WO2007086840A3 - A magnetic resonance system and method to detect and confirm analytes - Google Patents

A magnetic resonance system and method to detect and confirm analytes Download PDF

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Publication number
WO2007086840A3
WO2007086840A3 PCT/US2006/002368 US2006002368W WO2007086840A3 WO 2007086840 A3 WO2007086840 A3 WO 2007086840A3 US 2006002368 W US2006002368 W US 2006002368W WO 2007086840 A3 WO2007086840 A3 WO 2007086840A3
Authority
WO
WIPO (PCT)
Prior art keywords
magnetic resonance
detect
analyte
resonance system
analytes
Prior art date
Application number
PCT/US2006/002368
Other languages
French (fr)
Other versions
WO2007086840A2 (en
Inventor
Suresh M Menon
David E Newman
Terry J Henderson
J Manuel Perez
Original Assignee
Menon & Associates
Suresh M Menon
David E Newman
Terry J Henderson
J Manuel Perez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menon & Associates, Suresh M Menon, David E Newman, Terry J Henderson, J Manuel Perez filed Critical Menon & Associates
Priority to ES06849669.4T priority Critical patent/ES2495718T3/en
Priority to CN2006800188550A priority patent/CN101512384B/en
Priority to CA2604150A priority patent/CA2604150C/en
Priority to EP06849669.4A priority patent/EP1869466B1/en
Priority to JP2008505292A priority patent/JP5289939B2/en
Publication of WO2007086840A2 publication Critical patent/WO2007086840A2/en
Publication of WO2007086840A3 publication Critical patent/WO2007086840A3/en
Priority to HK09110078.5A priority patent/HK1132552A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281—Means for the use of in vitro contrast agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34046—Volume type coils, e.g. bird-cage coils; Quadrature bird-cage coils; Circularly polarised coils
    • G01R33/34053—Solenoid coils; Toroidal coils
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/3806—Open magnet assemblies for improved access to the sample, e.g. C-type or U-type magnets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/383—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using permanent magnets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/084—Detection of potentially hazardous samples, e.g. toxic samples, explosives, drugs, firearms, weapons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/81—Of specified metal or metal alloy composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/92—Detection of biochemical

Abstract

A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the analyte.
PCT/US2006/002368 2005-04-07 2006-01-24 A magnetic resonance system and method to detect and confirm analytes WO2007086840A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES06849669.4T ES2495718T3 (en) 2005-04-07 2006-01-24 An MRI method to detect and confirm analytes
CN2006800188550A CN101512384B (en) 2005-04-07 2006-01-24 A magnetic resonance system and method to detect and confirm analytes
CA2604150A CA2604150C (en) 2005-04-07 2006-01-24 A magnetic resonance system and method to detect and confirm analytes
EP06849669.4A EP1869466B1 (en) 2005-04-07 2006-01-24 A magnetic resonance method to detect and confirm analytes
JP2008505292A JP5289939B2 (en) 2005-04-07 2006-01-24 How to detect a specimen
HK09110078.5A HK1132552A1 (en) 2005-04-07 2009-10-29 A magnetic resonance system and method to detect and confirm analytes

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US66901905P 2005-04-07 2005-04-07
US60/669,019 2005-04-07
US67338205P 2005-04-21 2005-04-21
US60/673,382 2005-04-21
US11/335,995 2006-01-20
US11/335,995 US7781228B2 (en) 2005-04-07 2006-01-20 Magnetic resonance system and method to detect and confirm analytes

Publications (2)

Publication Number Publication Date
WO2007086840A2 WO2007086840A2 (en) 2007-08-02
WO2007086840A3 true WO2007086840A3 (en) 2009-05-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/002368 WO2007086840A2 (en) 2005-04-07 2006-01-24 A magnetic resonance system and method to detect and confirm analytes

Country Status (8)

Country Link
US (2) US7781228B2 (en)
EP (1) EP1869466B1 (en)
JP (1) JP5289939B2 (en)
CN (1) CN101512384B (en)
CA (1) CA2604150C (en)
ES (1) ES2495718T3 (en)
HK (1) HK1132552A1 (en)
WO (1) WO2007086840A2 (en)

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ES2495718T3 (en) 2014-09-17
EP1869466A4 (en) 2009-11-11
EP1869466A2 (en) 2007-12-26
US7781228B2 (en) 2010-08-24
EP1869466B1 (en) 2014-08-20
US20070020701A1 (en) 2007-01-25
HK1132552A1 (en) 2010-02-26
CA2604150C (en) 2013-03-19
US9442110B2 (en) 2016-09-13
JP2008542684A (en) 2008-11-27
CN101512384A (en) 2009-08-19
CN101512384B (en) 2012-05-30
WO2007086840A2 (en) 2007-08-02
CA2604150A1 (en) 2007-08-02
JP5289939B2 (en) 2013-09-11
US20110012596A1 (en) 2011-01-20

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