WO2007131238A8 - Compounds and methods for modulating expression apob - Google Patents

Compounds and methods for modulating expression apob Download PDF

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Publication number
WO2007131238A8
WO2007131238A8 PCT/US2007/068403 US2007068403W WO2007131238A8 WO 2007131238 A8 WO2007131238 A8 WO 2007131238A8 US 2007068403 W US2007068403 W US 2007068403W WO 2007131238 A8 WO2007131238 A8 WO 2007131238A8
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WO
WIPO (PCT)
Prior art keywords
short antisense
antisense compounds
compounds
reduction
monomers
Prior art date
Application number
PCT/US2007/068403
Other languages
French (fr)
Other versions
WO2007131238A2 (en
WO2007131238A3 (en
Inventor
Sanjay Bhanot
Richard S. Geary
Robert Mckay
Brett P. Monia
Punit P. Seth
Andrew M. Siwkowski
Eric E. Swayze
Edward Wancewicz
Original Assignee
Isis Pharmaceuticals , Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40134111&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007131238(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2007/061183 external-priority patent/WO2007090071A2/en
Application filed by Isis Pharmaceuticals , Inc. filed Critical Isis Pharmaceuticals , Inc.
Priority to EP07811873.4A priority Critical patent/EP2015758B1/en
Priority to DK07811873.4T priority patent/DK2015758T3/en
Priority to JP2009510131A priority patent/JP5825754B2/en
Priority to ES07811873.4T priority patent/ES2471978T3/en
Priority to US12/299,764 priority patent/US8673871B2/en
Publication of WO2007131238A2 publication Critical patent/WO2007131238A2/en
Publication of WO2007131238A3 publication Critical patent/WO2007131238A3/en
Publication of WO2007131238A8 publication Critical patent/WO2007131238A8/en
Priority to US14/216,600 priority patent/US20150057329A1/en

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

Abstract

The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animals with increased potency and improved therapeutic index. Thus, provided herein are short antisense compounds comprising high-affinity nucleotide modifications useful for reducing a target RNA in vivo. Such short antisense compounds are effective at lower doses than previously described antisense compounds, allowing for a reduction in toxicity and cost of treatment. In addition, the described short antisense compounds have greater potential for oral dosing.
PCT/US2007/068403 2006-05-05 2007-05-07 Compounds and methods for modulating expression apob WO2007131238A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP07811873.4A EP2015758B1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression apob
DK07811873.4T DK2015758T3 (en) 2006-05-05 2007-05-07 RELATIONS AND PROCEDURES FOR MODULATING APOB EXPRESSION
JP2009510131A JP5825754B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating the expression of APOB
ES07811873.4T ES2471978T3 (en) 2006-05-05 2007-05-07 Compounds and procedures to modulate ApoB expression
US12/299,764 US8673871B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression ApoB
US14/216,600 US20150057329A1 (en) 2006-05-05 2014-03-17 Compounds and methods for modulating expression apob

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US74663106P 2006-05-05 2006-05-05
US60/746,631 2006-05-05
US74705906P 2006-05-11 2006-05-11
US60/747,059 2006-05-11
US80566006P 2006-06-23 2006-06-23
US60/805,660 2006-06-23
US86455406P 2006-11-06 2006-11-06
US60/864,554 2006-11-06
USPCT/US2007/061183 2007-01-27
PCT/US2007/061183 WO2007090071A2 (en) 2006-01-27 2007-01-27 6-modified bicyclic nucleic acid analogs

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/061183 Continuation-In-Part WO2007090071A2 (en) 2006-01-27 2007-01-27 6-modified bicyclic nucleic acid analogs

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/299,764 A-371-Of-International US8673871B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression ApoB
US14/216,600 Continuation US20150057329A1 (en) 2006-05-05 2014-03-17 Compounds and methods for modulating expression apob

Publications (3)

Publication Number Publication Date
WO2007131238A2 WO2007131238A2 (en) 2007-11-15
WO2007131238A3 WO2007131238A3 (en) 2008-07-10
WO2007131238A8 true WO2007131238A8 (en) 2009-12-17

Family

ID=40134111

Family Applications (9)

Application Number Title Priority Date Filing Date
PCT/US2007/068402 WO2007131237A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of ptp1b
PCT/US2007/068408 WO2007143317A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of crp
PCT/US2007/068401 WO2007146511A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
PCT/US2007/068406 WO2007143316A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of sglt2
PCT/US2007/068403 WO2007131238A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression apob
PCT/US2007/068404 WO2007143315A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of pcsk9
PCT/US2007/068415 WO2007136989A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of dgat2
PCT/US2007/068410 WO2007136988A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gccr
PCT/US2007/068412 WO2007134014A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gcgr

Family Applications Before (4)

Application Number Title Priority Date Filing Date
PCT/US2007/068402 WO2007131237A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of ptp1b
PCT/US2007/068408 WO2007143317A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of crp
PCT/US2007/068401 WO2007146511A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
PCT/US2007/068406 WO2007143316A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of sglt2

Family Applications After (4)

Application Number Title Priority Date Filing Date
PCT/US2007/068404 WO2007143315A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of pcsk9
PCT/US2007/068415 WO2007136989A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of dgat2
PCT/US2007/068410 WO2007136988A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gccr
PCT/US2007/068412 WO2007134014A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gcgr

Country Status (16)

Country Link
US (14) US20090326042A1 (en)
EP (10) EP2023940B1 (en)
JP (7) JP5825754B2 (en)
KR (1) KR101441700B1 (en)
CN (1) CN103554205A (en)
AT (2) ATE513912T1 (en)
AU (4) AU2007258117B2 (en)
BR (1) BRPI0711429A2 (en)
CA (3) CA3044969A1 (en)
DK (5) DK2363481T3 (en)
ES (2) ES2471978T3 (en)
HK (1) HK1128418A1 (en)
MX (1) MX2008014100A (en)
NO (1) NO20084738L (en)
PT (1) PT2015758E (en)
WO (9) WO2007131237A2 (en)

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