WO2008154416A3 - Electrochemical biosensors and arrays - Google Patents

Electrochemical biosensors and arrays Download PDF

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Publication number
WO2008154416A3
WO2008154416A3 PCT/US2008/066172 US2008066172W WO2008154416A3 WO 2008154416 A3 WO2008154416 A3 WO 2008154416A3 US 2008066172 W US2008066172 W US 2008066172W WO 2008154416 A3 WO2008154416 A3 WO 2008154416A3
Authority
WO
WIPO (PCT)
Prior art keywords
reservoir
analyte
outside
working electrode
chemistry
Prior art date
Application number
PCT/US2008/066172
Other languages
French (fr)
Other versions
WO2008154416A2 (en
Inventor
Norman F Sheppard Jr
John T Santini Jr
Original Assignee
Microchips Inc
Norman F Sheppard Jr
John T Santini Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microchips Inc, Norman F Sheppard Jr, John T Santini Jr filed Critical Microchips Inc
Priority to EP08770378A priority Critical patent/EP2157907B1/en
Publication of WO2008154416A2 publication Critical patent/WO2008154416A2/en
Publication of WO2008154416A3 publication Critical patent/WO2008154416A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels

Abstract

Electrochemical sensor devices are provided, in various amperometric, potentiometric, and conductometric sensor device configurations. An amperometric sensor device (100) may include a structural body (102) which has at least one reservoir (110) that has at least one opening; a working electrode (112) located within the reservoir; analyte sensor chemistry (122) located within the reservoir and deposited on at least the working electrode; an auxiliary electrode (116) located outside of the reservoir; a reference electrode (114); at least one reservoir cap (118) closing the opening to isolate the working electrode and analyte sensor chemistry within the reservoir and to prevent an analyte outside of the reservoir from contacting the analyte sensor chemistry; and means for rupturing or displacing the reservoir cap to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry.
PCT/US2008/066172 2007-06-07 2008-06-06 Electrochemical biosensors and arrays WO2008154416A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08770378A EP2157907B1 (en) 2007-06-07 2008-06-06 Electrochemical biosensors and arrays

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94259407P 2007-06-07 2007-06-07
US60/942,594 2007-06-07

Publications (2)

Publication Number Publication Date
WO2008154416A2 WO2008154416A2 (en) 2008-12-18
WO2008154416A3 true WO2008154416A3 (en) 2009-02-05

Family

ID=39718948

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/066172 WO2008154416A2 (en) 2007-06-07 2008-06-06 Electrochemical biosensors and arrays

Country Status (3)

Country Link
US (1) US8649840B2 (en)
EP (2) EP2471457A1 (en)
WO (1) WO2008154416A2 (en)

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EP2157907B1 (en) 2013-03-27
US8649840B2 (en) 2014-02-11
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EP2157907A2 (en) 2010-03-03
US20080302659A1 (en) 2008-12-11

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