WO2007069233A3 - Automatic characterization of pathological specimen - Google Patents

Automatic characterization of pathological specimen Download PDF

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Publication number
WO2007069233A3
WO2007069233A3 PCT/IL2006/001382 IL2006001382W WO2007069233A3 WO 2007069233 A3 WO2007069233 A3 WO 2007069233A3 IL 2006001382 W IL2006001382 W IL 2006001382W WO 2007069233 A3 WO2007069233 A3 WO 2007069233A3
Authority
WO
WIPO (PCT)
Prior art keywords
pathological specimen
picture
specimen
elements
image
Prior art date
Application number
PCT/IL2006/001382
Other languages
French (fr)
Other versions
WO2007069233A2 (en
Inventor
Tsafrir Kolatt
Original Assignee
Applied Spectral Imaging Ltd
Tsafrir Kolatt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Spectral Imaging Ltd, Tsafrir Kolatt filed Critical Applied Spectral Imaging Ltd
Publication of WO2007069233A2 publication Critical patent/WO2007069233A2/en
Priority to IL192057A priority Critical patent/IL192057A0/en
Publication of WO2007069233A3 publication Critical patent/WO2007069233A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G01N15/1433—
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30072—Microarray; Biochip, DNA array; Well plate

Abstract

A method for characterizing a stained pathological specimen is disclosed. The method comprises obtaining an image of the specimen, classifying the picture-elements of the image into classification groups, and using the classification groups to define at least one set of picture-elements corresponding to at least one tissue region of the pathological specimen. The method further comprises applying, on each set of picture-elements, at least one set-operator so as to characterize the tissue regions according to image data and spatial characteristics of the set.
PCT/IL2006/001382 2005-12-13 2006-11-30 Automatic characterization of pathological specimen WO2007069233A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL192057A IL192057A0 (en) 2005-12-13 2008-06-11 Automatic characterization of pathological specimen

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74958905P 2005-12-13 2005-12-13
US60/749,589 2005-12-13
US11/480,480 US20070135999A1 (en) 2005-12-13 2006-07-05 Method, apparatus and system for characterizing pathological specimen
US11/480,480 2006-07-05

Publications (2)

Publication Number Publication Date
WO2007069233A2 WO2007069233A2 (en) 2007-06-21
WO2007069233A3 true WO2007069233A3 (en) 2008-12-24

Family

ID=38140501

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/001382 WO2007069233A2 (en) 2005-12-13 2006-11-30 Automatic characterization of pathological specimen

Country Status (2)

Country Link
US (1) US20070135999A1 (en)
WO (1) WO2007069233A2 (en)

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CN101151623B (en) 2005-01-27 2010-06-23 剑桥研究和仪器设备股份有限公司 Method and equipment for classifying sample image features
US20070031043A1 (en) * 2005-08-02 2007-02-08 Perz Cynthia B System for and method of intelligently directed segmentation analysis for automated microscope systems
WO2008108059A1 (en) * 2007-03-01 2008-09-12 Nec Corporation Breast cancer pathologic image diagnosis supporting system, breast cancer pathologic image diagnosis supporting method, beast cancer pathologic image diagnosis supporting program, and recording medium in which brest cancer pathologic image diagnosis supporting program is recorded
US8712139B2 (en) * 2008-03-21 2014-04-29 General Electric Company Methods and systems for automated segmentation of dense cell populations
US8644565B2 (en) * 2008-07-23 2014-02-04 Indiana University Research And Technology Corp. System and method for non-cooperative iris image acquisition
JP5387147B2 (en) * 2009-06-03 2014-01-15 日本電気株式会社 Pathological image diagnostic system, pathological image processing method, pathological image diagnostic program
JP5660273B2 (en) * 2010-01-04 2015-01-28 日本電気株式会社 Image diagnosis method, image diagnosis apparatus, and image diagnosis program
CN103140757A (en) * 2010-09-30 2013-06-05 日本电气株式会社 Information processing apparatus, information processing system, information processing method, program, and recording medium
US9607374B2 (en) 2011-11-10 2017-03-28 Cadess Medical Ab Color decomposition in histology
US8699022B2 (en) 2012-02-07 2014-04-15 Materialytics, LLC Methods and systems for analyzing samples
US8849041B2 (en) * 2012-06-04 2014-09-30 Comcast Cable Communications, Llc Data recognition in content
JP6161146B2 (en) * 2013-01-11 2017-07-12 国立大学法人東京工業大学 Pathological tissue image analysis method, pathological tissue image analysis apparatus, and pathological tissue image analysis program
WO2014150696A1 (en) 2013-03-15 2014-09-25 Materialytics, LLC Methods and systems for analyzing samples
US9786050B2 (en) * 2013-03-15 2017-10-10 The Board Of Trustees Of The University Of Illinois Stain-free histopathology by chemical imaging
GB2542765A (en) * 2015-09-23 2017-04-05 Pathxl Ltd Method and apparatus for tissue recognition
US9916658B2 (en) * 2013-09-19 2018-03-13 Keio University Disease analysis apparatus, control method, and program
JP2015087167A (en) * 2013-10-29 2015-05-07 キヤノン株式会社 Image processing method and image processing system
US9784665B1 (en) * 2014-12-29 2017-10-10 Flagship Biosciences, Inc. Methods for quantitative assessment of muscle fibers in muscular dystrophy
DE102015109340A1 (en) * 2015-06-11 2016-12-15 Sick Ag Spectrometer and analyzer
CN105678110B (en) * 2016-01-29 2019-03-29 东南大学 A kind of method of sample combinatory analysis nucleic acid sequence
JP7054787B2 (en) * 2016-12-22 2022-04-15 パナソニックＩｐマネジメント株式会社 Control methods, information terminals, and programs
CN108646034B (en) * 2018-07-03 2020-10-23 珠海圣美生物诊断技术有限公司 Method for determining rare cells in cell population
CN109709302A (en) * 2018-11-30 2019-05-03 中国海洋石油集团有限公司 The method of clastic rock material resource system is differentiated based on multi-parameter comprehensive
US20200388032A1 (en) * 2019-06-04 2020-12-10 JelloX Biotech Inc. Three dimensional histopathology imaging method and system thereof
US20220375604A1 (en) * 2021-04-18 2022-11-24 Mary Hitchcock Memorial Hospital, For Itself And On Behalf Of Dartmouth-Hitchcock Clinic System and method for automation of surgical pathology processes using artificial intelligence
TWI792461B (en) * 2021-07-30 2023-02-11 國立臺灣大學 Margin assessment method

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US5544650A (en) * 1988-04-08 1996-08-13 Neuromedical Systems, Inc. Automated specimen classification system and method
US5740270A (en) * 1988-04-08 1998-04-14 Neuromedical Systems, Inc. Automated cytological specimen classification system and method
US20050070020A1 (en) * 2003-09-30 2005-03-31 Trudee Klautky Automated cytological sample classification

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US6750964B2 (en) * 1999-08-06 2004-06-15 Cambridge Research And Instrumentation, Inc. Spectral imaging methods and systems
US6697509B2 (en) * 2001-10-04 2004-02-24 Chromavision Medical Systems, Inc. Method and apparatus for scoring the uptake of markers in cells
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CN101151623B (en) * 2005-01-27 2010-06-23 剑桥研究和仪器设备股份有限公司 Method and equipment for classifying sample image features
US7796815B2 (en) * 2005-06-10 2010-09-14 The Cleveland Clinic Foundation Image analysis of biological objects

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US4945476A (en) * 1988-02-26 1990-07-31 Elsevier Science Publishing Company, Inc. Interactive system and method for creating and editing a knowledge base for use as a computerized aid to the cognitive process of diagnosis
US5544650A (en) * 1988-04-08 1996-08-13 Neuromedical Systems, Inc. Automated specimen classification system and method
US5740270A (en) * 1988-04-08 1998-04-14 Neuromedical Systems, Inc. Automated cytological specimen classification system and method
US20050070020A1 (en) * 2003-09-30 2005-03-31 Trudee Klautky Automated cytological sample classification

Also Published As

Publication number Publication date
US20070135999A1 (en) 2007-06-14
WO2007069233A2 (en) 2007-06-21

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