WO2008060833A3 - Composition, method, system, and kit for optical electrophysiology - Google Patents
Composition, method, system, and kit for optical electrophysiology Download PDFInfo
- Publication number
- WO2008060833A3 WO2008060833A3 PCT/US2007/082386 US2007082386W WO2008060833A3 WO 2008060833 A3 WO2008060833 A3 WO 2008060833A3 US 2007082386 W US2007082386 W US 2007082386W WO 2008060833 A3 WO2008060833 A3 WO 2008060833A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tissue
- kit
- composition
- thick portion
- treated
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000003287 optical effect Effects 0.000 title abstract 2
- 230000007831 electrophysiology Effects 0.000 title 1
- 238000002001 electrophysiology Methods 0.000 title 1
- 239000000523 sample Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 230000005670 electromagnetic radiation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0075—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of an heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/10—The polymethine chain containing an even number of >CH- groups
- C09B23/107—The polymethine chain containing an even number of >CH- groups four >CH- groups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Organic Chemistry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing chemical probe to create a thick portion of treated tissue; applying a first range of wavelengths of electromagnetic radiation to the treated portion of tissue; and detecting a plurality of depth-specific emission wavelengths emitted from the thick portion of treated tissue.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85441806P | 2006-10-24 | 2006-10-24 | |
US60/854,418 | 2006-10-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008060833A2 WO2008060833A2 (en) | 2008-05-22 |
WO2008060833A3 true WO2008060833A3 (en) | 2008-11-20 |
Family
ID=39402369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/082386 WO2008060833A2 (en) | 2006-10-24 | 2007-10-24 | Composition, method, system, and kit for optical electrophysiology |
Country Status (2)
Country | Link |
---|---|
US (3) | US8155730B2 (en) |
WO (1) | WO2008060833A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102008040804B4 (en) * | 2008-07-28 | 2021-07-29 | Carl Zeiss Meditec Ag | Method, surgical microscope and analysis system for the quantitative representation of blood flow |
JP2013122443A (en) * | 2011-11-11 | 2013-06-20 | Hideo Ando | Biological activity measuring method, biological activity measuring device, method for transfer of biological activity detection signal and method for provision of service using biological activity information |
WO2015095344A1 (en) * | 2013-12-17 | 2015-06-25 | University Of Chicago | Voltage sensitive composition and method of use thereof |
US10299692B2 (en) | 2015-05-13 | 2019-05-28 | Ep Solutions, S.A. | Systems, components, devices and methods for cardiac mapping using numerical reconstruction of cardiac action potentials |
CA3028084A1 (en) * | 2015-07-06 | 2017-01-12 | Scinovia Corp. | Fluorescence based flow imaging and measurements |
EP3589639A4 (en) | 2017-03-02 | 2021-03-17 | Akita Innovations LLC | Voltage sensitive dyes |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5865738A (en) * | 1993-12-10 | 1999-02-02 | Regents Of The University Of California | Tissue viability monitor |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5627027A (en) | 1986-04-18 | 1997-05-06 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
EP0449883B1 (en) * | 1988-12-21 | 1996-01-31 | Massachusetts Institute Of Technology | A method for laser induced fluorescence of tissue |
US5046501A (en) * | 1989-01-18 | 1991-09-10 | Wayne State University | Atherosclerotic identification |
GB9015793D0 (en) * | 1990-07-18 | 1990-09-05 | Medical Res Council | Confocal scanning optical microscope |
US5845639A (en) * | 1990-08-10 | 1998-12-08 | Board Of Regents Of The University Of Washington | Optical imaging methods |
US5127730A (en) * | 1990-08-10 | 1992-07-07 | Regents Of The University Of Minnesota | Multi-color laser scanning confocal imaging system |
US6671540B1 (en) | 1990-08-10 | 2003-12-30 | Daryl W. Hochman | Methods and systems for detecting abnormal tissue using spectroscopic techniques |
ATE145805T1 (en) | 1991-03-25 | 1996-12-15 | Hoeft Andreas | DEVICE AND METHOD FOR DETERMINING THE CARDIAC OUTPUT |
US5208651A (en) * | 1991-07-16 | 1993-05-04 | The Regents Of The University Of California | Apparatus and method for measuring fluorescence intensities at a plurality of wavelengths and lifetimes |
US5698397A (en) * | 1995-06-07 | 1997-12-16 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
EP0627643B1 (en) * | 1993-06-03 | 1999-05-06 | Hamamatsu Photonics K.K. | Laser scanning optical system using axicon |
DE4445065A1 (en) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Methods for in-vivo diagnostics using NIR radiation |
US5697373A (en) * | 1995-03-14 | 1997-12-16 | Board Of Regents, The University Of Texas System | Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies |
US5631141A (en) | 1995-05-05 | 1997-05-20 | The Regents Of The University Of California | High resolution biosensor for in-situ microthermometry |
US5616502A (en) | 1995-05-19 | 1997-04-01 | Molecular Probes, Inc. | Non-specific protein staining using merocyanine dyes |
US6342379B1 (en) | 1995-06-07 | 2002-01-29 | The Regents Of The University Of California | Detection of transmembrane potentials by optical methods |
US5865754A (en) * | 1995-08-24 | 1999-02-02 | Purdue Research Foundation Office Of Technology Transfer | Fluorescence imaging system and method |
US5862273A (en) * | 1996-02-23 | 1999-01-19 | Kaiser Optical Systems, Inc. | Fiber optic probe with integral optical filtering |
US5842995A (en) * | 1996-06-28 | 1998-12-01 | Board Of Regents, The Univerisity Of Texas System | Spectroscopic probe for in vivo measurement of raman signals |
DE19635038A1 (en) | 1996-08-29 | 1998-03-12 | Pulsion Verwaltungs Gmbh & Co | Method for the non-invasive determination of cerebral blood flow by means of near infrared spectroscopy |
EP0893965B1 (en) | 1997-01-08 | 2005-03-09 | Biosense Webster, Inc. | Monitoring of myocardial revascularization |
US6201989B1 (en) * | 1997-03-13 | 2001-03-13 | Biomax Technologies Inc. | Methods and apparatus for detecting the rejection of transplanted tissue |
US6297018B1 (en) * | 1998-04-17 | 2001-10-02 | Ljl Biosystems, Inc. | Methods and apparatus for detecting nucleic acid polymorphisms |
US5955737A (en) * | 1997-10-27 | 1999-09-21 | Systems & Processes Engineering Corporation | Chemometric analysis for extraction of individual fluorescence spectrum and lifetimes from a target mixture |
US6151522A (en) * | 1998-03-16 | 2000-11-21 | The Research Foundation Of Cuny | Method and system for examining biological materials using low power CW excitation raman spectroscopy |
IL125614A (en) | 1998-07-31 | 2003-01-12 | Amiram Grinvald | System and method for non-invasive imaging of retinal function |
US6272376B1 (en) * | 1999-01-22 | 2001-08-07 | Cedars-Sinai Medical Center | Time-resolved, laser-induced fluorescence for the characterization of organic material |
US6339714B1 (en) | 1999-09-13 | 2002-01-15 | Bo Chen | Apparatus and method for measuring concentrations of a dye in a living organism |
CN1409818A (en) * | 1999-11-19 | 2003-04-09 | 乔宾伊冯公司 | Compact spectrofluorometer |
US7597878B2 (en) | 2000-09-19 | 2009-10-06 | Li-Cor, Inc. | Optical fluorescent imaging |
US6663847B1 (en) | 2000-10-13 | 2003-12-16 | Mallinckrodt Inc. | Dynamic organ function monitoring agents |
AU2002236683A1 (en) | 2000-10-27 | 2002-05-21 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
WO2002038806A2 (en) * | 2000-11-13 | 2002-05-16 | Gnothis Holding Sa | Detection of nucleic acid polymorphisms |
US7139598B2 (en) * | 2002-04-04 | 2006-11-21 | Veralight, Inc. | Determination of a measure of a glycation end-product or disease state using tissue fluorescence |
US20020158211A1 (en) * | 2001-04-16 | 2002-10-31 | Dakota Technologies, Inc. | Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures |
DE10120980B4 (en) | 2001-05-01 | 2009-12-03 | Pulsion Medical Systems Ag | A method, apparatus and computer program for determining blood flow in a tissue or organ region |
US6757554B2 (en) | 2001-05-22 | 2004-06-29 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution |
EP1401479B1 (en) * | 2001-06-04 | 2007-04-18 | The General Hospital Corporation | Detection and therapy of vulnerable plaque with photodynamic compounds |
DE10137530A1 (en) * | 2001-08-01 | 2003-02-13 | Presens Prec Sensing Gmbh | Arrangement and method for multiple fluorescence measurement |
US7272252B2 (en) * | 2002-06-12 | 2007-09-18 | Clarient, Inc. | Automated system for combining bright field and fluorescent microscopy |
US7754884B2 (en) | 2005-01-03 | 2010-07-13 | Vanderbilt University | Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging |
US7190993B2 (en) | 2003-11-04 | 2007-03-13 | Medtronic, Inc. | Implantable medical device having optical fiber for sensing electrical activity |
DE10358735B4 (en) * | 2003-12-15 | 2011-04-21 | Siemens Ag | Catheter device comprising a catheter, in particular an intravascular catheter |
WO2006058187A2 (en) * | 2004-11-23 | 2006-06-01 | Robert Eric Betzig | Optical lattice microscopy |
WO2006102167A2 (en) | 2005-03-18 | 2006-09-28 | Stanford University | Compounds for tissue imaging and methods of use thereof |
US8227621B2 (en) | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
EP1760467A1 (en) | 2005-09-02 | 2007-03-07 | Schering AG | Optically fluorescent nanoparticles |
US20070135803A1 (en) | 2005-09-14 | 2007-06-14 | Amir Belson | Methods and apparatus for performing transluminal and other procedures |
WO2007047690A1 (en) * | 2005-10-14 | 2007-04-26 | The General Hospital Corporation | Spectral- and frequency- encoded fluorescence imaging |
US20070223006A1 (en) * | 2006-01-19 | 2007-09-27 | The General Hospital Corporation | Systems and methods for performing rapid fluorescence lifetime, excitation and emission spectral measurements |
US20080038686A1 (en) * | 2006-04-18 | 2008-02-14 | Shigemi Nagai | Methods and kits for early stage caries detection |
US8554035B2 (en) * | 2006-10-26 | 2013-10-08 | Cornell Research Foundation, Inc. | Production of optical pulses at a desired wavelength using soliton self-frequency shift in higher-order-mode fiber |
-
2007
- 2007-10-24 WO PCT/US2007/082386 patent/WO2008060833A2/en active Application Filing
- 2007-10-24 US US11/923,282 patent/US8155730B2/en active Active
-
2012
- 2012-04-09 US US13/442,407 patent/US9357924B2/en active Active
-
2016
- 2016-05-19 US US15/159,376 patent/US9636424B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5865738A (en) * | 1993-12-10 | 1999-02-02 | Regents Of The University Of California | Tissue viability monitor |
Also Published As
Publication number | Publication date |
---|---|
US9636424B2 (en) | 2017-05-02 |
US8155730B2 (en) | 2012-04-10 |
US20160256576A1 (en) | 2016-09-08 |
US9357924B2 (en) | 2016-06-07 |
WO2008060833A2 (en) | 2008-05-22 |
US20120196893A1 (en) | 2012-08-02 |
US20080097222A1 (en) | 2008-04-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2008060833A3 (en) | Composition, method, system, and kit for optical electrophysiology | |
ES2530843T3 (en) | MicroRNA based methods for the diagnosis of pancreatic cancer | |
EP3501384A3 (en) | Method for fluorescence-based imaging and monitoring | |
WO2012021015A3 (en) | Method for simultaneously detecting fluorescence and raman signals for multiple fluorescence and raman signal targets, and medical imaging device for simultaneously detecting multiple targets using the method | |
WO2007002323A3 (en) | System and method for monitoring of end organ oxygenation by measurement of in vivo cellular energy status | |
WO2010120942A3 (en) | Histone modification patterns for clinical diagnosis and prognosis of cancer | |
WO2010083204A3 (en) | Noninvasive measurement of flavonoid compounds in biological tissue | |
WO2006119431A3 (en) | Electromagnetic characterization of tissue | |
WO2013009655A3 (en) | Uses of labeled hsp90 inhibitors | |
WO2007087315A3 (en) | Method and system for combined raman and libs detection | |
BRPI0915240A2 (en) | method for treating cancer, method for evaluating a patient undergoing cancer treatment, method for evaluating a patient who has or suspected cancer and using an anti-c-met antibody | |
NZ596163A (en) | Diagnostic devices and related methods | |
AR057323A1 (en) | METHOD FOR PREDICTION OF THE RESPONSE TO A TREATMENT | |
CL2008002089A1 (en) | Compound for regeneration of tissues comprising at least one substance derived from blood and hyaluronic acid and / or at least one compound derived from hyaluronic acid; method for the preparation of said compound. | |
WO2010031056A3 (en) | Methods and compositions for modulating ire1, src, and abl activity | |
WO2010015607A3 (en) | Method of evaluating oral cancer risk in human | |
BR112012014925A2 (en) | beta cell replication promoting compounds and methods of using them | |
BRPI0912927A2 (en) | "Method of detecting a vegf independent tumor in an individual and method of treating a vegf independent tumor in an individual" | |
HK1133295A1 (en) | Use of protein s100a12 as a marker for colorectal cancer s100a12 | |
WO2013140350A3 (en) | Method and apparatus for characterising samples by measuring light scattering and fluorescence | |
WO2008034968A3 (en) | Method for the quantitative measurement of biomolecular targets deposited on a biochip, and device for implementing it | |
WO2008117027A3 (en) | Altered mitochondrial activity in diseases resulting from oxidative stress | |
WO2006066917A3 (en) | Use of asc as a marker for colorectal cancer | |
WO2011008814A3 (en) | Multiplexed measurement of exogenous and endogenous dna | |
FR2897940B1 (en) | METHOD FOR COLORING TISSUE BY FLUORESCENCE |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07868564 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07868564 Country of ref document: EP Kind code of ref document: A2 |