WO2008066869A3 - Systems and methods for monitoring the amplification and dissociation behavior of dna molecules - Google Patents

Systems and methods for monitoring the amplification and dissociation behavior of dna molecules Download PDF

Info

Publication number
WO2008066869A3
WO2008066869A3 PCT/US2007/024538 US2007024538W WO2008066869A3 WO 2008066869 A3 WO2008066869 A3 WO 2008066869A3 US 2007024538 W US2007024538 W US 2007024538W WO 2008066869 A3 WO2008066869 A3 WO 2008066869A3
Authority
WO
WIPO (PCT)
Prior art keywords
dna molecules
amplification
monitoring
systems
methods
Prior art date
Application number
PCT/US2007/024538
Other languages
French (fr)
Other versions
WO2008066869A2 (en
Inventor
Kenton C Hasson
Gregory A Dale
John P Keady
Original Assignee
Canon Us Life Sciences Inc
Kenton C Hasson
Gregory A Dale
John P Keady
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Canon Us Life Sciences Inc, Kenton C Hasson, Gregory A Dale, John P Keady filed Critical Canon Us Life Sciences Inc
Priority to JP2009539314A priority Critical patent/JP5100757B2/en
Priority to EP07853171A priority patent/EP2100254A2/en
Publication of WO2008066869A2 publication Critical patent/WO2008066869A2/en
Publication of WO2008066869A3 publication Critical patent/WO2008066869A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/14—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation and specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
    • H01L27/144—Devices controlled by radiation
    • H01L27/146—Imager structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Abstract

The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
PCT/US2007/024538 2006-11-30 2007-11-29 Systems and methods for monitoring the amplification and dissociation behavior of dna molecules WO2008066869A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009539314A JP5100757B2 (en) 2006-11-30 2007-11-29 System and method for monitoring amplification and dissociation reactions of DNA molecules
EP07853171A EP2100254A2 (en) 2006-11-30 2007-11-29 Systems and methods for monitoring the amplification and dissociation behavior of dna molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86171206P 2006-11-30 2006-11-30
US60/861,712 2006-11-30

Publications (2)

Publication Number Publication Date
WO2008066869A2 WO2008066869A2 (en) 2008-06-05
WO2008066869A3 true WO2008066869A3 (en) 2008-11-06

Family

ID=39468502

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/024538 WO2008066869A2 (en) 2006-11-30 2007-11-29 Systems and methods for monitoring the amplification and dissociation behavior of dna molecules

Country Status (4)

Country Link
US (4) US7593560B2 (en)
EP (1) EP2100254A2 (en)
JP (1) JP5100757B2 (en)
WO (1) WO2008066869A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010009415A1 (en) * 2008-07-18 2010-01-21 Canon U.S. Life Sciences, Inc. Methods and systems for microfluidic dna sample preparation
US8304185B2 (en) * 2009-07-17 2012-11-06 Canon U.S. Life Sciences, Inc. Methods and systems for DNA isolation on a microfluidic device
US7943320B2 (en) * 2008-12-30 2011-05-17 Canon U.S. Life Sciences, Inc. Unsymmetrical cyanine dyes for high resolution nucleic acid melting analysis
US8422740B2 (en) 2009-01-15 2013-04-16 Scott Dylewski Methods for determining a liquid front position on a test strip
US8709356B2 (en) 2009-04-10 2014-04-29 Canon U.S. Life Sciences, Inc. Systems and methods for minimization or elimination of diffusion effects in a microfluidic system
US9114399B2 (en) 2010-08-31 2015-08-25 Canon U.S. Life Sciences, Inc. System and method for serial processing of multiple nucleic acid assays
JP2013544490A (en) 2010-08-31 2013-12-19 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッド Optical system for detection of high resolution thermal melting.
US9109961B2 (en) 2010-08-31 2015-08-18 Canon U.S. Life Sciences, Inc. Compound calibrator for thermal sensors
US9447458B2 (en) 2011-11-16 2016-09-20 Canon U.S. Life Sciences, Inc. Detection of neighboring variants
US10866184B2 (en) * 2015-11-06 2020-12-15 California Institute Of Technology Devices and methods for direct visual detection and readout of single nucleic acid molecules
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same

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US4589140A (en) * 1983-03-21 1986-05-13 Beltronics, Inc. Method of and apparatus for real-time high-speed inspection of objects for identifying or recognizing known and unknown portions thereof, including defects and the like
US4642813A (en) * 1983-04-18 1987-02-10 Object Recognition Systems, Inc. Electro-optical quality control inspection of elements on a product
US4984075A (en) * 1988-07-18 1991-01-08 Nippondenso Co., Ltd. Contour detecting apparatus
US5717780A (en) * 1993-07-13 1998-02-10 Sharp Kabushiki Kaisha Checking apparatus for flat type display panels
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US20020160405A1 (en) * 1997-04-28 2002-10-31 Ramsey J. Michael Method for analyzing nucleic acids by means of a substrate having a microchannel structure containing immobilized nucleic acid probes

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US5699157A (en) 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
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US7028899B2 (en) 1999-06-07 2006-04-18 Metrologic Instruments, Inc. Method of speckle-noise pattern reduction and apparatus therefore based on reducing the temporal-coherence of the planar laser illumination beam before it illuminates the target object by applying temporal phase modulation techniques during the transmission of the plib towards the target
US6281931B1 (en) * 1997-11-04 2001-08-28 Tien Ren Tsao Method and apparatus for determining and correcting geometric distortions in electronic imaging systems
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US4589140A (en) * 1983-03-21 1986-05-13 Beltronics, Inc. Method of and apparatus for real-time high-speed inspection of objects for identifying or recognizing known and unknown portions thereof, including defects and the like
US4642813A (en) * 1983-04-18 1987-02-10 Object Recognition Systems, Inc. Electro-optical quality control inspection of elements on a product
US4984075A (en) * 1988-07-18 1991-01-08 Nippondenso Co., Ltd. Contour detecting apparatus
US5717780A (en) * 1993-07-13 1998-02-10 Sharp Kabushiki Kaisha Checking apparatus for flat type display panels
US20010048483A1 (en) * 1995-09-08 2001-12-06 Orad Hi-Tec Systems Limited Method and apparatus for determining the position of a TV camera for use in a virtual studio
US20020160405A1 (en) * 1997-04-28 2002-10-31 Ramsey J. Michael Method for analyzing nucleic acids by means of a substrate having a microchannel structure containing immobilized nucleic acid probes

Also Published As

Publication number Publication date
US7593560B2 (en) 2009-09-22
US20130244240A1 (en) 2013-09-19
US8989466B2 (en) 2015-03-24
JP2010511383A (en) 2010-04-15
EP2100254A2 (en) 2009-09-16
JP5100757B2 (en) 2012-12-19
US20080130971A1 (en) 2008-06-05
WO2008066869A2 (en) 2008-06-05
US9732380B2 (en) 2017-08-15
US8306294B2 (en) 2012-11-06
US20160017404A1 (en) 2016-01-21
US20090324037A1 (en) 2009-12-31

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