WO2008007277A3 - Detection of analytes in a dual-mediator electrochemical test strip - Google Patents
Detection of analytes in a dual-mediator electrochemical test strip Download PDFInfo
- Publication number
- WO2008007277A3 WO2008007277A3 PCT/IB2007/052474 IB2007052474W WO2008007277A3 WO 2008007277 A3 WO2008007277 A3 WO 2008007277A3 IB 2007052474 W IB2007052474 W IB 2007052474W WO 2008007277 A3 WO2008007277 A3 WO 2008007277A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mediator
- electron transfer
- analytes
- dual
- detection
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 238000000840 electrochemical analysis Methods 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 239000012491 analyte Substances 0.000 abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 239000012992 electron transfer agent Substances 0.000 abstract 2
- 230000027756 respiratory electron transport chain Effects 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/004—Enzyme electrodes mediator-assisted
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
Abstract
Determination of an analyte such as glucose in a sample is done making use of a plurality of electron transfer reagents, for example two electron transfer reagents, that work together to transfer electrons between the enzyme and the electrodes. The first electron transfer agent is a mediator that interacts with the enzyme after it has acted on the analyte to regenerate enzyme in its active form. The second electron transfer agent is a shuttle that interacts with the electrodes and optionally the mediator. The oxidation and reduction of the shuttle serves as the major source of current that is measured as an indication of analyte.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80591806P | 2006-06-27 | 2006-06-27 | |
US60/805,918 | 2006-06-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008007277A2 WO2008007277A2 (en) | 2008-01-17 |
WO2008007277A3 true WO2008007277A3 (en) | 2008-05-15 |
Family
ID=38923632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2007/052474 WO2008007277A2 (en) | 2006-06-27 | 2007-06-26 | Detection of analytes in a dual-mediator electrochemical test strip |
Country Status (2)
Country | Link |
---|---|
US (2) | US8057659B2 (en) |
WO (1) | WO2008007277A2 (en) |
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Also Published As
Publication number | Publication date |
---|---|
US20070295616A1 (en) | 2007-12-27 |
US20110108417A1 (en) | 2011-05-12 |
WO2008007277A2 (en) | 2008-01-17 |
US8057659B2 (en) | 2011-11-15 |
US8207336B2 (en) | 2012-06-26 |
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