apoenzyme reactivation electrochemical detection method and assay

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1234567A (en) * 1915-09-14 1917-07-24 Edward J Quigley Soft collar.
US4213893A (en) 1978-10-12 1980-07-22 Miles Laboratories, Inc. Flavin adenine dinucleotide-labeled conjugates for use in specific binding assays
US4708933A (en) * 1984-06-12 1987-11-24 Leaf Huang Immunoliposome assay-methods and products
US4622294A (en) 1985-02-08 1986-11-11 Kung Viola T Liposome immunoassay reagent and method
IL86754A (en) 1987-07-02 1991-11-21 Hughes Aircraft Co Method of forming deep nested filament winding
CA2024548C (en) 1989-09-05 2002-05-28 David Issachar Analyte specific chemical sensor
GB9018195D0 (en) 1990-08-18 1990-10-03 Fisons Plc Analytical device
GB9212416D0 (en) 1992-06-11 1992-07-22 Medical Res Council Reversible binding substances
US6022748A (en) 1997-08-29 2000-02-08 Sandia Corporation - New Mexico Regents Of The University Of California Sol-gel matrices for direct colorimetric detection of analytes
US5427912A (en) * 1993-08-27 1995-06-27 Boehringer Mannheim Corporation Electrochemical enzymatic complementation immunoassay
US5756362A (en) 1993-10-12 1998-05-26 Cornell Research Foundation, Inc. Liposome-enhanced immunoaggregation assay and test device
JPH07227298A (en) 1993-12-22 1995-08-29 Wako Pure Chem Ind Ltd Method for immunoassay
IL116921A (en) * 1996-01-26 2000-11-21 Yissum Res Dev Co Electrochemical system for determination of an analyte in a liquid medium
WO1998004743A1 (en) 1996-07-29 1998-02-05 The Regents Of The University Of California Polymeric assemblies for sensitive colorimetric assays
GB9623149D0 (en) 1996-11-07 1997-01-08 Univ Manchester Sensor
EP1186059B1 (en) 1999-04-09 2006-03-01 Auburn University Method for forming monolayers
CA2733852A1 (en) * 2000-07-14 2002-01-24 Lifescan, Inc. Electrochemical method for measuring chemical reaction rates
US6319007B1 (en) 2000-07-24 2001-11-20 Gus J. Livaditis Vital pulp therapy
DE10038900A1 (en) 2000-08-09 2002-03-07 Haemosys Gmbh Simple method for drug monitoring of GPIIb / IIIa receptor antagonists
US6436386B1 (en) 2000-11-14 2002-08-20 Shearwater Corporation Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
JP5118288B2 (en) 2002-05-16 2013-01-16 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト Method for producing polymer layer
GB0212701D0 (en) 2002-05-31 2002-07-10 Imp College Innovations Ltd Immunoliposomes
US7291256B2 (en) * 2002-09-12 2007-11-06 Lifescan, Inc. Mediator stabilized reagent compositions and methods for their use in electrochemical analyte detection assays
JP4142404B2 (en) 2002-11-06 2008-09-03 出光興産株式会社 Aromatic amine derivative and organic electroluminescence device using the same
CA2412206A1 (en) 2002-11-20 2004-05-20 Labbell Inc. Method of testing photosynthetic activities
WO2005000902A1 (en) 2003-06-30 2005-01-06 Mu-Hyeon Choe The dimer of chimeric recombinant binding domain-functional group fusion formed via disulfide-bond-bridge and the processes for producing the same
DE602005009819D1 (en) 2004-05-13 2008-10-30 Univ Pretoria METHOD FOR DETECTING INFECTIONS WITH MYCOBACTERIES
EP1793837A2 (en) 2004-09-27 2007-06-13 Technion Research & Development Foundation Limited Fatty acid modified polylysines as antimicrobial agents
WO2006046524A1 (en) 2004-10-27 2006-05-04 Toyo Boseki Kabushiki Kaisha Pqq-dependent glucose dehydrogenase composition
JP2008523820A (en) * 2004-12-16 2008-07-10 アクセラー８ テクノロジー コーポレイション Fast microbial detection and antimicrobial susceptibility testing
WO2006096619A2 (en) 2005-03-04 2006-09-14 Bayer Healthcare Llc Stabilizing the activity of pqq-dependent glucose dehydrogenase in electrochemical biosensors
US7465380B2 (en) 2005-04-12 2008-12-16 Lifescan Scotland, Ltd. Water-miscible conductive ink for use in enzymatic electrochemical-based sensors
US20060275825A1 (en) 2005-04-12 2006-12-07 Sru Biosystems, Inc. Proteolipid membrane and lipid membrane biosensor
AU2005336057A1 (en) * 2005-08-31 2007-03-08 Egomedical Technologies Ag Analyte test system using non-enzymatic analyte recognition elements
US7955484B2 (en) 2005-12-14 2011-06-07 Nova Biomedical Corporation Glucose biosensor and method

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007398A1 (en) * 1995-08-11 1997-02-27 Dade International Inc. Polypeptide-dendrimer complexes
WO1999018433A1 (en) * 1997-10-02 1999-04-15 Biosite Diagnostics, Incorporated A lysis chamber for use in an assay device
WO2002008763A2 (en) * 2000-07-14 2002-01-31 Usf Filtration And Separations Group Inc. Immunosensor
US20040203137A1 (en) * 2000-07-14 2004-10-14 Alastair Hodges Immunosensor
WO2002082078A2 (en) * 2001-04-09 2002-10-17 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Activated enzyme-linked detection systems for detecting and quantifying nucleid acids, antigens antibodies and other analytes
US20070289880A1 (en) * 2001-09-04 2007-12-20 Zweig Stephen E Apoenzyme reactivation electrochemical detection method and assay
EP1347302A2 (en) * 2002-03-21 2003-09-24 Lifescan, Inc. Direct immunosensor assay
US20060134713A1 (en) * 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use

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