WO2008093346A3 - Compositions for topical application comprising a peroxide and retinoid - Google Patents

Compositions for topical application comprising a peroxide and retinoid Download PDF

Info

Publication number
WO2008093346A3
WO2008093346A3 PCT/IL2008/000140 IL2008000140W WO2008093346A3 WO 2008093346 A3 WO2008093346 A3 WO 2008093346A3 IL 2008000140 W IL2008000140 W IL 2008000140W WO 2008093346 A3 WO2008093346 A3 WO 2008093346A3
Authority
WO
WIPO (PCT)
Prior art keywords
retinoid
peroxide
active ingredient
composition
topical application
Prior art date
Application number
PCT/IL2008/000140
Other languages
French (fr)
Other versions
WO2008093346A2 (en
Inventor
Ofer Toledano
Hanan Sertchook
Natalia Loboda
Haim Bar-Simantov
Leora Shapiro
Raed Abu-Reziq
Original Assignee
Sol Gel Technologies Ltd
Ofer Toledano
Hanan Sertchook
Natalia Loboda
Haim Bar-Simantov
Leora Shapiro
Raed Abu-Reziq
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2009547810A priority Critical patent/JP2010517996A/en
Application filed by Sol Gel Technologies Ltd, Ofer Toledano, Hanan Sertchook, Natalia Loboda, Haim Bar-Simantov, Leora Shapiro, Raed Abu-Reziq filed Critical Sol Gel Technologies Ltd
Priority to MX2009008250A priority patent/MX2009008250A/en
Priority to AU2008211553A priority patent/AU2008211553B2/en
Priority to EP08702719.9A priority patent/EP2109445B1/en
Priority to CA2677184A priority patent/CA2677184C/en
Priority to US12/525,329 priority patent/US20100047357A1/en
Priority to ES08702719T priority patent/ES2912051T3/en
Priority to EA200970724A priority patent/EA200970724A1/en
Priority to BRPI0808163-8A2A priority patent/BRPI0808163A2/en
Publication of WO2008093346A2 publication Critical patent/WO2008093346A2/en
Publication of WO2008093346A3 publication Critical patent/WO2008093346A3/en
Priority to IL200174A priority patent/IL200174A0/en
Priority to US13/495,701 priority patent/US8617580B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/327—Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation

Abstract

The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.
PCT/IL2008/000140 2007-02-01 2008-02-03 Compositions for topical application comprising a peroxide and retinoid WO2008093346A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
US12/525,329 US20100047357A1 (en) 2007-02-01 2008-02-03 Compositions for topical application comprising a peroxide and retinoid
MX2009008250A MX2009008250A (en) 2007-02-01 2008-02-03 Compositions for topical application comprising a peroxide and retinoid.
AU2008211553A AU2008211553B2 (en) 2007-02-01 2008-02-03 Compositions for topical application comprising a peroxide and retinoid
EP08702719.9A EP2109445B1 (en) 2007-02-01 2008-02-03 Compositions for topical application comprising a peroxide and retinoid
CA2677184A CA2677184C (en) 2007-02-01 2008-02-03 Compositions for topical application comprising a peroxide and retinoid
JP2009547810A JP2010517996A (en) 2007-02-01 2008-02-03 Composition for topical application comprising peroxide and retinoid
ES08702719T ES2912051T3 (en) 2007-02-01 2008-02-03 Compositions for topical application comprising a peroxide and retinoid
EA200970724A EA200970724A1 (en) 2007-02-01 2008-02-03 COMPOSITIONS FOR LOCAL APPLICATION CONTAINING PEROXIDE AND RETINOID
BRPI0808163-8A2A BRPI0808163A2 (en) 2007-02-01 2008-02-03 TOPICAL APPLICATION COMPOSITION, METHODS FOR TREATING A SURFACE CONDITION ON AN INDIVIDUAL, PREPARING A COMPOSITION, AND USING THE KIT, AND, KIT
IL200174A IL200174A0 (en) 2007-02-01 2009-07-30 Compositions for topical application comprising a peroxide and retinoid
US13/495,701 US8617580B2 (en) 2007-02-01 2012-06-13 Compositions for topical application comprising a peroxide and retinoid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89870107P 2007-02-01 2007-02-01
US60/898,701 2007-02-01

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/525,329 A-371-Of-International US20100047357A1 (en) 2007-02-01 2008-02-03 Compositions for topical application comprising a peroxide and retinoid
US13/495,701 Continuation US8617580B2 (en) 2007-02-01 2012-06-13 Compositions for topical application comprising a peroxide and retinoid

Publications (2)

Publication Number Publication Date
WO2008093346A2 WO2008093346A2 (en) 2008-08-07
WO2008093346A3 true WO2008093346A3 (en) 2009-05-28

Family

ID=39273433

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2008/000140 WO2008093346A2 (en) 2007-02-01 2008-02-03 Compositions for topical application comprising a peroxide and retinoid

Country Status (11)

Country Link
US (2) US20100047357A1 (en)
EP (1) EP2109445B1 (en)
JP (2) JP2010517996A (en)
KR (1) KR20090125243A (en)
AU (1) AU2008211553B2 (en)
BR (1) BRPI0808163A2 (en)
CA (1) CA2677184C (en)
EA (1) EA200970724A1 (en)
ES (1) ES2912051T3 (en)
MX (1) MX2009008250A (en)
WO (1) WO2008093346A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2533406C (en) 2003-07-31 2013-01-22 Sol-Gel Technologies Ltd. Microcapsules loaded with active ingredients and a method for their preparation
KR101158162B1 (en) 2005-08-02 2012-06-19 솔-겔 테크놀로지스 리미티드 Metal oxide coating of water insoluble ingredients
BRPI0808160A2 (en) * 2007-02-01 2014-09-23 Sol Gel Technologies Ltd PROCESS FOR COATING A SOLID, WATER-INSOLATED PRIVATE MATERIAL WITH A METAL OXIDE, COATED PARTICULATED MATERIALS, METHODS TO TREAT A SURFACE CONDITION ON AN INDIVIDUAL, AND TO PREVENT, REDUCE, OR ELIMINATE, OR ELIMINATE, USE OF COATED PRIVATE MATERIAL
EA201170271A1 (en) 2008-07-31 2011-10-31 Сол-Джел Текнолоджиз Лтд. MICROCAPSULES CONTAINING ACTIVE INGREDIENTS AND METAL OXIDE SHELL, METHOD OF THEIR RECEPTION AND THEIR APPLICATION
CN102573765A (en) * 2009-01-05 2012-07-11 溶胶凝胶技术公司 Topical compositions containing coated active agents
EP2453746A4 (en) * 2009-07-16 2013-04-24 Stiefel Laboratories Tazarotene derivatives
US10653899B2 (en) 2009-12-31 2020-05-19 Sol-Gel Technologies Ltd. Core stabilized microcapsules, method of their preparation and uses thereof
US11071878B2 (en) 2009-12-31 2021-07-27 Sol-Gel Technologies Ltd. Core stabilized microcapsules, method of their preparation and uses thereof
AU2010337830B2 (en) 2009-12-31 2013-10-03 Sol-Gel Technologies Ltd. Core stabilized microcapsules, method of their preparation and uses thereof
WO2011154421A1 (en) * 2010-06-09 2011-12-15 Basf Se Microcapsules containing active substance and having a metal oxide-containing shell
CA2806592C (en) 2010-08-27 2020-10-27 Sienna Labs, Inc. Compositions and methods for targeted thermomodulation
US9572880B2 (en) 2010-08-27 2017-02-21 Sienna Biopharmaceuticals, Inc. Ultrasound delivery of nanoparticles
ES2902498T3 (en) * 2011-06-29 2022-03-28 Sol Gel Tech Ltd Stabilized topical formulations containing core-shell microcapsules
PL2906286T3 (en) 2012-10-11 2018-03-30 Nanocomposix, Inc. Silver nanoplate compositions and methods
MX2015005515A (en) * 2012-11-27 2015-07-17 Sol Gel Technologies Ltd Compositions for the treatment of rosacea.
US9687465B2 (en) 2012-11-27 2017-06-27 Sol-Gel Technologies Ltd. Compositions for the treatment of rosacea
WO2015092602A1 (en) * 2013-12-17 2015-06-25 Ranbaxy Laboratories Limited Topical pharmaceutical composition of a retinoid
US11160745B2 (en) 2014-04-18 2021-11-02 Gregory P. Pilant Methods and compositions for topical delivery for skin care
CA2996022C (en) * 2015-08-20 2021-01-05 Sol-Gel Technologies Ltd. Compositions for topical application comprising benzoyl peroxide and adapalene
CA3016436A1 (en) * 2016-03-04 2017-09-08 Arkema Inc. Encapsulation of peroxides for skin applications
US20190015368A1 (en) * 2017-07-12 2019-01-17 Sol-Gel Technologies Ltd. Method of acne treatment by concomitant topical administration of benzoyl peroxide and tretinoin
WO2019012537A1 (en) 2017-07-12 2019-01-17 Sol-Gel Technologies Ltd Compositions comprising encapsulated tretinoin
CA3069287C (en) 2017-07-12 2022-08-30 Sol-Gel Technologies Ltd. Methods and compositions for the treatment of acne
JP6811213B2 (en) * 2018-07-03 2021-01-13 ソル − ゲル テクノロジーズ リミテッド Composition for the treatment of rosacea
WO2020044344A1 (en) * 2018-08-29 2020-03-05 Sol-Gel Technologies Ltd Compositions comprising ozenoxacin
WO2020170033A2 (en) 2019-02-19 2020-08-27 Sol-Gel Technologies Ltd. Method for treatment of moderate to severe erythema symptoms in rosacea patients
JP7241967B2 (en) 2020-03-27 2023-03-17 三菱電機株式会社 air conditioner
BR112022023798A2 (en) * 2020-05-22 2023-01-03 Sol Gel Tech Ltd STABILIZED MICROCAPSULES, METHOD OF THEIR PREPARATION AND USES THEREOF
WO2023105227A1 (en) * 2021-12-08 2023-06-15 Nanexa Ab New injectable combination formulation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020064541A1 (en) * 2000-04-21 2002-05-30 Noa Lapidot Composition exhibiting enhanced formulation stability and delivery of topical active ingredients
WO2004064769A2 (en) * 2003-01-21 2004-08-05 Hector Herrera Methods for making and using topical delivery agents

Family Cites Families (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2885366A (en) 1956-06-28 1959-05-05 Du Pont Product comprising a skin of dense, hydrated amorphous silica bound upon a core of another solid material and process of making same
US3785798A (en) 1967-04-26 1974-01-15 Gaf Corp Biologically active particulate material and the process for manufacturing same
GB1399344A (en) 1971-06-03 1975-07-02 Ici Ltd Method of producing vesiculated particles of inorganic materials
US3826670A (en) 1972-11-07 1974-07-30 Sherwin Williams Co Encapsulation of organic pigments
US3957971A (en) 1974-07-29 1976-05-18 Lever Brothers Company Moisturizing units and moisturizing compositions containing the same
US4087555A (en) 1975-09-08 1978-05-02 Helena Rubinstein, Inc. Skin cream containing milk protein
US4497794A (en) * 1980-12-08 1985-02-05 Dermik Laboratories, Inc. Erythromycin/benzoyl peroxide composition for the treatment of acne
US4349456A (en) 1976-04-22 1982-09-14 Minnesota Mining And Manufacturing Company Non-vitreous ceramic metal oxide microcapsules and process for making same
DE2642032A1 (en) 1976-09-18 1978-03-30 Merck Patent Gmbh PREPARATIONS CONTAINING SILICON DIOXIDE AND METHOD FOR THEIR MANUFACTURING
US4361584A (en) * 1977-10-07 1982-11-30 A.H.C. Pharmacal, Inc. Composition and method for the treatment of acne
US4350681A (en) * 1977-10-07 1982-09-21 A.H.C. Pharmacal, Inc. Stabilized benzoyl peroxide compositions
US4606913A (en) 1978-09-25 1986-08-19 Lever Brothers Company High internal phase emulsions
US4387107A (en) * 1979-07-25 1983-06-07 Dermik Laboratories, Inc. Stable benzoyl peroxide composition
US4464317A (en) 1980-01-28 1984-08-07 The Washington University Method of encapsulating active agents with inorganic coatings
US4692329A (en) 1980-12-08 1987-09-08 William H. Rorer, Inc. Erythromycin/benzoyl peroxide antiacne compositions
GB2110083B (en) 1981-11-24 1985-05-30 Colgate Palmolive Co Visually clear coloured dentifrice
LU85111A1 (en) * 1983-12-01 1985-09-12 Oreal ANTI-ACNETIC COMPOSITION BASED ON BENZOYL PEROXIDE AND AT LEAST ONE SOLAR FILTER
JPS6191137A (en) 1984-10-11 1986-05-09 Kao Corp External drug composition
US5086075A (en) * 1985-01-24 1992-02-04 Board Of Regents, The University Of Texas System Therapeutic compositions containing benzoyl peroxide
US4769080A (en) 1985-06-24 1988-09-06 The Dow Chemical Company Insoluble pigments and preparation thereof
US4690825A (en) * 1985-10-04 1987-09-01 Advanced Polymer Systems, Inc. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen
US5446028A (en) 1985-12-12 1995-08-29 Dermik Laboratories, Inc. Anti-acne method and composition
US5879716A (en) * 1985-12-18 1999-03-09 Advanced Polymer Systems, Inc. Methods and compositions for topical delivery of benzoyl peroxide
US5955109A (en) * 1985-12-18 1999-09-21 Advanced Polymer Systems, Inc. Methods and compositions for topical delivery of retinoic acid
US5145675A (en) * 1986-03-31 1992-09-08 Advanced Polymer Systems, Inc. Two step method for preparation of controlled release formulations
EP0281034A3 (en) 1987-02-26 1990-09-19 Tohru Yamamoto An aromatic composition and a method for the production of the same
AT389465B (en) * 1987-08-18 1989-12-11 Kwizda Fa F Johann METHOD FOR FORMING MICROCAPSULES OR MICROMATRIX BODIES
FR2628319B1 (en) * 1988-03-09 1990-12-07 Oreal PHARMACEUTICAL AND COSMETIC COMPOSITIONS BASED ON BENZOYL PEROXIDE AND QUATERNARY AMMONIUM SALTS
US4891211A (en) 1988-06-29 1990-01-02 Church & Dwight Co., Inc. Stable hydrogen peroxide-releasing dentifice
US5126915A (en) 1989-07-28 1992-06-30 E. I. Du Pont De Nemours And Company Metal oxide-coated electrically conductive powders and compositions thereof
IL93134A (en) 1990-01-23 1997-11-20 Yissum Res Dev Co Doped sol-gel glasses for obtaining chemical interactions
US5318797A (en) 1990-06-20 1994-06-07 Clarkson University Coated particles, hollow particles, and process for manufacturing the same
GB9021061D0 (en) 1990-09-27 1990-11-07 Unilever Plc Encapsulating method and products containing encapsulated material
US5223250A (en) 1991-02-05 1993-06-29 Sun Smart, Inc. Visibly transparent UV sunblock cosmetic compositions
US5733531A (en) 1991-02-05 1998-03-31 Sunsmart, Inc. Composite UV sunblock compositions
US5165914A (en) 1991-03-04 1992-11-24 David G. Vlock Oral compositions containing zinc lactate complexes
FR2675398B1 (en) 1991-04-19 1994-04-01 Roussel Uclaf MICRO-CAPSULES OF SOLAR FILTERS, THEIR PREPARATION METHOD, THE COSMETIC AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR APPLICATIONS.
US5200334A (en) 1991-08-13 1993-04-06 The Regents Of The University Of California Sol-gel encapsulated enzyme
FR2681248B1 (en) 1991-09-13 1995-04-28 Oreal COMPOSITION FOR A LONG-TERM COSMETIC AND / OR PHARMACEUTICAL TREATMENT OF THE TOP LAYERS OF THE EPIDERMIS BY TOPICAL APPLICATION TO THE SKIN.
US5269840A (en) 1992-02-04 1993-12-14 Minnesota Mining And Manufacturing Company Sol bonded colorant clusters and process for making
US6117843A (en) * 1992-02-18 2000-09-12 Lloyd J. Baroody Compositions for the treatment of acne containing clindamycin and benzoyl peroxide
US5520917A (en) 1992-07-27 1996-05-28 Suzuki Yushi Industries Co., Ltd. Materials in the form of colored spherical fine particles
FR2694894B1 (en) 1992-08-20 1994-11-10 Coletica Use of a transacylation reaction between an esterified polysaccharide and a polyamine or polyhydroxylated substance for the manufacture of microparticles, process and composition.
FR2694895B1 (en) 1992-08-20 1994-11-10 Coletica Process for the production of emulsion microparticles by modification of the chemical composition of the dispersed phase after emulsification.
FR2703927B1 (en) 1993-04-13 1995-07-13 Coletica Use of a transacylation reaction between an esterified polysaccharide and a polyamine to form in an aqueous medium a membrane at least on the surface of gelled particles.
DE4321005A1 (en) 1993-06-24 1995-01-05 Merck Patent Gmbh Pearlescent pigment for water-based paint systems
US5895757A (en) 1993-06-30 1999-04-20 Pope; Edward J. A. Encapsulation of living tissue cells in inorganic microspheres prepared from an organosilicon
US5739020A (en) 1995-01-10 1998-04-14 Pope; Edward J. A. Encapsulation of animal and microbial cells in an inorganic gel prepared from an organosilicon
US5846554A (en) 1993-11-15 1998-12-08 Zeneca Limited Microcapsules containing suspensions of biologically active compounds and ultraviolet protectant
DE4341113B4 (en) 1993-12-02 2006-04-13 IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG Stable multiple X / O / Y emulsion
US5466446A (en) * 1994-02-16 1995-11-14 Stiefel Laboratories, Inc. Topical compositions containing bensoyl peroxide and clindamycin and method of use thereof
FR2719218B1 (en) 1994-04-28 1996-07-05 Oreal Use of a colloidal suspension based on mineral fillers as a cosmetic composition making it possible to form a film on the hair, the skin and / or the nails.
EP0680753A3 (en) 1994-05-06 1996-08-28 Feinchemie Gmbh Sebnitz Metal oxide composite with controllable release.
DE4416003C2 (en) 1994-05-06 1999-02-11 Feinchemie Gmbh Sebnitz Metal oxide powders and films with incorporated organic liquids and oils, their manufacture and use
FR2720632B1 (en) 1994-06-03 1996-07-05 Oreal Photoprotective cosmetic compositions containing a system for filtering UV rays and specific polymers and uses.
US5591453A (en) 1994-07-27 1997-01-07 The Trustees Of The University Of Pennsylvania Incorporation of biologically active molecules into bioactive glasses
US5445823A (en) 1994-10-20 1995-08-29 The Procter & Gamble Company Dermatological compositions and method of treatment of skin lesions therewith
US5632996A (en) * 1995-04-14 1997-05-27 Imaginative Research Associates, Inc. Benzoyl peroxide and benzoate ester containing compositions suitable for contact with skin
US5576097A (en) 1995-04-24 1996-11-19 Brite-Line Industries, Inc. High brightness durable retro-reflecting microspheres and method of making the same
US5700451A (en) 1995-05-24 1997-12-23 The Procter & Gamble Company Sunscreen composition
US5851538A (en) * 1995-12-29 1998-12-22 Advanced Polymer Systems, Inc. Retinoid formulations in porous microspheres for reduced irritation and enhanced stability
US5874105A (en) 1996-01-31 1999-02-23 Collaborative Laboratories, Inc. Lipid vesicles formed with alkylammonium fatty acid salts
US5785977A (en) 1996-02-07 1998-07-28 Breithbarth; Richard Non-metallic microparticle carrier materials
US5998392A (en) * 1996-04-10 1999-12-07 Gattefosse S.A. Benzoyl peroxide flocculent materials and methods of their preparation
FR2747668B1 (en) 1996-04-22 1998-05-22 Rhone Poulenc Chimie PROCESS FOR THE PREPARATION OF SILICA COMPRISING A SILICA BARK AND A HEART OF ANOTHER MATERIAL
US5876699A (en) 1996-05-14 1999-03-02 Disomma; Joseph Sunblock composition suitable for sensitive skin areas
DE19625267A1 (en) 1996-06-25 1998-01-08 Bayer Ag Process for the production of inorganic coated pigments and fillers
GB9616978D0 (en) 1996-08-13 1996-09-25 Tioxide Specialties Ltd Zinc oxide dispersions
FR2755856B1 (en) 1996-11-21 1999-01-29 Merck Clevenot Laboratoires MICROCAPSULES OF CHINA OR CHINA DERIVATIVES CONTAINING A HYDROPHOBIC SUBSTANCE, IN PARTICULAR A SUN FILTER AND PROCESS FOR PREPARING SUCH MICROCAPSULES
IL120022A (en) 1997-01-16 2003-02-12 Yissum Res Dev Co Sunscreens for protection from sun radiation
FR2758826B1 (en) 1997-01-27 1999-04-16 Rhodia Chimie Sa NOVEL TITANIUM DIOXIDE PIGMENT, PROCESS FOR PREPARING IT, AND USE THEREOF IN PAINT COMPOSITIONS
US5962517A (en) 1997-01-31 1999-10-05 Murad; Howard Pharmaceutical compositions and methods for treating acne
US5906811A (en) 1997-06-27 1999-05-25 Thione International, Inc. Intra-oral antioxidant preparations
FR2766090B1 (en) 1997-07-15 1999-10-08 Coletica PARTICLES, IN PARTICULAR MICRO- OR NANOPARTICLES OF CROSS-LINKED VEGETAL PROTEINS, THEIR PREPARATION PROCESS AND COSMETIC, PHARMACEUTICAL OR FOOD COMPOSITIONS, CONTAINING
US6280746B1 (en) 1997-10-17 2001-08-28 International Flora Technologies Ltd. Dry emollient compositions
US6090399A (en) 1997-12-11 2000-07-18 Rohm And Haas Company Controlled release composition incorporating metal oxide glass comprising biologically active compound
US6015548A (en) 1998-07-10 2000-01-18 Shaklee Corporation High efficiency skin protection formulation with sunscreen agents and antioxidants
US6337089B1 (en) * 1998-02-06 2002-01-08 Seiwa Kasei Company, Limited Microcapsule containing core material and method for producing the same
FR2774906B1 (en) 1998-02-13 2000-05-12 Rhodia Chimie Sa ORGANIC HEART AND MINERAL BARK ENCAPSULATION SYSTEM BASED ON ALUMINUM HYDROXYCARBONATE AND PREPARATION METHOD THEREOF
DE19810803A1 (en) 1998-03-12 1999-09-16 Wacker Chemie Gmbh Process for the production of microencapsulated products with organopolysiloxane walls
DE19811900C2 (en) 1998-03-18 2003-12-11 Kallies Feinchemie Ag Biocompatible composite material, process for its production and its use
EP1064088B1 (en) 1998-03-19 2002-12-04 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates
EP0972563A1 (en) 1998-07-15 2000-01-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates
US6013637A (en) * 1998-06-12 2000-01-11 Dermik Laboratories Inc. Anti-acne method and composition
FR2780901B1 (en) 1998-07-09 2000-09-29 Coletica PARTICLES, IN PARTICULAR MICRO- OR NANOPARTICLES OF CROSSLINKED MONOSACCHARIDES AND OLIGOSACCHARIDES, THEIR PREPARATION METHODS AND COSMETIC, PHARMACEUTICAL OR FOOD COMPOSITIONS CONTAINING THE SAME
US6146664A (en) 1998-07-10 2000-11-14 Shaklee Corporation Stable topical ascorbic acid compositions
US6074629A (en) 1998-07-27 2000-06-13 J. M. Huber Corporation Dentifrice with a dye absorbing silica for imparting a speckled appearance thereto
US6103267A (en) 1998-07-27 2000-08-15 Sunsmart, Inc. Stabilized ascorbic acid, composition, and method of use
AU5132799A (en) * 1998-07-28 2000-02-21 Bershad, Susan Short contact treatment of acne and photoaging with topical retinoids
IL141411A0 (en) 1998-08-13 2002-03-10 Sol Gel Technologies Ltd Method for the preparation of oxide microcapsules loaded with functional molecules and the product obtained thereof
US6217852B1 (en) 1998-08-15 2001-04-17 Skinnovative Dermatologic Concepts, L.L.C. Personal cleansing compositions having photoprotective agents
DE19842766A1 (en) 1998-09-18 2000-03-23 Beiersdorf Ag Emulsifier-free finely dispersed systems of the oil-in-water and water-in-oil type
FR2785292B1 (en) 1998-10-30 2002-06-28 Rhodia Chimie Sa POROUS MINERAL BARK CAPSULES IN WHICH THEY ARE IMMOBILIZED IN A LIQUID BIOLOGICAL MEDIUM, ONE OR MORE BIOLOGICAL MATERIALS, THEIR PREPARATION METHODS AND USES
FR2785199B1 (en) 1998-10-30 2001-01-05 Rhodia Chimie Sa PROCESS FOR THE PREPARATION OF CAPSULES CONSISTING OF A CORE OF LIQUID ACTIVE MATERIAL SURROUNDED BY A MINERAL BARK
US6238650B1 (en) 1999-05-26 2001-05-29 Sol-Gel Technologies Ltd. Sunscreen composition containing sol-gel microcapsules
US6468509B2 (en) * 1998-12-18 2002-10-22 Sol-Gel Technologies Ltd. Sunscreen composition containing sol-gel microcapsules
WO2000042112A1 (en) 1999-01-11 2000-07-20 Showa Denko K. K. Cosmetic preparation, surface-hydrophobized silica-coated metal oxide particles, sol of silica-coated metal oxide, and processes for producing these
US6395299B1 (en) 1999-02-12 2002-05-28 Biostream, Inc. Matrices for drug delivery and methods for making and using the same
US6495352B1 (en) 1999-04-15 2002-12-17 Sandia Corporation Sol-gel method for encapsulating molecules
US6143280A (en) 1999-05-18 2000-11-07 J. M. Huber Corporation Color containing silica resistant to dye migration and method of making the same
AU4775400A (en) * 1999-05-25 2000-12-12 Sol-Gel Technologies Ltd. A method for obtaining photostable sunscreen compositions
FR2799119B1 (en) 1999-10-01 2001-11-30 Oreal PROCESS FOR IMPROVING THE STABILITY TO UV RADIATION OF PHOTOSENSITIVE SOLAR FILTERS
DE10001172A1 (en) 2000-01-13 2001-07-26 Max Planck Gesellschaft Templating solid particles with polymer multilayers
SI2517710T1 (en) 2000-02-08 2015-07-31 Euro-Celtique S.A. Tamper-resistant oral opioid agonist formulations
EP1335693A2 (en) 2000-04-21 2003-08-20 Sol-Gel Technologies Ltd. Composition exhibiting enhanced formulation stability and delivery of topical active ingredients
US6303290B1 (en) 2000-09-13 2001-10-16 The Trustees Of The University Of Pennsylvania Encapsulation of biomaterials in porous glass-like matrices prepared via an aqueous colloidal sol-gel process
US7060732B2 (en) 2000-12-12 2006-06-13 Imaginative Research Associates, Inc. Antibiotic/benzoyl peroxide dispenser
US20020193321A1 (en) * 2000-12-12 2002-12-19 Mohan Vishnupad Dual dispenser for aesthitically acceptable delivery of anhydrous skin treatment compositions
US20020151527A1 (en) 2000-12-20 2002-10-17 Benjamin Wiegand Method for reducing acne or improving skin tone
GB2377078B (en) 2001-06-27 2003-06-04 Morgan Crucible Co Fuel cell or electrolyser construction
JP3900863B2 (en) 2001-06-28 2007-04-04 シャープ株式会社 Data transfer control device, semiconductor memory device and information equipment
US6913825B2 (en) 2001-09-20 2005-07-05 University Of Notre Dame Du Lac Process for making mesoporous silicate nanoparticle coatings and hollow mesoporous silica nano-shells
US7037513B1 (en) 2005-01-31 2006-05-02 Aquea Scientific Corporation Bodywash additives
EP1446086A1 (en) * 2001-11-08 2004-08-18 Sol-Gel Technologies Ltd. Compositions containing oils having a specific gravity higher than the specific gravity of water
US7820186B2 (en) * 2001-12-21 2010-10-26 Galderma Research & Development Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt
FR2833841B1 (en) * 2001-12-21 2005-07-22 Galderma Res & Dev GEL COMPRISING AT LEAST ONE RETINOID AND BENZOYL PEROXIDE
GB0202853D0 (en) 2002-02-07 2002-03-27 Dow Corning Encapsulation process and encapsulated compositions
US6875264B2 (en) 2003-01-17 2005-04-05 Engelhard Corporation Multi-layer effect pigment
GB0301577D0 (en) 2003-01-23 2003-02-26 Edko Pazarlama Tanitim Ltd Sti Topical pharmaceutical and/or cosmetic dispense systems
FR2850576B1 (en) 2003-02-05 2007-03-23 Ethypharm Sa COMPOSITION COMPRISING A MIXTURE OF ACTIVE INGREDIENTS AND PROCESS FOR PREPARING THE SAME
WO2004081222A2 (en) 2003-03-14 2004-09-23 Sol-Gel Technologies Ltd. Agent-encapsulating micro- and nanoparticles, methods for preparation of same and products containing same
KR100524820B1 (en) * 2003-06-17 2005-10-31 한국화학연구원 A preparation method of silica microcapsule
CA2533406C (en) 2003-07-31 2013-01-22 Sol-Gel Technologies Ltd. Microcapsules loaded with active ingredients and a method for their preparation
US20050208134A1 (en) 2004-02-25 2005-09-22 Shlomo Magdassi Biocompatible polymeric beads and use thereof
US20050276807A1 (en) * 2004-06-15 2005-12-15 Advanced Biotherapy, Inc. Treatment of acne
GB2416524A (en) 2004-07-24 2006-02-01 Dow Corning Microcapsules with siloxane walls formed in situ
US7001592B1 (en) 2005-01-31 2006-02-21 Aquea Scientific Corporation Sunscreen compositions and methods of use
AR054805A1 (en) 2005-06-29 2007-07-18 Stiefel Laboratories TOPICAL COMPOSITIONS FOR SKIN TREATMENT
KR101158162B1 (en) 2005-08-02 2012-06-19 솔-겔 테크놀로지스 리미티드 Metal oxide coating of water insoluble ingredients

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020064541A1 (en) * 2000-04-21 2002-05-30 Noa Lapidot Composition exhibiting enhanced formulation stability and delivery of topical active ingredients
WO2004064769A2 (en) * 2003-01-21 2004-08-05 Hector Herrera Methods for making and using topical delivery agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Martindale: the extra Pharmacopeia", 1999, PHARMACEUTICAL PRESS, USA, XP002477043 *

Also Published As

Publication number Publication date
KR20090125243A (en) 2009-12-04
EP2109445B1 (en) 2022-04-20
JP5923065B2 (en) 2016-05-24
JP2010517996A (en) 2010-05-27
US20100047357A1 (en) 2010-02-25
EA200970724A1 (en) 2010-02-26
AU2008211553A1 (en) 2008-08-07
US20120269874A1 (en) 2012-10-25
AU2008211553B2 (en) 2013-06-20
MX2009008250A (en) 2009-08-27
ES2912051T3 (en) 2022-05-24
WO2008093346A2 (en) 2008-08-07
BRPI0808163A2 (en) 2014-11-04
CA2677184A1 (en) 2008-08-07
US8617580B2 (en) 2013-12-31
EP2109445A2 (en) 2009-10-21
CA2677184C (en) 2014-12-23
JP2013213063A (en) 2013-10-17

Similar Documents

Publication Publication Date Title
WO2008093346A3 (en) Compositions for topical application comprising a peroxide and retinoid
WO2008048963A3 (en) Natural compositions for killing parasites on a companion animal
WO2009021986A8 (en) Seed treatment compositions and methods
WO2012037294A3 (en) Compositions and methods of treating edible matter and substrates therefor
WO2008065316A3 (en) Ointment compositions comprising a vitamin d derivative
WO2010117740A3 (en) Enhanced formulations, compositions and methods for pest control
WO2009100441A3 (en) Depot formulations
WO2006119283A3 (en) Anti-odor compositions and therapeutic use
WO2007149520A8 (en) Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof
WO2010125323A8 (en) Biocidal composition
WO2006083630A3 (en) Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent in combination with an anti-dandruff active
WO2009147075A3 (en) Pharmaceutical compositions containing a crystalline form of posaconazole
WO2012046229A3 (en) Cosmetic skin care compositions comprising insoluble copper oxide
WO2011107713A3 (en) Novel agent for improving the deposition of oil on hair
WO2009080628A3 (en) Kit comprising an alginate and a complexing agent in the form of a water-soluble salt
WO2007122581A3 (en) Compositions and kits of phenylephrine
MY163311A (en) A coating composition
WO2009090237A3 (en) Fungicide hydroximoyl-tetrazole derivatives
WO2010043717A3 (en) Pharmaceutical topical compositions
WO2004091645A3 (en) Composition comprising rosmarinic acid, borneol and ginsenoside
WO2006083631A3 (en) Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent
WO2010019611A3 (en) Bridged polycyclic compound based compositions for topical and oral applications
WO2012075015A3 (en) Oral metronidazole pharmaceutical compositions
WO2008046796A3 (en) Use of c10-c14-alkane-1,2-diols in the preparation of a composition for the prophylaxis and/or treatment of dermatophyte infections
WO2009101322A3 (en) Cosmetic composition comprising a cationic surfactant compound, use thereof as a hair conditioner, and cosmetic treatment method

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08702719

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 200174

Country of ref document: IL

ENP Entry into the national phase

Ref document number: 2009547810

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2677184

Country of ref document: CA

Ref document number: MX/A/2009/008250

Country of ref document: MX

Ref document number: 2008702719

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2008211553

Country of ref document: AU

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2008211553

Country of ref document: AU

Date of ref document: 20080203

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1020097018024

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 200970724

Country of ref document: EA

WWE Wipo information: entry into national phase

Ref document number: 12525329

Country of ref document: US

ENP Entry into the national phase

Ref document number: PI0808163

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20090731