WO2007092735A3 - An extracorporeal cell-based therapeutic device and delivery system - Google Patents

An extracorporeal cell-based therapeutic device and delivery system Download PDF

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Publication number
WO2007092735A3
WO2007092735A3 PCT/US2007/061468 US2007061468W WO2007092735A3 WO 2007092735 A3 WO2007092735 A3 WO 2007092735A3 US 2007061468 W US2007061468 W US 2007061468W WO 2007092735 A3 WO2007092735 A3 WO 2007092735A3
Authority
WO
WIPO (PCT)
Prior art keywords
extracorporeal
blood
cells
disclosed
capsule
Prior art date
Application number
PCT/US2007/061468
Other languages
French (fr)
Other versions
WO2007092735A2 (en
Inventor
H David Humes
Original Assignee
Innovative Bio Therapies
H David Humes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovative Bio Therapies, H David Humes filed Critical Innovative Bio Therapies
Priority to CA002637686A priority Critical patent/CA2637686A1/en
Priority to JP2008553503A priority patent/JP2009525781A/en
Priority to EP07763504.3A priority patent/EP1989144A4/en
Priority to AU2007212110A priority patent/AU2007212110A1/en
Publication of WO2007092735A2 publication Critical patent/WO2007092735A2/en
Publication of WO2007092735A3 publication Critical patent/WO2007092735A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A61M1/3689—Chemical treatment by biological cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
    • A61M1/3655—Arterio-venous shunts or fistulae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/09—Body tissue

Abstract

Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in response to a dynamic physiologic environment. Exemplary designs are disclosed. In a first exemplary embodiment the device includes long hollow fibers in which a layer of cells are grown within the intraluminal volume or within a double hollow-filled chamber. In another exemplary embodiment the device includes a wafer or a series of wafers forms a substrate onto which cells are grown. The wafer(s) are then inserted into a device. The devices are intended to be extracorporeal. Disclosed is a device for delivering a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation. The device may also deliver a member of different cell products. The device comprises an anchoring element that can be anchored to an inner wall of an extracorporeal tube for blood. The device also comprises a capsule that is held in place within the extracorporeal tube for blood or fluid by an anchor. The device is adapted to secure viable cells which produce and secrete the pre-selected molecule into blood or fluid passing the capsule. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel or body cavity the device of the invention.
PCT/US2007/061468 2006-02-02 2007-02-01 An extracorporeal cell-based therapeutic device and delivery system WO2007092735A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002637686A CA2637686A1 (en) 2006-02-02 2007-02-01 An extracorporeal cell-based therapeutic device and delivery system
JP2008553503A JP2009525781A (en) 2006-02-02 2007-02-01 Cell-based extracorporeal therapy device and delivery system
EP07763504.3A EP1989144A4 (en) 2006-02-02 2007-02-01 An extracorporeal cell-based therapeutic device and delivery system
AU2007212110A AU2007212110A1 (en) 2006-02-02 2007-02-01 An extracorporeal cell-based therapeutic device and delivery system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76435706P 2006-02-02 2006-02-02
US60/764,357 2006-02-02

Publications (2)

Publication Number Publication Date
WO2007092735A2 WO2007092735A2 (en) 2007-08-16
WO2007092735A3 true WO2007092735A3 (en) 2008-12-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/061468 WO2007092735A2 (en) 2006-02-02 2007-02-01 An extracorporeal cell-based therapeutic device and delivery system

Country Status (6)

Country Link
US (1) US8048419B2 (en)
EP (1) EP1989144A4 (en)
JP (1) JP2009525781A (en)
AU (1) AU2007212110A1 (en)
CA (1) CA2637686A1 (en)
WO (1) WO2007092735A2 (en)

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AU2007212110A1 (en) 2006-02-02 2007-08-16 Innovative Bio Therapies An extracorporeal cell-based therapeutic device and delivery system
WO2008002914A2 (en) * 2006-06-26 2008-01-03 Gambro Bct, Inc. Method of culturing mesenchymal stem cells
CN102171332A (en) 2008-06-18 2011-08-31 创新生物制剂疗法公司 Methods for enhanced propagation of cells
EP2323725A4 (en) * 2008-08-15 2014-01-29 Innovative Biotherapies Inc An extracorporeal cell-based therapeutic device and delivery system
ATE545440T1 (en) 2008-09-25 2012-03-15 Gambro Lundia Ab HYBRID BIOLOGICAL ARTIFICIAL KIDNEY
EP2168666A1 (en) 2008-09-25 2010-03-31 Gambro Lundia AB Irradiated membrane for cell expansion
EP2168668A1 (en) 2008-09-25 2010-03-31 Gambro Lundia AB Membrane for cell expansion
EP2177603A1 (en) 2008-09-25 2010-04-21 Gambro Lundia AB Device for renal cell expansion
US8430831B2 (en) * 2009-02-25 2013-04-30 The Invention Science Fund I, Llc Device, system, and method for controllably reducing inflammatory mediators in a subject
EP2412798A1 (en) 2010-07-27 2012-02-01 Gambro Lundia AB Biomimetic membrane for cell expansion
JP2014500735A (en) 2010-10-15 2014-01-16 サイトフェリックス インコーポレイテッド Cytopheresis cartridge and its use
WO2013106109A1 (en) 2012-01-09 2013-07-18 Humes, H., David Cartridge and method for increasing myocardial function
US9101707B2 (en) 2012-04-27 2015-08-11 Gregory Zeltser Implantable bioartificial perfusion system
WO2018048900A1 (en) 2016-09-06 2018-03-15 President And Fellows Of Harvard College Living devices for replacement of organs or specific organ functions, methods and uses of the same

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