WO2008060607A3 - Methods and compositions for monitoring and risk prediction in cardiorenal syndrome - Google Patents
Methods and compositions for monitoring and risk prediction in cardiorenal syndrome Download PDFInfo
- Publication number
- WO2008060607A3 WO2008060607A3 PCT/US2007/024033 US2007024033W WO2008060607A3 WO 2008060607 A3 WO2008060607 A3 WO 2008060607A3 US 2007024033 W US2007024033 W US 2007024033W WO 2008060607 A3 WO2008060607 A3 WO 2008060607A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- compositions
- monitoring
- cardiorenal syndrome
- risk prediction
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
Abstract
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to monitor cardiorenal syndrome using assays that detect NGAL, preferably together with assays that detect natriuretic peptides such as BNP. Such methods and compositions can provide early indications of a deterioration in cardiorenal syndrome status, including prognosis regarding mortality and worsening renal function.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07870895.5A EP2095107B1 (en) | 2006-11-14 | 2007-11-14 | Methods for risk assignment |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85913706P | 2006-11-14 | 2006-11-14 | |
US60/859,137 | 2006-11-14 | ||
US89134207P | 2007-02-23 | 2007-02-23 | |
US60/891,342 | 2007-02-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008060607A2 WO2008060607A2 (en) | 2008-05-22 |
WO2008060607A3 true WO2008060607A3 (en) | 2008-10-23 |
Family
ID=39402271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/024033 WO2008060607A2 (en) | 2006-11-14 | 2007-11-14 | Methods and compositions for monitoring and risk prediction in cardiorenal syndrome |
Country Status (3)
Country | Link |
---|---|
US (5) | US7842472B2 (en) |
EP (2) | EP2500723B1 (en) |
WO (1) | WO2008060607A2 (en) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6991907B1 (en) | 1995-04-18 | 2006-01-31 | Biosite, Inc. | Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays |
US6627404B1 (en) * | 1995-04-18 | 2003-09-30 | Biosite, Inc. | Methods for improving the recovery of troponin I and T in membranes, filters and vessels |
US7524635B2 (en) * | 2003-04-17 | 2009-04-28 | Biosite Incorporated | Methods and compositions for measuring natriuretic peptides and uses thereof |
US7632647B2 (en) * | 2001-04-13 | 2009-12-15 | Biosite Incorporated | Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes |
US7300494B2 (en) * | 2005-02-24 | 2007-11-27 | Hamilton Sundstrand Corporation | On-board inert gas generation system with compressor surge protection |
WO2007028070A2 (en) * | 2005-08-30 | 2007-03-08 | Biosite, Inc. | Use of soluble flt-1 and its fragments in cardiovascular conditions |
EP2500723B1 (en) | 2006-11-14 | 2015-07-08 | Alere San Diego, Inc. | Methods for monitoring and risk prediction in cardiorenal syndrome |
US8524462B2 (en) | 2006-11-14 | 2013-09-03 | Alere San Diego, Inc. | Methods and compositions for diagnosis and prognosis of renal artery stenosis |
EP2115477B1 (en) | 2007-01-25 | 2015-06-24 | Roche Diagnostics GmbH | Use of igfbp-7 in the assessment of heart failure |
US8030097B2 (en) * | 2008-04-30 | 2011-10-04 | Versitech Limited and R & C Biogenius Limited | Lipocalin-2 as a prognostic and diagnostic marker for heart and stroke risks |
US8383351B2 (en) * | 2008-06-11 | 2013-02-26 | Oxford Brookes University | Antibody to inhibin/ activin β-B subunit |
EP2743702B1 (en) | 2008-08-28 | 2017-08-09 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
CN105021826A (en) | 2008-08-29 | 2015-11-04 | 阿斯图特医药公司 | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
EP2347260A4 (en) * | 2008-10-21 | 2012-09-26 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
EP3246707B1 (en) * | 2008-10-21 | 2020-09-30 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
US20110257140A1 (en) * | 2008-10-24 | 2011-10-20 | Inserm (Institut National De La Sante Et De La Rec Herche Medicale) | Biomarkers of Mineralocorticoid Receptor Activation |
EP2913676A1 (en) | 2008-11-10 | 2015-09-02 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
NZ592552A (en) * | 2008-11-22 | 2013-12-20 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
US20120021444A1 (en) * | 2008-12-18 | 2012-01-26 | Eidia Co., Ltd. | Method for diagnosis of cystic fibrosis using kl-6 levels |
NZ601575A (en) * | 2009-02-06 | 2014-08-29 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and failure |
US9229010B2 (en) | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
JP5981144B2 (en) * | 2009-02-06 | 2016-08-31 | アスチュート メディカル,インコーポレイテッド | Diagnosis and prognosis of kidney damage and renal failure |
BRPI1007917A2 (en) * | 2009-02-06 | 2019-09-24 | Astute Medical Inc | method for assessing renal status in an individual, and use of one or more markers of renal injury |
EP2425255A1 (en) * | 2009-04-30 | 2012-03-07 | Roche Diagnostics GmbH | Means and methods for diagnosing a heart failure associated kidney damage in individuals in need of a suitable therapy |
WO2010125161A1 (en) * | 2009-04-30 | 2010-11-04 | Roche Diagnostics Gmbh | Means and methods for the differentiation of cardiac and diabetes mellitus-based causes of kidney damage |
EP2462440B1 (en) | 2009-08-07 | 2017-05-17 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
CN102576012B (en) * | 2009-09-18 | 2015-07-15 | 阿斯图特医药公司 | Methods and composition for diagnosis and prognosis of renal injury and renal failure |
NZ599105A (en) * | 2009-09-21 | 2014-08-29 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
WO2011053832A1 (en) * | 2009-10-29 | 2011-05-05 | The Trustees Of Columbia University In The City Of New York | Use of urinary ngal to diagnose sepsis in very low birth weight infants |
EA201290195A1 (en) * | 2009-11-07 | 2012-12-28 | Астьют Медикал, Инк. | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PREDICTION OF KIDNEY DAMAGE AND RENAL FAILURE |
MX340078B (en) | 2009-11-07 | 2016-06-24 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure. |
JP5728488B2 (en) * | 2009-11-13 | 2015-06-03 | ビージー メディシン, インコーポレイテッド | Risk factors and prediction of myocardial infarction |
EP3246708A3 (en) * | 2009-12-18 | 2018-01-03 | Roche Diagnostics GmbH | Troponins for predicting kidney failure in heart surgery patients |
NZ600828A (en) | 2009-12-20 | 2014-09-26 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
SI2666872T1 (en) | 2010-02-05 | 2016-08-31 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
AU2011220413B2 (en) | 2010-02-26 | 2015-07-23 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
AU2011269847A1 (en) | 2010-02-26 | 2013-01-31 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
EP2576587B1 (en) | 2010-05-24 | 2018-03-21 | The Trustees of Columbia University in the City of New York | Mutant ngal proteins and uses thereof |
WO2011162821A1 (en) | 2010-06-23 | 2011-12-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
DE102010047583A1 (en) * | 2010-10-07 | 2012-04-12 | Justus-Liebig-Universität Giessen | Diagnosis of specific cardiovascular diseases, comprises determining the concentration of metabolites of B-type natriuretic peptide (BNP)1-32 in a sample of an individual to be examined |
US8486717B2 (en) | 2011-01-18 | 2013-07-16 | Symbolics, Llc | Lateral flow assays using two dimensional features |
WO2013009573A1 (en) * | 2011-07-09 | 2013-01-17 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
US9988687B2 (en) | 2011-09-20 | 2018-06-05 | The George Washington Univeristy | Companion diagnostics for cancer and screening methods to identify companion diagnostics for cancer based on splicing variants |
EP3282257A1 (en) * | 2011-11-22 | 2018-02-14 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
WO2013086359A1 (en) | 2011-12-08 | 2013-06-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
US9874556B2 (en) | 2012-07-18 | 2018-01-23 | Symbolics, Llc | Lateral flow assays using two dimensional features |
EP2925337B1 (en) | 2012-11-21 | 2019-07-03 | The Trustees of Columbia University in the City of New York | Mutant ngal proteins and uses thereof |
WO2014113558A1 (en) | 2013-01-17 | 2014-07-24 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
US20160116472A1 (en) * | 2013-02-04 | 2016-04-28 | The General Hospital Corporation | Biomarkers for stroke diagnosis |
US20160003850A1 (en) * | 2013-02-26 | 2016-01-07 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
CN108051590B (en) | 2013-09-13 | 2020-12-11 | Symbolics有限责任公司 | Lateral flow assay using two-dimensional test and control signal readout modes |
CA2936805C (en) | 2014-01-17 | 2024-02-20 | Minomic International Ltd. | Cell surface prostate cancer antigen for diagnosis |
US11243217B2 (en) | 2016-06-06 | 2022-02-08 | Astute Medical, Inc. | Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 |
EP3577458A4 (en) | 2017-02-06 | 2021-04-07 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
CN106950381B (en) * | 2017-03-21 | 2018-10-09 | 中国人民解放军第四五八医院 | A kind of kit of joint-detection acute myocardial infarction AMI biomarker |
AU2018276361A1 (en) * | 2017-05-30 | 2019-12-05 | Sphingotec Gmbh | A method for diagnosing or monitoring kidney function or diagnosing kidney dysfunction |
WO2019053124A1 (en) * | 2017-09-13 | 2019-03-21 | B.R.A.H.M.S Gmbh | Proadrenomedullin as indicator for renal replacement therapy in critically ill patients |
MX2021003435A (en) | 2018-09-28 | 2021-06-15 | Massachusetts Inst Technology | Collagen-localized immunomodulatory molecules and methods thereof. |
CN112348166A (en) * | 2020-09-25 | 2021-02-09 | 四川大学华西医院 | Method for screening sarcopenia based on serum creatinine and cystatin C prediction muscle strength decline |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004088276A2 (en) * | 2003-03-27 | 2004-10-14 | Children's Hospital Medical Center | A method and kit for detecting the early onset of renal tubular cell injury |
WO2005121788A2 (en) * | 2004-06-07 | 2005-12-22 | Children's Hospital Medical Center | Method for the early detection of renal disease and injury |
WO2006066587A1 (en) * | 2004-12-20 | 2006-06-29 | Antibodyshop A/S | Determination of neutrophil gelatinase-associated lipocalin (ngal) as a diagnostic marker for renal disorders |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4900662A (en) * | 1987-07-21 | 1990-02-13 | International Immunoassay Laboratories, Inc. | CK-MM myocardial infarction immunoassay |
US5382522A (en) * | 1987-07-21 | 1995-01-17 | International Immunoassay Laboratories, Inc. | Immunoassay for creatine kinase-MB and creatine kinase-BB isoforms and reagents |
US5382515A (en) * | 1987-07-21 | 1995-01-17 | International Immunoassay Laboratories, Inc. | Creative kinase-MB immunoassay for myocardial infarction and reagents |
US5453359A (en) * | 1988-06-13 | 1995-09-26 | American Biogenetic Sciences, Inc. | Immunoassay and kit for in vitro detection of soluble DesAABB fibrin polymers |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5939272A (en) | 1989-01-10 | 1999-08-17 | Biosite Diagnostics Incorporated | Non-competitive threshold ligand-receptor assays |
US5028535A (en) * | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
US5922615A (en) | 1990-03-12 | 1999-07-13 | Biosite Diagnostics Incorporated | Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network |
WO1992005282A1 (en) | 1990-09-14 | 1992-04-02 | Biosite Diagnostics, Inc. | Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays |
US5955377A (en) | 1991-02-11 | 1999-09-21 | Biostar, Inc. | Methods and kits for the amplification of thin film based assays |
ATE177841T1 (en) | 1991-04-10 | 1999-04-15 | Biosite Diagnostics Inc | CROSSTALK OR CROSSTALK INHIBITORS AND THEIR USE |
AU1911592A (en) | 1991-04-10 | 1992-11-17 | Biosite Diagnostics Incorporated | Novel conjugates and assays for simultaneous detection of multiple ligands |
US6156270A (en) | 1992-05-21 | 2000-12-05 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
US6019944A (en) | 1992-05-21 | 2000-02-01 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
US5458852A (en) | 1992-05-21 | 1995-10-17 | Biosite Diagnostics, Inc. | Diagnostic devices for the controlled movement of reagents without membranes |
US6143576A (en) | 1992-05-21 | 2000-11-07 | Biosite Diagnostics, Inc. | Non-porous diagnostic devices for the controlled movement of reagents |
US5494829A (en) | 1992-07-31 | 1996-02-27 | Biostar, Inc. | Devices and methods for detection of an analyte based upon light interference |
US6238931B1 (en) | 1993-09-24 | 2001-05-29 | Biosite Diagnostics, Inc. | Fluorescence energy transfer in particles |
US6251687B1 (en) * | 1993-09-24 | 2001-06-26 | Biosite Diagnostics, Inc. | Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds |
US5824799A (en) | 1993-09-24 | 1998-10-20 | Biosite Diagnostics Incorporated | Hybrid phthalocyanine derivatives and their uses |
DE4343479A1 (en) | 1993-12-21 | 1995-06-22 | Boehringer Mannheim Gmbh | Acylated protein aggregates and their use in the suppression of immunoassays |
AU2365895A (en) | 1994-04-26 | 1995-11-16 | Regents Of The University Of Michigan, The | Unitary sandwich enzyme immunoassay cassette, device and method of use |
US6627404B1 (en) | 1995-04-18 | 2003-09-30 | Biosite, Inc. | Methods for improving the recovery of troponin I and T in membranes, filters and vessels |
US5795725A (en) * | 1995-04-18 | 1998-08-18 | Biosite Diagnostics Incorporated | Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays |
US6991907B1 (en) | 1995-04-18 | 2006-01-31 | Biosite, Inc. | Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays |
US6174686B1 (en) * | 1995-04-18 | 2001-01-16 | Biosite Diagnostics, Inc. | Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays |
US5768163A (en) | 1996-04-15 | 1998-06-16 | Hewlett-Packard | Versatile attachment of handheld devices to a host computing system |
GB9608510D0 (en) | 1996-04-25 | 1996-07-03 | Medical Res Council | Calcium dependent binding ligands |
US6391265B1 (en) | 1996-08-26 | 2002-05-21 | Biosite Diagnostics, Inc. | Devices incorporating filters for filtering fluid samples |
US6113855A (en) | 1996-11-15 | 2000-09-05 | Biosite Diagnostics, Inc. | Devices comprising multiple capillarity inducing surfaces |
US6156521A (en) * | 1997-12-19 | 2000-12-05 | Biosite Diagnostics, Inc. | Methods for the recovery and measurement of troponin complexes |
US5947124A (en) * | 1997-03-11 | 1999-09-07 | Biosite Diagnostics Incorporated | Diagnostic for determining the time of a heart attack |
US6057098A (en) * | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
US20040176914A1 (en) * | 2001-04-13 | 2004-09-09 | Biosite Incorporated | Methods and compositions for measuring biologically active natriuretic peptides and for improving their therapeutic potential |
US20030199000A1 (en) * | 2001-08-20 | 2003-10-23 | Valkirs Gunars E. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
US20040121350A1 (en) * | 2002-12-24 | 2004-06-24 | Biosite Incorporated | System and method for identifying a panel of indicators |
US7524635B2 (en) | 2003-04-17 | 2009-04-28 | Biosite Incorporated | Methods and compositions for measuring natriuretic peptides and uses thereof |
US7632647B2 (en) * | 2001-04-13 | 2009-12-15 | Biosite Incorporated | Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes |
US20040203083A1 (en) * | 2001-04-13 | 2004-10-14 | Biosite, Inc. | Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases |
US20040126767A1 (en) * | 2002-12-27 | 2004-07-01 | Biosite Incorporated | Method and system for disease detection using marker combinations |
US20030219734A1 (en) * | 2001-04-13 | 2003-11-27 | Biosite Incorporated | Polypeptides related to natriuretic peptides and methods of their identification and use |
US20040253637A1 (en) * | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
EP1666881B1 (en) * | 2001-05-04 | 2010-02-17 | Biosite Incorporated | Diagnostic markers of acute coronary syndromes and methods of use thereof |
JP2005522669A (en) * | 2001-08-20 | 2005-07-28 | バイオサイト インコーポレイテッド | Diagnostic markers for stroke and brain injury and methods of use thereof |
US20040209307A1 (en) * | 2001-08-20 | 2004-10-21 | Biosite Incorporated | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
US7608406B2 (en) * | 2001-08-20 | 2009-10-27 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
US20040219509A1 (en) * | 2001-08-20 | 2004-11-04 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
CA2511501A1 (en) | 2002-12-24 | 2004-07-15 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
WO2004058055A2 (en) | 2002-12-24 | 2004-07-15 | Biosite Incorporated | Method and system for disease detection using marker combinations |
JP2006527190A (en) * | 2003-04-17 | 2006-11-30 | サイファージェン バイオシステムズ インコーポレイテッド | Polypeptides related to natriuretic peptides and their identification and use |
GB0329288D0 (en) | 2003-12-18 | 2004-01-21 | Inverness Medical Switzerland | Monitoring method and apparatus |
WO2005107793A2 (en) * | 2004-05-06 | 2005-11-17 | The Trustees Of Columbia University | Ngal for reduction and amelioration of ischemic and nephrotoxic injuries |
US20060105419A1 (en) * | 2004-08-16 | 2006-05-18 | Biosite, Inc. | Use of a glutathione peroxidase 1 as a marker in cardiovascular conditions |
US20060051825A1 (en) * | 2004-09-09 | 2006-03-09 | Buechler Kenneth F | Methods and compositions for measuring canine BNP and uses thereof |
US20070092911A1 (en) * | 2005-10-03 | 2007-04-26 | Buechler Kenneth F | Methods and compositions for diagnosis and /or prognosis in systemic inflammatory response syndromes |
US20080050832A1 (en) * | 2004-12-23 | 2008-02-28 | Buechler Kenneth F | Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes |
US7879979B2 (en) * | 2005-01-21 | 2011-02-01 | Alere International | Arginine analogs, and methods for their synthesis and use |
US20070087387A1 (en) * | 2005-04-21 | 2007-04-19 | Prasad Devarajan | Method for the Early Detection of Renal Disease Using Proteomics |
US20070269836A1 (en) * | 2005-06-09 | 2007-11-22 | Mcpherson Paul H | Methods and compositions for the diagnosis of venous thromboembolic disease |
WO2007028070A2 (en) * | 2005-08-30 | 2007-03-08 | Biosite, Inc. | Use of soluble flt-1 and its fragments in cardiovascular conditions |
EP2005168A4 (en) * | 2006-03-09 | 2009-05-20 | Biosite Inc | Methods and compositions for the diagnosis of diseases of the aorta |
US20080118924A1 (en) * | 2006-05-26 | 2008-05-22 | Buechler Kenneth F | Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases |
EP2500723B1 (en) | 2006-11-14 | 2015-07-08 | Alere San Diego, Inc. | Methods for monitoring and risk prediction in cardiorenal syndrome |
US8524462B2 (en) * | 2006-11-14 | 2013-09-03 | Alere San Diego, Inc. | Methods and compositions for diagnosis and prognosis of renal artery stenosis |
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2007
- 2007-11-14 EP EP12172006.4A patent/EP2500723B1/en active Active
- 2007-11-14 US US11/940,111 patent/US7842472B2/en active Active
- 2007-11-14 EP EP07870895.5A patent/EP2095107B1/en active Active
- 2007-11-14 WO PCT/US2007/024033 patent/WO2008060607A2/en active Application Filing
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2010
- 2010-10-21 US US12/909,654 patent/US7985560B2/en active Active
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2011
- 2011-06-02 US US13/152,009 patent/US8283128B2/en active Active
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2012
- 2012-07-03 US US13/541,232 patent/US20130122527A1/en not_active Abandoned
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2014
- 2014-03-04 US US14/196,346 patent/US8969018B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004088276A2 (en) * | 2003-03-27 | 2004-10-14 | Children's Hospital Medical Center | A method and kit for detecting the early onset of renal tubular cell injury |
WO2005121788A2 (en) * | 2004-06-07 | 2005-12-22 | Children's Hospital Medical Center | Method for the early detection of renal disease and injury |
WO2006066587A1 (en) * | 2004-12-20 | 2006-06-29 | Antibodyshop A/S | Determination of neutrophil gelatinase-associated lipocalin (ngal) as a diagnostic marker for renal disorders |
Non-Patent Citations (1)
Title |
---|
See also references of EP2095107A4 * |
Also Published As
Publication number | Publication date |
---|---|
EP2095107A4 (en) | 2011-12-28 |
US7842472B2 (en) | 2010-11-30 |
US20110281280A1 (en) | 2011-11-17 |
US8283128B2 (en) | 2012-10-09 |
US7985560B2 (en) | 2011-07-26 |
US20080254485A1 (en) | 2008-10-16 |
WO2008060607A2 (en) | 2008-05-22 |
EP2095107B1 (en) | 2014-07-02 |
US8969018B2 (en) | 2015-03-03 |
EP2500723A2 (en) | 2012-09-19 |
US20140349868A1 (en) | 2014-11-27 |
US20110104726A1 (en) | 2011-05-05 |
US20130122527A1 (en) | 2013-05-16 |
EP2500723A3 (en) | 2013-03-06 |
EP2500723B1 (en) | 2015-07-08 |
EP2095107A2 (en) | 2009-09-02 |
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