WO2009086525A3 - Luminescent reporter modality for analyzing an assay - Google Patents

Luminescent reporter modality for analyzing an assay Download PDF

Info

Publication number
WO2009086525A3
WO2009086525A3 PCT/US2008/088465 US2008088465W WO2009086525A3 WO 2009086525 A3 WO2009086525 A3 WO 2009086525A3 US 2008088465 W US2008088465 W US 2008088465W WO 2009086525 A3 WO2009086525 A3 WO 2009086525A3
Authority
WO
WIPO (PCT)
Prior art keywords
assay
particles
luminescent
activation
optical analysis
Prior art date
Application number
PCT/US2008/088465
Other languages
French (fr)
Other versions
WO2009086525A2 (en
WO2009086525A4 (en
Inventor
Oliver H. Meek
Original Assignee
Luminex Corporation
Schneider, Roland
Baker, Harold, N.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luminex Corporation, Schneider, Roland, Baker, Harold, N. filed Critical Luminex Corporation
Publication of WO2009086525A2 publication Critical patent/WO2009086525A2/en
Publication of WO2009086525A3 publication Critical patent/WO2009086525A3/en
Publication of WO2009086525A4 publication Critical patent/WO2009086525A4/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

An optical analysis flow system and a method of assay analysis includes a means for facilitating activation of a luminescent material coupled to particles entrained within a fluid assay, wherein the means is arranged such that the activation of the luminescent material is conducted at a site along a flow path of the fluid assay prior to an examination zone of the optical analysis flow system. The method further includes measuring luminescent light emitting from the particles as they flow through the examination zone. Another method of assay analysis includes respectively measuring different types of luminescent light emission from a first set and a second set of particles comprising a fluid assay. An optical analysis system includes at least two distinct means for respectively facilitating the activation of at least two different luminescent materials coupled to particles of a fluid assay.
PCT/US2008/088465 2007-12-27 2008-12-29 Luminescent reporter modality for analyzing an assay WO2009086525A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1687907P 2007-12-27 2007-12-27
US61/016,879 2007-12-27

Publications (3)

Publication Number Publication Date
WO2009086525A2 WO2009086525A2 (en) 2009-07-09
WO2009086525A3 true WO2009086525A3 (en) 2009-09-24
WO2009086525A4 WO2009086525A4 (en) 2009-11-19

Family

ID=40798940

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/088465 WO2009086525A2 (en) 2007-12-27 2008-12-29 Luminescent reporter modality for analyzing an assay

Country Status (2)

Country Link
US (1) US20090170214A1 (en)
WO (1) WO2009086525A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010054879B4 (en) * 2010-12-17 2013-07-18 Institut für Bioprozess- und Analysenmesstechnik e.V. Arrangement and method for conditioning fluid compartments
US9395308B2 (en) * 2013-10-10 2016-07-19 University Of Akron Apparatus for quantitative measurements of stress distributions from mechanoluminescene materials
US11041756B2 (en) 2017-10-20 2021-06-22 Charted Scientific Inc. Method and apparatus of filtering light using a spectrometer enhanced with additional spectral filters with optical analysis of fluorescence and scattered light from particles suspended in a liquid medium using confocal and non confocal illumination and imaging
US10585028B2 (en) 2017-10-20 2020-03-10 Charted Scientific, Inc. Method and apparatus for optical analysis

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4573796A (en) * 1984-01-06 1986-03-04 The United States Of America As Represented By The United States Department Of Energy Apparatus for eliminating background interference in fluorescence measurements
US5032381A (en) * 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US20020123059A1 (en) * 2001-03-05 2002-09-05 Ho Winston Z. Chemiluminescence-based microfluidic biochip
US6524790B1 (en) * 1997-06-09 2003-02-25 Caliper Technologies Corp. Apparatus and methods for correcting for variable velocity in microfluidic systems
US20060228720A1 (en) * 2005-04-12 2006-10-12 Eastman Kodak Company Method for imaging an array of microspheres

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2943116C2 (en) * 1979-10-25 1986-06-19 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Device for flow cytometric reaction and / or diffusion measurement
AU7398996A (en) * 1995-10-11 1997-04-30 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6449562B1 (en) * 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
KR20010031140A (en) * 1997-10-14 2001-04-16 루미넥스 코포레이션 Precision fluorescently dyed particles and methods of making and using same
DE69907630T2 (en) * 1998-01-22 2004-02-26 Luminex Corp., Austin MICROPARTICLES WITH MULTIPLE FLUORESCENCE SIGNALS
AU3996299A (en) * 1998-05-14 1999-11-29 Luminex Corporation Diode laser based measurement apparatus
JP3946444B2 (en) * 1998-05-14 2007-07-18 ルミネックス コーポレイション Configuration and method for zero dead time of flow cytometer
WO1999058955A1 (en) * 1998-05-14 1999-11-18 Luminex Corporation Multi-analyte diagnostic system and computer implemented process for same
US6315952B1 (en) * 1998-10-05 2001-11-13 The University Of New Mexico Plug flow cytometry for high throughput screening and drug discovery
AU6779700A (en) * 1999-08-17 2001-03-13 Luminex Corporation Microparticles with multiple fluorescent signals and methods of using same
AU6779200A (en) * 1999-08-17 2001-03-13 Luminex Corporation Encapsulation of fluorescent particles
US20030113714A1 (en) * 2001-09-28 2003-06-19 Belcher Angela M. Biological control of nanoparticles
EP1820001A1 (en) * 2004-11-12 2007-08-22 Luminex Corporation Methods and systems for positioning microspheres for imaging
CN102621053B (en) * 2005-09-21 2015-05-06 卢米尼克斯股份有限公司 Methods and systems for image data processing
EP2765423B1 (en) * 2006-06-02 2016-11-02 Luminex Corporation Systems and methods for performing measurements of one or more analytes comprising using magnetic particles and applying a magnetic field
WO2008061058A2 (en) * 2006-11-10 2008-05-22 Luminex Corporation Flow cytometer and fluidic line assembly with multiple injection needles

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4573796A (en) * 1984-01-06 1986-03-04 The United States Of America As Represented By The United States Department Of Energy Apparatus for eliminating background interference in fluorescence measurements
US5032381A (en) * 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US6524790B1 (en) * 1997-06-09 2003-02-25 Caliper Technologies Corp. Apparatus and methods for correcting for variable velocity in microfluidic systems
US20020123059A1 (en) * 2001-03-05 2002-09-05 Ho Winston Z. Chemiluminescence-based microfluidic biochip
US20060228720A1 (en) * 2005-04-12 2006-10-12 Eastman Kodak Company Method for imaging an array of microspheres

Also Published As

Publication number Publication date
US20090170214A1 (en) 2009-07-02
WO2009086525A2 (en) 2009-07-09
WO2009086525A4 (en) 2009-11-19

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