WO2009079135A3 - Compositions comprising solid particles entrapped in collapsed polymeric microspheres, and methods of making the same - Google Patents

Compositions comprising solid particles entrapped in collapsed polymeric microspheres, and methods of making the same Download PDF

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Publication number
WO2009079135A3
WO2009079135A3 PCT/US2008/083607 US2008083607W WO2009079135A3 WO 2009079135 A3 WO2009079135 A3 WO 2009079135A3 US 2008083607 W US2008083607 W US 2008083607W WO 2009079135 A3 WO2009079135 A3 WO 2009079135A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid particles
compositions
making
methods
same
Prior art date
Application number
PCT/US2008/083607
Other languages
French (fr)
Other versions
WO2009079135A2 (en
Inventor
Milan F. Sojka
Phillip Cummins
Christina G. Fthenakis
Jean Harry Xavier
Original Assignee
Elc Management Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elc Management Llc filed Critical Elc Management Llc
Priority to ES08863316.9T priority Critical patent/ES2620455T3/en
Priority to AU2008338845A priority patent/AU2008338845C1/en
Priority to JP2010536966A priority patent/JP5608092B2/en
Priority to CA2706148A priority patent/CA2706148C/en
Priority to KR1020107013233A priority patent/KR101226290B1/en
Priority to EP08863316.9A priority patent/EP2234583B1/en
Publication of WO2009079135A2 publication Critical patent/WO2009079135A2/en
Publication of WO2009079135A3 publication Critical patent/WO2009079135A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/025—Explicitly spheroidal or spherical shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0275—Containing agglomerated particulates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/61—Surface treated
    • A61K2800/62—Coated
    • A61K2800/63—More than one coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Abstract

The present invention relates to topical compositions containing solid particles that are stabilized via entrapment by microspheres. Each of the microspheres contains a collapsed polymeric shell that has entrapped therein one or more solid particles. The solid particles are preferably formed of zinc oxide or titanium dioxide or both, which can readily be used either alone or in combination with other sunscreen agents to form sunscreen compositions of broader UV protection spectrum and enhanced photostability.
PCT/US2008/083607 2007-12-17 2008-11-14 Compositions comprising solid particles entrapped in collapsed polymeric microspheres, and methods of making the same WO2009079135A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES08863316.9T ES2620455T3 (en) 2007-12-17 2008-11-14 Compositions comprising solid particles trapped in collapsed polymer microspheres and manufacturing processes
AU2008338845A AU2008338845C1 (en) 2007-12-17 2008-11-14 Compositions comprising solid particles entrapped in collapsed polymeric microspheres, and methods of making the same
JP2010536966A JP5608092B2 (en) 2007-12-17 2008-11-14 Composition comprising solid particles entrapped in shrunk polymeric microspheres and method for producing the same
CA2706148A CA2706148C (en) 2007-12-17 2008-11-14 Compositions comprising solid particles entrapped in collapsed polymeric microspheres, and methods of making the same
KR1020107013233A KR101226290B1 (en) 2007-12-17 2008-11-14 Compositions comprising solid particles entrapped in collapsed polymeric microspheres, and methods of making the same
EP08863316.9A EP2234583B1 (en) 2007-12-17 2008-11-14 Compositions comprising solid particles entrapped in collapsed polymeric microspheres, and methods of making the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1423507P 2007-12-17 2007-12-17
US61/014,235 2007-12-17

Publications (2)

Publication Number Publication Date
WO2009079135A2 WO2009079135A2 (en) 2009-06-25
WO2009079135A3 true WO2009079135A3 (en) 2009-08-27

Family

ID=40753581

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/083607 WO2009079135A2 (en) 2007-12-17 2008-11-14 Compositions comprising solid particles entrapped in collapsed polymeric microspheres, and methods of making the same

Country Status (7)

Country Link
US (3) US20090155371A1 (en)
EP (1) EP2234583B1 (en)
JP (1) JP5608092B2 (en)
KR (1) KR101226290B1 (en)
AU (1) AU2008338845C1 (en)
CA (1) CA2706148C (en)
WO (1) WO2009079135A2 (en)

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US8383160B2 (en) 2013-02-26
WO2009079135A2 (en) 2009-06-25
AU2008338845A1 (en) 2009-06-25
KR101226290B1 (en) 2013-01-24
AU2008338845C1 (en) 2012-11-15
US20120045579A1 (en) 2012-02-23
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