WO2008109508A3 - Automatic parameter selection and therapy timing for increasing efficiency in responsive neurodevice therapies - Google Patents

Automatic parameter selection and therapy timing for increasing efficiency in responsive neurodevice therapies Download PDF

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Publication number
WO2008109508A3
WO2008109508A3 PCT/US2008/055629 US2008055629W WO2008109508A3 WO 2008109508 A3 WO2008109508 A3 WO 2008109508A3 US 2008055629 W US2008055629 W US 2008055629W WO 2008109508 A3 WO2008109508 A3 WO 2008109508A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapy
timing
responsive
neurodevice
therapies
Prior art date
Application number
PCT/US2008/055629
Other languages
French (fr)
Other versions
WO2008109508A2 (en
Inventor
Brian Litt
Javier R Echauz
Original Assignee
Univ Pennsylvania
Brian Litt
Javier R Echauz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania, Brian Litt, Javier R Echauz filed Critical Univ Pennsylvania
Publication of WO2008109508A2 publication Critical patent/WO2008109508A2/en
Publication of WO2008109508A3 publication Critical patent/WO2008109508A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/70—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36064—Epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

An automatic fully responsive neurotherapy system and method are provided that recognizes and automatically selects efficacious therapy parameters, to finely manipulate the on-off timing of therapy delivery aimed at improving efficacy over the entire lifespan of the device. The system incorporates auto tuning of the character, dose, and timing of neurostimulation across patients, and on-the-fly, on a patient-specific, event-by-event basis. 'Pre-' and 'post-therapy effectivity' features are derived from biological signals and seizure detection subsystems, and a self-organizing 'therapy rulebase' is developed from the storage/archiving subsystems to make sense of these 'effectivity' features, and subsequently command their trajectories in directions of clinical improvement.
PCT/US2008/055629 2007-03-02 2008-03-03 Automatic parameter selection and therapy timing for increasing efficiency in responsive neurodevice therapies WO2008109508A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89264907P 2007-03-02 2007-03-02
US60/892,649 2007-03-02

Publications (2)

Publication Number Publication Date
WO2008109508A2 WO2008109508A2 (en) 2008-09-12
WO2008109508A3 true WO2008109508A3 (en) 2008-11-06

Family

ID=39739047

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/055629 WO2008109508A2 (en) 2007-03-02 2008-03-03 Automatic parameter selection and therapy timing for increasing efficiency in responsive neurodevice therapies

Country Status (1)

Country Link
WO (1) WO2008109508A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8099170B2 (en) 2010-03-19 2012-01-17 Medtronic, Inc. Electrical stimulation based on phase response mapping
US8447406B2 (en) 2010-06-29 2013-05-21 Medtronic, Inc. Medical method and device for monitoring a neural brain network
DE102012002437B4 (en) * 2012-02-08 2014-08-21 Forschungszentrum Jülich GmbH Device for calibrating an invasive, electrical and desynchronizing neurostimulation
EP3307163B1 (en) 2015-06-09 2023-03-08 The Governing Council Of The University Of Toronto Systems for in situ electrochemical imaging
US11036294B2 (en) 2015-10-07 2021-06-15 The Governing Council Of The University Of Toronto Wireless power and data transmission system for wearable and implantable devices
US10953230B2 (en) 2016-07-20 2021-03-23 The Governing Council Of The University Of Toronto Neurostimulator and method for delivering a stimulation in response to a predicted or detected neurophysiological condition
US10420953B2 (en) 2016-08-27 2019-09-24 Wave Neuroscience, Inc. RTMS pulse frequency optimization
CN111243758B (en) * 2020-01-08 2023-06-30 杭州费尔斯通科技有限公司 Modeling method applied to scene with characteristic of multiple feedback adjustment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6491647B1 (en) * 1998-09-23 2002-12-10 Active Signal Technologies, Inc. Physiological sensing device
US20060111754A1 (en) * 2000-01-20 2006-05-25 Ali Rezai Methods of treating medical conditions by neuromodulation of the sympathetic nervous system
US20060212093A1 (en) * 2000-04-05 2006-09-21 Pless Benjamin D Differential neurostimulation therapy driven by physiological therapy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6491647B1 (en) * 1998-09-23 2002-12-10 Active Signal Technologies, Inc. Physiological sensing device
US20060111754A1 (en) * 2000-01-20 2006-05-25 Ali Rezai Methods of treating medical conditions by neuromodulation of the sympathetic nervous system
US20060212093A1 (en) * 2000-04-05 2006-09-21 Pless Benjamin D Differential neurostimulation therapy driven by physiological therapy

Also Published As

Publication number Publication date
WO2008109508A2 (en) 2008-09-12

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