WO2007125173A3 - Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease - Google Patents
Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease Download PDFInfo
- Publication number
- WO2007125173A3 WO2007125173A3 PCT/FI2007/050231 FI2007050231W WO2007125173A3 WO 2007125173 A3 WO2007125173 A3 WO 2007125173A3 FI 2007050231 W FI2007050231 W FI 2007050231W WO 2007125173 A3 WO2007125173 A3 WO 2007125173A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- modified oligonucleotide
- strongly bound
- antisense agents
- artificial nuclease
- bound base
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/333—Modified A
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/335—Modified T or U
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/336—Modified G
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3511—Conjugate intercalating or cleaving agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0711182-7A BRPI0711182A2 (en) | 2006-05-03 | 2007-04-26 | antisense agents combining tightly bound base-modified oligonucleotide and artificial nuclease |
EP07730718A EP2013344B1 (en) | 2006-05-03 | 2007-04-26 | Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease |
AU2007245599A AU2007245599B2 (en) | 2006-05-03 | 2007-04-26 | Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease |
JP2009508407A JP2009535383A (en) | 2006-05-03 | 2007-04-26 | Antisense agents combining oligonucleotides modified with strongly bound bases and artificial nucleases |
CA002651031A CA2651031A1 (en) | 2006-05-03 | 2007-04-26 | Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease |
MX2008014005A MX2008014005A (en) | 2006-05-03 | 2007-04-26 | Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79744806P | 2006-05-03 | 2006-05-03 | |
US60/797,448 | 2006-05-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007125173A2 WO2007125173A2 (en) | 2007-11-08 |
WO2007125173A3 true WO2007125173A3 (en) | 2008-01-17 |
Family
ID=38542139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FI2007/050231 WO2007125173A2 (en) | 2006-05-03 | 2007-04-26 | Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease |
Country Status (10)
Country | Link |
---|---|
US (2) | US7786292B2 (en) |
EP (1) | EP2013344B1 (en) |
JP (1) | JP2009535383A (en) |
CN (1) | CN101437943A (en) |
AU (1) | AU2007245599B2 (en) |
BR (1) | BRPI0711182A2 (en) |
CA (1) | CA2651031A1 (en) |
MX (1) | MX2008014005A (en) |
WO (1) | WO2007125173A2 (en) |
ZA (1) | ZA200809048B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EE200600004A (en) * | 2006-03-03 | 2007-10-15 | O� Raidenil | Infrared sensitive composite material |
CN101970662A (en) * | 2007-11-05 | 2011-02-09 | 波罗的科技发展有限公司 | Use of oligonucleotides with modified bases as antiviral agents |
CA2704560A1 (en) * | 2007-11-05 | 2009-05-14 | Baltic Technology Development, Ltd. | Use of oligonucleotides with modified bases in hybridization of nucleic acids |
WO2009144365A1 (en) * | 2008-05-30 | 2009-12-03 | Baltic Technology Development, Ltd. | Use of oligonucleotides with modified bases as antiviral agents |
US10260089B2 (en) | 2012-10-29 | 2019-04-16 | The Research Foundation Of The State University Of New York | Compositions and methods for recognition of RNA using triple helical peptide nucleic acids |
EP3265098A4 (en) * | 2015-03-03 | 2019-02-13 | Ionis Pharmaceuticals, Inc. | Compositions for modulating mecp2 expression |
US11129844B2 (en) | 2015-03-03 | 2021-09-28 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating MECP2 expression |
JP2021534101A (en) | 2018-08-09 | 2021-12-09 | ヴェルソー セラピューティクス, インコーポレイテッド | Oligonucleotide compositions for targeting CCR2 and CSF1R and their use |
KR102422293B1 (en) * | 2020-08-24 | 2022-07-18 | 수원대학교산학협력단 | Helix 73-derived RNA molecules interacting with Erm protein and methods of use thereof |
GB202117314D0 (en) | 2021-11-30 | 2022-01-12 | Clarke David John | Cyclic nucleic acid fragmentation |
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CA2651031A1 (en) | 2007-11-08 |
AU2007245599B2 (en) | 2012-05-10 |
JP2009535383A (en) | 2009-10-01 |
EP2013344B1 (en) | 2012-08-29 |
WO2007125173A2 (en) | 2007-11-08 |
MX2008014005A (en) | 2009-01-27 |
EP2013344A2 (en) | 2009-01-14 |
ZA200809048B (en) | 2010-01-27 |
CN101437943A (en) | 2009-05-20 |
US20120171279A1 (en) | 2012-07-05 |
AU2007245599A1 (en) | 2007-11-08 |
US7786292B2 (en) | 2010-08-31 |
US20070259830A1 (en) | 2007-11-08 |
BRPI0711182A2 (en) | 2011-08-23 |
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