WO2007019479A3 - Multi-channel flow cells - Google Patents
Multi-channel flow cells Download PDFInfo
- Publication number
- WO2007019479A3 WO2007019479A3 PCT/US2006/030824 US2006030824W WO2007019479A3 WO 2007019479 A3 WO2007019479 A3 WO 2007019479A3 US 2006030824 W US2006030824 W US 2006030824W WO 2007019479 A3 WO2007019479 A3 WO 2007019479A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- channels
- flow cell
- loading
- outlet
- channel
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00513—Essentially linear supports
- B01J2219/0052—Essentially linear supports in the shape of elongated tubes
- B01J2219/00522—Essentially linear supports in the shape of elongated tubes in a multiple parallel arrangement
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
- B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
- B01L2300/163—Biocompatibility
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
- B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
Abstract
A multi-channel flow cell can allow for reduced cross-contamination in sample loading and the ability to observe activity within the flow cell once the channels are loaded. A multi-channel flow cell includes a plurality of independently-addressable channels sandwiched between a two substrates. Each of the channels can be coated with a layer that facilitates support-binding of an analyte. Each of the channels terminates on one end in an inlet and on the other end in an outlet. A loading block having inlet ports that match the inlets of the channels can be mated to the inlets of the channels, and an outlet block can be mated to the outlets of the channels. Analytes can be introduced into the channels via the inlet ports of the loading block and are pulled through the channels by capillary action or by vacuum. Once analyte has been introduced into each of the channels, the loading and outlet blocks can be removed and the device turned over. Such a flow cell can be used for streamlining the process of reaction and interrogation of biochemical assays at the microfluidic level. Reagents can be introduced into each of the channels of the flow cell for chemical reactions therein, excess reagent being washed out through the channel outlets. Observation of optically-detectable moieties is then conducted. With such a flow cell optical labels associated with incorporation in a sequencing-by-synthesis reaction can be observed.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008525280A JP2009503555A (en) | 2005-08-04 | 2006-08-04 | Multi-channel flow cell |
US11/997,382 US20090129980A1 (en) | 2005-08-04 | 2006-08-04 | Multi-Channel Flow Cells |
EP06789561A EP1910688A4 (en) | 2005-08-04 | 2006-08-04 | Multi-channel flow cells |
CA002617606A CA2617606A1 (en) | 2005-08-04 | 2006-08-04 | Multi-channel flow cells |
US12/043,116 US20080219890A1 (en) | 2005-08-04 | 2008-03-05 | Sample loading and recovery |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70584705P | 2005-08-04 | 2005-08-04 | |
US60/705,847 | 2005-08-04 | ||
US81342806P | 2006-06-13 | 2006-06-13 | |
US60/813,428 | 2006-06-13 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/043,116 Continuation-In-Part US20080219890A1 (en) | 2005-08-04 | 2008-03-05 | Sample loading and recovery |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007019479A2 WO2007019479A2 (en) | 2007-02-15 |
WO2007019479A3 true WO2007019479A3 (en) | 2007-09-20 |
Family
ID=37727991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/030824 WO2007019479A2 (en) | 2005-08-04 | 2006-08-04 | Multi-channel flow cells |
Country Status (5)
Country | Link |
---|---|
US (2) | US20090129980A1 (en) |
EP (1) | EP1910688A4 (en) |
JP (1) | JP2009503555A (en) |
CA (1) | CA2617606A1 (en) |
WO (1) | WO2007019479A2 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3492602A1 (en) | 2005-06-15 | 2019-06-05 | Complete Genomics, Inc. | Single molecule arrays for genetic and chemical analysis |
US8975216B2 (en) | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
AU2012216605C1 (en) * | 2006-03-30 | 2014-11-06 | Pacific Biosciences Of California, Inc. | Articles having localized molecules disposed thereon and methods of producing same |
JP5122555B2 (en) * | 2006-03-31 | 2013-01-16 | ソレクサ・インコーポレイテッド | Synthetic sequencing system and apparatus |
EP2200744B1 (en) | 2007-09-14 | 2020-05-27 | Biosensia Patents Limited | An analysis system |
US20120028822A1 (en) * | 2008-11-04 | 2012-02-02 | Helicos Biosciences Corporation | Methods, flow cells and systems for single cell analysis |
US20100261185A1 (en) | 2009-03-27 | 2010-10-14 | Life Technologies Corporation | Labeled enzyme compositions, methods and systems |
JP5424723B2 (en) * | 2009-06-03 | 2014-02-26 | ベックマン コールター, インコーポレイテッド | Microfluidic chip and mixing method |
US8501406B1 (en) | 2009-07-14 | 2013-08-06 | Pacific Biosciences Of California, Inc. | Selectively functionalized arrays |
WO2011026136A1 (en) | 2009-08-31 | 2011-03-03 | Life Technologies Corporation | Low-volume sequencing system and method of use |
US9199232B2 (en) | 2010-04-07 | 2015-12-01 | Biosensia Patents Limited | Flow control device for assays |
JP2013527769A (en) | 2010-05-06 | 2013-07-04 | アイビス バイオサイエンシズ インコーポレイティッド | Integrated sample preparation system and stabilized enzyme mixture |
US8951781B2 (en) * | 2011-01-10 | 2015-02-10 | Illumina, Inc. | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
WO2012123750A1 (en) | 2011-03-15 | 2012-09-20 | Carclo Technical Plastics Limited | Surface preparation |
US9958438B2 (en) | 2011-09-30 | 2018-05-01 | Ge Healthcare Bio-Sciences Ab | Multi-channel flowcell |
US9803239B2 (en) | 2012-03-29 | 2017-10-31 | Complete Genomics, Inc. | Flow cells for high density array chips |
US9346063B2 (en) * | 2012-04-30 | 2016-05-24 | Life Technologies Corporation | Centrifuge and method for loading a device |
EP3473905B1 (en) | 2013-01-25 | 2020-07-29 | Bio-rad Laboratories, Inc. | System and method for performing droplet inflation |
JP6288650B2 (en) * | 2013-03-19 | 2018-03-07 | 国立研究開発法人理化学研究所 | Flow cell for nucleic acid sequencing |
JP5941092B2 (en) * | 2014-04-14 | 2016-06-29 | アークレイ株式会社 | Analysis apparatus and analysis method |
EP3212757A4 (en) * | 2014-10-27 | 2018-07-04 | The Governing Council of the University of Toronto | Microfluidic device for cell-based assays |
RU2016151351A (en) * | 2015-01-28 | 2019-02-28 | КАБУСИКИ КАЙСЯ ДиЭнЭйФОРМ | ANALYSIS DEVICE, ANALYSIS CHIP, ANALYSIS KIT AND METHOD OF ANALYSIS WITH THEIR APPLICATION |
CN107376796B (en) * | 2017-07-10 | 2019-09-17 | 于志远 | A kind of processing method and microreactor of microreactor |
US11287422B2 (en) * | 2019-09-23 | 2022-03-29 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
US20220339632A1 (en) | 2019-09-27 | 2022-10-27 | Mgi Tech Co., Ltd. | Flow cell and biochemical substance reaction device using the flow cell |
CN113933227B (en) * | 2021-12-17 | 2022-03-18 | 睿克环境科技(中国)有限公司 | Multi-channel microscopic observation counting frame and clamping device with same |
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US5520787A (en) * | 1994-02-09 | 1996-05-28 | Abbott Laboratories | Diagnostic flow cell device |
US5644395A (en) * | 1995-07-14 | 1997-07-01 | Regents Of The University Of California | Miniaturized flow injection analysis system |
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US6649348B2 (en) * | 2001-06-29 | 2003-11-18 | Agilent Technologies Inc. | Methods for manufacturing arrays |
US6788409B2 (en) * | 2001-09-07 | 2004-09-07 | Becton, Dickinson And Company | Flow cell system for solubility testing |
US6911345B2 (en) * | 1999-06-28 | 2005-06-28 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
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-
2006
- 2006-08-04 WO PCT/US2006/030824 patent/WO2007019479A2/en active Application Filing
- 2006-08-04 JP JP2008525280A patent/JP2009503555A/en not_active Withdrawn
- 2006-08-04 US US11/997,382 patent/US20090129980A1/en not_active Abandoned
- 2006-08-04 CA CA002617606A patent/CA2617606A1/en not_active Abandoned
- 2006-08-04 EP EP06789561A patent/EP1910688A4/en not_active Withdrawn
-
2007
- 2007-10-30 US US11/928,799 patent/US20080219888A1/en not_active Abandoned
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Publication number | Priority date | Publication date | Assignee | Title |
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US6540961B1 (en) * | 1993-11-01 | 2003-04-01 | Nanogen, Inc. | Multicomponent devices for molecular biological analysis and diagnostics |
US5520787A (en) * | 1994-02-09 | 1996-05-28 | Abbott Laboratories | Diagnostic flow cell device |
US5644395A (en) * | 1995-07-14 | 1997-07-01 | Regents Of The University Of California | Miniaturized flow injection analysis system |
US6911345B2 (en) * | 1999-06-28 | 2005-06-28 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US6649348B2 (en) * | 2001-06-29 | 2003-11-18 | Agilent Technologies Inc. | Methods for manufacturing arrays |
US6788409B2 (en) * | 2001-09-07 | 2004-09-07 | Becton, Dickinson And Company | Flow cell system for solubility testing |
Also Published As
Publication number | Publication date |
---|---|
WO2007019479A2 (en) | 2007-02-15 |
US20090129980A1 (en) | 2009-05-21 |
CA2617606A1 (en) | 2007-02-15 |
EP1910688A4 (en) | 2010-03-03 |
US20080219888A1 (en) | 2008-09-11 |
JP2009503555A (en) | 2009-01-29 |
EP1910688A2 (en) | 2008-04-16 |
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