WO2007021557A3 - Optical tomography of small objects using parallel ray illumination and post-specimen optical magnification - Google Patents

Optical tomography of small objects using parallel ray illumination and post-specimen optical magnification Download PDF

Info

Publication number
WO2007021557A3
WO2007021557A3 PCT/US2006/030155 US2006030155W WO2007021557A3 WO 2007021557 A3 WO2007021557 A3 WO 2007021557A3 US 2006030155 W US2006030155 W US 2006030155W WO 2007021557 A3 WO2007021557 A3 WO 2007021557A3
Authority
WO
WIPO (PCT)
Prior art keywords
optical
post
small objects
parallel ray
interest
Prior art date
Application number
PCT/US2006/030155
Other languages
French (fr)
Other versions
WO2007021557A2 (en
Inventor
Michael G Meyer
John Richard Rahn
Alan C Nelson
Roger H Johnson
Original Assignee
Visiongate Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Visiongate Inc filed Critical Visiongate Inc
Publication of WO2007021557A2 publication Critical patent/WO2007021557A2/en
Publication of WO2007021557A3 publication Critical patent/WO2007021557A3/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4795Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G01N15/1433
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N15/147Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream

Abstract

A shadowgram optical tomography system for imaging an object of interest (1). The shadowgram optical tomography system includes a parallel ray light source (35) for illuminating the object of interest (1) with a plurality of parallel radiation beams (36), an object containing tube (304), where the object of interest (1) is held within the object containing tube (304) such that it is illuminated by the plurality of parallel radiation beams (36) to produce emerging radiation (61) from the object containing tube (304), a detector array (39) located to receive the emerging radiation (61), and a system and method for tracking an image of the object of interest (1).
PCT/US2006/030155 2005-08-15 2006-08-02 Optical tomography of small objects using parallel ray illumination and post-specimen optical magnification WO2007021557A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/203,878 2005-08-15
US11/203,878 US20060023219A1 (en) 2001-03-28 2005-08-15 Optical tomography of small objects using parallel ray illumination and post-specimen optical magnification

Publications (2)

Publication Number Publication Date
WO2007021557A2 WO2007021557A2 (en) 2007-02-22
WO2007021557A3 true WO2007021557A3 (en) 2007-11-15

Family

ID=37758053

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/030155 WO2007021557A2 (en) 2005-08-15 2006-08-02 Optical tomography of small objects using parallel ray illumination and post-specimen optical magnification

Country Status (2)

Country Link
US (1) US20060023219A1 (en)
WO (1) WO2007021557A2 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7907765B2 (en) * 2001-03-28 2011-03-15 University Of Washington Focal plane tracking for optical microtomography
ITUD20050118A1 (en) * 2005-07-13 2007-01-14 Sire Analytical Systems Srl PROCEDURE FOR THE CALIBRATION OF MACHINES FOR THE ANALYSIS OF BLOOD PARAMETERS CONNECTED TO THE BLOOD DENSITY, SUCH AS THE ERITROSEDIMENTATION AND / OR AGGREGATION SPEED OF THE RED GLOBULES
US7996188B2 (en) 2005-08-22 2011-08-09 Accuri Cytometers, Inc. User interface for a flow cytometer system
US8017402B2 (en) 2006-03-08 2011-09-13 Accuri Cytometers, Inc. Fluidic system for a flow cytometer
US8303894B2 (en) 2005-10-13 2012-11-06 Accuri Cytometers, Inc. Detection and fluidic system of a flow cytometer
US8031340B2 (en) * 2006-02-22 2011-10-04 Accuri Cytometers, Inc. Optical system for a flow cytometer
US8149402B2 (en) * 2006-02-22 2012-04-03 Accuri Cytometers, Inc. Optical system for a flow cytometer
US7780916B2 (en) 2006-03-08 2010-08-24 Accuri Cytometers, Inc. Flow cytometer system with unclogging feature
US8283177B2 (en) 2006-03-08 2012-10-09 Accuri Cytometers, Inc. Fluidic system with washing capabilities for a flow cytometer
US8715573B2 (en) 2006-10-13 2014-05-06 Accuri Cytometers, Inc. Fluidic system for a flow cytometer with temporal processing
US8445286B2 (en) * 2006-11-07 2013-05-21 Accuri Cytometers, Inc. Flow cell for a flow cytometer system
US7739060B2 (en) * 2006-12-22 2010-06-15 Accuri Cytometers, Inc. Detection system and user interface for a flow cytometer system
US7867778B2 (en) * 2007-02-23 2011-01-11 Visiongate, Inc. Fluid focusing for positional control of a specimen for 3-D imaging
DE102007015061A1 (en) * 2007-03-29 2008-10-02 Carl Zeiss Microimaging Gmbh Sample holder for a microscope
US7835561B2 (en) 2007-05-18 2010-11-16 Visiongate, Inc. Method for image processing and reconstruction of images for optical tomography
DE102007047461A1 (en) * 2007-09-28 2009-04-02 Carl Zeiss Microimaging Gmbh Method and optical arrangement for examining a sample
DE102007048409A1 (en) * 2007-10-09 2009-04-16 Carl Zeiss Microimaging Gmbh Method for positioning biological samples in a microscopic arrangement
US7787112B2 (en) 2007-10-22 2010-08-31 Visiongate, Inc. Depth of field extension for optical tomography
US8432541B2 (en) 2007-12-17 2013-04-30 Accuri Cytometers, Inc. Optical system for a flow cytometer with an interrogation zone
US7843561B2 (en) 2007-12-17 2010-11-30 Accuri Cytometers, Inc. Optical system for a flow cytometer with an interrogation zone
US8143600B2 (en) 2008-02-18 2012-03-27 Visiongate, Inc. 3D imaging of live cells with ultraviolet radiation
US8090183B2 (en) 2009-03-12 2012-01-03 Visiongate, Inc. Pattern noise correction for pseudo projections
WO2009155151A2 (en) * 2008-06-20 2009-12-23 Visiongate, Inc. Functional imaging of cells optical projection tomography
US8254023B2 (en) * 2009-02-23 2012-08-28 Visiongate, Inc. Optical tomography system with high-speed scanner
US8155420B2 (en) * 2009-05-21 2012-04-10 Visiongate, Inc System and method for detecting poor quality in 3D reconstructions
US8507279B2 (en) 2009-06-02 2013-08-13 Accuri Cytometers, Inc. System and method of verification of a prepared sample for a flow cytometer
JP2011095181A (en) * 2009-10-30 2011-05-12 Sysmex Corp Particle analyzer
WO2011106402A1 (en) 2010-02-23 2011-09-01 Accuri Cytometers, Inc. Method and system for detecting fluorochromes in a flow cytometer
US9551600B2 (en) 2010-06-14 2017-01-24 Accuri Cytometers, Inc. System and method for creating a flow cytometer network
CN103168225B (en) 2010-10-25 2015-11-25 阿库里赛托梅特斯公司 For collecting system and the user interface of the data set in flow cytometer
US9939379B2 (en) * 2012-10-15 2018-04-10 Pharmaseq, Inc. Compact analyzer for acquiring characteristics of small tabs placed in a vessel
EP2851730A1 (en) * 2013-09-18 2015-03-25 Hochschule Aalen Sample holder for rotation of three-dimensional specimens in microscopy
JP2017512999A (en) * 2014-03-25 2017-05-25 マルバーン インストゥルメンツ リミテッド Structural investigation of proteins dispersed in liquid phase by Raman spectroscopy
US11069054B2 (en) 2015-12-30 2021-07-20 Visiongate, Inc. System and method for automated detection and monitoring of dysplasia and administration of immunotherapy and chemotherapy
CN110892421A (en) * 2017-05-29 2020-03-17 根特大学 Mixed wave based computation
CN108445052B (en) * 2018-06-15 2023-06-06 华北电力大学(保定) Static experimental platform for capacitance tomography and application method thereof
US11128129B2 (en) * 2019-04-08 2021-09-21 Kandou Labs, S.A. Distributed electrostatic discharge scheme to improve analog front-end bandwidth of receiver in high-speed signaling system
US11546129B2 (en) 2020-02-14 2023-01-03 P-Chip Ip Holdings Inc. Light-triggered transponder
CN111812131B (en) 2020-07-21 2020-12-25 中国科学院地质与地球物理研究所 Visual test system and method for secondary generation or decomposition process of hydrate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6091983A (en) * 1997-02-07 2000-07-18 Alfano; Robert R. Imaging of objects in turbid media based upon the preservation of polarized luminescence emitted from contrast agents

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470373A (en) * 1966-10-18 1969-09-30 Litton Systems Inc Method for analysis and identification of biologic entities by phosphorescence
US3497690A (en) * 1967-09-21 1970-02-24 Bausch & Lomb Method and apparatus for classifying biological cells by measuring the size and fluorescent response thereof
US3598471A (en) * 1968-11-22 1971-08-10 Corning Glass Works Optical contrast enhancement system
US3657537A (en) * 1970-04-03 1972-04-18 Bausch & Lomb Computerized slit-scan cyto-fluorometer for automated cell recognition
US3748468A (en) * 1971-12-22 1973-07-24 Gen Electric Automatic electron microscope field counter
US3999047A (en) * 1972-09-05 1976-12-21 Green James E Method and apparatus utilizing color algebra for analyzing scene regions
US3833762A (en) * 1973-06-04 1974-09-03 Rockwell International Corp Solid state integrating, image motion compensating imager
US4200353A (en) * 1974-06-05 1980-04-29 Robert Hoffman Modulation contrast microscope with three regions
US3960449A (en) * 1975-06-05 1976-06-01 The Board Of Trustees Of Leland Stanford Junior University Measurement of angular dependence of scattered light in a flowing stream
US4175860A (en) * 1977-05-31 1979-11-27 Rush-Presbyterian-St. Luke's Medical Center Dual resolution method and apparatus for use in automated classification of pap smear and other samples
US4183623A (en) * 1977-10-11 1980-01-15 Haines Kenneth A Tomographic cross-sectional imaging using incoherent optical processing
US4293221A (en) * 1979-04-17 1981-10-06 Research Corporation Multidimensional slit-scan flow system
US4360885A (en) * 1980-01-02 1982-11-23 Edgar Albert D Micro-optical tomography
DE3424108A1 (en) * 1984-06-29 1986-01-09 Bernhard Prof. Dr.-Ing. 4300 Essen Schrader SPECTROMETRY SAMPLE ARRANGEMENT, METHOD FOR MEASURING LUMINESCENCE AND SCATTERING AND USE OF THE SAMPLE ARRANGEMENT
US5281517A (en) * 1985-11-04 1994-01-25 Cell Analysis Systems, Inc. Methods for immunoploidy analysis
US4873653A (en) * 1986-04-09 1989-10-10 Carl-Zeiss-Stiftung Microscope system for providing three-dimensional resolution
US4858128A (en) * 1986-08-11 1989-08-15 General Electric Company View-to-view image correction for object motion
US4891829A (en) * 1986-11-19 1990-01-02 Exxon Research And Engineering Company Method and apparatus for utilizing an electro-optic detector in a microtomography system
DE3905619C2 (en) * 1988-02-23 2000-04-13 Olympus Optical Co Image input / output device
US5141609A (en) * 1990-11-16 1992-08-25 The Trustees Of The Leland Stanford Junior University Method and device employing time-delayed integration for detecting sample components after separation
EP0581871B2 (en) * 1991-04-29 2009-08-12 Massachusetts Institute Of Technology Apparatus for optical imaging and measurement
JPH04337446A (en) * 1991-05-15 1992-11-25 Hitachi Ltd Method and device for measuring fine grain and constant quantity method
GB9218482D0 (en) * 1992-09-01 1992-10-14 Dixon Arthur E Apparatus and method for scanning laser imaging of macroscopic samples
US5668887A (en) * 1992-05-29 1997-09-16 Eastman Kodak Company Coating density analyzer and method using non-synchronous TDI camera
JP3327948B2 (en) * 1992-06-09 2002-09-24 オリンパス光学工業株式会社 Optical image reconstruction device
US5312535A (en) * 1992-07-17 1994-05-17 Beckman Instruments, Inc. Capillary electrophoresis detection
US6159686A (en) * 1992-09-14 2000-12-12 Sri International Up-converting reporters for biological and other assays
US6026174A (en) * 1992-10-14 2000-02-15 Accumed International, Inc. System and method for automatically detecting malignant cells and cells having malignancy-associated changes
US5402460A (en) * 1993-08-02 1995-03-28 University Of Washington Three-dimensional microtomographic analysis system
US6215587B1 (en) * 1994-02-14 2001-04-10 Robert R. Alfano Microscope imaging inside highly scattering media
WO1996009594A1 (en) * 1994-09-20 1996-03-28 Neopath, Inc. Apparatus for automated identification of thick cell groupings on a biological specimen
US5710429A (en) * 1995-04-06 1998-01-20 Alfano; Robert R. Ultrafast optical imaging of objects in or behind scattering media
US5582705A (en) * 1995-05-19 1996-12-10 Iowa State University Research Foundation, Inc. Multiplexed capillary electrophoresis system
US6252979B1 (en) * 1995-06-07 2001-06-26 Tripath Imaging, Inc. Interactive method and apparatus for sorting biological specimens
JP2000500322A (en) * 1995-10-02 2000-01-18 アメリカ合衆国 Epithelial proteins and their DNA for use in early cancer detection
FI97665C (en) * 1995-11-21 1997-01-27 Planmed Oy Procedures and apparatus for photographing an object
US6165734A (en) * 1995-12-12 2000-12-26 Applied Spectral Imaging Ltd. In-situ method of analyzing cells
FR2743462B1 (en) * 1996-01-04 1998-01-30 Commissariat Energie Atomique DEVICE FOR READING DETECTOR ARRAYS WITH TDI EFFECT
JPH09247545A (en) * 1996-03-11 1997-09-19 Matsushita Electric Ind Co Ltd Scanner type electronic camera
US6038067A (en) * 1996-05-23 2000-03-14 The Regents Of The University Of California Scanning computed confocal imager
US5915048A (en) * 1996-06-05 1999-06-22 Zetetic Institute Method and apparatus for discriminating in-focus images from out-of-focus light signals from background and foreground light sources
US5880838A (en) * 1996-06-05 1999-03-09 California Institute Of California System and method for optically measuring a structure
US6047080A (en) * 1996-06-19 2000-04-04 Arch Development Corporation Method and apparatus for three-dimensional reconstruction of coronary vessels from angiographic images
ATE271829T1 (en) * 1996-11-29 2004-08-15 Imaging Diagnostic Systems Inc METHOD FOR IMAGING A BODY BY SCANNING BY A LASER IMAGING DEVICE
US5760901A (en) * 1997-01-28 1998-06-02 Zetetic Institute Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation
DE19714221A1 (en) * 1997-04-07 1998-10-08 Zeiss Carl Fa Confocal microscope with a motorized scanning table
US5878103A (en) * 1997-06-30 1999-03-02 Siemens Corporate Research, Inc. Adaptive detector masking for speed-up of cone beam reconstruction
US5909476A (en) * 1997-09-22 1999-06-01 University Of Iowa Research Foundation Iterative process for reconstructing cone-beam tomographic images
US6388809B1 (en) * 1997-10-29 2002-05-14 Digital Optical Imaging Corporation Methods and apparatus for improved depth resolution use of out-of-focus information in microscopy
CA2310672A1 (en) * 1997-11-19 1999-05-27 University Of Washington High throughput optical scanner
US6251615B1 (en) * 1998-02-20 2001-06-26 Cell Analytics, Inc. Cell analysis methods
US6248988B1 (en) * 1998-05-05 2001-06-19 Kla-Tencor Corporation Conventional and confocal multi-spot scanning optical microscope
US6529614B1 (en) * 1998-08-05 2003-03-04 California Institute Of Technology Advanced miniature processing handware for ATR applications
AU763570B2 (en) * 1998-08-14 2003-07-24 Spectro Scientific, Inc. On-site analyzer
US6640014B1 (en) * 1999-01-22 2003-10-28 Jeffrey H. Price Automatic on-the-fly focusing for continuous image acquisition in high-resolution microscopy
US6249341B1 (en) * 1999-01-25 2001-06-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6239871B1 (en) * 1999-08-24 2001-05-29 Waters Investments Limited Laser induced fluorescence capillary interface
ATE502295T1 (en) * 2000-12-15 2011-04-15 Kla Tencor Corp METHOD AND DEVICE FOR EXAMINING A SUBSTRATE
US6944322B2 (en) * 2001-03-28 2005-09-13 Visiongate, Inc. Optical tomography of small objects using parallel ray illumination and post-specimen optical magnification
US6522775B2 (en) * 2001-03-28 2003-02-18 Alan C. Nelson Apparatus and method for imaging small objects in a flow stream using optical tomography
US6591003B2 (en) * 2001-03-28 2003-07-08 Visiongate, Inc. Optical tomography of small moving objects using time delay and integration imaging
US6519355B2 (en) * 2001-03-28 2003-02-11 Alan C. Nelson Optical projection imaging system and method for automatically detecting cells having nuclear and cytoplasmic densitometric features associated with disease
US6636623B2 (en) * 2001-08-10 2003-10-21 Visiongate, Inc. Optical projection imaging system and method for automatically detecting cells with molecular marker compartmentalization associated with malignancy and disease
US6741730B2 (en) * 2001-08-10 2004-05-25 Visiongate, Inc. Method and apparatus for three-dimensional imaging in the fourier domain
US7283253B2 (en) * 2002-03-13 2007-10-16 Applied Precision, Llc Multi-axis integration system and method
US7260253B2 (en) * 2002-04-19 2007-08-21 Visiongate, Inc. Method for correction of relative object-detector motion between successive views
US7811825B2 (en) * 2002-04-19 2010-10-12 University Of Washington System and method for processing specimens and images for optical tomography
US7738945B2 (en) * 2002-04-19 2010-06-15 University Of Washington Method and apparatus for pseudo-projection formation for optical tomography
US20050085708A1 (en) * 2002-04-19 2005-04-21 University Of Washington System and method for preparation of cells for 3D image acquisition
US7197355B2 (en) * 2002-04-19 2007-03-27 Visiongate, Inc. Variable-motion optical tomography of small objects
US6697508B2 (en) * 2002-05-10 2004-02-24 Visiongate, Inc. Tomographic reconstruction of small objects using a priori knowledge
US6770893B2 (en) * 2002-05-13 2004-08-03 Visiongate, Inc. Method and apparatus for emission computed tomography using temporal signatures
US20040008515A1 (en) * 2002-06-11 2004-01-15 Applied Precision Fluorescence illumination optimization for three-dimensional microscopy
US7408176B2 (en) * 2003-06-19 2008-08-05 Applied Precision, Llc System and method employing photokinetic techniques in cell biology imaging applications

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6091983A (en) * 1997-02-07 2000-07-18 Alfano; Robert R. Imaging of objects in turbid media based upon the preservation of polarized luminescence emitted from contrast agents

Also Published As

Publication number Publication date
US20060023219A1 (en) 2006-02-02
WO2007021557A2 (en) 2007-02-22

Similar Documents

Publication Publication Date Title
WO2007021557A3 (en) Optical tomography of small objects using parallel ray illumination and post-specimen optical magnification
WO2004051565A3 (en) Optical tomography of small objects using parallel ray illumination and post-specimen optical magnification
IL194851A (en) X-ray imaging of baggage and personnel using arrays of discrete sources and multiple collimated beams
TW200739061A (en) Method and system for inspecting surfaces with improved light efficiency
WO2007111669A3 (en) Combined x-ray and optical tomographic imaging system
WO2007030741A3 (en) Imaging system using dynamic speckle illumination
WO2005008200A3 (en) Method and apparatus for compact dispersive imaging spectrometer
WO2003060423A8 (en) Apparatus for low coherence ranging
WO2009009414A3 (en) Simultaneous acquisition of differing image types
WO2004081227A3 (en) Optical imaging apparatus and method
EP1718084A3 (en) Illumination unit and image projection apparatus having the same
EP2191774A3 (en) Systems and methods for in-vivo optical imaging and measurement
EP1705708A3 (en) Detector assembly and method of manufacture
EP2261723A3 (en) Illumination optical system and image display apparatus making use thereof
WO2008125605A3 (en) Method and assembly for optical reproduction with depth discrimination
RU2005118398A (en) SYSTEM AND METHOD FOR DETECTING SURFACE DEFECTS OF AN EXTENDED BAR, MOVED IN THE DIRECTION OF ITS LONGITUDINAL AXIS
DE60303613D1 (en) OPTICAL PROJECTION TOMOGRAPHY
CN107102008B (en) Detection and/or track monitoring device and method of operation and use of arrangement in device
BR0315850A (en) Method and device for imaging quantum efficiency of the photosynthetic system for the purpose of determining the quality of plant material and a method and device for measuring, classifying and choosing plant material
WO2005069841A3 (en) Optical analysis systems
EP1898648A3 (en) One-dimensional illumination apparatus and image generating apparatus
CN106461927A (en) Imaging device for a microscope
WO2013025691A3 (en) System and method for diffuse imaging with time-varying illumination intensity
EP1797818A3 (en) Method and system for tomographic imaging using fluorescent proteins
WO2008021834A3 (en) High-resolution microscope using optical amplification

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06800676

Country of ref document: EP

Kind code of ref document: A2