WO2007054940A3 - Breath test device and method - Google Patents

Breath test device and method Download PDF

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Publication number
WO2007054940A3
WO2007054940A3 PCT/IL2006/001296 IL2006001296W WO2007054940A3 WO 2007054940 A3 WO2007054940 A3 WO 2007054940A3 IL 2006001296 W IL2006001296 W IL 2006001296W WO 2007054940 A3 WO2007054940 A3 WO 2007054940A3
Authority
WO
WIPO (PCT)
Prior art keywords
methacetin
liver
derivative
salt
subject
Prior art date
Application number
PCT/IL2006/001296
Other languages
French (fr)
Other versions
WO2007054940A2 (en
Inventor
Ilan Ben-Oren
Avraham Hershkowitz
Eli Kaplan
Yaron Ilan
Original Assignee
Breathid (2006)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Breathid (2006) filed Critical Breathid (2006)
Priority to US12/084,629 priority Critical patent/US8622920B2/en
Priority to EP06809856A priority patent/EP1960004A4/en
Priority to JP2008539609A priority patent/JP2009516534A/en
Publication of WO2007054940A2 publication Critical patent/WO2007054940A2/en
Priority to US12/219,824 priority patent/US8512258B2/en
Publication of WO2007054940A3 publication Critical patent/WO2007054940A3/en
Priority to US13/943,466 priority patent/US10827969B2/en
Priority to US17/060,503 priority patent/US20210100493A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1206—Administration of radioactive gases, aerosols or breath tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1268—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules host-guest, closed hollow molecules, inclusion complexes, e.g. with cyclodextrins, clathrates, cavitates, fullerenes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The disclosure relates breath test devices and methods for the evaluation of liver functional and metabolic capacity or to assess liver heath and/or degree of liver injury. Specifically, there is provided a method of evaluating a liver condition, the method includes on-line monitoring a metabolic product of methacetin, a salt or a derivative of methacetin, in a subject's breath after administering to the subject isotope labeled methacetin, a salt or a derivative thereof in water solution form. There is also provided a device for evaluating a liver condition, the device includes one or more sensors adapted to monitor on-line an isotope level of a metabolic product of labeled methacetin, or a salt or a derivative of methacetin in a subject's breath and a controller adapted to sample measurements of the one or more sensors at a continuous mode.
PCT/IL2006/001296 2005-11-11 2006-11-12 Breath test device and method WO2007054940A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US12/084,629 US8622920B2 (en) 2005-11-11 2006-11-12 Breath test device and method
EP06809856A EP1960004A4 (en) 2005-11-11 2006-11-12 Breath test device and method
JP2008539609A JP2009516534A (en) 2005-11-11 2006-11-12 Breath test apparatus and method
US12/219,824 US8512258B2 (en) 2005-11-11 2008-07-29 Breath test device and method
US13/943,466 US10827969B2 (en) 2005-11-11 2013-07-16 Breath test device and method
US17/060,503 US20210100493A1 (en) 2005-11-11 2020-10-01 Breath test device and method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73547905P 2005-11-11 2005-11-11
US60/735,479 2005-11-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/084,629 A-371-Of-International US8622920B2 (en) 2005-11-11 2006-11-12 Breath test device and method
US12/219,824 Continuation-In-Part US8512258B2 (en) 2005-11-11 2008-07-29 Breath test device and method

Publications (2)

Publication Number Publication Date
WO2007054940A2 WO2007054940A2 (en) 2007-05-18
WO2007054940A3 true WO2007054940A3 (en) 2009-09-03

Family

ID=38023667

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/001296 WO2007054940A2 (en) 2005-11-11 2006-11-12 Breath test device and method

Country Status (4)

Country Link
US (1) US8622920B2 (en)
EP (1) EP1960004A4 (en)
JP (1) JP2009516534A (en)
WO (1) WO2007054940A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202006021184U1 (en) * 2005-06-25 2013-06-05 Charité - Universitätsmedizin Berlin Aqueous methacetin solution
US8512258B2 (en) 2005-11-11 2013-08-20 Exalenz Bioscience Ltd. Breath test device and method
DE102006018862A1 (en) * 2006-03-17 2007-09-20 Charité - Universitätsmedizin Berlin Device for the spectroscopic analysis of a gas
ES2683631T3 (en) * 2009-02-26 2018-09-27 Université d'Angers Diagnostic improvement in liver fibrosis or cirrhosis
DE102009055320B4 (en) 2009-12-24 2011-09-01 Humedics Gmbh Measuring device and method for examining a sample gas by means of infrared absorption spectroscopy
US8753889B1 (en) * 2010-04-01 2014-06-17 Beverly L. Roeder Methods for diagnosing and treating disease in animals by the analysis of isotopes in elements such as carbon and nitrogen in animal substrate
DE102011007310A1 (en) 2011-04-13 2012-10-18 Humedics Gmbh Method for determining the metabolic performance of at least one enzyme
EP2696756A4 (en) 2011-04-14 2014-11-05 Exalenz Bioscience Ltd Methods for diagnosis, prognosis, monitoring and treatment of hepatocellular carcinoma
US8512676B1 (en) * 2012-03-07 2013-08-20 Wisconsin Alumni Research Foundation Detection of rate changes in systematic oscillations of metabolic athways by monitoring isotope ratios
US20170181686A1 (en) * 2014-04-02 2017-06-29 Exalenz Bioscience Ltd. Breath test for assessing liver disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050177056A1 (en) * 2002-03-03 2005-08-11 Oridion Breathid Ltd Breath collection system

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DE59304180D1 (en) * 1992-07-22 1996-11-21 Mannesmann Ag Non-dispersive infrared spectrometer
US5386832A (en) * 1993-06-11 1995-02-07 New England Deaconess Hospital Liver function breath test using aromatic amino acids
US6186958B1 (en) * 1997-02-26 2001-02-13 Oridion Medical Breath test analyzer
JP3340391B2 (en) * 1997-09-11 2002-11-05 東京瓦斯株式会社 Liver surgery evaluation reagent
USRE38728E1 (en) * 1997-09-11 2005-04-19 Oridion Medical, LTD Breath test analyzer
ATE379989T1 (en) 1997-09-11 2007-12-15 Oridion Breathid Ltd BREATH TEST ANALYZER
JP4007664B2 (en) * 1998-01-16 2007-11-14 東京瓦斯株式会社 Liver function diagnostic agent
CA2249173C (en) * 1997-10-06 2008-12-16 Tokyo Gas Co., Ltd. Diagnostic agent for liver function
JP4007660B2 (en) * 1997-12-11 2007-11-14 東京瓦斯株式会社 Liver function diagnostic agent
JP4007647B2 (en) * 1997-10-06 2007-11-14 東京瓦斯株式会社 Liver function diagnostic agent
JP4007669B2 (en) * 1997-10-21 2007-11-14 東京瓦斯株式会社 Liver function diagnostic agent
CA2250485C (en) * 1997-10-21 2008-04-29 Tokyo Gas Co., Ltd. Diagnostic agent for diabetes
US6656127B1 (en) * 1999-06-08 2003-12-02 Oridion Breathid Ltd. Breath test apparatus and methods
US6486474B1 (en) * 1999-08-13 2002-11-26 Regents Of The University Of Minnesota Infrared spectrometer for the measurement of isotopic ratios
GB0106923D0 (en) * 2001-03-20 2001-05-09 Univ Dundee Liver function test
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
JP2005503205A (en) * 2001-08-23 2005-02-03 オリディオン ブレシド リミティド Management of gastrointestinal disorders
US6778269B2 (en) * 2001-09-04 2004-08-17 Board Of Regents, The University Of Texas System Detecting isotopes and determining isotope ratios using raman spectroscopy
US7490085B2 (en) * 2002-12-18 2009-02-10 Ge Medical Systems Global Technology Company, Llc Computer-assisted data processing system and method incorporating automated learning
US8778299B2 (en) * 2005-01-26 2014-07-15 The Regents Of The University Of Colorado, A Body Corporate Methods for diagnosis and intervention of hepatic disorders
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
AU2006237863A1 (en) * 2005-04-16 2006-10-26 Cambridge Isotope Laboratories, Inc. Method and composition to evaluate cytochrome P450 2D6 isoenzyme activity using a breath test
DE202006021184U1 (en) * 2005-06-25 2013-06-05 Charité - Universitätsmedizin Berlin Aqueous methacetin solution
US8512258B2 (en) * 2005-11-11 2013-08-20 Exalenz Bioscience Ltd. Breath test device and method
US7662105B2 (en) * 2005-12-14 2010-02-16 Cardiac Pacemakers, Inc. Systems and methods for determining respiration metrics

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050177056A1 (en) * 2002-03-03 2005-08-11 Oridion Breathid Ltd Breath collection system

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BRADEN ET AL.: "13C-methacetin breath test as liver function test in patients with chronic hepatitis C virus infection.", ALIMENT PHARMACOLOGY & THERAPEUTICS 2005, vol. 21, 15 January 2005 (2005-01-15), pages 179 - 185, XP002400542 *
PETROALTI ET AL.: "13C-Methacetin Breath Test For Monitoring Hepatic Function in Cirrhotic Patients Before and After Liver Transplantation.", ALIMENTARY PHARMACOLOGY & THERAPEUTICS, vol. 18, 15 October 2003 (2003-10-15), pages 785 - 790, XP008126341 *

Also Published As

Publication number Publication date
JP2009516534A (en) 2009-04-23
US20100036273A1 (en) 2010-02-11
US8622920B2 (en) 2014-01-07
WO2007054940A2 (en) 2007-05-18
EP1960004A4 (en) 2011-04-20
EP1960004A2 (en) 2008-08-27

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