WO2007025129A3 - Compositions and liquid crystals - Google Patents

Compositions and liquid crystals Download PDF

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Publication number
WO2007025129A3
WO2007025129A3 PCT/US2006/033221 US2006033221W WO2007025129A3 WO 2007025129 A3 WO2007025129 A3 WO 2007025129A3 US 2006033221 W US2006033221 W US 2006033221W WO 2007025129 A3 WO2007025129 A3 WO 2007025129A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
liquid crystals
detection
biomolecules
analytes
Prior art date
Application number
PCT/US2006/033221
Other languages
French (fr)
Other versions
WO2007025129A2 (en
Inventor
Nicholas Abbott
Christopher Murphy
Barbara Israel
Original Assignee
Platypus Technologies Llc
Nicholas Abbott
Christopher Murphy
Barbara Israel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Platypus Technologies Llc, Nicholas Abbott, Christopher Murphy, Barbara Israel filed Critical Platypus Technologies Llc
Publication of WO2007025129A2 publication Critical patent/WO2007025129A2/en
Publication of WO2007025129A3 publication Critical patent/WO2007025129A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K19/00—Liquid crystal materials
    • C09K19/04—Liquid crystal materials characterised by the chemical structure of the liquid crystal components, e.g. by a specific unit
    • C09K19/06—Non-steroidal liquid crystal compounds
    • C09K19/34—Non-steroidal liquid crystal compounds containing at least one heterocyclic ring
    • C09K19/3402—Non-steroidal liquid crystal compounds containing at least one heterocyclic ring having oxygen as hetero atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K19/00—Liquid crystal materials
    • C09K19/04—Liquid crystal materials characterised by the chemical structure of the liquid crystal components, e.g. by a specific unit
    • C09K19/06—Non-steroidal liquid crystal compounds
    • C09K19/34—Non-steroidal liquid crystal compounds containing at least one heterocyclic ring
    • C09K19/3402—Non-steroidal liquid crystal compounds containing at least one heterocyclic ring having oxygen as hetero atom
    • C09K2019/3422—Non-steroidal liquid crystal compounds containing at least one heterocyclic ring having oxygen as hetero atom the heterocyclic ring being a six-membered ring
    • C09K2019/3425—Six-membered ring with oxygen(s) in fused, bridged or spiro ring systems

Abstract

The present invention relates to compounds, compositions, and methods in the field of detection of analytes. In particular to detection of viruses, cells, bacteria, lipid-membrane containing organisms, proteins, nucleic acids, carbohydrates and other biomolecules, organic molecules and inorganic molecules using a liquid crystal assay format.
PCT/US2006/033221 2005-08-25 2006-08-25 Compositions and liquid crystals WO2007025129A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71111105P 2005-08-25 2005-08-25
US60/711,111 2005-08-25

Publications (2)

Publication Number Publication Date
WO2007025129A2 WO2007025129A2 (en) 2007-03-01
WO2007025129A3 true WO2007025129A3 (en) 2007-09-27

Family

ID=37772433

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/033221 WO2007025129A2 (en) 2005-08-25 2006-08-25 Compositions and liquid crystals

Country Status (2)

Country Link
US (1) US7662572B2 (en)
WO (1) WO2007025129A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666661B2 (en) 2001-08-27 2010-02-23 Platypus Technologies, Llc Substrates, devices, and methods for quantitative liquid crystal assays
CA2486812A1 (en) * 2002-05-22 2004-05-21 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
US20050064395A1 (en) 2003-07-25 2005-03-24 Platypus Technologies, Llc Liquid crystal based analyte detection
CA2545482A1 (en) 2003-11-10 2005-05-26 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
US7531366B2 (en) * 2004-07-23 2009-05-12 Platypus Technologies, Llc Bead based assays using a liquid crystal reporter
US7662572B2 (en) 2005-08-25 2010-02-16 Platypus Technologies, Llc. Compositions and liquid crystals
US8586389B2 (en) * 2005-09-28 2013-11-19 Kent State University Ligand concentrating, liquid crystal biosensor system
RU2459866C2 (en) * 2005-10-12 2012-08-27 Зе Скрипс Ресеч Инститьют Selective post-translational modification of phage-displayed polypeptides
US7842499B2 (en) * 2006-08-07 2010-11-30 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
EP2193365A4 (en) 2007-08-20 2015-05-13 Platypus Technologies Llc Improved devices for cell assays
US9150788B2 (en) * 2007-09-18 2015-10-06 Syracuse University Non-amphiphile-based water-in-water emulsion and uses thereof
US8178355B2 (en) 2008-09-15 2012-05-15 Platypus Technologies, Llc. Detection of vapor phase compounds by changes in physical properties of a liquid crystal
US8925373B2 (en) * 2009-04-22 2015-01-06 Wisconsin Alumni Research Foundation Microfluidic device integrating sensing element and method
US8435333B2 (en) * 2010-07-30 2013-05-07 University Of Rochester Photo-switchable membrane and method
WO2013096804A2 (en) 2011-12-23 2013-06-27 Abbott Point Of Care Inc Optical assay device with pneumatic sample actuation
WO2013096801A1 (en) 2011-12-23 2013-06-27 Abbott Point Of Care Inc Reader devices for optical and electrochemical test devices
US9140693B2 (en) 2011-12-23 2015-09-22 Abbott Point Of Care Inc. Integrated test device for optical detection of microarrays
WO2013096822A2 (en) 2011-12-23 2013-06-27 Abbott Point Of Care Inc Integrated test device for optical and electrochemical assays
US9372142B2 (en) * 2012-02-27 2016-06-21 Wisconsin Alumni Research Foundation Liquid crystal device and method for screening protein stabilizing agents or optimal protein concentrations to prevent unfolding
KR101768192B1 (en) * 2013-09-30 2017-08-16 주식회사 엘지화학 Composition for forming guest-host polarizer and guest-host polarizer comprising the same
KR101768191B1 (en) * 2013-09-30 2017-08-16 주식회사 엘지화학 Composition for forming guest-host polarizer and guest-host polarizer comprising the same
GB201617508D0 (en) * 2016-10-14 2016-11-30 Cambridge Enterprise Limited And Universitat Polit�Cnica De Catalunya And Universitat De Barc Use of Barocaloric materials and Barocaloric devices
EP3607397A4 (en) 2017-04-04 2021-01-20 University of Central Florida Research Foundation, Inc. Dynamically tunable, single pixel full-color plasmonic display, method and applications
CN112834599B (en) * 2020-07-21 2024-04-05 宁波大学 Position isomerism analysis reagent and method for position isomerism amino biphenyl molecule

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551264A (en) * 1982-03-13 1985-11-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Polyhalogenoaromatic compounds for liquid crystal compositions
US6858423B1 (en) * 1998-06-05 2005-02-22 The Regents Of The University Of California Optical Amplification of molecular interactions using liquid crystals

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2639815A (en) 1949-07-22 1953-05-26 Alexander E Paluck Tool rack
US3910763A (en) 1969-10-03 1975-10-07 Us Army Method of detecting organophosphorus agents using 1-phenyl-1,2,3-butanetrione-2-oxime and cyanide indicating composition
US3645693A (en) 1969-11-03 1972-02-29 Us Army Chemical detector
US3883398A (en) 1973-05-07 1975-05-13 Bellco Glass Inc Microculture slide chamber
JPS5638924B2 (en) 1973-12-20 1981-09-09
GB1501718A (en) 1974-12-23 1978-02-22 Suwa Seikosha Kk Nematic liquid crystal material
US4285697A (en) 1978-09-26 1981-08-25 Neary Michael P Food spoilage indicator
ATE34618T1 (en) 1982-09-02 1988-06-15 Hettich Andreas Fa CENTRIFUGATION CHAMBERS FOR THE CYTODIAGNOSTIC PREPARATION OF EPITHELIAL CELLS AND THEIR USE.
US4597942A (en) 1983-05-25 1986-07-01 Graphic Controls Canada Ltd. Device to indicate the concentration of ethylene oxide in the workplace
US5059394A (en) 1986-08-13 1991-10-22 Lifescan, Inc. Analytical device for the automated determination of analytes in fluids
US4795253A (en) 1987-04-24 1989-01-03 Mobay Corporation Remote sensing gas analyzer
DE3842657A1 (en) 1988-12-19 1990-06-21 Merck Patent Gmbh METHOD AND MEANS FOR DETERMINING MALEIMID GROUPS
US4927879A (en) 1988-02-25 1990-05-22 Purdue Research Foundation Method for solid phase membrane mimetics
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5191064A (en) 1988-09-30 1993-03-02 The Research Foundation For Microbial Diseases (Osaka University) Non-a, non-b hepatitis virus antigen peptide
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5073294A (en) 1990-03-07 1991-12-17 Hercules Incorporated Process of preparing compositions having multiple oriented mesogens
US5104804A (en) 1990-06-04 1992-04-14 Molecular Devices Corporation Cell assay device used in a microphysiometer
US5141718A (en) 1990-10-30 1992-08-25 Millipore Corporation Test plate apparatus
US5370841A (en) 1990-11-26 1994-12-06 Mcdonnell; Joseph A. Microwave leakage detector
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US6051380A (en) 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
AU675054B2 (en) 1991-11-22 1997-01-23 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5355215A (en) 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US6045996A (en) 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US6068818A (en) 1993-11-01 2000-05-30 Nanogen, Inc. Multicomponent devices for molecular biological analysis and diagnostics
US5601980A (en) 1994-09-23 1997-02-11 Hewlett-Packard Company Manufacturing method and apparatus for biological probe arrays using vision-assisted micropipetting
US5599919A (en) 1994-12-09 1997-02-04 Fox Chase Cancer Center Nucleic acid encoding a transiently-expressed kinetochore protein, and methods of use
GB2297549B (en) * 1995-02-06 1999-06-30 Merck Patent Gmbh Direactive mesogenic compound
US20030127396A1 (en) 1995-02-21 2003-07-10 Siddiqi Iqbal Waheed Apparatus and method for processing magnetic particles
US6884357B2 (en) 1995-02-21 2005-04-26 Iqbal Waheed Siddiqi Apparatus and method for processing magnetic particles
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
US6001311A (en) 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
GB9704623D0 (en) 1997-03-06 1997-04-23 Sharp Kk Liquid crytal optical element and liquid crystal device incorporating same
US6171780B1 (en) 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
DE19753271A1 (en) 1997-12-01 1999-06-02 Sued Chemie Ag Color developer pigment for carbonless papers
US5908786A (en) 1997-12-12 1999-06-01 Akzo Nobel, N.V. Blood coagulation monitoring device with liquid crystal and gradient heater
US6284197B1 (en) * 1998-06-05 2001-09-04 The Regents Of The University Of California Optical amplification of molecular interactions using liquid crystals
US6171802B1 (en) * 1998-06-10 2001-01-09 Kent State University Detection and amplification of ligands
US20020052002A1 (en) 1998-06-10 2002-05-02 Niehaus Gary D. Detection and amplification of ligands
US6576478B1 (en) 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6468657B1 (en) 1998-12-04 2002-10-22 The Regents Of The University Of California Controllable ion-exchange membranes
US6277489B1 (en) 1998-12-04 2001-08-21 The Regents Of The University Of California Support for high performance affinity chromatography and other uses
US6288392B1 (en) 1999-01-19 2001-09-11 The Regents Of The University Of California Quantitative characterization of obliquely-deposited substrates of gold by atomic force microscopy: influence of substrate topography on anchoring of liquid crystals
WO2000050570A2 (en) 1999-02-23 2000-08-31 University Of British Columbia Compositions and methods for modulating growth or differentiation of growth-factor dependent cells
US6413587B1 (en) 1999-03-02 2002-07-02 International Business Machines Corporation Method for forming polymer brush pattern on a substrate surface
US6242266B1 (en) 1999-04-30 2001-06-05 Agilent Technologies Inc. Preparation of biopolymer arrays
US6586257B1 (en) 1999-10-12 2003-07-01 Vertex Pharmaceuticals Incorporated Multiwell scanner and scanning method
ATE469350T1 (en) 2000-02-16 2010-06-15 Wisconsin Alumni Res Found BIOCHEMICAL BLOCKING LAYER FOR LIQUID CRYSTAL
AU774638B2 (en) 2000-02-16 2004-07-01 Wisconsin Alumni Research Foundation Method and apparatus for detection of microscopic pathogens
US6444254B1 (en) 2000-03-03 2002-09-03 Duke University Microstamping activated polymer surfaces
US7374906B2 (en) 2000-11-08 2008-05-20 Surface Logix, Inc. Biological assays using gradients formed in microfluidic systems
US6844184B2 (en) 2000-11-08 2005-01-18 Surface Logix, Inc. Device for arraying biomolecules and for monitoring cell motility in real-time
US7371563B2 (en) 2000-11-08 2008-05-13 Surface Logix, Inc. Peelable and resealable devices for biochemical assays
US20020123134A1 (en) 2000-12-26 2002-09-05 Mingxian Huang Active and biocompatible platforms prepared by polymerization of surface coating films
WO2002071929A2 (en) 2001-03-14 2002-09-19 Burnstein Technologies, Inc. Methods of decreasing non-specific binding in dual bead assays and system apparatus for detecting medical targets
US7135143B2 (en) 2001-03-14 2006-11-14 Wisconsin Alumni Research Foundation Detecting compounds with liquid crystals
US6811752B2 (en) 2001-05-15 2004-11-02 Biocrystal, Ltd. Device having microchambers and microfluidics
US20020173033A1 (en) 2001-05-17 2002-11-21 Kyle Hammerick Device and method or three-dimensional spatial localization and functional interconnection of different types of cells
WO2003017737A2 (en) 2001-08-16 2003-02-27 Dow Global Technologies Inc. Cascade arc plasma and abrasion resistant coatings made therefrom
US7666661B2 (en) 2001-08-27 2010-02-23 Platypus Technologies, Llc Substrates, devices, and methods for quantitative liquid crystal assays
ATE438883T1 (en) 2001-09-04 2009-08-15 Wisconsin Alumni Res Found LIQUID CRYSTAL SWITCHING MECHANISM
JP2005528582A (en) 2001-09-07 2005-09-22 コーニング インコーポレイテッド Array based on a microcolumn platform for high-throughput analysis
AU2002341900A1 (en) 2001-10-04 2003-04-14 Wisconsin Alumni Research Foundation Detection of dna hybridization on surfaces
US20080187949A1 (en) 2001-10-26 2008-08-07 Millipore Corporation Multiplexed assays of cell migration
US20040009583A1 (en) 2002-02-05 2004-01-15 Genome Therapeutics Corporation Seal for microtiter plate and methods of use thereof
WO2003078565A1 (en) 2002-03-12 2003-09-25 Surface Logix, Inc. Cell motility and chemotaxis test device and methods of using same
US7807348B2 (en) 2002-03-20 2010-10-05 Wisconsin Alumni Research Foundation Optical imaging of nanostructured substrates
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US7125592B2 (en) 2002-04-10 2006-10-24 Wisconsin Alumni Research Foundation Detecting interactions at biomimetic interfaces with liquid crystals
CA2486812A1 (en) 2002-05-22 2004-05-21 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
US7470533B2 (en) 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
AU2002368337A1 (en) 2002-11-08 2004-06-03 Wisconsin Alumni Research Foundation Surfaces with gradients in surface topography
US7303694B2 (en) 2003-07-17 2007-12-04 Wisconsin Alumni Research Foundation Liquid crystals with reduced toxicity and applications thereof
US20050064395A1 (en) 2003-07-25 2005-03-24 Platypus Technologies, Llc Liquid crystal based analyte detection
US8133680B2 (en) 2003-09-23 2012-03-13 Wisconsin Alumni Research Foundation Using liquid crystals to detect affinity microcontact printed biomolecules
US7795007B2 (en) 2003-09-23 2010-09-14 Wisconsin Alumni Research Foundation Detection of post-translationally modified peptides with liquid crystals
US20070004046A1 (en) 2005-07-01 2007-01-04 Platypus Technologies, Llc Detection of analytes
US7531366B2 (en) 2004-07-23 2009-05-12 Platypus Technologies, Llc Bead based assays using a liquid crystal reporter
AU2006244486A1 (en) 2005-05-06 2006-11-16 Platypus Technologies, Llc Liquid crystal based analyte detection
US7662572B2 (en) 2005-08-25 2010-02-16 Platypus Technologies, Llc. Compositions and liquid crystals
WO2007111681A2 (en) 2005-10-31 2007-10-04 Wisconsin Alumni Research Foundation Device and methods for liquid crystal-based bioagent detection
US7732152B2 (en) 2005-11-30 2010-06-08 Wisconsin Alumni Research Foundation Liquid crystalline substrates for culturing cells
US7842499B2 (en) 2006-08-07 2010-11-30 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
EP2193365A4 (en) 2007-08-20 2015-05-13 Platypus Technologies Llc Improved devices for cell assays

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551264A (en) * 1982-03-13 1985-11-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Polyhalogenoaromatic compounds for liquid crystal compositions
US6858423B1 (en) * 1998-06-05 2005-02-22 The Regents Of The University Of California Optical Amplification of molecular interactions using liquid crystals

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US20070099249A1 (en) 2007-05-03
US7662572B2 (en) 2010-02-16
WO2007025129A2 (en) 2007-03-01

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