WO2009017833A8 - Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis - Google Patents

Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis Download PDF

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Publication number
WO2009017833A8
WO2009017833A8 PCT/US2008/009354 US2008009354W WO2009017833A8 WO 2009017833 A8 WO2009017833 A8 WO 2009017833A8 US 2008009354 W US2008009354 W US 2008009354W WO 2009017833 A8 WO2009017833 A8 WO 2009017833A8
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WO
WIPO (PCT)
Prior art keywords
fibrosis
angiogenesis
loxl
lox
inhibitor
Prior art date
Application number
PCT/US2008/009354
Other languages
French (fr)
Other versions
WO2009017833A3 (en
WO2009017833A2 (en
Inventor
Victoria Smith
Scott Ogg
Peter Van Vlasselaer
Vivian E. Barry
Derek Marshall
Alison Kay Holzer
Hector Rodriguez
Miho Oyasu
Scott Alan Mccauley
Carlos Aurelio Garcia
Donna Hiroko Tokuoka Biermann
Original Assignee
Arresto Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2010519951A priority Critical patent/JP5659014B2/en
Priority to EP08795003A priority patent/EP2182981B1/en
Priority to CN200880110519A priority patent/CN101842114A/en
Priority to AU2008282739A priority patent/AU2008282739B2/en
Priority to DK08795003.6T priority patent/DK2182981T3/en
Priority to SI200830930T priority patent/SI2182981T1/en
Priority to PL08795003T priority patent/PL2182981T3/en
Priority to ES08795003T priority patent/ES2402334T3/en
Application filed by Arresto Biosciences, Inc. filed Critical Arresto Biosciences, Inc.
Priority to CA2693208A priority patent/CA2693208A1/en
Publication of WO2009017833A2 publication Critical patent/WO2009017833A2/en
Publication of WO2009017833A3 publication Critical patent/WO2009017833A3/en
Publication of WO2009017833A8 publication Critical patent/WO2009017833A8/en
Priority to HK10110176.3A priority patent/HK1143736A1/en
Priority to HRP20130287AT priority patent/HRP20130287T1/en

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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/906—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
    • G01N2333/90605—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4)
    • G01N2333/90633—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3) in general

Abstract

The present disclosure provides innovative methodology and related compositions and kits for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of LOX and an inhibitor of a LOXL, or a synergistic combination of an inhibitor of LOX or LOXL combined with other therapeutic agents. Also provided are innovative methods for selecting agents that prevent or inhibit tumor invasion, angiogenesis and metastasis, by contacting cells that are in an epithelial-mesenchymal transition (EMT) state with a candidate agent and detecting a change in the EMT state of the cells. Methods and related compositions and kits for diagnosing or monitoring various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using molecules or agents that specifically recognize processed forms of LOX or LOXL are also provided. Also provided herein are methods and related compositions, medical devices, systems and kits for preventing or treating various diseases and conditions associated with fibrosis with compositions comprising inhibitors of LOX or LOXL. Such diseases or conditions include pathological cardiovascular conditions and diseases such as hypertension, hypertensive heart disease, myocardial infarction, atherosclerosis, and restenosis, liver fibrosis, kidney fibrosis, lung fibrosis, dermal scaring, keloid formation, and Alzheimer's disease.
PCT/US2008/009354 2007-08-02 2008-08-01 Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis WO2009017833A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
PL08795003T PL2182981T3 (en) 2007-08-02 2008-08-01 Methods and compositions for treatment and diagnosis of fibrosis
CN200880110519A CN101842114A (en) 2007-08-02 2008-08-01 Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
AU2008282739A AU2008282739B2 (en) 2007-08-02 2008-08-01 Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
DK08795003.6T DK2182981T3 (en) 2007-08-02 2008-08-01 Methods and compositions for treatment and diagnosis of fibrosis.
SI200830930T SI2182981T1 (en) 2007-08-02 2008-08-01 Methods and compositions for treatment and diagnosis of fibrosis
JP2010519951A JP5659014B2 (en) 2007-08-02 2008-08-01 Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis and metastasis
ES08795003T ES2402334T3 (en) 2007-08-02 2008-08-01 Procedures and compositions for the treatment and diagnosis of fibrosis
EP08795003A EP2182981B1 (en) 2007-08-02 2008-08-01 Methods and compositions for treatment and diagnosis of fibrosis
CA2693208A CA2693208A1 (en) 2007-08-02 2008-08-01 Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
HK10110176.3A HK1143736A1 (en) 2007-08-02 2010-10-29 Methods and compositions for treatment and diagnosis of fibrosis
HRP20130287AT HRP20130287T1 (en) 2007-08-02 2013-03-28 Methods and compositions for treatment and diagnosis of fibrosis

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US96324807P 2007-08-02 2007-08-02
US96321407P 2007-08-02 2007-08-02
US96324607P 2007-08-02 2007-08-02
US96324907P 2007-08-02 2007-08-02
US96328207P 2007-08-02 2007-08-02
US60/963,248 2007-08-02
US60/963,214 2007-08-02
US60/963,282 2007-08-02
US60/963,246 2007-08-02
US60/963,249 2007-08-02

Publications (3)

Publication Number Publication Date
WO2009017833A2 WO2009017833A2 (en) 2009-02-05
WO2009017833A3 WO2009017833A3 (en) 2009-06-25
WO2009017833A8 true WO2009017833A8 (en) 2010-10-14

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Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2008/072039 WO2009035791A1 (en) 2007-08-02 2008-08-01 Lox and l0xl2 inhibitors and uses thereof
PCT/US2008/009354 WO2009017833A2 (en) 2007-08-02 2008-08-01 Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2008/072039 WO2009035791A1 (en) 2007-08-02 2008-08-01 Lox and l0xl2 inhibitors and uses thereof

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US (10) US8461303B2 (en)
EP (4) EP2543389A3 (en)
JP (8) JP5659014B2 (en)
CN (6) CN105622756B (en)
AU (4) AU2008299784B9 (en)
CA (2) CA2693310C (en)
CY (2) CY1113897T1 (en)
DK (2) DK2185198T3 (en)
ES (3) ES2402334T3 (en)
HK (2) HK1143543A1 (en)
HR (2) HRP20130287T1 (en)
HU (1) HUE025283T2 (en)
PL (2) PL2182981T3 (en)
PT (3) PT2537529T (en)
SI (2) SI2185198T1 (en)
WO (2) WO2009035791A1 (en)

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US8927700B2 (en) 2009-08-21 2015-01-06 Gilead Biologics, Inc. Catalytic domains from lysyl oxidase and LOXL2
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions

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US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
GB0604647D0 (en) 2006-03-08 2006-04-19 Shchepinov Mikhail Stabilized food supplements and their derivatives
JP5659014B2 (en) * 2007-08-02 2015-01-28 ジリード バイオロジクス，インク． Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis and metastasis
EP2268604B1 (en) * 2008-03-14 2017-02-15 Retrotope, Inc. Therapies for cancer using isotopically substituted lysine
CA2751438A1 (en) * 2009-02-06 2010-08-12 Arresto Biosciences, Inc. Methods and compositions for treatment of neovascularization
JP2012519282A (en) * 2009-02-27 2012-08-23 オーエスアイ・ファーマシューティカルズ，エルエルシー Methods for identifying mesenchymal tumor cells or agents that inhibit their production
BRPI1013201A2 (en) * 2009-05-05 2019-02-26 Yeda res & development co ltd means and methods for recognizing the development of cardiovascular disease in an individual
MX2012002271A (en) * 2009-08-21 2012-07-20 Gilead Biologics Inc Therapeutic methods and compositions.
WO2011022670A1 (en) * 2009-08-21 2011-02-24 Arresto Biosciences, Inc In vivo screening assays
JP2013502228A (en) * 2009-08-21 2013-01-24 ギリアド バイオロジクス，インク． In vitro screening assay
KR20120054077A (en) * 2009-08-21 2012-05-29 길리아드 바이오로직스, 인크. Methods and compositions for treatment of pulmonary fibrotic disorders
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