WO2007089884A3 - Optimized sample injection structures in microfluidic separations - Google Patents

Optimized sample injection structures in microfluidic separations Download PDF

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Publication number
WO2007089884A3
WO2007089884A3 PCT/US2007/002721 US2007002721W WO2007089884A3 WO 2007089884 A3 WO2007089884 A3 WO 2007089884A3 US 2007002721 W US2007002721 W US 2007002721W WO 2007089884 A3 WO2007089884 A3 WO 2007089884A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
sample injection
channel
symmetrical
related methods
Prior art date
Application number
PCT/US2007/002721
Other languages
French (fr)
Other versions
WO2007089884A2 (en
WO2007089884A8 (en
Inventor
Michael Nguyen
Luc Bousse
Original Assignee
Microchip Biotechnologies Inc
Michael Nguyen
Luc Bousse
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microchip Biotechnologies Inc, Michael Nguyen, Luc Bousse filed Critical Microchip Biotechnologies Inc
Publication of WO2007089884A2 publication Critical patent/WO2007089884A2/en
Publication of WO2007089884A3 publication Critical patent/WO2007089884A3/en
Publication of WO2007089884A8 publication Critical patent/WO2007089884A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/24—Extraction; Separation; Purification by electrochemical means
    • C07K1/26—Electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

The invention herein provides improved sample injection systems and related methods to create microfluidic devices with symmetrical channel configurations that can produce relatively large sample volumes. An embodiment of the invention provides microfluidic structures with different geometries that are symmetrical from the perspective of a sample load channel and a sample waste channel, which essentially eliminates issues of time offset and other problems commonly associated with twin-T sample formation techniques. A split-injection approach and related methods of sample plug formation are therefore provided.
PCT/US2007/002721 2006-02-01 2007-01-31 Optimized sample injection structures in microfluidic separations WO2007089884A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76439306P 2006-02-01 2006-02-01
US60/764,393 2006-02-01
US11/460,236 2006-07-26
US11/460,236 US7749365B2 (en) 2006-02-01 2006-07-26 Optimized sample injection structures in microfluidic separations

Publications (3)

Publication Number Publication Date
WO2007089884A2 WO2007089884A2 (en) 2007-08-09
WO2007089884A3 true WO2007089884A3 (en) 2007-12-21
WO2007089884A8 WO2007089884A8 (en) 2008-02-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/002721 WO2007089884A2 (en) 2006-02-01 2007-01-31 Optimized sample injection structures in microfluidic separations

Country Status (2)

Country Link
US (1) US7749365B2 (en)
WO (1) WO2007089884A2 (en)

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Also Published As

Publication number Publication date
WO2007089884A2 (en) 2007-08-09
WO2007089884A8 (en) 2008-02-07
US7749365B2 (en) 2010-07-06
US20070175756A1 (en) 2007-08-02

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