WO2008115549A1 - Screw systems and methods for use in stabilization of bone structures - Google Patents
Screw systems and methods for use in stabilization of bone structures Download PDFInfo
- Publication number
- WO2008115549A1 WO2008115549A1 PCT/US2008/003677 US2008003677W WO2008115549A1 WO 2008115549 A1 WO2008115549 A1 WO 2008115549A1 US 2008003677 W US2008003677 W US 2008003677W WO 2008115549 A1 WO2008115549 A1 WO 2008115549A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- seat
- rod
- coupler
- receiving portion
- cap
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 115
- 238000000034 method Methods 0.000 title claims abstract description 63
- 230000006641 stabilisation Effects 0.000 title abstract description 17
- 238000011105 stabilization Methods 0.000 title abstract description 17
- 230000033001 locomotion Effects 0.000 claims abstract description 51
- 230000007246 mechanism Effects 0.000 claims description 43
- KJLPSBMDOIVXSN-UHFFFAOYSA-N 4-[4-[2-[4-(3,4-dicarboxyphenoxy)phenyl]propan-2-yl]phenoxy]phthalic acid Chemical compound C=1C=C(OC=2C=C(C(C(O)=O)=CC=2)C(O)=O)C=CC=1C(C)(C)C(C=C1)=CC=C1OC1=CC=C(C(O)=O)C(C(O)=O)=C1 KJLPSBMDOIVXSN-UHFFFAOYSA-N 0.000 claims description 23
- 230000000717 retained effect Effects 0.000 claims description 19
- 238000003780 insertion Methods 0.000 claims description 18
- 230000037431 insertion Effects 0.000 claims description 18
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- 208000007103 Spondylolisthesis Diseases 0.000 description 2
- 210000003484 anatomy Anatomy 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7032—Screws or hooks with U-shaped head or back through which longitudinal rods pass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7002—Longitudinal elements, e.g. rods
- A61B17/7004—Longitudinal elements, e.g. rods with a cross-section which varies along its length
- A61B17/7005—Parts of the longitudinal elements, e.g. their ends, being specially adapted to fit in the screw or hook heads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7035—Screws or hooks, wherein a rod-clamping part and a bone-anchoring part can pivot relative to each other
- A61B17/7037—Screws or hooks, wherein a rod-clamping part and a bone-anchoring part can pivot relative to each other wherein pivoting is blocked when the rod is clamped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7035—Screws or hooks, wherein a rod-clamping part and a bone-anchoring part can pivot relative to each other
- A61B17/704—Screws or hooks, wherein a rod-clamping part and a bone-anchoring part can pivot relative to each other the longitudinal element passing through a ball-joint in the screw head
Definitions
- U.S. Patent Application Serial No. 11/427,738 is also a continuation-in-part of U.S. Patent Application Serial No. 1 1/362,366 filed on February 23, 2006, which is a continuation-in-part of U.S. Patent Application Serial No. 60/701,660 filed on July 22, 2005, all of which are incorporated herein by reference in their entirety.
- This application is also a continuation-in-part of U.S. Patent Application Serial No. 11/586,849 entitled “Systems and methods for stabilization of bone structures" filed on October 25, 2006, which is a continuation-in-part of U.S. Patent Application Serial No. 11/362,366 filed on February 23, 2006, which is a continuation-in-part of U.S. Patent Application Serial No. 60/701,660 filed on July 22, 2005, all of which are incorporated herein by reference in their entirety.
- the present invention generally relates to surgical instruments and methods for using these instruments. More particularly, but not exclusively, minimally invasive methods of stabilizing one or more bone structures are disclosed.
- Figs. 1 A-IB illustrate a portion of the human spine having a superior vertebra 2 and an inferior vertebra 4, with an intervertebral disc 6 located in between the two vertebral bodies.
- the superior vertebra 2 has superior facet joints 8a and 8b, inferior facet joints 10a and 10b, posterior arch 16 and spinous process 18.
- Pedicles 3a and 3b interconnect the respective superior facet joints 8a, 8b to the vertebral body 2. Extending laterally from superior facet joints 8a, 8b are transverse processes 7a and 7b, respectively. Extending between each inferior facet joints 10a and 10b and the spinous process 18 are lamina 5a and 5b, respectively.
- inferior vertebra 4 has superior facet joints 12a and 12b, superior pedicles 9a and 9b, transverse processes 1 Ia and l ib, inferior facet joints 14a and 14b, lamina 15a and 15b, posterior arch 20, spinous process 22.
- Each spinal motion segment enables motion along three orthogonal axis, both in rotation and in translation.
- the various spinal motions are illustrated in Figs. 1C- ID.
- Fig. 1C illustrates flexion and extension motions, anterior translation, and axial loading
- Fig. ID illustrates lateral bending motion and lateral translation motion.
- a normally functioning spinal motion segment provides physiological limits and stiffness in each rotational and translational direction to create a stable and strong column structure to support physiological loads.
- Various disorders of the spine can produce debilitating pain that can affect a spinal motion segment's ability to properly function.
- the specific location or source of spinal pain is most often an affected intervertebral disc or facet joint.
- a disorder in one location or spinal component can lead to eventual deterioration or disorder, and ultimately, pain in the other.
- Spine fusion is a procedure in which two or more adjacent vertebral bodies are fused together. While spine fusion generally helps to eliminate certain types of pain, it has been shown to decrease function by limiting the range of motion for patients in flexion, extension, rotation and lateral bending. Furthermore, the fusion creates increased stresses on adjacent non-fused motion segments and accelerated degeneration of the motion segments.
- Dynamic posterior stabilization surgical-based technologies, referred to as “dynamic posterior stabilization,” have been developed to address spinal pain resulting from more than one disorder, when more than one structure of the spine have been compromised.
- An objective of such technologies is to provide the support of fusion-based implants while maximizing the natural biomechanics of the spine.
- Dynamic posterior stabilization systems typically fall into one of two general categories: (1) interspinous spacers and (2) posterior pedicle screw-based systems.
- a bone screw system is provided.
- the bone screw includes a threaded section and a screw head section integrally connected to the threaded section.
- the system includes a coupler having a screw head receiving portion configured to receive at least a portion of the screw head section of the screw.
- the coupler also includes a rod receiving portion integral with the screw head receiving portion.
- the rod receiving portion is configured to receive a rod.
- the system includes a seat having a first end and a second end.
- the seat further includes at least one sidewall extending between the first end and the second end, a cap receiving portion configured to receive a cap at the first end and a coupler receiving portion configured to receive the coupler.
- the seat includes a bottom opening at the second end and a top opening at the first end.
- the system includes a cap configured to close the top opening of the seat.
- the cap has a top surface and a bottom surface interconnected by an outer surface and an inner surface.
- the inner surface defines a threaded set screw receiving portion and the outer surface defines at least one seat-engagement feature for engagement with the cap receiving portion of the seat.
- the system includes a set screw having a top surface and a bottom surface interconnected by a threaded outer surface.
- the set screw is configured to be threadingly engaged with the set screw receiving portion of the cap.
- the system further includes a retainer configured to retain the coupler inside the seat.
- a rod is provided.
- the rod has a first end and a second end.
- the first end of the rod is configured to connect to the rod receiving portion of the coupler. At least a portion of the screw head section is disposed inside the screw head receiving portion of the coupler.
- the screw is inserted in the bottom opening of the seat and the coupler is retained inside the seat via the retainer pressed between the coupler and the seat.
- the first end of the rod is removably connected to the rod receiving portion of the coupler.
- the cap is removably inserted into the cap receiving portion of the seat and retained therein via the at least one seat-engagement feature on the outer surface of the cap.
- the set screw is disposed in the set screw receiving portion of the cap.
- the rod is disposed in the rod channel with the cap disposed in the cap receiving portion of the seat. Upon advancement of the screw, the bottom surface of the set screw contacts at least a portion of the rod within the seat and the bone screw and rod is locked into position with advancement of the set screw into the seat.
- a bone screw system having a locked configuration and an unlocked configuration.
- the bone screw system includes a rod and a seat.
- the seat has a first end and a second end and is configured to receive at least a portion of the rod inside the seat such that the rod has a range of motion relative to the seat while in the unlocked configuration.
- a bone screw having a first end and a second end is also provided. At least a portion of the first end of the bone screw is disposed inside the seat.
- the screw has a range of motion relative to the seat when in the unlocked configuration.
- a lock down mechanism is removably disposed inside the seat at the first end of the seat.
- At least a portion of the rod is located between the lock down mechanism and the first end of the screw.
- the lock down mechanism is operable between a locked configuration and an unlocked configuration such that both the rod or the screw is locked into position as the lock down mechanism operates from the unlocked configuration to the locked configuration.
- a bone screw system includes a rod and a bone screw having a first end and a second end.
- the system includes a seat having a bottom opening.
- a coupler having a rod receiving portion and a bone screw receiving portion.
- the rod receiving portion of the coupler is configured to connect to the rod and the bone screw receiving portion is configured to house at least a portion of the first end of the bone screw.
- At least a portion of the bone screw is retained in the bone screw receiving portion of the coupler which is retained inside the seat such that the bone screw is connected to the seat via the coupler and such that the bone screw extends through the bottom opening of the seat.
- the rod is connected to the rod receiving portion of the coupler.
- a system for housing at least a portion of a bone screw includes a seat having a first end and a second end, and an inner surface and an outer surface. At least a portion of the bone screw is retained inside the seat.
- the seat includes a top opening at the first end and a bottom opening at the second end. At least one sidewall extends between the first end and the second end.
- the seat includes a closure mechanism receiving portion and a screw receiving portion.
- a method for inserting a screw system includes the step of providing a system that includes a bone screw and a seat.
- the seat has a first end, a second end, an inner surface and an outer surface. At least a portion of the bone screw is retained inside the seat.
- the seat includes a top opening at the first end and at least one sidewall extending between the first end and the second end.
- a flange is formed on the outer surface of the seat such that the flange extends outwardly from the seat; the flange has an upper surface, a lower surface and an outer surface.
- the method includes the step of providing an instrument having a first portion and a second portion at a distal end of the instrument.
- the first and second portions are controllable at the instrument's proximal end by a user.
- the method includes the steps of contacting at least a portion of the lower surface of the flange with the first portion of the instrument and contacting at least a portion of the upper surface of the flange with the second portion of the instrument.
- the second portion of the instrument is advanced to apply a force on the flange.
- the force is biased by the first portion of the instrument to secure the instrument to the seat.
- the system includes the step of delivering the system into the patient with the instrument.
- a method includes the step of providing a system comprising a seat having a first end and a second end.
- the seat includes at least one sidewall extending between the first end and the second end and at least one rod channel formed in the sidewall.
- the seat also has a top opening at the first end.
- the system includes a coupler retained inside the seat.
- the coupler has a rod receiving portion and a screw receiving portion.
- the system further includes a bone screw that is retained inside the screw receiving portion of the coupler.
- the method includes the steps of delivering the system into a patient and inserting the bone screw into a bone of the patient.
- the method includes the step of providing a rod having a first end and a second end and delivering the rod into the patient.
- the first end of the rod is pivotally connected to the rod receiving portion of the coupler.
- the method includes the step of pivoting the rod into position.
- a closure mechanism is provided. The closure mechanism is delivered into the patient to close the top opening of the seat.
- a bone screw system is provided.
- the system includes a bone screw and a seat having a first end and a second end.
- the seat retains the bone screw inside the seat.
- the seat includes at least one sidewall extending between the first end and the second end.
- the seat has a top opening at the first end and a cap receiving portion in the at least one sidewall.
- the cap receiving portion is configured to receive a cap within the seat at the first end.
- the cap receiving portion has at least one wing groove that has an upper surface.
- the system includes a cap that is configured to close the top opening of the seat.
- the cap has a top surface and a bottom surface interconnected by an outer surface and an inner surface.
- the inner surface defines a set screw receiving portion.
- the outer surface of the cap defines at least one wing lug extending outwardly from the outer surface of the cap.
- the wing lug is configured to mate with the at least one wing groove of the seat by rotation of the wing lug into the wing groove.
- the system includes a set screw having a top surface and a bottom surface interconnected by a threaded outer surface.
- the set screw is configured to be threadingly engaged with the set screw receiving portion of the cap.
- the set screw is inserted into the set screw receiving portion of the cap.
- the cap is removably inserted into the cap receiving portion of the seat closing the top opening. With the cap in the seat, the cap is rotated to position the at least one wing lug inside the at least one wing groove.
- the set screw is advanced into the seat. Set screw advancement is biased by the seat raising the cap such that the at least one wing lug contacts the upper surface of the wing groove, secures the cap to the seat and prevents splaying of the seat sidewall.
- Advantages of the invention may include one or more of the following.
- Insertion of certain of the described screws and pivoting rods may be performed with reduced insertion forces, and may feature simplified usage.
- Rotational locking may be employed to secure the pivoting rod against movement.
- Embodiments of the invention allow reduced stress on the pivoting rod.
- Embodiments of the invention are compatible with other pedicle screw systems and/or spinal implants.
- Embodiments of the invention may be applicable to patients with degenerative disc disease, spinal stenosis, spondylolisthesis, spinal deformities, fractures, pseudarthrosis, tumors, failed prior fusions, or other vertebral segment trauma and disease.
- the polyaxial seat of the screw of the present invention advantageously allows the seat to swivel on top of the screw such that they may be lined up regardless of the orientation of the screws' axes and can even thus be made to accommodate a certain amount of misalignment from difference in height once they are inserted into bone.
- the polyaxial motion of the seat allows the rod channels to be lined-up so that the rod can be placed or attached between the screws without having their axes perfectly aligned to do so. Then the seat can be modified to eliminate motion and stabilize one or more vertebral segments.
- Figs. IA and IB illustrate perspective views of a portion of the human spine having two vertebral segments, where the spinous process and the lamina of the superior vertebra have been resected in Fig. IB.
- Figs. 1C, ID and IE illustrate left, dorsal and top views, respectively, of the spinal segments of Fig. 1 A-IB under going various motions.
- Fig. 1C, ID and IE illustrate left, dorsal and top views, respectively, of the spinal segments of Fig. 1 A-IB under going various motions.
- FIG. 2 A illustrates a perspective exploded and perspective view of a screw system which may be employed in an embodiment of the present invention.
- Fig. 2B illustrates a perspective view of a pivoting rod which may be employed in an embodiment of the present invention.
- Fig. 2C illustrates a perspective exploded and perspective view of a cap and set screw system which may be employed in an embodiment of the present invention.
- Fig. 2D illustrates a perspective view of a pivoting rod which may be employed in an embodiment of the present invention.
- Fig. 2E illustrates a perspective view of a pivoting rod which may be employed in an embodiment of the present invention.
- Fig. 2A illustrates a perspective exploded and perspective view of a screw system which may be employed in an embodiment of the present invention.
- Fig. 2B illustrates a perspective view of a pivoting rod which may be employed in an embodiment of the present invention.
- Fig. 2C illustrates a perspective exploded and perspective view of a cap and set screw system which may be
- FIG. 3 and 3 A illustrate top and enlarged top views of a rod attachment mechanism which may be employed in an embodiment of the present invention.
- Fig. 4 and 4 A illustrate top and enlarged top views of another rod attachment mechanism which may be employed in an embodiment of the present invention.
- Fig. 4B and 4C illustrate side cross-sectional view of details of a set screw system for use in the system of Figs. 4 and 4A.
- Fig. 5 A is a perspective detailed view of a seat and retaining ring according to an embodiment of the present invention.
- Fig. 5B is a perspective view of a seat, coupler, retaining ring and screw according to an embodiment of the present invention.
- FIG. 6A and 6B illustrate bottom perspective and top perspective views of a cap and set screw system according to an embodiment of the invention.
- Fig. 7 illustrates a perspective view of a coupler system according to an embodiment of the invention.
- Fig. 8 A illustrates a perspective exploded view of a screw system according to an embodiment of the present invention.
- Fig. 8B illustrates a perspective exploded view of a screw system according to an embodiment of the present invention.
- Fig. 8C illustrates a side elevational view of a screw system according to an embodiment of the present invention.
- Fig. 9A illustrates a side exploded view of a screw/seat/cap and set screw combination.
- Figs. 9A illustrates a side exploded view of a screw/seat/cap and set screw combination.
- FIGS. 9B-9D illustrate the combination system of Fig. 9A in unlocked, partially locked, and fully locked configurations.
- Figs. 10A- 1OC illustrate a screw/seat/pivoting rod combination system in exploded, connected but not deployed, and post-rotation configurations, respectively.
- Figs. 1 IA and 1 IB show the installed device in top and perspective views, respectively.
- Fig. ⁇ 2 illustrates a side cross-sectional view of the seat with a seat- gripping instrument engaging the seat according to one aspect of the invention.
- system when referring to a system of the present invention, most typically refers to a set of components which includes multiple bone stabilization components such as a superior, cephalad or rostral (towards the head) component configured for implantation into a superior vertebra of a vertebral motion segment and an inferior or caudal (towards the feet) component configured for implantation into an inferior vertebra of a vertebral motion segment.
- a pair of such component sets may include one set of components configured for implantation into and stabilization of the left side of a vertebral segment and another set configured for the implantation into and stabilization of the right side of a vertebral segment.
- system may refer to two or more pairs of component sets, i.e., two or more left sets and/or two or more right sets of components.
- Such a multilevel system involves stacking of component sets in which each set includes a superior component, an inferior component, and one or more medial components therebetween.
- the superior and inferior components when operatively implanted, may be engaged or interface with each other in a manner that enables the treated spinal motion segment to mimic the function and movement of a healthy segment, or may simply fuse the segments such as to eliminate pain and/or promote or enhance healing.
- the interconnecting or interface means include one or more structures or members that enables, limits and/or otherwise selectively controls spinal or other body motion.
- the structures may perform such functions by exerting various forces on the system components, and thus on the target vertebrae.
- the manner of coupling, interfacing, engagement or interconnection between the subject system components may involve compression, distraction, rotation or torsion, or a combination thereof.
- the extent or degree of these forces or motions between the components may be intraoperatively selected and/or adjusted to address the condition being treated, to accommodate the particular spinal anatomy into which the system is implanted, and to achieve the desired therapeutic result.
- the multiple components are mechanically coupled to each other by one or more interconnecting or interfacing means.
- components interface in a manner that constrains their relative movement and enables the treated segment to mimic the function or partial function and/or movement or partial movement of a healthy segment.
- spinal interconnecting means is a dorsally positioned component, i.e., positioned posteriorly of the superior and inferior components, or may be a laterally positioned component, i.e., positioned to the outer side of the posterior and inferior components.
- the structures may include one or more struts and/or joints that provide for stabilized spinal motion.
- the various system embodiments may further include a band, interchangeably referred to as a ligament, which provides a tensioned relationship between the superior and inferior components and helps to maintain the proper relationship between the components.
- FIG. 2 A illustrates a perspective exploded and perspective view of a screw system which may be employed in an embodiment of the present invention.
- a screw system 20 is shown having a screw 30 with threads 28.
- the threads 28 are appropriate for entering the bone of a patient.
- a ball end 32 At a proximal end of screw 30 is a ball end 32. While a ball end 32 is shown, various other shapes may also be employed.
- a hex socket 34 that is interconnected with a guidewire lumen (not shown) extends thru the general axial center of screw 30, and also can extend through the retaining ring 22, coupler 24 and seat 26.
- the system is suitable for being installed in a patient for treating at least one or more of the following: degenerative disc disease, spinal stenosis, spondylolisthesis, spinal deformities, fractures, pseudarthrosis, tumors, failed previous fusions, other vertebral segment trauma or diseases.
- the ball end 32 of screw 30 is fitted into the bottom of the coupler 24, which has a spherical interior shape, as will be described in greater detail below. If end 32 has a different shape, the shape of the interior of the bottom of the coupler 24 may be similarly complimentary. No matter the shape, when the ball end is fitted into the bottom end of end of the coupler 24, the coupler 24 may be fitted into the "bucket- shaped" seat 26. Retaining ring 22 ensures that coupler 24 does not escape from the interior of seat 26, and is described in greater detail below.
- Fig. 2B illustrates a perspective view of a pivoting rod 40 which is employed in an embodiment of the present invention.
- the pivoting rod 40 in Fig. 2B is shown to be straight, however, the invention is not so limited and a curved pivoting rod that conforms to the natural curve of the spine may be employed.
- the pivoting rod 40 has a shaft 42, a ball end 44, and two pins 46 (one of which is not shown in Fig. 2B) for insertion into the coupler 24.
- the shaft 42 may vary in length, or may be adjustable by the physician, either by a telescoping mechanism or by being cut to measure.
- the end of the shaft 42 opposite that of ball end 44 may be straight, as shown, or may itself incorporate a ball end (not shown) or other type of end to enable trapping and capture in a seat of a pedicle screw system mounted to another spinal segment.
- the ball end 44 need not actually be a ball, and may be a square or rectangular solid, or other such shape, so long as the shape allows rotation of the pivoting rod.
- the rod 40 and coupler 24 include mating features adapted to connect together.
- sides 47 of the ball end, perpendicular to the pins 46 are flattened.
- the flat sides 47 that are substantially perpendicular to the pins 46 also assist in confining the range of motion of the rod substantially within a single plane.
- the flattened sides 47 surrounding the pins 46 provide for a greater surface area that is in contact with the coupler 24 and thereby create an advantageous snug- fit engagement with the coupler. Because of the flattened sides 47, when the rod 40 is inserted and the pins 46 are connected into the coupler 24, the greater surface area of contact of the flattened sides 47 with the coupler provides for a snug- fit engagement with the coupler that would otherwise be the case with a rounded rod end. As a result, the rod advantageously does not pivot on its own in a direction away from the insertion angle or other angle at which the rod is positioned subsequent to insertion into the coupler. This feature facilitates insertion for the surgeon.
- additional flat portions 45 are formed on the ball end 44 of the rod 40 as shown in Fig. 2B.
- the flat portions 45 are substantially perpendicular to the flattened sides 47 on the ball end 44.
- the pins 46 are substantially parallel to the flat portions 45.
- the flat portions 45 face upwardly and downwardly and as a result provide a lower profile for the rod within the seat.
- the flat portions 45 provide a flat contact surface for the set screw on the upper surface of the rod and a flat contact surface for the coupler on the bottom surface of the rod.
- the rod is not limited to having two flat portions 45 and/or two flattened sides 47 and any number and combination of flat portions 45 and sides 47 are within the scope of the present invention.
- Fig. 2C illustrates a perspective exploded and perspective view of a closure mechanism 50.
- the closure mechanism is shown as a cap and set screw system 50 which may be employed in an embodiment of the present invention. It should be noted that the closure mechanism is not limited to a cap and set screw combination as shown and described herein and various other closure mechanisms evident to a person having ordinary skill in the art are within the scope of the invention. Some examples of closure mechanisms include but are not limited to a threaded closure mechanism having external threads that engage with a threaded internal portion of the seat, a sliding closure mechanism, a compression fit closure mechanism, and a snap fit closure mechanism.
- the closure mechanism 50 when fully installed in the seat 26, secures the rod 40 against movement.
- the system 50 includes a cap 48 and a set screw 52.
- the cap 48 includes a set screw receiving portion.
- the cap and set screw are configured to close the top opening of the seat 26.
- the external shape of the cap 48 is substantially cylindrical.
- the cap 48 includes a top surface and a bottom surface interconnected by an outer surface and an inner surface.
- the cap 48 includes external flanges or features 54, discussed in more detail below, and internal screw threads 56.
- the set screw 52 includes external screw threads 58 and a socket 62 for a driving tool, the socket 62 being substantially coaxial with the screw threads 58.
- the set screw 52 also includes a flange 51 at the bottom end of the set screw 52.
- the flange 51 is configured to extend outwardly from the circumference of the set screw to serve as a stop and to prevent the set screw 52 from being backed-out as the set screw is retracted upwardly with respect to the cap 48.
- a first pedicle screw assembly would be installed in a patient, this first pedicle screw assembly having a hinge assembly that attaches to a proximal end of the pivoting rod.
- a second pedicle screw assembly would also be installed in a patient, this second pedicle screw assembly having a receiving cradle that accepts the distal end of the pivoting rod. Except for the hinge assembly and the receiving cradle, other parts of the screw assemblies may be the same and/or interchangeable.
- Each pedicle screw assembly also includes a set screw and cap assembly as described above and below.
- the pivoting rod may include a dynamic element at some point along its length if desired, as described, e.g., in U.S. Patent Application Serial No. 11/427,738, filed June 29, 2006, U.S. Patent Application Serial No. 10/970, 366 filed October 20, 2004, U.S. Patent Application Serial No. 11/006,495 filed December 6, 2004, U.S. Patent Application Serial No. 11/033,452 filed January 10, 2005, and U.S. Patent Application Serial No. 11/436,407 filed on May 17, 2006, all of which are incorporated by reference herein in their entirety for all purposes.
- the pins 46 are chamfered to ease the insertion of the pivoting rod by the clinician into the coupler and also ease removal of the pivoting rod from the coupler, if desired. Pins are not the only means of attachment of the rod 42 to the coupler 24 and other variations and means are within the scope of the invention.
- the ball end 44 of the rod can include cutout portions 43 that result in the ball end not having a completely spherical shape but permits attachment to and rotation relative to the coupler 24.
- Fig. 2E Another example is shown in Fig. 2E. In Fig.
- a rod 40 is provided with a ball portion 41 having a bore 39 passing through it.
- the rod 40 of Fig. 2E is positioned inside the bore 39 of the ball portion 41 such that the ball portion 41 is allowed to rotate and slide relative to the rod as indicated by the arrows in Fig. 2E.
- This embodiment advantageously provides yet another degree of freedom of motion and facilitates installation by the surgeon.
- the embodiment of Fig. 2E advantageously permits the bone screw to be locked into position independently of rod and in another variation it permits the rod to be locked into position independently of the bone screw. More details of the independent lock down capability of this embodiment will be described in greater detail hereinbelow.
- FIG. 3 and Fig. 3 A An alternative way in which the pivoting rod 40 may be attached to the coupler that employs pins is shown in Fig. 3 and Fig. 3 A.
- a set of two pins 64 may be employed which mate with a corresponding set of holes 66 in the coupler.
- the pin 64 may be spring-loaded with springs 68.
- This spring-biased hinge pin allows pivoting of the rod and also allows the pin to move radially inward during insertion, and then "pop" out when in place. The pin may then be retracted for removal.
- the pin may be permanently locked in place by injecting cement or glue or another such material into the travel volume of the pin.
- pins 72 may again be spring-biased but may be movable via action of a set screw 76.
- pins 72 are biased by springs 74 in a retracted state; i.e., they are not extended so as to engage or mate with holes in the coupler. Instead, a portion of the pins 72 extends into a threaded hole 70 within a proximal end of pivoting rod 40, i.e., ball end 44.
- a set screw 76 When a set screw 76, with conical distal surface 82, is advanced into the threaded hole 70, the distal surface 82 impinges on pins 72 and drives the same outward, such that they may engagedly mate with the holes in the coupler.
- the set screw 76 may have a slot 78 and/or other tool engagement means (not shown) in its proximal (top) surface to allow for such driving. In this way, the extendable/retractable hinge pins extend after insertion to pivotally lock the pins in place.
- the extension and retraction may be accomplished with hydraulics or pneumatics, rather than springs and set screws.
- a fluid injection port may be provided which is integral, or not, to the pivoting rod.
- the pins may be permanently locked in place, if desired by the physician, by injecting cement or glue into the pin travel volume.
- a seat 26 and retaining ring 22 are shown in an exploded view.
- Retaining ring 22 is shown with two projections 86, also known as keys, which engage features on the seat 26, to hold the coupler in place (the coupler is not shown in the figure for clarity).
- Ring rod channel bevels 84 are shown on opposite ends of a diameter of the ring, adjacent the projections 86, although in alternative embodiments they need not be adjacent. Ring rod channel bevels 84 are depressed areas along an upper surface of the circumference of the ring 22, and assist in receiving the pivoting rod (also not shown for clarity).
- Another variation of the retaining ring 22 is shown in Fig. 8B.
- the retaining ring 22 of Fig. 8B includes a split such that the retaining ring 22 is approximately C-shaped. The split retaining ring 22 snaps into place inside the seat 26 to secure the assembly.
- the seat 26 includes an inner surface and an outer surface and a first end 81 and a second end 83. At least one sidewall 79 extends between the first end 81 and the second end 83 forming a top opening at the first end 81 and at least one "U"-shaped void or rod channel 90 into which the pivoting rod may pivot when installed.
- a void or keyway 98 is provided near the base of the seat to engage each projection 86 to orient the ring in a press-fit fashion with respect to the coupler and seat.
- the keyways 98 are adjacent the rod channel bevels 84 and 94 because the keys 86 are adjacent the same; however, the keys and keyways need not be along the same diameter as the bevels.
- the ring and seat rod channel bevels may generally match each other in shape, pitch, angle, slope, etc., and assist in orienting the rod pivot arc as well as orienting the rod channel to receive the rod on the cradle or receiving assembly.
- the seat 26 includes a closure mechanism receiving portion or a cap receiving portion 75 configured to receive a cap at the first end 81 and a coupler receiving portion 73 configured to receive a coupler.
- the coupler receiving portion 73 includes a tapered ramp that corresponds to a tapered ramp on the coupler.
- the cap receiving portion 75 includes a locking lug groove 88 that is provided near the top of the seat 26 to slidingly receive a corresponding locking lug or projection of the cap, described below. Cap rotation of, for example 90 degrees, secures the cap in place.
- the locking lug groove 88 may further include an anti-rotation mechanism, such as a mechanical stop. In this way, the locking lugs may be fixed in the amount of rotation needed to secure them in place.
- a wing groove 92 is also provided on the seat 26, to slidingly receive and engage a corresponding wing lug or projection on the cap, as described below.
- the wing groove 92 may also be provided with a mechanical stop that prevents further rotation of the wing within the wing groove similar to the locking lug groove.
- the flange has an upper surface, lower surface and an outer surface.
- Figs. 6A-6B show bottom and top perspective views, respectively, of the cap system 50 having cap 48 and set screw 52.
- the cap 48 incorporates at least one groove 1 12 and recess 113 for engagement with an inserter or driving tool to accomplish the partial rotation needed to lock the cap 48 into the seat 26.
- the inserter or driving tool may grip the cap for rotation: the recess provides room for "tangs" of the inserter tool, and the groove allows the "tangs" to clear the inner surfaces of the seat.
- a flange 116 may be provided which is an annular projection at the top surface. The flange 116 acts as a mechanical stop, to limit the amount of insertion of the cap into the seat.
- the outer surface of the cap includes at least one seat-engagement feature for engagement with the cap-receiving portion of the seat.
- One seat-engagement feature on the cap is at least one locking lug 110 that is provided in at least one location around the circumference of the cap 48 and extending from the outer surface of the cap. As shown in Fig. 6 A and 6B, two locking lugs 110 are provided on or are integral with the flange 116 opposite from one another. The locking lugs 110 are sized for insertion into the rod channel 90. Also, the locking lugs 110 are configured to be rotatably inserted into the locking lug groove 88 in the seat 26. Typically, the locking lugs 110 are first inserted into the rod channel 90 and then rotated into position inside the locking lug groove 88.
- Another seat-engagement feature on the cap is at least one wing 54 that is provided in at least one location around the circumference of the cap 48 extending outwardly from the outer surface of the cap.
- two wings 54 are provided in opposed locations around the circumference of the cap 48.
- the two wings 54 are aligned with the two locking lugs 110 wherein the wings 54 are located below locking lugs 110.
- the wings are sized for insertion into the rod channel 90. Also, the wings are configured to be rotatably inserted into the wing groove 92.
- the cap 48 is placed into the seat 26 with the two wings 54 and the two locking lugs 110 in alignment with the rod channel 90 such that the cap 48 drops into the seat until the flange 116 abuts a surface of the locking lug groove 88. After the cap is seated, it is capable of being turned. Turning of the cap 48 rotates the wings 54 and the locking lugs 110 into the wing grooves 92 and locking lug grooves 88, respectively. To effect the rotation, a tool is used to engage the groove 1 12 and/or recess 113 of the cap to turn the cap 48 while it is inside the seat.
- the cap (not shown) is turned until rotation is stopped by a wall 85 located in the locking lug groove 88 against which the locking lugs 110 abut.
- a second locking wall (not shown) may also formed in the opposite locking lug groove generally diagonally from wall 85.
- the degree of rotation is preferably approximately 90 degrees but the invention is not so limited and any degree of rotation is within the scope of the invention.
- the wall serves as an anti-rotation mechanism that prevents the cap from turning past a locked position. Other anti-rotation mechanisms may also be employed.
- a set screw 52 located inside the cap 48 is tightened.
- the cap 48 rises relative to the seat 26, that is, the cap will move upwardly relative to the seat.
- This rise is arrested by the wings 54, also known as wing lugs, contacting the upper surface of the wing groove 92.
- the locking lugs alone or in conjunction with the wings are employed to arrest the rise of the cap as the set screw is advanced and a force, resulting from the set screw being biased against the seat, is applied to the rod below the set screw.
- the cap 48 counter-rotation of the cap 48 is prevented as the set screw is advanced and the locking lugs 110 rise relative to the seat 26 into a recess 89 or window formed inside the locking lug groove 88 as shown in Fig. 5B.
- the recess or window 89 includes a stop 91 against which the locking lugs 110 abut to prevent counter-rotation.
- the locking lugs 110 are substantially moved out of the locking lug groove 88 and they cannot be moved back into the groove 88, and thus the cap cannot be removed, until the set screw is "backed off' and the cap drops or is "lowered” such that the locking lugs 110 reside again in the groove 88.
- a corresponding recess 89 and a corresponding wall 91 is formed in the other side of the cap receiving portion of the seat.
- the wing 54 has a reverse angle surface 114 to inhibit spreading of the seat.
- the wing or wing lug groove 92 defined by the interior of seat 26 slidingly receives the wing 54 or wing lug of the cap 48, and the cap is locked into the seat when the cap is rotated, for example, by 90 degrees.
- the reverse angle surface 1 14 keeps the seat 26 from splaying as the set screw 52 is rotated.
- the reverse angle surface 114 keeps the walls of the seat 26 from spreading outward. Otherwise, the forces of the cap upward movement would tend to spread the seat.
- the wings may snap into recesses of the wing lug groove 92 when an appropriate or predetermined degree of rotation has been achieved. Appropriate spring-loading may be employed to achieve this snapping feature.
- the bottom surface of the set screw 52 includes a dome 118 that protrudes from the bottom surface of the set screw 52.
- the feature 1 18 contacts the rod 40 and creates a single point, line or smaller surface area of contact than would otherwise be the case between the cap system 50 and the rod 40. This restrains less of the rod, allows some flexion and thus reduces the stiffness of the total device between the screws, leading to a better stress distribution through the construct, a lower stress concentration and enhanced fatigue performance.
- Examples of other features in the bottom surface of the set screw include but are not limited to any one or more of the following used alone or in combination: a dome, nipple, aperture, raised surface, and a dome with an aperture.
- Fig. 7 shows additional details of the coupler 24.
- the coupler 24 generally has a bone screw receiving portion 128 and a rod receiving portion 122.
- the rod receiving portion is shown in one variation as two upstanding forks 122 each of which has a receiving hole 66 for receiving the rod pin.
- the upstanding forks 122 may have a tapered end, a closed end and/or an open end.
- Fig. 7 shows a beveled region 124 radially exterior of each fork that lessens the amount of material in each fork, allowing greater amounts of flex.
- the coupler access bore hole 108 provides access to the engagement means of the screw such as a hex socket.
- the inner surfaces of the rod receiving portion of the coupler and the screw head receiving portion are provided with grit-blasting to increase the surface roughness and resultant friction coefficient between the coupler and/or the rod.
- a lip 102 is provided to mate with the retaining ring
- An approximately spherical bore 128 or screw head receiving portion is provided in the interior of the bottom of the coupler 24 that "snap-fits" over the head 32 of the screw 30 to allow a limited amount of rotation, for example 60 degrees of polyaxial rotation.
- the exterior surface of the coupler, exterior of the spherical bore 128, may be a generally tapered ramp 126. Slits 109 may further be provided to allow circumferential compression around the screw head.
- the screw With the cap in the cap-receiving portion of the seat and as the set screw is advanced within the cap, the screw contacts the rod and the cap rises relative to the seat until the wing lugs contact the upper surface of the wing lug groove and the cap is thereby biased into a locked configuration by the seat. Further advancement of the set screw exerts additional force onto the rod and it is transferred to the coupler and drives the coupler downward. As the set screw drives the coupler downward, e.g., through a force transmitted through the rod, the coupler is pushed downward, further into the seat. The tapered ramp of the coupler engages the corresponding tapered ramp in the seat.
- the coupler is radially compressed (which is possible because of the slits 109), thus gripping the screw head securely and simultaneously locking the bone screw and the rod into the desired position.
- the lockdown of the bone screw does not occur simultaneously with the lockdown of the rod.
- advancement of the set screw contacts the ball portion 41 that slides and rotates with respect to the rod 40.
- the contact with the set screw transmits force directly to the coupler to effect the lockdown of the bone screw relative to the seat without locking down the rod relative to the seat, thereby, allowing the rod to slide and rotate with respect to the ball portion 41.
- the advancement of the set screw compresses the ball portion 41 locking the rod into position relative to the ball portion 41 after the bone screw has been locked.
- the advancement of the set screw contacts the ball portion 41 and compresses the ball portion 41 to effect lockdown of the rod with respect to the seat without locking down the bone screw relative to the seat.
- Further advancement of the set screw transmits force to the coupler to effect lockdown of the bone screw relative to the seat after the rod has been locked first.
- This independent lockdown mechanism permits the selective lockdown of the rod relative to the seat and bone screw relative to the seat. Prior to the set screw being tightened, the bone screw and rod each were allowed movement relative to the seat. After the set screw is tightened, movement of both the bone screw and rod is generally eliminated.
- the cap set screw system in combination with the seat and coupler provide a lockdown mechanism just described that operates between a locked configuration in which the rod and the bone screw are locked into position and an unlocked configuration in which the rod and the bone screw each have a range of motion relative the seat.
- the rod is not in vertical alignment with the seat, but instead, at least a portion of the rod extends through the rod channel 90. However, the rod still retains a range of motion while disposed in the rod channel and in the unlocked configuration.
- the system permits some degree of motion of the rod and bone screw even when the system is in the locked configuration.
- the term “locked” is used to describe the restriction of motion of the rod and/or screw relative to the unlocked configuration. Also, the term “locked” is used with respect to the cap to describe the cap being seated inside the seat whether or not the set screw is advanced to the locked configuration to set the position of the rod and/or screw.
- a recess or keyway 106 is provided in which a driving tool may be disposed to receive the keys or projections 86 on the retaining ring 22.
- a "lead-in" ramp 104 may be employed as a chamfered edge, providing a mechanical advantage to spread the coupler forks.
- the forks may be configured to flex and also be resiliently biased. All of these features allow the hinge pins to more conveniently slide in and snap securely into the receiving holes 66.
- the coupler may be generally the same and may further include a smooth surface 133 which incorporates a radiused edge which increases the contacting surface area and reduces high stress concentrations. In this way, the rod may be even more tightly received between the forks reducing the stress concentration on the rod and coupler.
- Fig. 8 A is a more expanded view of Fig. 2A.
- the basic four set of components, ring, coupler, seat, and screw may be the same or similar for both the hinged assembly and the receiving cradle.
- the seat snaps onto the screw, the coupler is placed into the seat, and the ring is press-fitted into the seat to retain the coupler.
- the seat 26 may have an internal tapered bore to hold the coupler and screw in a snug configuration.
- Fig. 8B is a perspective view of another variation of the present invention showing the screw 30, seat 26, coupler 24 and retaining ring 22 in an exploded view and Fig. 8C is a side-elevational view of the system wherein like elements are referenced with like numerals.
- the screw includes a flange 111 located below the screw head 32.
- the flange 111 extends outwardly from and around the screw; however, the invention is not so limited and the flange 111 may be noncontinuous forming two or more flange pieces around the circumference of the screw for example.
- the flange 111 is configured to serve as a stop and prevent the screw from being inserted into the bone beyond the flange.
- the flange 111 is sufficiently broad that it does not dig into the bone as the screw is attempted to be advanced beyond the flange-to-bone contact.
- the flange surrounds the circumference of the screw at a distance below the screw head that permits maximum angular and polyaxial adjustment and rotation of the seat.
- the flange 111 may be formed or located closer to the screw head to constrain the degree of freedom of the polyaxial adjustment and rotation of the seat if it is so desired.
- the flange advantageously provides a tactile signal to the clinician when the flange 111 abuts the bone when inserting the screw into the bone.
- the clinician must verify advancement of the screw under fluoroscopy to avoid the screw head being completely driven to the surface of the bone which would impede the ability of the polyaxial seat to rotate and angulate freely. Because the flanged screw facilitates screw insertion, it is particularly advantageous in minimally invasive procedures.
- the retaining ring 22 of Fig. 8B includes a split such that the retaining ring 22 is approximately C-shaped.
- the bone screw head 32 is inserted into the coupler 24 and the split retaining ring 22 is inserted into the seat 26.
- the screw and coupler assembly is passed through the top of the seat 26 and attached together to complete assembly of the screw system.
- Figs. 9A-9D Various methods of use are now described with respect to Figs. 9A-9D.
- the set screw 52 is partially advanced into the cap 48 and the same is situated above the seat 26 as shown in Fig. 9A.
- the locking lugs and the wings of cap 48 are half in-the-page and half out-of-the page. In the same way, one rod channel is below the page and the other is above the page.
- Fig. 9B shows an approximately 45 degrees turn counter-clockwise. In this configuration, the cap is partially locked onto the seat.
- Fig. 9D the cap has been rotated 90 degrees with respect to the orientation of Fig. 9B, and the cap is now locked onto the seat.
- a mechanical stop 91 may be employed to prevent further rotation.
- Fig. 10A- 1OC illustrates a method of rod installation which is typically accomplished just prior to the cap and set screw fixation shown in Fig. 9A-9D.
- Pivoting rod system 40 is disposed in the screw system 20.
- the chamfered nature of pins 46 eases the installation into the receiving holes of the coupler, as does the ramp 104 on the coupler.
- the same may be rotated to approximately the position shown in Fig. 1OC, though the actual amount of rotation will vary based on the shape of the patient's spine.
- Fig. 1OA and 1OB illustrate the rod 40 in a vertical orientation that is substantially parallel to the screw orientation
- the rod 40 may be oriented 90 degrees in Fig. 1OA and 1OB such that it is substantially perpendicular to the screw orientation and be capable of insertion into the seat.
- the rod 40 can be oriented at any angle relative to the screw that permits insertion into the seat.
- the screw system 20 allows for the bone screw to be first set into the bone and then, following the insertion of the bone screw, the rod is attached in any of the various orientations of the rod relative to the screw just discussed.
- the system is versatile such that the rod may be attached first to the seat in the various orientations of the rod relative to the screw just described and then the entire system 20 (the rod-plus-screw combination) set into the bone simultaneously using instrumentation that grips the seat 26 at the flange 21 and/or recesses 23, for example, or the rod 40 itself.
- the cap is seated and locked. Prior to the locked configuration, that is a complete tightening of the set screw, and with or without the cap in position, the system retains two levels of freedom of motion.
- the rod is free to be adjusted with respect to the seat and secondly, the seat is free to be adjusted relative to the screw.
- both the rod and the screw retain a degree of motion relative to seat, with or without the cap in place, which allows the clinician to custom orientate the seat with respect to the bone screw.
- the freedom of motion also permits the clinician to custom orientate the rod with respect to the seat with the system deployed inside the patient and in the unlocked configuration. This freedom of motion advantageously provides the surgeon with a much-needed, increased ease of implantation.
- Figs. 1 IA and 1 IB show a typical installation environment of the devices in two spinal segments of a patient.
- Fig. 12 illustrates a side cross-sectional view of the seat 26 with a sectional view of a seat-gripping instrument 130 engaging the seat.
- the flange 21 of the seat 26 includes an upper surface 136, an outer surface 138 and a lower surface 140 and extends outwardly from the outer surface of the seat.
- Fig. 12 shows a single circumferentially continuous flange 21, the invention is not so limited and more than one flange may be formed.
- the instrument 130 includes a first portion 132 and a second portion 134 interconnected with a handle portion (not shown).
- the first portion 132 of the instrument is configured to contact at least a portion of the flange outer surface 138 and/or at least a portion of the flange lower surface 140.
- the second portion 134 of the instrument is configured to slide with respect to the first portion 132 and contact the upper surface 136 of the flange as shown in Fig. 12.
- the second portion 134 is advanced to tighten against the upper surface and securely retain the seat within the instrument 130 for deployment into the patient.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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CA002682180A CA2682180A1 (en) | 2007-03-20 | 2008-03-20 | Screw systems and methods for use in stabilization of bone structures |
AU2008229323A AU2008229323A1 (en) | 2007-03-20 | 2008-03-20 | Screw systems and methods for use in stabilization of bone structures |
EP08727028A EP2142119A4 (en) | 2007-03-20 | 2008-03-20 | Screw systems and methods for use in stabilization of bone structures |
IL201031A IL201031A0 (en) | 2007-03-20 | 2009-09-17 | Screw systems and methods for use in stabilization of bone structures |
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US11/726,093 US8267969B2 (en) | 2004-10-20 | 2007-03-20 | Screw systems and methods for use in stabilization of bone structures |
US11/726,093 | 2007-03-20 |
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WO2008115549A1 true WO2008115549A1 (en) | 2008-09-25 |
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PCT/US2008/003677 WO2008115549A1 (en) | 2007-03-20 | 2008-03-20 | Screw systems and methods for use in stabilization of bone structures |
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US (2) | US8267969B2 (en) |
EP (1) | EP2142119A4 (en) |
AU (1) | AU2008229323A1 (en) |
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US8226690B2 (en) | 2005-07-22 | 2012-07-24 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for stabilization of bone structures |
US8267969B2 (en) | 2004-10-20 | 2012-09-18 | Exactech, Inc. | Screw systems and methods for use in stabilization of bone structures |
US8523865B2 (en) | 2005-07-22 | 2013-09-03 | Exactech, Inc. | Tissue splitter |
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Also Published As
Publication number | Publication date |
---|---|
AU2008229323A1 (en) | 2008-09-25 |
US20110144701A1 (en) | 2011-06-16 |
US20070167949A1 (en) | 2007-07-19 |
US8551142B2 (en) | 2013-10-08 |
EP2142119A4 (en) | 2012-08-15 |
US8267969B2 (en) | 2012-09-18 |
IL201031A0 (en) | 2010-05-17 |
CA2682180A1 (en) | 2008-09-25 |
EP2142119A1 (en) | 2010-01-13 |
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