WO2008060788A3 - Compositions, methods, and devices for treating liver disease - Google Patents
Compositions, methods, and devices for treating liver disease Download PDFInfo
- Publication number
- WO2008060788A3 WO2008060788A3 PCT/US2007/081142 US2007081142W WO2008060788A3 WO 2008060788 A3 WO2008060788 A3 WO 2008060788A3 US 2007081142 W US2007081142 W US 2007081142W WO 2008060788 A3 WO2008060788 A3 WO 2008060788A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- liver disease
- compositions
- methods
- devices
- treating liver
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
- A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3687—Chemical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3687—Chemical treatment
- A61M1/3689—Chemical treatment by biological cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5067—Liver cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1352—Mesenchymal stem cells
- C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
- G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Vascular Medicine (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Anesthesiology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
Abstract
Described are compositions and methods for treating liver disease, e.g., acute liver disease, using bone marrow-derived stem cells and bone marrow-derived stem cell conditioned media.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07868423A EP2076116A4 (en) | 2006-10-11 | 2007-10-11 | Compositions, methods, and devices for treating liver disease |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85077806P | 2006-10-11 | 2006-10-11 | |
US60/850,778 | 2006-10-11 | ||
US85123406P | 2006-10-12 | 2006-10-12 | |
US60/851,234 | 2006-10-12 | ||
US92313807P | 2007-04-12 | 2007-04-12 | |
US60/923,138 | 2007-04-12 | ||
US99531607P | 2007-09-26 | 2007-09-26 | |
US60/995,316 | 2007-09-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008060788A2 WO2008060788A2 (en) | 2008-05-22 |
WO2008060788A3 true WO2008060788A3 (en) | 2008-12-04 |
Family
ID=39402354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/081142 WO2008060788A2 (en) | 2006-10-11 | 2007-10-11 | Compositions, methods, and devices for treating liver disease |
Country Status (7)
Country | Link |
---|---|
US (3) | US8172784B2 (en) |
EP (2) | EP2076116A4 (en) |
DK (1) | DK2578081T3 (en) |
ES (1) | ES2583371T3 (en) |
PL (1) | PL2578081T3 (en) |
PT (1) | PT2578081E (en) |
WO (1) | WO2008060788A2 (en) |
Families Citing this family (30)
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GB0329449D0 (en) * | 2003-12-19 | 2004-01-28 | Omnicyte Ltd | Stem cells |
US8172784B2 (en) | 2006-10-11 | 2012-05-08 | The General Hospital Corporation | Compositions, methods, and devices for treating liver disease |
US20110190680A1 (en) | 2008-09-29 | 2011-08-04 | Yoram Vodovotz | Self-Regulating Device for Modulating Inflammation |
GB0818725D0 (en) * | 2008-10-13 | 2008-11-19 | Habib Nagy A | Pharmaceutical composition |
WO2011156338A2 (en) | 2010-06-07 | 2011-12-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods for modeling hepatic inflammation |
CN102641297B (en) * | 2011-02-21 | 2016-02-24 | 杨子江 | Preparation of the ischemic disease that treatment Peripheral atherosclerosis causes and preparation method thereof |
CN102641292B (en) * | 2011-02-21 | 2015-11-25 | 杨子江 | Preparation of short blood vessel and perienchyma's reparation or regeneration and preparation method thereof |
CN102641293B (en) * | 2011-02-21 | 2016-02-24 | 杨子江 | Preparation being used for the treatment of ischemic cerebrovascular and preparation method thereof |
ES2629502T3 (en) | 2011-03-11 | 2017-08-10 | Children's Medical Center Corporation | Methods and compositions related to mesenchymal stem cell exosomes |
EP2508607A1 (en) * | 2011-04-07 | 2012-10-10 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for liver regeneration and for treatment of liver failure |
ES2526816B1 (en) * | 2013-06-14 | 2015-10-27 | Fundación Pública Andaluza Progreso Y Salud | Compositions for the treatment of liver damage |
DK3016665T3 (en) | 2013-07-05 | 2019-11-25 | Univ Catholique Louvain | CONDITIONED MEDIUM FROM HUMAN ADULT LIVER STEM CELLS AND ITS USE IN THE TREATMENT OF HEALTH DISEASES |
AU2015264519B2 (en) | 2014-05-18 | 2021-01-28 | Children's Medical Center Corporation | Methods and compositions relating to exosomes |
ES2573354B1 (en) * | 2014-11-06 | 2017-03-24 | Servicio Andaluz De Salud | Lysenchymal stem cell lysates for the treatment of skeletal muscle lesions |
EP3277297B1 (en) * | 2015-04-01 | 2021-07-28 | SanBio, Inc. | Methods and compositions for stimulation of cell proliferation and provision of biologically active mixtures of fgf2 isoforms |
US11291689B2 (en) | 2015-06-03 | 2022-04-05 | Aelan Cell Technologies, Inc. | Methods and devices for the production and delivery of beneficial factors from adipose-derived stem cells |
US20180185446A1 (en) * | 2015-06-15 | 2018-07-05 | Vital Therapies, Inc. | Composition and method for inducing anti-apoptosis, survival or proliferation of a cell |
US20180220642A1 (en) * | 2015-07-29 | 2018-08-09 | Indiana University Research And Technology Corporation | Materials and methods for treating and evaluating ischemic and/or reperfusion-injured tissue and/or tissue susceptible to same |
US10328122B2 (en) * | 2015-09-15 | 2019-06-25 | Zhejiang University | Method of treating fulminant hepatic failure using DLL4 cytokine |
CN117496638A (en) | 2016-08-02 | 2024-02-02 | 天使集团股份有限公司 | Inspection system and management system |
US20190350192A1 (en) * | 2016-10-28 | 2019-11-21 | Vital Therapies, Inc. | Use of conditioned media from extracorporeal blood detoxifying system to supplement organ perfusion solutions |
JP6950887B2 (en) * | 2017-04-28 | 2021-10-13 | 米満 吉和 | Extracorporeal artificial liver and equipment for extracorporeal artificial liver or hepatocyte culture |
GB2568928B (en) * | 2017-12-01 | 2023-03-08 | Young Cell Biomedical Tech Inc | Neuroprotective composition, preparation process thereof and medical uses thereof |
GB2618001B (en) * | 2018-02-20 | 2024-01-31 | Emulate Inc | Human microphysiological cell system for liver disease |
JP2022512953A (en) * | 2018-11-09 | 2022-02-07 | フィジーン、エルエルシー | Means and methods to prevent or reverse aging |
AU2020388572A1 (en) * | 2019-11-20 | 2022-05-26 | Alkahest, Inc. | Blood plasma fractions for use in liver regeneration |
EP4036221A1 (en) * | 2021-01-29 | 2022-08-03 | Baer, Hans Ulrich | Method for stimulating cell growth and proliferation of cells of interest, and method for preparing a liver or pancreas implant |
CN113016778A (en) * | 2021-02-08 | 2021-06-25 | 广东乾晖生物科技有限公司 | Isolated organ perfusion preservation system based on mesenchymal stem cells |
CN113082337A (en) * | 2021-02-23 | 2021-07-09 | 广东乾晖生物科技有限公司 | Biological artificial liver support system based on placenta mesenchymal stem cell bioreactor |
CN115725708A (en) * | 2021-08-30 | 2023-03-03 | 四川大学 | Method for detecting nucleotide by using biological Hermite |
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US8172784B2 (en) | 2006-10-11 | 2012-05-08 | The General Hospital Corporation | Compositions, methods, and devices for treating liver disease |
-
2007
- 2007-10-11 US US11/871,071 patent/US8172784B2/en active Active
- 2007-10-11 WO PCT/US2007/081142 patent/WO2008060788A2/en active Application Filing
- 2007-10-11 EP EP07868423A patent/EP2076116A4/en not_active Withdrawn
- 2007-10-11 PL PL12176014.4T patent/PL2578081T3/en unknown
- 2007-10-11 EP EP12176014.4A patent/EP2578081B1/en active Active
- 2007-10-11 DK DK12176014.4T patent/DK2578081T3/en active
- 2007-10-11 ES ES12176014.4T patent/ES2583371T3/en active Active
- 2007-10-11 PT PT121760144T patent/PT2578081E/en unknown
-
2012
- 2012-04-30 US US13/460,315 patent/US20120225130A1/en not_active Abandoned
-
2015
- 2015-12-11 US US14/967,028 patent/US10363276B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5605835A (en) * | 1988-05-23 | 1997-02-25 | Regents Of The University Of Minnesota | Bioreactor device with application as a bioartificial liver |
Non-Patent Citations (2)
Title |
---|
QIHAO ET AL.: "Spheroid Formation and Differentiation into Hepatocyte-Like Cells of Rat Mesenchymal Stem Cell Induced by Co-Culture with Liver Cells", DNA AND CELL BIOLOGY, vol. 26, no. 7, 2007, pages 497 - 503, XP008109874 * |
TAKEDA ET AL.: "Availability of Bone Marrow Stromal Cells in Three-Dimensional Coculture with Hepatocyte and Transplantation into Liver-Damaged Mice", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 100, no. 1, 2005, pages 77 - 81, XP005046482 * |
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EP2578081A3 (en) | 2013-04-24 |
EP2076116A4 (en) | 2010-04-07 |
EP2578081A2 (en) | 2013-04-10 |
PL2578081T4 (en) | 2016-09-30 |
US20120225130A1 (en) | 2012-09-06 |
DK2578081T3 (en) | 2016-06-27 |
US20080145442A1 (en) | 2008-06-19 |
WO2008060788A2 (en) | 2008-05-22 |
PL2578081T3 (en) | 2016-09-30 |
PT2578081E (en) | 2016-06-17 |
ES2583371T3 (en) | 2016-09-20 |
US20160331784A1 (en) | 2016-11-17 |
EP2578081B1 (en) | 2016-03-09 |
US10363276B2 (en) | 2019-07-30 |
EP2076116A2 (en) | 2009-07-08 |
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