WO2007103152A3 - Dry powder inhaler with aeroelastic dispersion mechanism - Google Patents

Dry powder inhaler with aeroelastic dispersion mechanism Download PDF

Info

Publication number
WO2007103152A3
WO2007103152A3 PCT/US2007/005312 US2007005312W WO2007103152A3 WO 2007103152 A3 WO2007103152 A3 WO 2007103152A3 US 2007005312 W US2007005312 W US 2007005312W WO 2007103152 A3 WO2007103152 A3 WO 2007103152A3
Authority
WO
WIPO (PCT)
Prior art keywords
dpi
powder
aeroelastic
dispersion
patient
Prior art date
Application number
PCT/US2007/005312
Other languages
French (fr)
Other versions
WO2007103152A2 (en
Inventor
Hugh Smyth
Charles Randall Truman
Original Assignee
Stc Unm
Hugh Smyth
Charles Randall Truman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stc Unm, Hugh Smyth, Charles Randall Truman filed Critical Stc Unm
Priority to CA2644679A priority Critical patent/CA2644679C/en
Priority to EP07752039A priority patent/EP1993645A4/en
Priority to AU2007224178A priority patent/AU2007224178B2/en
Priority to JP2008558311A priority patent/JP5188991B2/en
Publication of WO2007103152A2 publication Critical patent/WO2007103152A2/en
Publication of WO2007103152A3 publication Critical patent/WO2007103152A3/en
Priority to AU2010257254A priority patent/AU2010257254A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/001—Details of inhalators; Constructional features thereof with means for agitating the medicament using ultrasonic means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8275—Mechanical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/14—Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Abstract

The present invention comprises a dry powder inhaler (DPI) that uses a patient's inhalation flow to concentrate energy in an aeroelastic element for deaggregation and dispersion of a powder dose. The result is a DPI that delivers a dose independent of inspiratory abilities of the patient, solving a major problem of conventional DPIs. Increased tension on the aeroelastic element causes higher frequency vibrations and improved powder dispersion. The tension of the aeroelastic element can be modified prior to dispensing the DPI to the patient, allowing for individualization for single patients or groups of patients. In addition, the DPI has features that increase the turbulence of the airflow as it passes through the device, further increasing the dispersion and deaggregation of the powder. The DPI can hold a single dose or multiple doses. The powder doses can be dispensed directly onto the aeroelastic element, or may be in adjacent blister packaging.
PCT/US2007/005312 2006-03-01 2007-03-01 Dry powder inhaler with aeroelastic dispersion mechanism WO2007103152A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2644679A CA2644679C (en) 2006-03-03 2007-03-01 Dry powder inhaler with aeroelastic dispersion mechanism
EP07752039A EP1993645A4 (en) 2006-03-03 2007-03-01 Dry powder inhaler with aeroelastic dispersion mechanism
AU2007224178A AU2007224178B2 (en) 2006-03-03 2007-03-01 Dry powder inhaler with aeroelastic dispersion mechanism
JP2008558311A JP5188991B2 (en) 2006-03-03 2007-03-01 Dry powder inhaler with aeroelastic distribution mechanism
AU2010257254A AU2010257254A1 (en) 2006-03-01 2010-12-16 Customizing DVR functionality

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77887806P 2006-03-03 2006-03-03
US60/778,878 2006-03-03

Publications (2)

Publication Number Publication Date
WO2007103152A2 WO2007103152A2 (en) 2007-09-13
WO2007103152A3 true WO2007103152A3 (en) 2008-05-02

Family

ID=38475400

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/005312 WO2007103152A2 (en) 2006-03-01 2007-03-01 Dry powder inhaler with aeroelastic dispersion mechanism

Country Status (7)

Country Link
US (1) US20070209661A1 (en)
EP (1) EP1993645A4 (en)
JP (1) JP5188991B2 (en)
CN (1) CN101437562A (en)
AU (1) AU2007224178B2 (en)
CA (1) CA2644679C (en)
WO (1) WO2007103152A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8127763B2 (en) * 2006-03-03 2012-03-06 Stc.Unm Dry powder inhaler with aeroelastic dispersion mechanism
DE102006044756A1 (en) * 2006-09-20 2008-04-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg inhaler
JP5570996B2 (en) 2007-12-14 2014-08-13 エアロデザインズ インコーポレイテッド Delivery of aerosolizable foodstuffs
WO2010008523A1 (en) * 2008-07-13 2010-01-21 Map Pharmaceuticals, Inc. Methods and apparatus for delivering aerosolized medication
US10387621B2 (en) 2009-01-16 2019-08-20 Cerner Innovation, Inc. Matching of vibratory inhalers to patient vocal tract for optimization of particle dispersion
BRPI1009072B1 (en) * 2009-05-18 2021-06-22 Adamis Pharmaceuticals Corporation DEVICE FOR DRY POWDER INHALATION AND DEVICE FOR DRY POWDER STORAGE
EP2498848A2 (en) 2009-11-12 2012-09-19 Stc.Unm Dry powder inhaler with flutter dispersion member
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
EP2654864B1 (en) 2010-12-22 2020-10-28 Syqe Medical Ltd. System for drug delivery
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
PL3160565T3 (en) 2014-06-30 2022-01-10 Syqe Medical Ltd. Devices and systems for pulmonary delivery of active agents
KR20230117250A (en) * 2014-06-30 2023-08-07 사이키 메디컬 엘티디. Drug dose cartridge for an inhaler device
US11298477B2 (en) 2014-06-30 2022-04-12 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
EP3656427A1 (en) 2014-06-30 2020-05-27 Syqe Medical Ltd. Flow regulating inhaler device
RU2690401C2 (en) 2014-06-30 2019-06-03 Сике Медикал Лтд. Method and device for evaporation and inhalation of released substances
AU2015283590B2 (en) 2014-06-30 2020-04-16 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
CN107427650A (en) 2015-01-14 2017-12-01 瑞必治公司 Powder process for dispersing and device
ES2874087T3 (en) 2016-01-06 2021-11-04 Syqe Medical Ltd Low-dose therapeutic treatment
JP2019514528A (en) * 2016-04-29 2019-06-06 ザ トラスティーズ オブ プリンストン ユニバーシティー Method and apparatus for controlled drug vaporization
JP7446309B2 (en) * 2019-01-14 2024-03-08 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム dry powder inhaler
WO2021026733A1 (en) * 2019-08-12 2021-02-18 张江 Inhalation administration device and combined inhalation administration structure

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5860419A (en) * 1990-03-02 1999-01-19 Glaxo Group Limited Inhalation device
US20040094152A1 (en) * 2000-10-31 2004-05-20 Harvey Stephen James Medicament dispenser
US20040244794A1 (en) * 2001-08-09 2004-12-09 Richards David Hugh Inhalation device with a pharmaceutical composition
US20050172962A1 (en) * 2004-02-06 2005-08-11 Microdose Technologies, Inc. Blister pack for use with an inhalation device

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US598286A (en) * 1898-02-01 Inhaler
US376819A (en) * 1888-01-24 Medicinal vapors
US361748A (en) * 1887-04-26 John w
US263451A (en) * 1882-08-29 adams
US2603216A (en) * 1952-07-15 Powder inhaler
US419942A (en) * 1890-01-21 Insufflator
US631621A (en) * 1898-11-16 1899-08-22 James J Curran Inhaler.
US844097A (en) * 1906-08-07 1907-02-12 Yancey Q Caldwell Inhaler.
US1752956A (en) * 1927-04-21 1930-04-01 Karl Zeyen Apparatus for spraying pulverulent material
US2513145A (en) * 1946-11-27 1950-06-27 Charles C Chapple Inhaler
US2470296A (en) * 1948-04-30 1949-05-17 Abbott Lab Inhalator
US2642063A (en) * 1948-07-31 1953-06-16 Frederick M Turnbull Inhaler
US2641255A (en) * 1949-03-31 1953-06-09 Abbott Lab Inhaler
US2517482A (en) * 1949-04-09 1950-08-01 Sharp & Dohme Inc Inhaler
US2549303A (en) * 1949-04-20 1951-04-17 Bristol Lab Inc Inhaler for crystalline pencilllin or the like
US2587215A (en) * 1949-04-27 1952-02-26 Frank P Priestly Inhalator
US2581182A (en) * 1950-03-14 1952-01-01 Abbott Lab Inhaler
GB705404A (en) * 1950-05-19 1954-03-10 A M Bickford & Sons Ltd An inhaler for medicinal substances
US2992645A (en) * 1958-05-06 1961-07-18 Benger Lab Ltd Disperser for powders
GB1182779A (en) * 1966-09-17 1970-03-04 Fisons Pharmaceuticals Ltd Inhalation Device
GB1268051A (en) * 1968-06-07 1972-03-22 Fisons Pharmaceuticals Ltd Inhalation device
IT941426B (en) * 1971-07-17 1973-03-01 Isf Spa SWIRL-CHAMBER INHALER FOR POWDER-SHAPING MEDICINAL SUBSTANCES
US3888253A (en) * 1972-08-04 1975-06-10 Beecham Group Ltd Device for administration of medicines
GB1459426A (en) * 1973-02-26 1976-12-22 Allen & Hanburys Ltd Inhalation devices
GB1387954A (en) * 1973-05-08 1975-03-19 Miles Lab Insufflator
US3888252A (en) * 1974-01-23 1975-06-10 Anthony J Side Powder inhaler
US3971377A (en) * 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
IT1017153B (en) * 1974-07-15 1977-07-20 Isf Spa APPARATUS FOR INHALATIONS
US3964483A (en) * 1975-01-13 1976-06-22 Syntex Puerto Rico, Inc. Inhalation device
GB1518998A (en) * 1975-08-28 1978-07-26 Gillette Co Packaging flowable materials
US4147166A (en) * 1977-05-02 1979-04-03 American Cyanamid Company Oral inhalator powder dispenser
IT1116047B (en) * 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti DEVICE FOR THE QUICK INHALATION OF POWDER DRUGS BY PERSONS SUFFERING FROM ASTHMA
CY1492A (en) * 1981-07-08 1990-02-16 Draco Ab Powder inhalator
US4570630A (en) * 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
PT83094B (en) * 1985-07-30 1993-07-30 Glaxo Group Ltd DEVICES PROPER FOR THE ADMINISTRATION OF MEDICINES TO PATIENTS
JPS62204756A (en) * 1986-03-04 1987-09-09 大研医工株式会社 Drug volatilizing method and apparatus
SE453566B (en) * 1986-03-07 1988-02-15 Draco Ab POWDER INHALATOR DEVICE
GB8909891D0 (en) * 1989-04-28 1989-06-14 Riker Laboratories Inc Device
US5176132A (en) * 1989-05-31 1993-01-05 Fisons Plc Medicament inhalation device and formulation
IT1237118B (en) * 1989-10-27 1993-05-18 Miat Spa MULTI-DOSE INHALER FOR POWDER DRUGS.
US5201308A (en) * 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
SK280967B6 (en) * 1990-03-02 2000-10-09 Glaxo Group Limited Inhalation device
US5615670A (en) * 1990-03-07 1997-04-01 Fisons Plc Powder inhaler with centrifugal force used to meter powder
IL98441A (en) * 1990-06-14 1995-12-31 Rhone Poulenc Rorer Ltd Powder inhalers
US5429122A (en) * 1990-09-26 1995-07-04 Zanen; Pieter Inhaler devices provided with a reservoir for several doses of medium for inhaling, transporting device, whirl chamber
GB9021433D0 (en) * 1990-10-02 1990-11-14 Atomic Energy Authority Uk Power inhaler
GB9024760D0 (en) * 1990-11-14 1991-01-02 Riker Laboratories Inc Inhalation device and medicament carrier
GB9027234D0 (en) * 1990-12-15 1991-02-06 Harris Pharma Ltd An inhalation device
US5186164A (en) * 1991-03-15 1993-02-16 Puthalath Raghuprasad Mist inhaler
US5327883A (en) * 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
CA2112674C (en) * 1991-07-02 2005-10-04 John S. Patton Method and device for delivering aerosolized medicaments
ATE139130T1 (en) * 1991-08-16 1996-06-15 Sandoz Ag INHALER FOR ADMINISTRATION OF POWDERED SUBSTANCES
US5394868A (en) * 1992-06-25 1995-03-07 Schering Corporation Inhalation device for powdered medicaments
US5743250A (en) * 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5372128A (en) * 1993-04-14 1994-12-13 Habley Medical Technology Corporation Fluidizing powder inhaler
SE9302550D0 (en) 1993-07-30 1993-07-30 Ernst Hoerlin POWDER INHALES
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
DE4340768A1 (en) * 1993-11-30 1995-06-01 Bayer Ag Inhalation device
US5415162A (en) * 1994-01-18 1995-05-16 Glaxo Inc. Multi-dose dry powder inhalation device
GB9417399D0 (en) * 1994-08-30 1994-10-19 Scherer Corp R P Ocular treatment device
FR2725626A1 (en) * 1994-10-18 1996-04-19 Sofab DEVICE FOR INHALING POWDERED PRODUCTS
GB9501841D0 (en) * 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
ES2168488T3 (en) * 1995-06-21 2002-06-16 Sofotec Gmbh & Co Kg PHARMACEUTICAL POWDER CARTRIDGE WITH INTEGRATED DOSING DEVICE AND INHALER FOR POWDERED MEDICINES.
SE504458C2 (en) * 1995-06-21 1997-02-17 Lars Gunnar Nilsson Inhalator for electrical dosing of substances
DE19523516C1 (en) * 1995-06-30 1996-10-31 Asta Medica Ag Inhaler for administering medication from blister packs
US6209538B1 (en) * 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
ES2148812T3 (en) * 1995-12-07 2000-10-16 Jago Res Ag INHALER FOR THE ADMINISTRATION OF MULTIPLE DOSE OF A DRY PHARMACOLOGICAL POWDER.
DE69617754T2 (en) * 1996-01-03 2002-08-08 Glaxo Group Ltd inhaler
US6026809A (en) * 1996-01-25 2000-02-22 Microdose Technologies, Inc. Inhalation device
JP3328132B2 (en) * 1996-03-21 2002-09-24 株式会社ユニシアジェックス Inhaler type dispenser
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
US5857456A (en) * 1996-06-10 1999-01-12 Sarnoff Corporation Inhaler apparatus with an electronic means for enhanced release of dry powders
SE9700424D0 (en) * 1997-02-07 1997-02-07 Astra Ab Powder inhales
SE9700937D0 (en) * 1997-03-14 1997-03-14 Astra Ab Powder inhales I
TW469832U (en) * 1997-03-14 2001-12-21 Astra Ab Inhalation device
US6237590B1 (en) * 1997-09-18 2001-05-29 Delsys Pharmaceutical Corporation Dry powder delivery system apparatus
US6237591B1 (en) * 1998-11-02 2001-05-29 Dura Pharmaceuticals, Inc. Turbine dry powder inhaler
SI20363A (en) * 1998-01-30 2001-04-30 Ig Spruehtechnik Gmbh & Co.Kg Inhalation apparatus for powder medications
GB9810126D0 (en) 1998-05-13 1998-07-08 Glaxo Group Ltd
US6257233B1 (en) * 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US6234169B1 (en) * 1998-08-14 2001-05-22 Arthur Slutsky Inhaler
GB9905538D0 (en) * 1999-03-10 1999-05-05 Glaxo Group Ltd A device
BR0017519B8 (en) * 1999-07-23 2021-06-22 Mannkind Corp medicine capsule for an inhaler, and process for manufacturing a capsule comprising a powdered medicine.
US6427688B1 (en) * 2000-02-01 2002-08-06 Dura Pharmaceuticals, Icn. Dry powder inhaler
US7069929B2 (en) * 2000-02-01 2006-07-04 Quadrant Technologies Limited Dry powder inhaler
AU2001283546A1 (en) * 2000-08-14 2002-02-25 Advanced Inhalation Research, Inc. Inhalation device and method
FI20002363A0 (en) * 2000-10-27 2000-10-27 Orion Yhtymae Oyj powder inhaler
US6626173B2 (en) * 2001-01-08 2003-09-30 Iep Pharmaceutical Devices Inc. Dry powder inhaler
JP2005506855A (en) * 2001-05-10 2005-03-10 ベクトゥラ デリバリー デバイシーズ リミテッド Inhaler
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
GB0120018D0 (en) * 2001-08-16 2001-10-10 Meridica Ltd Pack containing medicament and dispensing device
GR1004350B (en) * 2002-03-29 2003-09-26 Inhaler for dry powder
SE524957C2 (en) * 2002-04-12 2004-11-02 Microdrug Ag Method for dividing and distributing in air of dry powder drug
US6889690B2 (en) * 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
US7556035B2 (en) * 2004-05-28 2009-07-07 Quadrant Technologies Limited Unit dose dry powder inhaler
IL175664A0 (en) * 2006-05-16 2006-09-05 Aespira Ltd Dry-powder inhaler
US8127763B2 (en) * 2006-03-03 2012-03-06 Stc.Unm Dry powder inhaler with aeroelastic dispersion mechanism
PT103481B (en) * 2006-05-16 2008-08-01 Hovione Farmaciencia S A INHALER OF SIMPLE USE AND INHALATION METHOD
US20090084379A1 (en) * 2007-10-02 2009-04-02 Baxter International Inc. Dry powder inhaler
FR2933620B1 (en) * 2008-07-11 2010-09-03 Valois Sa INHALATION DEVICE FOR POWDER.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5860419A (en) * 1990-03-02 1999-01-19 Glaxo Group Limited Inhalation device
US20040094152A1 (en) * 2000-10-31 2004-05-20 Harvey Stephen James Medicament dispenser
US20040244794A1 (en) * 2001-08-09 2004-12-09 Richards David Hugh Inhalation device with a pharmaceutical composition
US20050172962A1 (en) * 2004-02-06 2005-08-11 Microdose Technologies, Inc. Blister pack for use with an inhalation device

Also Published As

Publication number Publication date
EP1993645A2 (en) 2008-11-26
EP1993645A4 (en) 2011-05-18
CA2644679A1 (en) 2007-09-13
CN101437562A (en) 2009-05-20
WO2007103152A2 (en) 2007-09-13
CA2644679C (en) 2013-12-03
AU2007224178A1 (en) 2007-09-13
AU2007224178B2 (en) 2013-03-07
JP2009528889A (en) 2009-08-13
US20070209661A1 (en) 2007-09-13
JP5188991B2 (en) 2013-04-24

Similar Documents

Publication Publication Date Title
WO2007103152A3 (en) Dry powder inhaler with aeroelastic dispersion mechanism
JP6586491B2 (en) Inhaler
US20100326438A1 (en) Dry powder inhaler
CA2846899C (en) Dry powder inhalation device
US9283336B2 (en) Delivery device and related methods
WO2007093310A3 (en) Dry powder inhaler device
US8127763B2 (en) Dry powder inhaler with aeroelastic dispersion mechanism
WO2009092434A3 (en) Inhaler
WO2008081327A3 (en) Delivery devices
JP5841429B2 (en) Inhaler with audible indicator means
WO2010086285A3 (en) Inhaler
EG25864A (en) Improvement of a dry powder inhaler
WO2005120615A1 (en) Dry powder inhaler
WO2007042822A2 (en) Unit dose dry powder inhaler
MY160369A (en) A simple capsule-based inhaler
WO2006031775A3 (en) Dry powder inhalers that inhibit agglomeration, related devices and methods
JP7250317B2 (en) drug inhaler
US9492625B2 (en) Dry powder inhaler with flutter dispersion member
US9649454B2 (en) Delivery device and related methods
JP2012505018A (en) Breath-actuated inhaler
US20170274161A1 (en) Spacer device with flow rate spirometer
US20070068524A1 (en) Inhaler for moisture sensitive drugs
US11779715B2 (en) Dry powder medicament inhaler

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2007224178

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2008558311

Country of ref document: JP

Ref document number: 2644679

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2007224178

Country of ref document: AU

Date of ref document: 20070301

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2007752039

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 200780015893.5

Country of ref document: CN

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)